Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
8
We explored the impact of a high omega-3, low omega-6 diet with fish oil on men with prostate cancer under active surveillance. In a year-long study involving 100 participants, those following the omega-rich regimen showed a notable 15% decrease in the Ki-67 index, a key marker for cancer progression.
In contrast, the control group experienced an increase in this index. While the diet showed promise in slowing down potential cancer growth, no significant differences were noted in other cancer-related measurements. Our findings encourage further research on dietary strategies in prostate cancer management.
In contrast, the control group experienced an increase in this index. While the diet showed promise in slowing down potential cancer growth, no significant differences were noted in other cancer-related measurements. Our findings encourage further research on dietary strategies in prostate cancer management.
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9
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Read More
8
Fish oil's preventive potential on cancer
We investigated how fish oil could help prevent skin cancer in mice exposed to specific carcinogens. The study included 70 Swiss albino mice divided into different groups, receiving fish oil either orally or topically, with some serving as controls.
While high doses of fish oil showed promising results, such as reduced cancer signs and decreased markers of oxidative stress, lower doses, notably 50 mg/kg/day, did not provide any benefits.
Overall, we found that fish oil has potential as a preventive treatment for skin cancer, especially at the right dosage.
While high doses of fish oil showed promising results, such as reduced cancer signs and decreased markers of oxidative stress, lower doses, notably 50 mg/kg/day, did not provide any benefits.
Overall, we found that fish oil has potential as a preventive treatment for skin cancer, especially at the right dosage.
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Most Useful Reviews
7.5
Cancer prevention benefits
33 people found this helpful
"Mega" omega is wonderful fish oil of excellent quality! It contains a natural fish oil concentrate rich in polyunsaturated fatty acids, which dramatically lower cholesterol levels, supporting cardiovascular health. Omega 3 is noted for slowing tumour development and is effective in preventing cancer. It aids in skin disease treatment and improves healing. This supplement also normalises digestion and fat metabolism, alleviates arthritis pain, and is essential for brain activity. Recommended dosage is 3-4 capsules daily with meals.
Read More
7.5
Supports cancer prevention
Regular use of Omega-3 fish oil promotes heart health and prevents thrombosis development. It lowers 'bad' cholesterol and atherogenic triglycerides, providing essential building blocks for cell membranes and normal brain development. Omega-3 fatty acids reduce cancer risk and support the body against malignant tumours. I take Omega for three months and then take a break. The packaging is cost-effective and lasts a long time.
Read More
7.5
Helps alleviate cancer
Omega-3-PUFAs are essential as they cannot be synthesised by the body and must come from food. They are vital for cardiovascular health and benefit women, particularly in pregnancy, where they lower the risk of premature birth. Omega-3-PUFAs also relieve menopausal symptoms and can protect against breast cancer. I appreciate that this brand doesn’t cause fishy burps!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.4
- All Researches
9.5
Omega-3 fatty acids inhibit tumors
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
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9
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Read More
We investigated the role of alpha-linolenic acid (ALA), a plant-based omega-3 found in perilla seed oil, in preventing colitis-associated colorectal cancer (CRC) using a mouse model.
Mice were given different diets, while only the control group received soybean oil.
The results showed that those on a 5% perilla seed oil diet had fewer tumors and lower markers of inflammation compared to those on fish oil or soybean oil.
Overall, perilla seed oil appeared to help slow tumor progression and restore gut health.
Mice were given different diets, while only the control group received soybean oil.
The results showed that those on a 5% perilla seed oil diet had fewer tumors and lower markers of inflammation compared to those on fish oil or soybean oil.
Overall, perilla seed oil appeared to help slow tumor progression and restore gut health.
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9
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
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9
We focused our research on the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its derivatives known as specialized pro-resolving mediators (SPMs). These mediators have shown promise in playing a role in the resolution of inflammation, which is crucial in various health conditions, including cancer.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cancer prevention benefits
33 people found this helpful
"Mega" omega is wonderful fish oil of excellent quality! It contains a natural fish oil concentrate rich in polyunsaturated fatty acids, which dramatically lower cholesterol levels, supporting cardiovascular health. Omega 3 is noted for slowing tumour development and is effective in preventing cancer. It aids in skin disease treatment and improves healing. This supplement also normalises digestion and fat metabolism, alleviates arthritis pain, and is essential for brain activity. Recommended dosage is 3-4 capsules daily with meals.
