We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Read More
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
Most Useful Reviews
8
Keeps me regular
8 people found this helpful
Fantastic for maintaining regularity. As an herbalist, I primarily use this to avoid addictive medications for irregularities or constipation. It’s a much healthier option and doesn’t cause diarrhoea. This magnesium performs better than others I've used, so I repeatedly buy it.
Read More
0
Inadequate form
5 people found this helpful
This is the least effective magnesium. It does help with constipation but has poor bioavailability. I recommend other forms for various needs.
Read More
9
Improved stool
1 people found this helpful
I chose magnesium oxide for my elderly mother suffering from severe constipation, having bowel movements only weekly. This magnesium helped her significantly; after two weeks, she now has daily bowel movements and has fewer leg cramps. I’m thrilled with her improvement.
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
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9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Fantastic for maintaining regularity. As an herbalist, I primarily use this to avoid addictive medications for irregularities or constipation. It’s a much healthier option and doesn’t cause diarrhoea. This magnesium performs better than others I've used, so I repeatedly buy it.
Read More
0
Inadequate form
5 people found this helpful
This is the least effective magnesium. It does help with constipation but has poor bioavailability. I recommend other forms for various needs.
Read More
9
Improved stool
1 people found this helpful
I chose magnesium oxide for my elderly mother suffering from severe constipation, having bowel movements only weekly. This magnesium helped her significantly; after two weeks, she now has daily bowel movements and has fewer leg cramps. I’m thrilled with her improvement.
Read More
9
Effective for sleep
1 people found this helpful
This magnesium has greatly helped in regulating my sleep, along with relieving constipation, muscle cramps, and pain. It's challenging to find the right magnesium without diarrhoea, and this one is effective for my brain focus and anxiety.
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7.5
Relieved tension
1 people found this helpful
I bought this magnesium to use it alone without other ingredients. Although I haven't taken it daily, after two months, it seems to have alleviated my constipation and helped with shoulder stiffness and sleep difficulties.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is often praised for its ability to support various bodily functions, and one of its lesser-known benefits is its potential to alleviate constipation. Magnesium acts as a natural laxative by attracting water into the intestines, which helps to soften stool and promote regular bowel movements. Various forms of magnesium supplements, such as magnesium citrate and magnesium hydroxide, are commonly used to relieve constipation. These forms are more bioavailable and have a reputation for being effective for those struggling with infrequent bowel movements.
That said, it's important to approach magnesium supplementation with care. While it can be beneficial, excessive magnesium intake can lead to adverse effects, including diarrhea and gastrointestinal discomfort. It’s always a good idea to consult with a healthcare provider or a dietitian before starting any supplementation, especially if you are considering magnesium as a treatment for constipation. They can help determine the appropriate dosage and form for your specific needs, ensuring that you reap the benefits while minimizing potential side effects.
Based on user reviews, the timeline for experiencing relief from constipation after starting magnesium supplementation can vary. Some users report noticing significant improvements in as little as two weeks. For instance, one review noted that an elderly individual went from having weekly bowel movements to daily ones after two weeks of using magnesium oxide Read Review. Other users indicated varying experiences, with some reporting effects after a month of use, especially those who did not take the supplement daily Read Review.
Additionally, the effectiveness seems to be influenced by individual factors such as dosage and whether or not other supplements are being taken alongside magnesium. Some reviewers found that consistent daily use was key to achieving regular bowel movements, while others had to adjust their intake or dosage to find what worked best for their bodies Read Review. Overall, while many users reported positive outcomes, the time it takes to see results can range from a couple of weeks to over a month.
Magnesium supplementation has garnered attention in the management of constipation, supported by various research studies. One systematic review of randomized controlled trials found that magnesium oxide significantly improved bowel movement frequency, with participants experiencing an average increase of about 3.7 additional movements per week, alongside better stool consistency [8]. Another study focusing on magnesium hydroxide syrup indicated that this form of magnesium contributed to quicker bowel movements in ICU patients recovering from acute myocardial infarction [3]. Moreover, magnesium's effectiveness as a potential laxative is consistent across studies, where it's demonstrated to help alleviate chronic constipation when included in treatment regimens [18].
However, it's worth noting that while magnesium shows promise, the strength of its effects can vary based on individual circumstances and how it's combined with other treatments [4]. For instance, a study found that magnesium combined with probiotics did not offer significant advantages over either treatment alone in elderly patients suffering from chronic constipation [1]. Therefore, while magnesium supplementation is supported by scientific research as a viable option for addressing constipation, its effectiveness may depend on the specific context of its use and individual health factors.
Users report a range of improvements when integrating magnesium into their routines, particularly regarding constipation relief. For instance, an elderly woman who previously experienced bowel movements only weekly saw a significant turnaround after two weeks, going to daily movements following magnesium oxide supplementation Read Review. Similarly, many users noted that the supplement not only mitigated their constipation but also contributed positively to sleep quality, muscle cramps, and overall digestive health. One user shared that they have effectively managed chronic constipation alongside better sleep, emphasizing a comprehensive improvement in both aspects of their health Read Review.
