Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 3 Soft Gels
Amount Per Serving
%DV
Calories
35
Total Fat
3 g
4%
Saturated Fat
0.5 g
3%
Trans Fat
0 g
†
Cholesterol
15 mg
5%
Vitamin A
30 mcg RAE
3%
Total Omega-3s
750 mg
†
EPA (Eicosapentaenoic Acid)
240 mg
†
DHA (Docosahexaenoic Acid)
360 mg
†
Other Omega-3s
150 mg
†
Top Medical Research Studies
8
DHA improves milk and reduces anxiety
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
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7
We investigated the effects of docosahexaenoic acid (DHA) on anxiety and other health aspects following long-term antibiotic treatment using an azithromycin mouse model. In our research, we divided thirty specific-pathogen-free BALB/c mice into three distinct groups: a control group, a group recovering naturally from azithromycin treatment, and a group receiving DHA.
Using various methods, including high-throughput sequencing and biochemical analysis, we explored how DHA influenced lipid metabolism and anxiety levels in these mice. Through our observations, we noted that prolonged exposure to azithromycin resulted in dyslipidemia and anxiety-like behaviors. Remarkably, DHA treatment significantly improved these anxiety-related symptoms, suggesting potential benefits in managing acute anxiety following antibiotic use.
While DHA did not alter the overall structure of the gut microbiome or bile acids content, it did enhance the levels of a crucial enzyme related to fat metabolism and normalized the expression of other key enzymes linked to lipid processing. This shows that DHA may support overall emotional well-being after antibiotic-induced imbalances, even if it doesn't change the gut microbiome dramatically.
Overall, our findings underscore DHA's promising effects in improving anxiety levels associated with antibiotic treatment, highlighting its potential as a supportive therapeutic approach for individuals experiencing similar health concerns.
Using various methods, including high-throughput sequencing and biochemical analysis, we explored how DHA influenced lipid metabolism and anxiety levels in these mice. Through our observations, we noted that prolonged exposure to azithromycin resulted in dyslipidemia and anxiety-like behaviors. Remarkably, DHA treatment significantly improved these anxiety-related symptoms, suggesting potential benefits in managing acute anxiety following antibiotic use.
While DHA did not alter the overall structure of the gut microbiome or bile acids content, it did enhance the levels of a crucial enzyme related to fat metabolism and normalized the expression of other key enzymes linked to lipid processing. This shows that DHA may support overall emotional well-being after antibiotic-induced imbalances, even if it doesn't change the gut microbiome dramatically.
Overall, our findings underscore DHA's promising effects in improving anxiety levels associated with antibiotic treatment, highlighting its potential as a supportive therapeutic approach for individuals experiencing similar health concerns.
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8
We examined how eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, influences anxiety levels in a juvenile mouse model affected by stress. Using an ultrasound (US) stress method, we subjected one-month-old C57/BL6 mice to varying sound frequencies that can mimic depressive-like symptoms.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Read More
Most Useful Reviews
9
Mental health rescue
91 people found this helpful
These capsules are a lifesaver for me. I take them for nutrition, immune support, hormonal balancing, and mental health. They significantly improve my anxiety and depression. It takes a few days to start working, so during stressful times, I double the dose. They helped me through post-partum depression after a miscarriage, stabilising my mood and clarity.
Read More
9
Life changing
I will definitely purchase this again. UPDATE: THIS PRODUCT IS TRANSFORMING MY LIFE. My body is beginning to look better, I experience less anxiety, and I feel more bold and ambitious with clearer thinking and skin. I adore this product and plan to order more for the year ahead.
Read More
7.5
Mood improvement
Omega-3 has become a fantastic addition to my diet during stressful times. After incorporating it, I noted an improvement in my mood, a reduction in my anxiety levels, and a boost in my concentration.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.2
- All Researches
9
EPA supplementation reduces anxiety
We explored how eicosapentaenoic acid (EPA), found in fish oil, impacts anxiety and mood disorders related to obesity. In our study, male mice were fed a high-fat diet for 20 weeks, which led to weight gain and anxiety-like behaviors.
