Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
We investigated the impact of diabetes on the levels of docosahexaenoic acid (DHA), an essential omega 3 fatty acid, in the retina of humans and mice. Our findings revealed that diabetic individuals had significantly lower DHA levels—40% less in peripheral regions and 25% less in the macula—compared to those without diabetes.
Additionally, we observed a reduction of retinal thickness and function in diabetic mice. Although there’s potential for dietary DHA to help with diabetic retinopathy, the current study suggests that diabetes is linked to reduced DHA and related retinal defects.
Additionally, we observed a reduction of retinal thickness and function in diabetic mice. Although there’s potential for dietary DHA to help with diabetic retinopathy, the current study suggests that diabetes is linked to reduced DHA and related retinal defects.
Read More
9
We examined the impact of omega-3 fatty acids from fish oil on diabetes in nonobese Goto-Kakizaki rats. Over eight weeks, these rats received fish oil supplements, while control groups were given plain water.
Our findings revealed that fish oil significantly enhanced glucose tolerance and insulin sensitivity in the diabetic rats. Additionally, it shifted T lymphocyte activity towards more immune-regulating patterns, reducing inflammation and promoting better overall metabolic health.
However, the study primarily involved animal models, so further research is needed to confirm these results in humans.
Our findings revealed that fish oil significantly enhanced glucose tolerance and insulin sensitivity in the diabetic rats. Additionally, it shifted T lymphocyte activity towards more immune-regulating patterns, reducing inflammation and promoting better overall metabolic health.
However, the study primarily involved animal models, so further research is needed to confirm these results in humans.
Read More
9
Omega-3 lowers type 2 diabetes odds
We conducted a study analyzing dietary omega-3 and omega-6 fatty acids and their connection to type 2 diabetes (T2DM) risk. Using data from 8,744 participants, we found that higher omega-3 intake was linked to a 58% lower chance of developing T2DM.
In contrast, a high omega-6 to omega-3 ratio appeared to increase the likelihood of T2DM. However, dietary omega-6 on its own didn’t show a significant effect in relation to diabetes risk. These findings suggest that enhancing omega-3 intake might be beneficial in managing T2DM risk.
In contrast, a high omega-6 to omega-3 ratio appeared to increase the likelihood of T2DM. However, dietary omega-6 on its own didn’t show a significant effect in relation to diabetes risk. These findings suggest that enhancing omega-3 intake might be beneficial in managing T2DM risk.
Read More
Most Useful Reviews
8
Supports heart and brain health
Omega-3 fatty acids are vital for beauty, youth, and health. They reduce heart disease risk, enhance blood circulation, cognitive functions, and lower blood pressure, making them useful in diabetes prevention. Natrol Omega aids in maintaining healthy triglyceride levels. Recommended dosage is one softgel twice daily with meals.
Read More
8
Supports diabetes prevention
We consume omega as a family, so we always have it stocked! Omega-3 fatty acids are crucial for maintaining beauty, youth, and health. They lower the risk of cardiovascular diseases, enhance blood circulation, cognitive function, and even reduce blood pressure while being beneficial for diabetes prevention. A deficiency can lead to various health issues, so prioritising omega-3 ensures we stay healthy!
Read More
8
Promotes cardiovascular health
Omega-3 fatty acids effectively reduce the risk of heart and vascular diseases, enhance blood circulation, and improve cognitive functions while also lowering blood pressure. These benefits extend further to the prevention of diabetes.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We investigated the impact of diabetes on the levels of docosahexaenoic acid (DHA), an essential omega 3 fatty acid, in the retina of humans and mice. Our findings revealed that diabetic individuals had significantly lower DHA levels—40% less in peripheral regions and 25% less in the macula—compared to those without diabetes.
Additionally, we observed a reduction of retinal thickness and function in diabetic mice. Although there’s potential for dietary DHA to help with diabetic retinopathy, the current study suggests that diabetes is linked to reduced DHA and related retinal defects.
Additionally, we observed a reduction of retinal thickness and function in diabetic mice. Although there’s potential for dietary DHA to help with diabetic retinopathy, the current study suggests that diabetes is linked to reduced DHA and related retinal defects.
