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SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 3 Soft Gels
Amount Per Serving
%DV
Calories
35
Total Fat
3 g
4%
Saturated Fat
0.5 g
3%
Trans Fat
0 g
†
Cholesterol
15 mg
5%
Vitamin A
30 mcg RAE
3%
Total Omega-3s
750 mg
†
EPA (Eicosapentaenoic Acid)
240 mg
†
DHA (Docosahexaenoic Acid)
360 mg
†
Other Omega-3s
150 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid aids heart recovery
Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.
Significant effects on cardiac remodeling
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
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9
DHA aids post-heart attack recovery
The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats.
Relevant to myocardial infarction treatments
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Read More
9
Cod liver oil aids heart stability
[Correction of disorders of cardiac electric stability in post-infarction cardiosclerosis using a diet enriched with polyunsaturated fatty acids].
Study shows promising results
We examined how cod liver oil might affect heart health following a heart attack. In our study, we fed rats a special form of cod liver oil called "eikonole," which is enriched with important fatty acids. After a period of feeding, we induced a heart attack and then looked at how the hearts functioned over the next month.
Our findings were promising. We observed that eikonole raised the heart's fibrillation threshold by 50%. This means that it took a stronger stimulus to trigger heart disturbances, which is a good sign for heart stability. Additionally, there was a significant reduction in both spontaneous extra heartbeats and those triggered by stimulation of the vagus nerve.
However, while eikonole improved certain aspects of heart function, it did not significantly change the overall pressure or speed of heart contractions. This suggests that while there are benefits, they may be limited to specific areas of cardiac function rather than an overall enhancement of heart performance.
Our findings were promising. We observed that eikonole raised the heart's fibrillation threshold by 50%. This means that it took a stronger stimulus to trigger heart disturbances, which is a good sign for heart stability. Additionally, there was a significant reduction in both spontaneous extra heartbeats and those triggered by stimulation of the vagus nerve.
However, while eikonole improved certain aspects of heart function, it did not significantly change the overall pressure or speed of heart contractions. This suggests that while there are benefits, they may be limited to specific areas of cardiac function rather than an overall enhancement of heart performance.
Read More
Most Useful Reviews
9.5
Asthma relief
My daughter's asthma symptoms improved remarkably after two weeks of taking cod liver oil. Prior to this, she experienced severe coughing and had to be rushed to the hospital. Now, she only has occasional flare-ups. I appreciate Nordic Naturals for their high processing standards and safety for children.
Read More
9.5
Cholesterol improvement
I bought cod liver oil for my mother to manage her cholesterol. After three months, her levels normalised, reducing inflammation and heart attack risks. The taste is acceptable, and it has good Omega-3 content, suitable for the elderly.
Read More
8.8
Improved heart health
Taking these soft gel tablets has greatly aided my cholesterol levels and heart health, preventing heart attacks. I've noticed improvements in inflammation and my asthma symptoms, and my hair has thickened. The absence of a fishy taste makes them easy to swallow. I take 2-3 daily after breakfast.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.6
9
Omega-3s reduce heart attack risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Clear links to heart attacks
We examined the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on the risk of heart attacks through a comprehensive analysis of the VITAL trial. This significant study included nearly 26,000 older adults in the U.S. who were monitored over an average of 5.3 years.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
Read More
9
Eicosapentaenoic acid aids recovery
Elevated eicosapentaenoic acid to arachidonic acid ratio and rapid coronary blood flow restoration in ST-elevation myocardial infarction.
Relevant to heart attack recovery
We explored the role of eicosapentaenoic acid (EPA) in heart attack recovery, particularly its effect on restoring blood flow during ST-elevation myocardial infarction (STEMI). Our focus was on understanding whether higher levels of EPA relative to arachidonic acid could lead to faster recovery and better outcomes for patients experiencing this type of heart attack.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
Read More
9
Eicosapentaenoic acid aids cardiac protection
A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury.
Significant role in cardiac health
We explored how eicosapentaenoic acid (EPA) and its metabolites can protect heart cells during a heart attack, specifically focusing on a laboratory model for ischemic injury. Our investigation centered on a specific receptor found in heart cells, known as the Free Fatty Acid Receptor 4 (Ffar4).
In our experiments, cardiac myocytes, or heart cells, were exposed to a controlled environment mimicking conditions of reduced blood flow followed by reoxygenation, essentially simulating a heart attack scenario. Applying an Ffar4 agonist, TUG-891, along with EPA-derived components like 18-hydroxyeicosapentaenoic acid (18-HEPE) and resolvin E1 (RvE1), we observed a significant reduction in harmful reactive oxygen species and heart cell death.
Notably, blocking the ChemR23 receptor with a specific antagonist negated the protective effects we noted from these treatments. This finding highlights that Ffar4 and ChemR23 work together in heart cells to defend against the damage that occurs after ischemic injury.
Overall, our data reinforce the idea that eicosapentaenoic acid has beneficial roles in protecting heart cells from ischemia, meriting further exploration as a potential therapeutic in heart attack management.
In our experiments, cardiac myocytes, or heart cells, were exposed to a controlled environment mimicking conditions of reduced blood flow followed by reoxygenation, essentially simulating a heart attack scenario. Applying an Ffar4 agonist, TUG-891, along with EPA-derived components like 18-hydroxyeicosapentaenoic acid (18-HEPE) and resolvin E1 (RvE1), we observed a significant reduction in harmful reactive oxygen species and heart cell death.