To see if EPA could help, we administered fish oil enriched with equal amounts of EPA and DHA for the last five weeks of the study. The results were quite promising. Mice that received the fish oil not only showed reduced anxiety behaviors but also demonstrated improved metabolic health.
Specifically, these mice had better glucose tolerance and reduced food intake, indicating that fish oil could potentially correct some of the metabolic issues that come with obesity. Overall, the addition of EPA-rich fish oil appears to lessen both anxiety and metabolic disturbances caused by a saturated high-fat diet, suggesting its potential benefits for mood and health in similar conditions.
To see if EPA could help, we administered fish oil enriched with equal amounts of EPA and DHA for the last five weeks of the study. The results were quite promising. Mice that received the fish oil not only showed reduced anxiety behaviors but also demonstrated improved metabolic health.
Specifically, these mice had better glucose tolerance and reduced food intake, indicating that fish oil could potentially correct some of the metabolic issues that come with obesity. Overall, the addition of EPA-rich fish oil appears to lessen both anxiety and metabolic disturbances caused by a saturated high-fat diet, suggesting its potential benefits for mood and health in similar conditions.
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9
We explored how a diet rich in specific nutrients, including eicosapentaenoic acid (an omega-3 fatty acid), can impact cognitive function and anxiety levels in adolescents. Using a mild stress model, we focused on the effects of social instability stress on young rats, which led to noticeable cognitive and behavioral changes.
Our findings revealed that when these stressed rats were given a prolonged diet enriched with eicosapentaenoic acid, docosahexaenoic acid, and vitamin A, their performance in memory tests improved significantly. In fact, their anxiety levels and cognitive function returned to levels comparable to those of non-stressed rats.
We also observed that the enriched diet helped normalize brain chemistry and the balance of gut microbiota, both of which were disrupted by stress. Importantly, these positive changes persisted into adulthood, indicating that proper nutrition during stressful periods could have long-lasting benefits.
By highlighting the protective effects of eicosapentaenoic acid within a nutritious diet, we suggest exciting possibilities for using diet to help manage stress and anxiety during key developmental years.
Our findings revealed that when these stressed rats were given a prolonged diet enriched with eicosapentaenoic acid, docosahexaenoic acid, and vitamin A, their performance in memory tests improved significantly. In fact, their anxiety levels and cognitive function returned to levels comparable to those of non-stressed rats.
We also observed that the enriched diet helped normalize brain chemistry and the balance of gut microbiota, both of which were disrupted by stress. Importantly, these positive changes persisted into adulthood, indicating that proper nutrition during stressful periods could have long-lasting benefits.
By highlighting the protective effects of eicosapentaenoic acid within a nutritious diet, we suggest exciting possibilities for using diet to help manage stress and anxiety during key developmental years.
Read More
9
We explored the potential benefits of docosahexaenoic acid (DHA) in reducing anxiety among middle-aged and elderly adults. This was part of a larger study involving over 102,000 participants, where we assessed the impact of various polyunsaturated fatty acids (PUFAs) on mental health conditions, including anxiety and depression.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Read More
8
We examined how eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, influences anxiety levels in a juvenile mouse model affected by stress. Using an ultrasound (US) stress method, we subjected one-month-old C57/BL6 mice to varying sound frequencies that can mimic depressive-like symptoms.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Read More
8
In a 12-week clinical trial, we explored the effects of eicosapentaenoic acid (EPA) on individuals suffering from episodic migraine. With 70 participants divided into two groups—one receiving EPA and the other a placebo—we aimed to understand how this omega-3 fatty acid might also impact anxiety levels.
The results were encouraging. Participants who took EPA not only reported fewer migraine days but also showed a noteworthy decline in anxiety symptoms. Specifically, they scored better on anxiety assessments compared to those who took the placebo. This suggests that EPA might play a role in enhancing overall mental well-being in migraine sufferers.