Read More
7.5
Supports cancer prevention
Regular use of Omega-3 fish oil promotes heart health and prevents thrombosis development. It lowers 'bad' cholesterol and atherogenic triglycerides, providing essential building blocks for cell membranes and normal brain development. Omega-3 fatty acids reduce cancer risk and support the body against malignant tumours. I take Omega for three months and then take a break. The packaging is cost-effective and lasts a long time.
Read More
7.5
Helps alleviate cancer
Omega-3-PUFAs are essential as they cannot be synthesised by the body and must come from food. They are vital for cardiovascular health and benefit women, particularly in pregnancy, where they lower the risk of premature birth. Omega-3-PUFAs also relieve menopausal symptoms and can protect against breast cancer. I appreciate that this brand doesn’t cause fishy burps!
Read More
Frequently Asked Questions
7.5
Supports cancer prevention
Regular use of Omega-3 fish oil promotes heart health and prevents thrombosis development. It lowers 'bad' cholesterol and atherogenic triglycerides, providing essential building blocks for cell membranes and normal brain development. Omega-3 fatty acids reduce cancer risk and support the body against malignant tumours. I take Omega for three months and then take a break. The packaging is cost-effective and lasts a long time.
7.5
Cancer prevention benefits
33 people found this helpful
"Mega" omega is wonderful fish oil of excellent quality! It contains a natural fish oil concentrate rich in polyunsaturated fatty acids, which dramatically lower cholesterol levels, supporting cardiovascular health. Omega 3 is noted for slowing tumour development and is effective in preventing cancer. It aids in skin disease treatment and improves healing. This supplement also normalises digestion and fat metabolism, alleviates arthritis pain, and is essential for brain activity. Recommended dosage is 3-4 capsules daily with meals.
7.5
Helps alleviate cancer
Omega-3-PUFAs are essential as they cannot be synthesised by the body and must come from food. They are vital for cardiovascular health and benefit women, particularly in pregnancy, where they lower the risk of premature birth. Omega-3-PUFAs also relieve menopausal symptoms and can protect against breast cancer. I appreciate that this brand doesn’t cause fishy burps!
7
Omega-3s may reduce cancer risk
We examined the connection between omega-3 fatty acids in the blood and the risk of colorectal cancer among UK Biobank participants. Our analysis showed that higher levels of omega-3s were linked to a decreased risk of developing colorectal cancer, especially in males and for proximal colon cancers.
Interestingly, the relationship was nonlinear, suggesting that benefits plateau at higher omega-3 concentrations. This study could influence nutritional guidelines if our findings are supported by further research in various populations.
Interestingly, the relationship was nonlinear, suggesting that benefits plateau at higher omega-3 concentrations. This study could influence nutritional guidelines if our findings are supported by further research in various populations.
9
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
7
We conducted a systematic review to evaluate how omega-3 supplementation affects the nutritional status of patients with pancreatic cancer. By examining multiple clinical trials, we found that omega-3s are generally safe and well-tolerated.
Most studies indicated that these supplements can help stabilize or increase body weight and reduce inflammation. This suggests that omega-3 fish oil may provide crucial support for those battling pancreatic cancer, enhancing their overall well-being.
Most studies indicated that these supplements can help stabilize or increase body weight and reduce inflammation. This suggests that omega-3 fish oil may provide crucial support for those battling pancreatic cancer, enhancing their overall well-being.
8
We examined the impact of omega-3 fish oil on chemotherapy-induced peripheral neuropathy (CIPN) in mice. Our findings indicate that this fish oil supplementation effectively prevented hypersensitivity caused by common chemotherapy drugs.
Over 30 days, it reduced neuroinflammation, which seems to be a key factor in mitigating pain and discomfort linked to treatments like paclitaxel and oxaliplatin.
By normalizing certain biochemical parameters, omega-3 fish oil holds potential to enhance the quality of life for cancer survivors facing CIPN.
Over 30 days, it reduced neuroinflammation, which seems to be a key factor in mitigating pain and discomfort linked to treatments like paclitaxel and oxaliplatin.
By normalizing certain biochemical parameters, omega-3 fish oil holds potential to enhance the quality of life for cancer survivors facing CIPN.
7
We looked into the use of omega-3 polyunsaturated fatty acids (PUFAs) in cancer treatment, finding that they are generally safe and can help reduce inflammation, potentially improving survival for some patients.
Despite these positive outcomes, the benefits can vary, and more comprehensive studies are needed. Current research is delving into how omega-3s may work alongside immunotherapy and impact young patients with leukemia.
Various elements like nutritional status and treatment side effects are being monitored, showing that while promising, we still need larger trials to clearly define their place in cancer care.
Despite these positive outcomes, the benefits can vary, and more comprehensive studies are needed. Current research is delving into how omega-3s may work alongside immunotherapy and impact young patients with leukemia.