Read More
9
We examined the impact of omega-3 fatty acids from fish oil on diabetes in nonobese Goto-Kakizaki rats. Over eight weeks, these rats received fish oil supplements, while control groups were given plain water.
Our findings revealed that fish oil significantly enhanced glucose tolerance and insulin sensitivity in the diabetic rats. Additionally, it shifted T lymphocyte activity towards more immune-regulating patterns, reducing inflammation and promoting better overall metabolic health.
However, the study primarily involved animal models, so further research is needed to confirm these results in humans.
Our findings revealed that fish oil significantly enhanced glucose tolerance and insulin sensitivity in the diabetic rats. Additionally, it shifted T lymphocyte activity towards more immune-regulating patterns, reducing inflammation and promoting better overall metabolic health.
However, the study primarily involved animal models, so further research is needed to confirm these results in humans.
Read More
9
Omega-3 lowers type 2 diabetes odds
We conducted a study analyzing dietary omega-3 and omega-6 fatty acids and their connection to type 2 diabetes (T2DM) risk. Using data from 8,744 participants, we found that higher omega-3 intake was linked to a 58% lower chance of developing T2DM.
In contrast, a high omega-6 to omega-3 ratio appeared to increase the likelihood of T2DM. However, dietary omega-6 on its own didn’t show a significant effect in relation to diabetes risk. These findings suggest that enhancing omega-3 intake might be beneficial in managing T2DM risk.
In contrast, a high omega-6 to omega-3 ratio appeared to increase the likelihood of T2DM. However, dietary omega-6 on its own didn’t show a significant effect in relation to diabetes risk. These findings suggest that enhancing omega-3 intake might be beneficial in managing T2DM risk.
Read More
9
We aimed to understand if docosahexaenoic acid (DHA) could protect diabetic mice from ischemic stroke. After administering DHA, we observed a significant reduction in brain injury and improved neurological function in these mice after stroke.
The treatment appeared to lower inflammation and cell death, as indicated by less neutrophils in the brain and changes in important proteins. Overall, DHA showed promise in managing stroke's damaging effects in diabetic models, suggesting potential benefits for clinical practice in diabetes care.
The treatment appeared to lower inflammation and cell death, as indicated by less neutrophils in the brain and changes in important proteins. Overall, DHA showed promise in managing stroke's damaging effects in diabetic models, suggesting potential benefits for clinical practice in diabetes care.
Read More
9
Omega-3 reduces inflammation, diabetes risk
We tested the effects of omega-3 fatty acids, specifically EPA and DHA, on diabetes risk factors linked to high levels of "bad" cholesterol. Over a 12-week period, individuals with elevated lipoprotein levels received daily omega-3 supplements.
We found that this intervention significantly reduced inflammation in fat tissue, improving factors like insulin function and fat metabolism. Overall, omega-3 supplementation showed promising results in lowering diabetes risk through its positive effects on inflammatory pathways.
However, while benefits were observed, the results indicated the need for further studies to fully understand the long-term impacts.
We found that this intervention significantly reduced inflammation in fat tissue, improving factors like insulin function and fat metabolism. Overall, omega-3 supplementation showed promising results in lowering diabetes risk through its positive effects on inflammatory pathways.
However, while benefits were observed, the results indicated the need for further studies to fully understand the long-term impacts.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Supports heart and brain health
Omega-3 fatty acids are vital for beauty, youth, and health. They reduce heart disease risk, enhance blood circulation, cognitive functions, and lower blood pressure, making them useful in diabetes prevention. Natrol Omega aids in maintaining healthy triglyceride levels. Recommended dosage is one softgel twice daily with meals.
Read More
8
Supports diabetes prevention
We consume omega as a family, so we always have it stocked! Omega-3 fatty acids are crucial for maintaining beauty, youth, and health. They lower the risk of cardiovascular diseases, enhance blood circulation, cognitive function, and even reduce blood pressure while being beneficial for diabetes prevention. A deficiency can lead to various health issues, so prioritising omega-3 ensures we stay healthy!