Importantly, the findings highlighted that those who benefitted most from the EPA were female participants. This could open new avenues for understanding how gender influences responses to migraine treatments. Overall, while our primary focus was on migraine relief, the positive effects on anxiety provide additional insight into the potential of EPA as a multifaceted treatment option.
The results were encouraging. Participants who took EPA not only reported fewer migraine days but also showed a noteworthy decline in anxiety symptoms. Specifically, they scored better on anxiety assessments compared to those who took the placebo. This suggests that EPA might play a role in enhancing overall mental well-being in migraine sufferers.
Importantly, the findings highlighted that those who benefitted most from the EPA were female participants. This could open new avenues for understanding how gender influences responses to migraine treatments. Overall, while our primary focus was on migraine relief, the positive effects on anxiety provide additional insight into the potential of EPA as a multifaceted treatment option.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Mental health rescue
91 people found this helpful
These capsules are a lifesaver for me. I take them for nutrition, immune support, hormonal balancing, and mental health. They significantly improve my anxiety and depression. It takes a few days to start working, so during stressful times, I double the dose. They helped me through post-partum depression after a miscarriage, stabilising my mood and clarity.
Read More
9
Life changing
I will definitely purchase this again. UPDATE: THIS PRODUCT IS TRANSFORMING MY LIFE. My body is beginning to look better, I experience less anxiety, and I feel more bold and ambitious with clearer thinking and skin. I adore this product and plan to order more for the year ahead.
Read More
7.5
Mood improvement
Omega-3 has become a fantastic addition to my diet during stressful times. After incorporating it, I noted an improvement in my mood, a reduction in my anxiety levels, and a boost in my concentration.
Read More
7.5
Less anxiety, better life
31 people found this helpful
I like it. Great so far, no burps or fishy tastes. UPDATE: THIS STUFF IS CHANGING MY LIFE. My body is starting to look better, I'm experiencing less anxiety, and I feel more bold and ambitious with clearer thinking and skin! I love this product... I'm about to buy more to last me a year.
Read More
Frequently Asked Questions
9
Life changing
I will definitely purchase this again. UPDATE: THIS PRODUCT IS TRANSFORMING MY LIFE. My body is beginning to look better, I experience less anxiety, and I feel more bold and ambitious with clearer thinking and skin. I adore this product and plan to order more for the year ahead.
7.5
Mood improvement
Omega-3 has become a fantastic addition to my diet during stressful times. After incorporating it, I noted an improvement in my mood, a reduction in my anxiety levels, and a boost in my concentration.
7
We explored the effects of eicosapentaenoic acid (EPA) on anxiety-like behavior in rats exposed to prolonged chronic unpredictable stress (PCUS). Through a 12-week experiment, we assessed how this treatment, along with fluoxetine and lipopolysaccharide, influenced both behavior and gene expression in their brains. The study found that PCUS led to signs of anxiety in the rats, but chronic treatment with EPA significantly corrected these behaviors.
However, while we noted changes in the rats' anxiety responses with EPA, the overall impact on brain gene expression wasn't markedly affected by the treatments. Some specific genes did show changes in expression when treated with fluoxetine, EPA, or their combination, hinting these could be targets for further investigation in stress-related conditions.
In summary, while EPA appears beneficial in reducing anxiety-like behavior, the complexities of its interactions with other treatments require more exploration to fully understand its role in managing anxiety. This study emphasizes the potential for EPA as a therapeutic option, while also inviting further research on its individual and combined effects with other treatments.
However, while we noted changes in the rats' anxiety responses with EPA, the overall impact on brain gene expression wasn't markedly affected by the treatments. Some specific genes did show changes in expression when treated with fluoxetine, EPA, or their combination, hinting these could be targets for further investigation in stress-related conditions.
In summary, while EPA appears beneficial in reducing anxiety-like behavior, the complexities of its interactions with other treatments require more exploration to fully understand its role in managing anxiety. This study emphasizes the potential for EPA as a therapeutic option, while also inviting further research on its individual and combined effects with other treatments.
