We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Read More
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
Most Useful Reviews
10
Miracle during pregnancy
11 people found this helpful
I experienced severe constipation during my second trimester of pregnancy. Now in my third trimester, I take these to help. They are a miracle! They make me regular and improve my overall wellbeing. You won't be disappointed!
Read More
0
Inadequate form
5 people found this helpful
This is the least effective magnesium. It does help with constipation but has poor bioavailability. I recommend other forms for various needs.
Read More
9
Fights constipation effectively
4 people found this helpful
I need magnesium to combat constipation, and this product does exactly that.
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
Read More
9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
I experienced severe constipation during my second trimester of pregnancy. Now in my third trimester, I take these to help. They are a miracle! They make me regular and improve my overall wellbeing. You won't be disappointed!
Read More
0
Inadequate form
5 people found this helpful
This is the least effective magnesium. It does help with constipation but has poor bioavailability. I recommend other forms for various needs.
Read More
9
Fights constipation effectively
4 people found this helpful
I need magnesium to combat constipation, and this product does exactly that.
Read More
9
Relieves hemorrhoids
2 people found this helpful
My proctologist recommended this for constipation, and it has been a tremendous relief for my hemorrhoids.
Read More
9
Improved stool
1 people found this helpful
I chose magnesium oxide for my elderly mother suffering from severe constipation, having bowel movements only weekly. This magnesium helped her significantly; after two weeks, she now has daily bowel movements and has fewer leg cramps. I’m thrilled with her improvement.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is often praised for its ability to support various bodily functions, and one of its lesser-known benefits is its potential to alleviate constipation. Magnesium acts as a natural laxative by attracting water into the intestines, which helps to soften stool and promote regular bowel movements. Various forms of magnesium supplements, such as magnesium citrate and magnesium hydroxide, are commonly used to relieve constipation. These forms are more bioavailable and have a reputation for being effective for those struggling with infrequent bowel movements.
That said, it's important to approach magnesium supplementation with care. While it can be beneficial, excessive magnesium intake can lead to adverse effects, including diarrhea and gastrointestinal discomfort. It’s always a good idea to consult with a healthcare provider or a dietitian before starting any supplementation, especially if you are considering magnesium as a treatment for constipation. They can help determine the appropriate dosage and form for your specific needs, ensuring that you reap the benefits while minimizing potential side effects.
Based on user reviews, the timeline for seeing results from magnesium supplements for constipation can vary. Some users report significant improvements as quickly as two weeks. For example, one reviewer noted that their elderly mother went from having bowel movements only weekly to achieving daily movements after just two weeks of taking magnesium oxide Read Review. Meanwhile, others indicated a longer timeframe; one user mentioned experiencing relief after two months Read Review.
In general, many users note that consistent use of magnesium helps maintain regularity, with some stating they see improvements shortly after they begin taking the supplement. Others emphasize the importance of dosage and that adjusting their intake can lead to quicker results Read Review. Overall, while experiences vary, it seems that users can expect to start feeling the effects within a couple of weeks to a few months of regular supplementation.
Scientific research supports the effectiveness of magnesium supplements as a treatment for constipation. Various studies have demonstrated magnesium's roles in easing bowel movement frequency and improving stool consistency. For instance, a systematic review involving 787 participants indicated that those who took magnesium oxide experienced an average increase of about 3.7 additional bowel movements per week and higher stool consistency scores on the Bristol stool chart [8]. Additionally, research on magnesium hydroxide syrup showed that it helped patients recover from constipation more quickly, with participants experiencing their first bowel movement significantly sooner than those treated with alternative methods like flaxseed powder [3].
However, the effectiveness of magnesium can vary based on several factors, including formulation and dosage frequency. One study noted that reducing the frequency of magnesium oxide doses did not lead to significant changes in bowel movement frequency or stool consistency [2]. Moreover, while magnesium can enhance laxative effects when combined with other treatments, its role may be less pronounced when used alongside probiotics or dietary changes [4]. Overall, magnesium appears to be a useful option for managing constipation, but further research is necessary to fully understand its mechanisms and optimal use.
Based on user reviews, many individuals have reported significant improvements in their symptoms related to constipation after using magnesium supplements. One user shared that their elderly mother went from having bowel movements only weekly to daily after just two weeks of taking magnesium oxide Read Review. Other reviewers have noted various enhancements in their digestive health and sleep, with some stating that magnesium effectively alleviates their constipation alongside muscle cramps and anxiety Read Review. One reviewer remarked on experiencing complete resolution of constipation during winter months after incorporating magnesium into their routine Read Review.
While the majority of users have had positive experiences with magnesium, it's important to recognize that individual results can vary significantly. Some have shared that dosage adjustment played a crucial role in achieving effective results, suggesting that for optimal relief, users may need to experiment with their intake Read Review. Conversely, a few reviewers reported less effective experiences, emphasizing that while magnesium worked for them, it was not a universal solution Read Review. Overall, those seeking relief from constipation may find magnesium a beneficial option based on the variety of experiences shared in these reviews.
