Last update
5/27/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Excellent
Based on 44 Reviews
9.1
Supplement Facts
Serving Size: 3 Tablets
Serving Per Container: 60
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol from ferment media)
25 mcg (1000 IU)
125%
Vitamin K1 (as phylloquinone from ferment media)
35 mcg
29%
Vitamin K2 (as menaquinone-7)
45 mcg
*
Calcium (from organic algae Lithothamnion spp.)
905 mg
70%
Magnesium (from organic algae Lithothamnion spp.)
62 mg
15%
Strontium (from organic algae Lithothamnion spp.)
5.5 mg
*
Vanadium (from organic algae Lithothamnion spp.)
14 mcg
*
Top Medical Research Studies
9
We examined how hyperoside, a compound in Semen cuscutae, can combat osteoporosis in ovariectomized mice, particularly after menopause. The study revealed that hyperoside effectively increased bone density and improved bone structure by reducing the differentiation of osteoclasts—cells that break down bone.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.
Read More
9
Zuogui Pills improve osteoporosis outcomes
We investigated how Zuogui Pills (ZGP), an herbal formula used in Traditional Chinese Medicine, can help with osteoporosis caused by excessive iron. Our study utilized both mouse models and osteoblast cells to examine its effects.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Read More
9
Nanoparticles enhance bone healing
We examined the potential of a new nano-formulation combining rosuvastatin and calcium carbonate in encouraging bone regeneration in osteoporotic rats. By injecting this formulation directly into bone defects, we found that it not only aided in healing but also improved bone structure over 30 days.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
Read More
Most Useful Reviews
10
Osteoporosis gone
728 people found this helpful
Defeats Osteoporosis. I have always taken additional calcium with my meals, often calcium carbonate or citrate. After a fall at 65 that required five surgeries, I was diagnosed with osteoporosis. I learned that calcium alone isn't enough; vitamins D3, K1, K2, and magnesium are also crucial. I discovered New Chapter Bone Strength, which combines everything I needed. I’m pleased to report that after two years on this regimen, my osteoporosis is GONE. My bond with New Chapter is permanent, and at 70, I feel confident I will never need fosamax, thanks to this supplement.
Read More
10
Miraculous improvements
270 people found this helpful
"Significant increase in bone mineral density since previous study done in March 2018" - those words were music to my ears. Diagnosed with osteoporosis in 2018, I initially took generic fosamax but experienced severe side effects. I decided to pursue alternative methods for two years, incorporating this supplement, hydration with lemon water, and consistent exercise. My 2020 bone density results showed stability or improvement, and I no longer meet the criteria for pharmacologic therapy. At over 65, achieving these results without medication feels miraculous.
Read More
10
Remarkable improvement
127 people found this helpful
New Chapter Bone Strength. I’m not one for reviews, but New Chapter Bone Strength truly deserves the praise. This product was recommended to me by my Naturopathic Doctor, and I cannot thank her enough. I've been using it for a year, and my recent Dexa Scan showed a reversal from osteoporosis to osteopenia. I was astounded as my regular MD led me to believe that such a reversal was not feasible...she even laughed at the idea. Well, I have the last laugh now! I wholeheartedly recommend this product and will continue taking it diligently. Looking to reverse osteopenia at my next scan.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9
Zuogui Pills improve osteoporosis outcomes
We investigated how Zuogui Pills (ZGP), an herbal formula used in Traditional Chinese Medicine, can help with osteoporosis caused by excessive iron. Our study utilized both mouse models and osteoblast cells to examine its effects.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Read More
9
Nanoparticles enhance bone healing
We examined the potential of a new nano-formulation combining rosuvastatin and calcium carbonate in encouraging bone regeneration in osteoporotic rats. By injecting this formulation directly into bone defects, we found that it not only aided in healing but also improved bone structure over 30 days.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
Read More
9
We examined the effects of 1,2,3,4,6-penta--galloyl-β-D-glucose (PGG), a natural antioxidant, on osteoporosis treatment. Using an in vitro osteoblast model and a zebrafish model for osteoporosis, we found PGG significantly improved cell survival and bone formation. It also enhanced bone-building signals through estrogen receptors. By reducing cell death and strengthening bone cells, PGG shows potential as a promising option for combating osteoporosis. These findings suggest that harnessing PGG could lead to better treatment strategies for those suffering from this condition.
Read More
9
We investigated how Bu-Sui-Dan (BSD), an ancient herbal formula, affects osteoporosis, particularly in postmenopausal women. The study utilized ovariectomized rats to assess BSD’s role in encouraging bone growth and differentiation of bone marrow stem cells.
Our findings indicated that BSD effectively enhanced osteoblast activity by increasing the levels of VGLL4, which combats RUNX2 transcription suppression. This suggests BSD could be a promising therapeutic option for osteoporosis, although more research is needed to fully understand its mechanisms.
Our findings indicated that BSD effectively enhanced osteoblast activity by increasing the levels of VGLL4, which combats RUNX2 transcription suppression. This suggests BSD could be a promising therapeutic option for osteoporosis, although more research is needed to fully understand its mechanisms.