8
We examined how eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, influences anxiety levels in a juvenile mouse model affected by stress. Using an ultrasound (US) stress method, we subjected one-month-old C57/BL6 mice to varying sound frequencies that can mimic depressive-like symptoms.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
8
In a 12-week clinical trial, we explored the effects of eicosapentaenoic acid (EPA) on individuals suffering from episodic migraine. With 70 participants divided into two groups—one receiving EPA and the other a placebo—we aimed to understand how this omega-3 fatty acid might also impact anxiety levels.
The results were encouraging. Participants who took EPA not only reported fewer migraine days but also showed a noteworthy decline in anxiety symptoms. Specifically, they scored better on anxiety assessments compared to those who took the placebo. This suggests that EPA might play a role in enhancing overall mental well-being in migraine sufferers.
Importantly, the findings highlighted that those who benefitted most from the EPA were female participants. This could open new avenues for understanding how gender influences responses to migraine treatments. Overall, while our primary focus was on migraine relief, the positive effects on anxiety provide additional insight into the potential of EPA as a multifaceted treatment option.
The results were encouraging. Participants who took EPA not only reported fewer migraine days but also showed a noteworthy decline in anxiety symptoms. Specifically, they scored better on anxiety assessments compared to those who took the placebo. This suggests that EPA might play a role in enhancing overall mental well-being in migraine sufferers.
Importantly, the findings highlighted that those who benefitted most from the EPA were female participants. This could open new avenues for understanding how gender influences responses to migraine treatments. Overall, while our primary focus was on migraine relief, the positive effects on anxiety provide additional insight into the potential of EPA as a multifaceted treatment option.
4
Uncertain effects of EPA on anxiety
We set out to evaluate how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, affects anxiety based on a systematic review of existing studies. Our analysis focused on randomized controlled trials (RCTs) that included a total of 1,426 participants. While we found some promising results related to depression, the findings regarding anxiety were not as conclusive. In fact, only one study in the review reported a reduction in anxiety symptoms when participants took 2.1 grams of EPA per day.
This limited data meant that a comprehensive meta-analysis on the effects of EPA on anxiety could not be conducted. As such, the impact of EPA specifically on anxiety remains unclear. It's important to note that although there was significant evidence for EPA's potential benefits for depression, we cannot confidently claim any similar effects for anxiety based on this review alone.
Overall, while we observed that EPA may help in managing depression, its role in alleviating anxiety requires further investigation. More high-quality research focusing on the unique aspects of EPA and its impact on anxiety will be essential for a clearer understanding of its therapeutic potential.
This limited data meant that a comprehensive meta-analysis on the effects of EPA on anxiety could not be conducted. As such, the impact of EPA specifically on anxiety remains unclear. It's important to note that although there was significant evidence for EPA's potential benefits for depression, we cannot confidently claim any similar effects for anxiety based on this review alone.
Overall, while we observed that EPA may help in managing depression, its role in alleviating anxiety requires further investigation. More high-quality research focusing on the unique aspects of EPA and its impact on anxiety will be essential for a clearer understanding of its therapeutic potential.
4
We investigated how eicosapentaenoic acid (EPA), a key fatty acid, influences anxiety levels in women with different subtypes of anorexia nervosa. Analyzing the effects in 96 participants—25 with the restricting type, 25 with the binging and purging type, and 46 healthy controls—helped us understand the connection between dietary fats and mental health.
What we found was intriguing. In women with the restricting type of anorexia (AN-R), higher levels of EPA were linked to increased anxiety. In contrast, for those with the binge-purge type (AN-BP), higher EPA levels were associated with lower anxiety. This suggests that the same fatty acid can affect anxiety differently depending on the individual's eating behavior.
These findings open the door to tailored dietary interventions that could improve mental health outcomes for those struggling with anorexia nervosa. Understanding the relationship between fat consumption and emotional well-being can lead to more effective treatment strategies.