Many users have reported positive results when combining magnesium supplements with other products to tackle constipation. For instance, one reviewer mentioned that using magnesium alongside lactic acid bacteria not only helped alleviate their constipation but also contributed to overall digestive health Read Review. Another user found that mixing magnesium with senna was effective, although they cautioned about the timing to prevent discomfort Read Review. This indicates that for some individuals, a combination approach can enhance the efficacy of magnesium in managing constipation.
However, it's important to note that user experiences with combination approaches can vary greatly. While some found success with additional supplements, others did not report the same level of effectiveness. One reviewer even mentioned that despite their efforts with magnesium, they experienced stomach discomfort instead of relief Read Review. This suggests that while there may be benefits to combining magnesium with other products for constipation relief, individual responses can differ significantly, making it essential for users to evaluate how such combinations affect their own digestive health.
Based on user reviews, the optimal dosage for magnesium in treating constipation seems to vary among individuals, but a common find is that two tablets daily often yields the best results. For instance, one user mentioned taking two tablets every morning to effectively manage their long-standing constipation issue, emphasizing that magnesium has proven to be the most natural and effective option for them without side effects Read Review. Another user found significant improvements by taking two tablets before bed, resulting in a notable increase in bathroom visits Read Review.
However, some users have reported that adjusting the dosage can be necessary for optimal results. One user noted a need to increase their intake of powdered magnesium oxide to see improvements, indicating that finding the right dosage can be a trial-and-error process Read Review. Overall, while two tablets per day appears to be a common effective dosage for many, individual experiences with magnesium dosage can vary significantly, highlighting the importance of personal adjustment based on individual needs and responses.
9
Improved stool
1 people found this helpful
I chose magnesium oxide for my elderly mother suffering from severe constipation, having bowel movements only weekly. This magnesium helped her significantly; after two weeks, she now has daily bowel movements and has fewer leg cramps. I’m thrilled with her improvement.
7.5
Relieved tension
1 people found this helpful
I bought this magnesium to use it alone without other ingredients. Although I haven't taken it daily, after two months, it seems to have alleviated my constipation and helped with shoulder stiffness and sleep difficulties.
7.5
Good for constipation
I purchase this for constipation and find it good. Unlike some popular brands that dissolve too easily and are hard to swallow, this magnesium is easier to swallow and not as large as I expected. The lid is easy to open too. A certain brand required taking three tablets, but this one works well with just one tablet in the morning and evening.
9
Effective for sleep
1 people found this helpful
This magnesium has greatly helped in regulating my sleep, along with relieving constipation, muscle cramps, and pain. It's challenging to find the right magnesium without diarrhoea, and this one is effective for my brain focus and anxiety.
9
Affordable solution
1 people found this helpful
I found this Magnesium to be inexpensive and effective. I used to struggle with constipation during winter, but after taking this magnesium oxide, my constipation issues have been resolved. It's an affordable solution.
4
Needs adjustment
I'm using powdered magnesium oxide for constipation but find it challenging to manage. I've learned I need to increase the dosage to see results.
2
Did not help
I tried this for constipation, but it didn’t work for me. It caused stomach discomfort instead, and I wouldn't recommend it.
9
Effective treatment
It effectively relieves constipation. If I stop taking it, my symptoms worsen, but using it alongside lactic acid bacteria helps.
7.5
Pain-free bowel movements
My constipation improved, and I can have bowel movements without pain. If I mix it with senna, I wait 2-3 hours to avoid discomfort. It's best to avoid yogurt and cheese when using magnesium.
9
Natural remedy
1 people found this helpful
I take two tablets every morning for my long-standing constipation. After trying many solutions, magnesium has proven to be the most natural and effective option, with no side effects.
7.5
Effective treatment
1 people found this helpful
I ordered this for constipation based on reviews. Taking two tablets before bed has improved my bathroom visits significantly.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
8
Magnesium's role in constipation treatment
Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.
We aimed to understand how magnesium, particularly when combined with probiotics, influences bowel movements in elderly orthopedic patients suffering from chronic constipation. A retrospective chart review allowed us to analyze various patient records, focusing specifically on the treatments they received and the outcomes.
Magnesium is often talked about as a potential remedy for constipation because it can help draw water into the intestines, making it easier to pass stools. However, since our study also involved probiotics, which can also impact gut health, it becomes harder to isolate the specific effects of magnesium alone.
After reviewing the data, we observed that the combination of magnesium and probiotics did not show a significant advantage in improving bowel movements for the patients involved. This indicates that while magnesium may play a supportive role, its effectiveness on constipation could vary depending on individual circumstances and may not be as pronounced when combined with other treatments.
Overall, this study serves as a reminder of the complexity of managing constipation, especially in the elderly population, where multiple factors can come into play.
References
Wei CC, Harris MB, Ye M, Nicholls A, Alkhatib A, et al. Defecation after magnesium supplementation enhances cognitive performance in triathletes. Sports Med Health Sci. 2025;7:102. doi:10.1016/j.smhs.2024.04.001
Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. doi:10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. doi:10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. doi:10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. doi:10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. doi:10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. doi:10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. doi:10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. doi:10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. doi:10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. doi:10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. doi:10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. doi:10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. doi:10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. doi:10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. doi:10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. doi:10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. doi:10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. doi:10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.