' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.5
USERS' SCORE
Very Good
Based on 3 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Impact of Omega-3 on Cancer
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Highly relevant cancer treatment insights
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
8
Eicosapentaenoic acid in CRC treatment
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Supports PUFA role in cancer
We explored how eicosapentaenoic acid (EPA), a type of dietary polyunsaturated fatty acid, affects cancer, specifically focusing on colorectal cancer (CRC). In our research, we investigated five different CRC cell lines to see how EPA and two other fatty acids—docosahexaenoic acid (DHA) and linoleic acid (LA)—impact the methylation of the PPARγ promoter, as well as the expression of PPARγ and COX2.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Read More
8
Eicosapentaenoic acid aids breast cancer
Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns.
Highly relevant to cancer research
We conducted a comprehensive 12-month trial focusing on how eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation affects breast cancer in women with hormone receptor-negative (ERPR-) subtypes. Specifically, we assessed the impacts of doses ranging from 1 to 5 grams per day of EPA plus DHA on breast adipose tissue.
Throughout this double-blind, randomized study, we collected blood and breast adipose samples every three months to analyze various biomarker effects. Our findings revealed that higher doses of EPA and DHA significantly increased the concentrations of these essential fatty acids and their beneficial oxylipin metabolites.
Interestingly, we also noted that these changes produce noticeable shifts in DNA methylation, particularly in gene promoters that are crucial to the metabolism pathways associated with ERPR- breast cancer development. This suggests that dietary n-3 fatty acids, like EPA and DHA, may not only influence metabolic processes but also lead to epigenetic changes, potentially acting as a preventive measure against this aggressive cancer type.
Throughout this double-blind, randomized study, we collected blood and breast adipose samples every three months to analyze various biomarker effects. Our findings revealed that higher doses of EPA and DHA significantly increased the concentrations of these essential fatty acids and their beneficial oxylipin metabolites.
Interestingly, we also noted that these changes produce noticeable shifts in DNA methylation, particularly in gene promoters that are crucial to the metabolism pathways associated with ERPR- breast cancer development. This suggests that dietary n-3 fatty acids, like EPA and DHA, may not only influence metabolic processes but also lead to epigenetic changes, potentially acting as a preventive measure against this aggressive cancer type.
Read More
Most Useful Reviews
8.8
Cancer prevention benefits
"Mega" omega is wonderful fish oil of excellent quality! It contains a natural fish oil concentrate rich in polyunsaturated fatty acids, which dramatically lower cholesterol levels, supporting cardiovascular health. Omega 3 is noted for slowing tumour development and is effective in preventing cancer. It aids in skin disease treatment and improves healing. This supplement also normalises digestion and fat metabolism, alleviates arthritis pain, and is essential for brain activity. Recommended dosage is 3-4 capsules daily with meals.
Read More
8.8
Supports cancer prevention
Regular use of Omega-3 fish oil promotes heart health and prevents thrombosis development. It lowers 'bad' cholesterol and atherogenic triglycerides, providing essential building blocks for cell membranes and normal brain development. Omega-3 fatty acids reduce cancer risk and support the body against malignant tumours. I take Omega for three months and then take a break. The packaging is cost-effective and lasts a long time.
Read More
8.8
Helps alleviate cancer
Omega-3-PUFAs are essential as they cannot be synthesised by the body and must come from food. They are vital for cardiovascular health and benefit women, particularly in pregnancy, where they lower the risk of premature birth. Omega-3-PUFAs also relieve menopausal symptoms and can protect against breast cancer. I appreciate that this brand doesn’t cause fishy burps!
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.5
9.5
Omega-3 fatty acids inhibit tumors
Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model.
Strong link to cancer treatment
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
Read More
9
Impact of Omega-3 on Cancer
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Highly relevant cancer treatment insights
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
9
Eicosapentaenoic acid's role explored
Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis.
Score indicates mixed effectiveness.
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
Read More
9
EPA's role in cancer treatment
Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer.
Explains eicosapentaenoic acid effects
We focused our research on the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its derivatives known as specialized pro-resolving mediators (SPMs). These mediators have shown promise in playing a role in the resolution of inflammation, which is crucial in various health conditions, including cancer.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Read More
8
Eicosapentaenoic acid in CRC treatment
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Supports PUFA role in cancer
We explored how eicosapentaenoic acid (EPA), a type of dietary polyunsaturated fatty acid, affects cancer, specifically focusing on colorectal cancer (CRC). In our research, we investigated five different CRC cell lines to see how EPA and two other fatty acids—docosahexaenoic acid (DHA) and linoleic acid (LA)—impact the methylation of the PPARγ promoter, as well as the expression of PPARγ and COX2.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 3 Reviews
8.8
8.8
Cancer prevention benefits
"Mega" omega is wonderful fish oil of excellent quality! It contains a natural fish oil concentrate rich in polyunsaturated fatty acids, which dramatically lower cholesterol levels, supporting cardiovascular health. Omega 3 is noted for slowing tumour development and is effective in preventing cancer. It aids in skin disease treatment and improves healing. This supplement also normalises digestion and fat metabolism, alleviates arthritis pain, and is essential for brain activity. Recommended dosage is 3-4 capsules daily with meals.
Read More
8.8
Supports cancer prevention
Regular use of Omega-3 fish oil promotes heart health and prevents thrombosis development. It lowers 'bad' cholesterol and atherogenic triglycerides, providing essential building blocks for cell membranes and normal brain development. Omega-3 fatty acids reduce cancer risk and support the body against malignant tumours. I take Omega for three months and then take a break. The packaging is cost-effective and lasts a long time.
Read More
8.8
Helps alleviate cancer
Omega-3-PUFAs are essential as they cannot be synthesised by the body and must come from food. They are vital for cardiovascular health and benefit women, particularly in pregnancy, where they lower the risk of premature birth. Omega-3-PUFAs also relieve menopausal symptoms and can protect against breast cancer. I appreciate that this brand doesn’t cause fishy burps!
Read More