Despite this, experiences can vary widely depending on individual physiology and specific circumstances, as evidenced by some users who found it less effective or caused stomach discomfort with similar use Read Review. Others noted that adjusting dosages or combining magnesium with additional aids like senna produced optimal results Read Review. Overall, while many users reported improvement in both constipation and associated symptoms, the nuances of personal reactions emphasize the importance of individual experimentation with dosage and form of magnesium supplementation.
Users report varied experiences when combining magnesium supplements with other aids for managing constipation. Some have found synergy with ingredients like senna, noting that their bowel movements became more comfortable when they waited a few hours after taking magnesium before consuming senna, to avoid potential discomfort Read Review. Additionally, users who mixed magnesium with lactic acid bacteria reported improved efficacy in relieving constipation Read Review.
However, not all combinations work for every user. Some experienced stomach discomfort when trying magnesium alone or with other substances, indicating the importance of personal testing to determine what combination is most effective Read Review. Overall, while many users have successfully found complementary aids to help with their magnesium supplementation, results can greatly depend on individual reactions and adjustments in dosage or combination.
Based on user reviews, there is a consensus that magnesium can be an effective treatment for constipation, with individual dosages varying widely from user to user. Several reviews indicate that two tablets taken either in the morning or before bed seem to be a common and effective dosage for relief from constipation symptoms. For instance, one user reported significant improvement with their using two tablets every morning, stating it was the most natural and effective option they had tried without any side effects Read Review. Another user echoed similar results, finding that taking two tablets, one in the morning and one in the evening, was effective for their needs Read Review.
However, some users caution that finding the right magnesium dosage can take trial and error. One user noted that they needed to increase their dosage to see proper results from powdered magnesium oxide Read Review. This highlights the variability in individual responses to magnesium supplementation. Overall, while two tablets appear to be a generally effective starting point for many, users suggest adjusting dosages based on their specific experiences for optimal results.
9
Improved stool
1 people found this helpful
I chose magnesium oxide for my elderly mother suffering from severe constipation, having bowel movements only weekly. This magnesium helped her significantly; after two weeks, she now has daily bowel movements and has fewer leg cramps. I’m thrilled with her improvement.
7.5
Relieved tension
1 people found this helpful
I bought this magnesium to use it alone without other ingredients. Although I haven't taken it daily, after two months, it seems to have alleviated my constipation and helped with shoulder stiffness and sleep difficulties.
9
Natural remedy
1 people found this helpful
I take two tablets every morning for my long-standing constipation. After trying many solutions, magnesium has proven to be the most natural and effective option, with no side effects.
9
Helps insomnia too
I bought this for chronic constipation and insomnia. Remarkably, it resolved my constipation and improved my sleep. I fall asleep easily after eating, and it’s more effective than sleeping pills.
2
Did not help
I tried this for constipation, but it didn’t work for me. It caused stomach discomfort instead, and I wouldn't recommend it.
7.5
Pain-free bowel movements
My constipation improved, and I can have bowel movements without pain. If I mix it with senna, I wait 2-3 hours to avoid discomfort. It's best to avoid yogurt and cheese when using magnesium.
9
Effective treatment
It effectively relieves constipation. If I stop taking it, my symptoms worsen, but using it alongside lactic acid bacteria helps.
7.5
Good for constipation
I purchase this for constipation and find it good. Unlike some popular brands that dissolve too easily and are hard to swallow, this magnesium is easier to swallow and not as large as I expected. The lid is easy to open too. A certain brand required taking three tablets, but this one works well with just one tablet in the morning and evening.
4
Needs adjustment
I'm using powdered magnesium oxide for constipation but find it challenging to manage. I've learned I need to increase the dosage to see results.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
8
Magnesium's role in constipation treatment
Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.
We aimed to understand how magnesium, particularly when combined with probiotics, influences bowel movements in elderly orthopedic patients suffering from chronic constipation. A retrospective chart review allowed us to analyze various patient records, focusing specifically on the treatments they received and the outcomes.
Magnesium is often talked about as a potential remedy for constipation because it can help draw water into the intestines, making it easier to pass stools. However, since our study also involved probiotics, which can also impact gut health, it becomes harder to isolate the specific effects of magnesium alone.
After reviewing the data, we observed that the combination of magnesium and probiotics did not show a significant advantage in improving bowel movements for the patients involved. This indicates that while magnesium may play a supportive role, its effectiveness on constipation could vary depending on individual circumstances and may not be as pronounced when combined with other treatments.
Overall, this study serves as a reminder of the complexity of managing constipation, especially in the elderly population, where multiple factors can come into play.
References
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Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. 10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. 10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. 10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. 10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. 10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. 10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. 10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. 10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. 10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. 10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. 10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. 10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. 10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. 10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. 10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. 10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. 10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. 10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. 10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. 10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.