Read More
8
Promotes cardiovascular health
Omega-3 fatty acids effectively reduce the risk of heart and vascular diseases, enhance blood circulation, and improve cognitive functions while also lowering blood pressure. These benefits extend further to the prevention of diabetes.
Read More
Frequently Asked Questions
8
Supports heart and brain health
Omega-3 fatty acids are vital for beauty, youth, and health. They reduce heart disease risk, enhance blood circulation, cognitive functions, and lower blood pressure, making them useful in diabetes prevention. Natrol Omega aids in maintaining healthy triglyceride levels. Recommended dosage is one softgel twice daily with meals.
8
Promotes cardiovascular health
Omega-3 fatty acids effectively reduce the risk of heart and vascular diseases, enhance blood circulation, and improve cognitive functions while also lowering blood pressure. These benefits extend further to the prevention of diabetes.
8
Supports diabetes prevention
We consume omega as a family, so we always have it stocked! Omega-3 fatty acids are crucial for maintaining beauty, youth, and health. They lower the risk of cardiovascular diseases, enhance blood circulation, cognitive function, and even reduce blood pressure while being beneficial for diabetes prevention. A deficiency can lead to various health issues, so prioritising omega-3 ensures we stay healthy!
9
We examined the impact of omega-3 fatty acids from fish oil on diabetes in nonobese Goto-Kakizaki rats. Over eight weeks, these rats received fish oil supplements, while control groups were given plain water.
Our findings revealed that fish oil significantly enhanced glucose tolerance and insulin sensitivity in the diabetic rats. Additionally, it shifted T lymphocyte activity towards more immune-regulating patterns, reducing inflammation and promoting better overall metabolic health.
However, the study primarily involved animal models, so further research is needed to confirm these results in humans.
Our findings revealed that fish oil significantly enhanced glucose tolerance and insulin sensitivity in the diabetic rats. Additionally, it shifted T lymphocyte activity towards more immune-regulating patterns, reducing inflammation and promoting better overall metabolic health.
However, the study primarily involved animal models, so further research is needed to confirm these results in humans.
7
We examined the connection between polyunsaturated fatty acids (PUFAs) and diabetes risk among older Italians in a cross-sectional study. By analyzing data from over 4,400 participants aged 65 and up, we found that higher consumption of omega-3s—especially EPA and DHA—was linked to lower blood glucose levels and decreased diabetes prevalence. Interestingly, while these fats showed beneficial effects, higher body mass index (BMI) values were associated with some omega-6 fats. Overall, our findings suggest dietary PUFAs may play a role in managing diabetes in older adults.
7
We investigated whether a supplement rich in docosahexaenoic acid (DHA) could help reduce harmful lipids in individuals with type 2 diabetes and painful neuropathy. Our study involved 40 participants who took DHA and eicosapentaenoic acid (EPA) daily while attending educational sessions. After three months, we found significant reductions in neurotoxic lipids and an improvement in pain symptoms. This suggests that omega-3 fatty acids may be beneficial in managing diabetic neuropathy, contributing to better overall health.
8
We explored whether fish oil supplements could help reduce the risk of chronic kidney disease (CKD) among diabetic patients. In a large study of nearly 25,000 individuals, we found that those using fish oil experienced significantly lower CKD rates over an extended follow-up period.
Remarkably, their risk was delayed by almost three years compared to those not using fish oil. The positive outcomes seemed linked to improvements in important health markers, like HbA1c and HDL cholesterol. This suggests promoting fish oil supplementation could be beneficial in managing diabetes-related complications.
Remarkably, their risk was delayed by almost three years compared to those not using fish oil. The positive outcomes seemed linked to improvements in important health markers, like HbA1c and HDL cholesterol. This suggests promoting fish oil supplementation could be beneficial in managing diabetes-related complications.
