' 
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Directly studies folic acid effects
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
Read More
7
Vitamin B12 and hypothyroid patients
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
Direct relevance to hypothyroid treatment
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Read More
9
Folate may aid hypothyroid treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
Relevant but mixed findings
We aimed to discover how certain B vitamins, particularly folate, could influence homocysteine metabolism in rats suffering from hypothyroidism. Through our study, we created conditions that mimicked hyperthyroidism and hypothyroidism in the animals over a period of 21 days.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Read More
Most Useful Reviews
8.8
Improved well-being
I adore this shape! This is my preferred form of vitamin B12, and the quality is outstanding. Following my endocrinologist's advice, I take it due to my AIT, hypothyroidism, and anaemia. I can’t manage without vitamin B12. The swelling has subsided, my overall health has improved, and my hair and nails are in much better condition! I’m delighted with the results! Wishing everyone good health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.3
- All Researches
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Directly studies folic acid effects
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
Read More
9
Folate may aid hypothyroid treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
Relevant but mixed findings
We aimed to discover how certain B vitamins, particularly folate, could influence homocysteine metabolism in rats suffering from hypothyroidism. Through our study, we created conditions that mimicked hyperthyroidism and hypothyroidism in the animals over a period of 21 days.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Read More
7
Folic acid may aid thyroid function
Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring.
Relevant but not definitive results.
We explored how different doses of lithium during pregnancy affected the neurodevelopment of offspring in rats, while evaluating if folic acid could provide any protective benefits. Pregnant rats were divided into various groups, including those exposed to high doses of lithium and others receiving folic acid alongside lithium treatment. More specifically, we examined how folic acid might lessen the negative effects associated with lithium administration, particularly concerning thyroid function.
Our observations revealed that high doses of lithium led to significant disruptions in both behavioral and biochemical markers linked to thyroid health. This included imbalances in thyroid hormones and evidence of oxidative stress. However, when we introduced folic acid at the highest dose, we found promising improvements. Folic acid appeared to reduce memory impairments and anxiety-like behaviors, along with improving antioxidant and anti-inflammatory indicators compared to groups receiving only lithium.
While our findings suggest that folic acid could offer protective effects during lithium treatment and hypothyroidism, we must also consider that lithium poses clear risks when prescribed to pregnant individuals. We emphasize that further research is necessary to fully understand the relationship between folic acid and thyroid function in such contexts.
Our observations revealed that high doses of lithium led to significant disruptions in both behavioral and biochemical markers linked to thyroid health. This included imbalances in thyroid hormones and evidence of oxidative stress. However, when we introduced folic acid at the highest dose, we found promising improvements. Folic acid appeared to reduce memory impairments and anxiety-like behaviors, along with improving antioxidant and anti-inflammatory indicators compared to groups receiving only lithium.
While our findings suggest that folic acid could offer protective effects during lithium treatment and hypothyroidism, we must also consider that lithium poses clear risks when prescribed to pregnant individuals. We emphasize that further research is necessary to fully understand the relationship between folic acid and thyroid function in such contexts.
Read More
7
Vitamin B12 and hypothyroid patients
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
Direct relevance to hypothyroid treatment
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Read More
4
Hypothyroidism linked to B12 deficiency
Thyroid function and its association with vitamin deficiencies: a case-control study in Duhok.
Association noted, treatment effect unclear
Our research centered on exploring how vitamin B12 levels relate to hypothyroidism, a condition where the thyroid doesn’t produce enough hormones. We analyzed data from a case-control study that included 885 participants, comparing 170 patients with hypothyroidism to 715 healthy individuals.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved well-being
I adore this shape! This is my preferred form of vitamin B12, and the quality is outstanding. Following my endocrinologist's advice, I take it due to my AIT, hypothyroidism, and anaemia. I can’t manage without vitamin B12. The swelling has subsided, my overall health has improved, and my hair and nails are in much better condition! I’m delighted with the results! Wishing everyone good health.
Read More