What we found was intriguing. In women with the restricting type of anorexia (AN-R), higher levels of EPA were linked to increased anxiety. In contrast, for those with the binge-purge type (AN-BP), higher EPA levels were associated with lower anxiety. This suggests that the same fatty acid can affect anxiety differently depending on the individual's eating behavior.
These findings open the door to tailored dietary interventions that could improve mental health outcomes for those struggling with anorexia nervosa. Understanding the relationship between fat consumption and emotional well-being can lead to more effective treatment strategies.
References
- Demin KA, Kolesnikova TO, Galstyan DS, Krotova NA, Ilyin NP, et al. The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety-Like Behavior and Hippocampal Transcriptomic Responses in Male Rats. J Neurosci Res. 2025;103:e70025. doi:10.1002/jnr.70025
- Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
- Nguyen N, Woodside DB, Lam E, Quehenberger O, German JB, et al. Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes. Int J Mol Sci. 2024;25. doi:10.3390/ijms25105516
- Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. doi:10.1016/j.bbi.2024.03.019
- Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. doi:10.1016/j.jad.2024.01.149
- Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, et al. Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome. Food Funct. 2023;14:5977. doi:10.1039/d3fo01452e
- Kelaiditis CF, Gibson EL, Dyall SC. Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2023;192:102572. doi:10.1016/j.plefa.2023.102572
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. doi:10.1038/s41398-022-02026-5
- Mengelberg A, Leathem J, Podd J, Hill S, Conlon C. The effects of docosahexaenoic acid supplementation on cognition and well-being in mild cognitive impairment: A 12-month randomised controlled trial. Int J Geriatr Psychiatry. 2022;37. doi:10.1002/gps.5707
- Neto J, Jantsch J, de Oliveira S, Braga MF, Castro LFDS, et al. DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats. Br J Nutr. 2022;128:964. doi:10.1017/S0007114521003998
- Wang CC, Du L, Shi HH, Ding L, Yanagita T, et al. Dietary EPA-Enriched Phospholipids Alleviate Chronic Stress and LPS-Induced Depression- and Anxiety-Like Behavior by Regulating Immunity and Neuroinflammation. Mol Nutr Food Res. 2021;65:e2100009. doi:10.1002/mnfr.202100009
- Demers G, Roy J, Machuca-Parra AI, Dashtehei Pour Z, Bairamian D, et al. Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice. Int J Obes (Lond). 2020;44:1936. doi:10.1038/s41366-020-0623-6
- Nakajima S, Fukasawa K, Gotoh M, Murakami-Murofushi K, Kunugi H. Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level. Int J Obes (Lond). 2020;44:727. doi:10.1038/s41366-019-0468-z
- Provensi G, Schmidt SD, Boehme M, Bastiaanssen TFS, Rani B, et al. Preventing adolescent stress-induced cognitive and microbiome changes by diet. Proc Natl Acad Sci U S A. 2019;116:9644. doi:10.1073/pnas.1820832116
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
- Gajdošová L, Katrenčíková B, Borbélyová V, Muchová J. The Effect of Omega-3 Fatty Acid Supplementation and Exercise on Locomotor Activity, Exploratory Activity, and Anxiety-Like Behavior in Adult and Aged Rats. Physiol Res. 2024;73:461.
- Zambrano E, Rodríguez-González GL, Reyes-Castro LA, Bautista CJ, Castro-Rodríguez DC, et al. DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring. Nutrients. 2021;13. doi:10.3390/nu13124243
- Tang Q, Li S, Fang C, Yu H. Evaluating the reparative effects and the mechanism of action of docosahexaenoic acid on azithromycin-induced lipid metabolism dysfunction. Food Chem Toxicol. 2022;159:112699. doi:10.1016/j.fct.2021.112699
- Ponomarenko AI, Tyrtyshnaia AA, Pislyagin EA, Dyuizen IV, Sultanov RM, et al. N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Sci Rep. 2021;11:756. doi:10.1038/s41598-020-80818-9