References
- Sugasini D, Yalagala PCR, Park JC, Ma G, Farooq Z, et al. Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2024;65:39. doi:10.1167/iovs.65.14.39
- Lobato TB, Santos ESS, Iser-Bem PN, Falcão HS, Gimenes GM, et al. Omega-3 Fatty Acids Weaken Lymphocyte Inflammatory Features and Improve Glycemic Control in Nonobese Diabetic Goto-Kakizaki Rats. Nutrients. 2024;16. doi:10.3390/nu16234106
- Coelho-Júnior HJ, Álvarez-Bustos A, Picca A, Calvani R, Rodriguez-Mañas L, et al. Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults. Nutrients. 2024;16. doi:10.3390/nu16234087
- Durán AM, Zamora F, De León M. Dietary Docosahexaenoic Acid-Rich Supplementation Decreases Neurotoxic Lipid Mediators in Participants with Type 2 Diabetes and Neuropathic Pain. Nutrients. 2024;16. doi:10.3390/nu16234025
- Soria-Utrilla V, Sasso CV, Romero-Zerbo SY, Adarve-Castro A, López-Urdiales R, et al. Biomarkers of oxidation, inflammation and intestinal permeability in persons with diabetes mellitus with parenteral nutrition: A multicenter randomized trial. Clin Nutr. 2025;44:155. doi:10.1016/j.clnu.2024.11.044
- You Y, Sarkar S, Deiter C, Elliott EC, Nicora CD, et al. Reduction of Chemokine CXCL9 Expression by Omega-3 Fatty Acids via ADP-Ribosylhydrolase ARH3 in MIN6 Insulin-Producing Cells. Proteomics. 2025;25:e202400053. doi:10.1002/pmic.202400053
- Shakiba E, Pasdar Y, Asoudeh F, Najafi F, Saber A, et al. The relationship of dietary omega-3 fatty acid and omega-6 to omega-3 ratio intake and likelihood of type 2 diabetes in a cross-sectional study. BMC Endocr Disord. 2024;24:259. doi:10.1186/s12902-024-01787-y
- Liu C, Guo J, Guan L, Li C, Hu X, et al. Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis. Exp Neurol. 2025;385:115075. doi:10.1016/j.expneurol.2024.115075
- Bayat M, Koohpeyma F, Montazeri-Najafabady N, Dabbaghmanesh MH, Asmarian N, et al. The effects of modest intake of soy milk enriched with Lactobacillus casei and omega-3 on the testis parameters in diabetic rats: a stereological study. Int Urol Nephrol. 2025;57:1123. doi:10.1007/s11255-024-04243-x
- Xia J, Yin S, Yu J, Wang J, Jin X, et al. Improvement in Glycolipid Metabolism Parameters After Supplementing Fish Oil-Derived Omega-3 Fatty Acids Is Associated with Gut Microbiota and Lipid Metabolites in Type 2 Diabetes Mellitus. Nutrients. 2024;16. doi:10.3390/nu16213755
- Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. doi:10.1038/s41598-024-73672-6
- Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. doi:10.1038/s44319-024-00271-x
- Schuchardt JP, Hahn A, Greupner T, Tintle NL, Westra J, et al. Higher docosahexaenoic acid proportions in blood are inversely associated with the prevalence of prediabetes: Evidence from the UK Biobank. Nutr Res. 2024;131:62. doi:10.1016/j.nutres.2024.09.009
- Rimmen EV, Mjøs SA, Søfteland E, Gudbrandsen OA. Intake of herring oil, but not of anchovy oil, resulted in a lower serum cholesterol concentration in male Zucker Diabetic Sprague Dawley rats. Br J Nutr. 2024;132:547. doi:10.1017/S0007114524001454
- Muzammil K, Khaleel AQ, Merza MS, Kyada A, Ariffin IA, et al. The effects of ω-3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A systematic review and meta-analysis of controlled trials. Prostaglandins Other Lipid Mediat. 2024;175:106887. doi:10.1016/j.prostaglandins.2024.106887
- Ao Y, Ye H, Liu X, Li Y, Liu H, et al. Fish oil supplementation in relation to the risk of chronic kidney disease among patients with diabetes. Diabetes Obes Metab. 2024;26:5283. doi:10.1111/dom.15880