Various elements like nutritional status and treatment side effects are being monitored, showing that while promising, we still need larger trials to clearly define their place in cancer care.
References
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- Melato J, Goldoni FC, Benvenutti L, Corrêa TP, Remor AP, et al. Omega-3-Enriched Fish oil reduces the chemotherapy-induced peripheral neuropathy in mice. Neuropharmacology. 2025;271:110384. doi:10.1016/j.neuropharm.2025.110384
- Cheniti H, Kadi A, Agred R, Kadi Y, Djeradi MK, et al. Fish Oil's Preventive Effect on Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Involvement of NF-ҝB Pathways and Oxidative Stress in a Dose- and Route Dependent Manner. Mol Nutr Food Res. 2025;69:e202400630. doi:10.1002/mnfr.202400630
- van der Meij B, Parsons S, Mazurak V. The impact of n-3 polyunsaturated fatty acids in patients with cancer: emerging themes. Curr Opin Clin Nutr Metab Care. 2025;28:75. doi:10.1097/MCO.0000000000001102
- Garay MI, Mazo T, Ferrero V, Barotto NN, Lagares C, et al. Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression. Carcinogenesis. 2025;46. doi:10.1093/carcin/bgae081
- Aldoori J, Zulyniak MA, Toogood GJ, Hull MA. Plasma n-3 Polyunsaturated Fatty Acid Levels and Colorectal Cancer Risk in the UK Biobank: Evidence of Nonlinearity, as Well as Tumor Site- and Sex-Specificity. Cancer Epidemiol Biomarkers Prev. 2025;34:394. doi:10.1158/1055-9965.EPI-24-1154
- Pires LBC, Salaroli LB, Podesta OPG, Haraguchi FK, Lopes-Júnior LC. Omega-3 Supplementation and Nutritional Status in Patients with Pancreatic Neoplasms: A Systematic Review. Nutrients. 2024;16. doi:10.3390/nu16234036
- Sun G, Fuller H, Fenton H, Race AD, Downing A, et al. The Relationship Between Dietary and Supplemental omega-3 Highly Unsaturated Fatty Acid Intake, Blood and Tissue omega-3 Highly Unsaturated Fatty Acid Concentrations, and Colorectal Polyp Recurrence: A Secondary Analysis of the seAFOod Polyp Prevention Trial. J Nutr. 2025;155:549. doi:10.1016/j.tjnut.2024.12.004
- Aronson WJ, Grogan T, Liang P, Jardack P, Liddell AR, et al. High Omega-3, Low Omega-6 Diet With Fish Oil for Men With Prostate Cancer on Active Surveillance: The CAPFISH-3 Randomized Clinical Trial. J Clin Oncol. 2025;43:800. doi:10.1200/JCO.24.00608
- Korsirikoon C, Techaniyom P, Kettawan A, Rungruang T, Metheetrairut C, et al. Cold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis in the AOM/DSS mice model of colitis-associated colorectal cancer. PLoS One. 2024;19:e0315172. doi:10.1371/journal.pone.0315172
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16223960
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. doi:10.1016/j.clnesp.2024.11.014
- Głowacka K, Ibanez S, Renoult O, Vermonden P, Giolito MV, et al. Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources. Nat Commun. 2024;15:10107. doi:10.1038/s41467-024-54435-3
- Machuca J, Wirkus J, Ead AS, Vahmani P, Matsukuma KE, et al. Dietary ω-3 Fatty Acids Mitigate Intestinal Barrier Integrity Alterations in Mice Fed a High-Fat Diet: Implications for Pancreatic Carcinogenesis. J Nutr. 2025;155:197. doi:10.1016/j.tjnut.2024.10.054
- Zhang Y, Sun Y, Song S, Khankari NK, Brenna JT, et al. Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: A population-based cohort study in UK Biobank. Int J Cancer. 2025;156:1154. doi:10.1002/ijc.35226
- Lam CS, Hua R, Loong HH, Chung VC, Cheung YT. Association between fish oil and glucosamine use and mortality in patients diagnosed with cancer: the role of the Life Essential 8 score and cancer prognosis. Nutr J. 2024;23:124. doi:10.1186/s12937-024-01032-1
- Elçi MP, Fatsa T, Ören S, Miser Salihoğlu E, Akaydın S. Investigation of the Effects of Polyunsaturated Fatty Acid Ratios in Human SH-SY5Y Cells by Methods. Turk J Pharm Sci. 2025;22:10. doi:10.4274/tjps.galenos.2024.40583
- Babaeenezhad E, Khosravi P, Moradi Sarabi M. Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines. Genes Nutr. 2025;20:2. doi:10.1186/s12263-025-00764-x
- Patel V, Li YN, Benhamou LE, Park HG, Raleigh M, et al. Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model. Cancers (Basel). 2025;17. doi:10.3390/cancers17030362
- Alharthy FH, Alsughayyir J, Alfhili MA. Eicosapentaenoic Acid Triggers Phosphatidylserine Externalization in the Erythrocyte Membrane through Calcium Signaling and Anticholinesterase Activity. Physiol Res. 2024;73:1075.