Read More
9
We explored the potential of a traditional Chinese herbal formula called Xianlinggubao (XLGB) in treating osteoporosis. In our study, we focused on a specific ingredient, XLGB28-sRNA, and found it could improve bone strength by promoting new bone formation while also reducing bone breakdown. When administered to mice, this combination significantly increased bone mineral density and enhanced bone structure. These findings suggest that XLGB28-sRNA may serve as a promising treatment for osteoporosis, although more research is needed to understand its full effects on humans.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 44 Reviews
9.1
- All Reviews
- Positive Reviews
- Negative Reviews
10
Osteoporosis gone
728 people found this helpful
Defeats Osteoporosis. I have always taken additional calcium with my meals, often calcium carbonate or citrate. After a fall at 65 that required five surgeries, I was diagnosed with osteoporosis. I learned that calcium alone isn't enough; vitamins D3, K1, K2, and magnesium are also crucial. I discovered New Chapter Bone Strength, which combines everything I needed. I’m pleased to report that after two years on this regimen, my osteoporosis is GONE. My bond with New Chapter is permanent, and at 70, I feel confident I will never need fosamax, thanks to this supplement.
Read More
10
Miraculous improvements
270 people found this helpful
"Significant increase in bone mineral density since previous study done in March 2018" - those words were music to my ears. Diagnosed with osteoporosis in 2018, I initially took generic fosamax but experienced severe side effects. I decided to pursue alternative methods for two years, incorporating this supplement, hydration with lemon water, and consistent exercise. My 2020 bone density results showed stability or improvement, and I no longer meet the criteria for pharmacologic therapy. At over 65, achieving these results without medication feels miraculous.
Read More
10
Remarkable improvement
127 people found this helpful
New Chapter Bone Strength. I’m not one for reviews, but New Chapter Bone Strength truly deserves the praise. This product was recommended to me by my Naturopathic Doctor, and I cannot thank her enough. I've been using it for a year, and my recent Dexa Scan showed a reversal from osteoporosis to osteopenia. I was astounded as my regular MD led me to believe that such a reversal was not feasible...she even laughed at the idea. Well, I have the last laugh now! I wholeheartedly recommend this product and will continue taking it diligently. Looking to reverse osteopenia at my next scan.
Read More
9
Bone density improvement
79 people found this helpful
Bone Strength. I did some research and found this supplement. I liked that the calcium came from a plant source and also included magnesium, strontium, vitamin D, and vitamin K, which all work together to strengthen bones. Each of these alone may not provide the correct proportions for optimal effect. For instance, strontium can improve bone density test results without actually reinforcing bone structure, potentially leaving them brittle. Six years ago, my bone density test showed -2.5 (osteoporosis) in my hips and back, and I experienced consistent aches. Within six months of starting this supplement, my knee pains stopped completely. Subsequent tests every two years showed improvement from -2.5 to -1.4. While some reviews suggest rapid improvement, I found better results take time. At 74, my bone density has improved significantly and has not deteriorated. This is good enough for me.
Read More
9
Remarkable improvement
60 people found this helpful
My doctor was amazed at the change! Diagnosed with osteopenia at 59.5, I knew I had a family history of osteoporosis and was keen to prevent it. After starting to exercise and improve my diet, my doctor recommended a calcium supplement. Two years later, my bone scan showed improvement, and he was pleased with my results. He advised me to continue my regimen, stating I was on the right track. I've had no side effects from these slim tablets and highly recommend this product!
Read More
Frequently Asked Questions
9
Osteopenia reversal
1 people found this helpful
Taken with Vitamin D and K2, this supplement helped reverse my osteopenia. Plant-based calcium is well absorbed.
0
Comprehensive ingredients
2 people found this helpful
After discovering my tendency towards osteoporosis, I took three capsules daily, hoping for improvements. Compared to other products, this one has more comprehensive ingredients and is reasonably priced. However, the pills are rather large, so caution is advised for those who struggle to swallow.
8
We investigated the effects of Zuogui Wan (ZGW), a traditional herbal formula, on bone health, particularly its potential in treating postmenopausal osteoporosis using a rat model.
Our results showed that ZGW significantly improved bone loss and the overall osteoporotic condition. This improvement was linked to ZGW's ability to balance immune cells that affect bone loss and promote bone-forming cells.
While our findings are promising, further research is needed to fully understand how ZGW acts in the body and its clinical applications for osteoporosis management.
Our results showed that ZGW significantly improved bone loss and the overall osteoporotic condition. This improvement was linked to ZGW's ability to balance immune cells that affect bone loss and promote bone-forming cells.
While our findings are promising, further research is needed to fully understand how ZGW acts in the body and its clinical applications for osteoporosis management.
8
YSGSF effective against postmenopausal osteoporosis
We examined the effectiveness of the Yishen Gushu Formula (YSGSF) in treating postmenopausal osteoporosis (PMOP). Utilizing advanced plant metabolomics and network pharmacology, we identified how YSGSF improves bone mineral density by affecting key signaling pathways in the body.