- Sun R, Zhang Y, Zhao X, Tang T, Cao Y, et al. Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer. Adv Sci (Weinh). 2025. doi:10.1002/advs.202412551
- Luo J, Peng S, Jiang Z, Wang Q, Zhang M, et al. Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer. iScience. 2025;28:111601. doi:10.1016/j.isci.2024.111601
- Frankhouser DE, DeWess T, Snodgrass IF, Cole RM, Steck S, et al. Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns. medRxiv. 2024. doi:10.1101/2024.09.16.24313691
- Ormiston K, Fitzgerald J, Andridge R, Lustberg MB, DeVries AC, et al. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutr Res. 2024;131:39. doi:10.1016/j.nutres.2024.09.004
- Ormiston K, Melink Z, Andridge R, Lustberg M, Courtney DeVries A, et al. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behav Immun. 2025;123:370. doi:10.1016/j.bbi.2024.09.021
- Chua AV, Hernandez ARB, Mendoza MJL, San Juan MD. Omega-3 Fatty Acids Increase Weight and Quality of Life Scores in Patients With Advanced Non-Small Cell Lung Cancer and Cancer Cachexia: A Meta-Analysis. Integr Cancer Ther. 2024;23:15347354241275052. doi:10.1177/15347354241275052
- Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, et al. The Impact of Dietary Unsaturated Fat or the Mediterranean Diet on Women Diagnosed With Breast Cancer: A Systematic Review. Cureus. 2024;16:e65362. doi:10.7759/cureus.65362
- Gholamalizadeh M, Tajadod S, Majidi N, Aghakhaninejad Z, Mahmoudi Z, et al. Associations between diet and nutritional supplements and colorectal cancer: A systematic review. JGH Open. 2024;8:e13108. doi:10.1002/jgh3.13108
- Chen X, Jiang T, Li Y, Zhang Y, Chen J, et al. Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis. Int J Biol Macromol. 2024;276:133942. doi:10.1016/j.ijbiomac.2024.133942
- Babar MU, Nassar AF, Nie X, Zhang T, He J, et al. Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer. Metabolites. 2024;14. doi:10.3390/metabo14060314
- Zhang Z, Zhou Q, Li Z, Huang F, Mo K, et al. DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. Drug Resist Updat. 2025;81:101224. doi:10.1016/j.drup.2025.101224
- Teng Y, Luo C, Qiu X, Mu J, Sriwastva MK, et al. Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites. Nat Commun. 2025;16:1295. doi:10.1038/s41467-025-56498-2
- Wang X, Ishimatsu K, Li J, Wen X, Ou W, et al. APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage. Hepat Oncol. 2024;11:2389031. doi:10.1080/20450923.2024.2389031
- Olkhovik DM, Silkina MO, Razumovskaya AV, Klycheva KV, Fatkulin AA, et al. Omega-3 Docosahexaenoic Acid as a Promising Inducer of Ferroptosis: Dynamics of Action in Prostate and Colorectal Cancer Models. Dokl Biochem Biophys. 2025. doi:10.1134/S160767292460132X
- Lin HL, Lin QY, Feng JN, Zheng WE, Yang C, et al. Plasma fatty acid levels and risk of non-small cell lung cancer: a large-scale prospective cohort study. Front Nutr. 2024;11:1462300. doi:10.3389/fnut.2024.1462300
- La Vecchia S, Fontana S, Salaroglio IC, Anobile DP, Digiovanni S, et al. Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy. Cancer Lett. 2024;604:217221. doi:10.1016/j.canlet.2024.217221
- Huang J, Li J, He L, Miao J, Zhu M, et al. The association between plasma fatty acids and risk of lung cancer: a prospective cohort study of the UK Biobank. J Clin Endocrinol Metab. 2024. doi:10.1210/clinem/dgae609
- Lin SC, Tsai YC, Chen YL, Lin HK, Huang YC, et al. Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer. Drug Resist Updat. 2024;77:101144. doi:10.1016/j.drup.2024.101144