Our study found that YSGSF decreases inflammatory markers and helps protect bone cells, which are crucial for maintaining bone health. While the formula shows promise, understanding its full impact requires further investigation into its mechanisms.
Our study found that YSGSF decreases inflammatory markers and helps protect bone cells, which are crucial for maintaining bone health. While the formula shows promise, understanding its full impact requires further investigation into its mechanisms.
9
We examined how hyperoside, a compound in Semen cuscutae, can combat osteoporosis in ovariectomized mice, particularly after menopause. The study revealed that hyperoside effectively increased bone density and improved bone structure by reducing the differentiation of osteoclasts—cells that break down bone.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.
References
- Lin Y, He Q, Chen B, Li Z, Chen C, et al. Zuogui Pills alleviate iron overload-induced osteoporosis by attenuating ROS-mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage. J Ethnopharmacol. 2025;344:119455. 10.1016/j.jep.2025.119455
- He MC, Xia SH, Pan H, Zhou TT, Wang XL, et al. Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity. Drug Des Devel Ther. 2024;18:5997. 10.2147/DDDT.S480077
- El-Salamouni NS, Gowayed MA, El Achy S, El Shahawy M, Ghareeb DA, et al. Rosuvastatin/calcium carbonate co-precipitated nanoparticles: A novel synergistic approach enhancing local bone regeneration in osteoporotic rat model. Int J Pharm. 2025;668:124977. 10.1016/j.ijpharm.2024.124977
- Zhao J, Wang Y, Wang S, Guo Q, Wang W, et al. Combining OSTA and BMR to predict osteoporosis in Chinese population. J Orthop Surg Res. 2024;19:767. 10.1186/s13018-024-05260-3
- Hua Y, Wang H, Chen T, Zhou Y, Chen Z, et al. Antioxidant 1,2,3,4,6-Penta--galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors. Molecules. 2024;29. 10.3390/molecules29215110
- Li M, Niu Y, Zhang T, Yang H, Tian L, et al. Wen-Shen-Tong-Luo-Zhi-Tong-Decoction inhibits bone loss in senile osteoporosis model mice by promoting testosterone production. J Ethnopharmacol. 2025;338:119033. 10.1016/j.jep.2024.119033
- Shen C, Deng M, Wang X, Li X, Chen X, et al. Zuogui Wan modulates macrophage polarization and promotes osteogenic differentiation through regulation of CD51-positive bone marrow mesenchymal stem cells. Sci Rep. 2024;14:26130. 10.1038/s41598-024-77590-5
- Tang MM, Sun LP, Song F, Chen H. Protective effects of arecanut seed phenols in retinoic acid induced osteoporosis and the potential mechanisms explored by network pharmacology. Front Endocrinol (Lausanne). 2024;15:1472146. 10.3389/fendo.2024.1472146
- Wei J, Dong R, Ma Y, Wang J, Tian S, et al. Single-cell sequencing reveals that specnuezhenide protects against osteoporosis via activation of METTL3 in LEPR BMSCs. Eur J Pharmacol. 2024;981:176908. 10.1016/j.ejphar.2024.176908
- Li C, Liu X, Chen X, Zhang J, Liao Y, et al. Bu-Sui-Dan Enhances Osteoblast Differentiation by Upregulating VGLL4 to Counteract TEAD4-Mediated RUNX2 Transcription Suppression in Ovariectomized Rats. J Ethnopharmacol. 2024;335:118690. 10.1016/j.jep.2024.118690
- Du X, Guo S, Mu X, Mei S, Yang R, et al. Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice. IUBMB Life. 2024;76:832. 10.1002/iub.2857
- Solgi S, Zayeri F, Abbasi B. Association between dietary insulin index and postmenopausal osteoporosis in Iranian women: a case-control study. BMC Womens Health. 2024;24:401. 10.1186/s12905-024-03248-z
- Liu H, Zhang C, Chai Y, Zhou Y, Zeng H, et al. Using broadly targeted plant metabolomics technology combined with network pharmacology to explore the mechanism of action of the Yishen Gushu formula in the treatment of postmenopausal osteoporosis in vivo. J Ethnopharmacol. 2024;333:118469. 10.1016/j.jep.2024.118469
- Wei Q, Ouyang M, Guo X, Fu X, Liu T, et al. Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway. Eur J Pharmacol. 2024;977:176666. 10.1016/j.ejphar.2024.176666
- Shang G, Zhou X, Yin J, Niu X, Zhao Y, et al. Multi-omics analysis of kidney, bone and bone marrow explored potential mechanisms of Erzhi Wan against osteoporosis with kidney-Yin deficiency. J Pharm Biomed Anal. 2024;246:116211. 10.1016/j.jpba.2024.116211
- Xiao D, Huang S, Tang Z, Liu M, Di D, et al. Mijiao formula regulates NAT10-mediated Runx2 mRNA ac4C modification to promote bone marrow mesenchymal stem cell osteogenic differentiation and improve osteoporosis in ovariectomized rats. J Ethnopharmacol. 2024;330:118191. 10.1016/j.jep.2024.118191