Notably, blocking the ChemR23 receptor with a specific antagonist negated the protective effects we noted from these treatments. This finding highlights that Ffar4 and ChemR23 work together in heart cells to defend against the damage that occurs after ischemic injury.
Overall, our data reinforce the idea that eicosapentaenoic acid has beneficial roles in protecting heart cells from ischemia, meriting further exploration as a potential therapeutic in heart attack management.
Read More
9
Significant heart attack risk reduction
Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT.
Focuses on cardiovascular event impact
In this extensive study involving nearly 5,800 patients with atherosclerotic cardiovascular disease (ASCVD) and high triglyceride levels, we explored the effectiveness of icosapent ethyl, a form of eicosapentaenoic acid, in reducing the risk of major adverse cardiovascular events (MACE) like heart attacks.
Patients were randomly assigned to receive either icosapent ethyl or a placebo, with their health monitored over a median follow-up of nearly five years. The results were promising: we noticed a significant reduction in MACE in the group receiving icosapent ethyl compared to those on placebo.
Specifically, there were 361 instances of MACE in the icosapent ethyl group versus 489 in the placebo group. This translates to a 28% lower risk of events like heart attacks or strokes for those taking icosapent ethyl. Furthermore, we observed that the absolute benefits were greatest for patients with higher baseline cardiovascular risk.
Overall, regardless of their initial risk levels, using icosapent ethyl showed an impressive potential to decrease the risk of major cardiovascular issues, including heart attacks. This study underscores the value of incorporating eicosapentaenoic acid into treatment plans for patients at risk of heart disease.
Patients were randomly assigned to receive either icosapent ethyl or a placebo, with their health monitored over a median follow-up of nearly five years. The results were promising: we noticed a significant reduction in MACE in the group receiving icosapent ethyl compared to those on placebo.
Specifically, there were 361 instances of MACE in the icosapent ethyl group versus 489 in the placebo group. This translates to a 28% lower risk of events like heart attacks or strokes for those taking icosapent ethyl. Furthermore, we observed that the absolute benefits were greatest for patients with higher baseline cardiovascular risk.
Overall, regardless of their initial risk levels, using icosapent ethyl showed an impressive potential to decrease the risk of major cardiovascular issues, including heart attacks. This study underscores the value of incorporating eicosapentaenoic acid into treatment plans for patients at risk of heart disease.
Read More
9
Eicosapentaenoic acid reduces heart attack risk
Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl.
Study highlights significant treatment benefits
We explored the cardiovascular benefits of eicosapentaenoic acid, specifically through a substance called icosapent ethyl (IPE), in individuals with elevated levels of lipoprotein(a). This post hoc analysis took place in a study called REDUCE-IT, which involved over 8,000 participants who were either battling established cardiovascular disease or were at high risk due to diabetes and other factors.
Participants in the study were given either IPE or a placebo while maintaining their statin therapy. We observed that elevated lipoprotein(a) concentrations were linked to an increased risk of major adverse cardiovascular events, even when low-density lipoprotein cholesterol was managed well.
Importantly, IPE demonstrated a consistent ability to lower the risk of these heart issues among participants, regardless of their lipoprotein(a) levels. This effect was particularly noticeable for those with elevated lipoprotein(a), showing that IPE could be beneficial in managing cardiovascular risk in this group.
Overall, the findings highlight the potential of eicosapentaenoic acid as a valuable treatment option for reducing heart attack risk in high-risk patients, emphasizing its importance alongside traditional therapies.
Participants in the study were given either IPE or a placebo while maintaining their statin therapy. We observed that elevated lipoprotein(a) concentrations were linked to an increased risk of major adverse cardiovascular events, even when low-density lipoprotein cholesterol was managed well.
Importantly, IPE demonstrated a consistent ability to lower the risk of these heart issues among participants, regardless of their lipoprotein(a) levels. This effect was particularly noticeable for those with elevated lipoprotein(a), showing that IPE could be beneficial in managing cardiovascular risk in this group.
Overall, the findings highlight the potential of eicosapentaenoic acid as a valuable treatment option for reducing heart attack risk in high-risk patients, emphasizing its importance alongside traditional therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Asthma relief
My daughter's asthma symptoms improved remarkably after two weeks of taking cod liver oil. Prior to this, she experienced severe coughing and had to be rushed to the hospital. Now, she only has occasional flare-ups. I appreciate Nordic Naturals for their high processing standards and safety for children.
Read More
9.5
Cholesterol improvement
I bought cod liver oil for my mother to manage her cholesterol. After three months, her levels normalised, reducing inflammation and heart attack risks. The taste is acceptable, and it has good Omega-3 content, suitable for the elderly.
8.8
Improved heart health
Taking these soft gel tablets has greatly aided my cholesterol levels and heart health, preventing heart attacks. I've noticed improvements in inflammation and my asthma symptoms, and my hair has thickened. The absence of a fishy taste makes them easy to swallow. I take 2-3 daily after breakfast.
Read More
8.8
Heart benefits
This pure Arctic Cod Liver Oil is an excellent and natural source of Omega-3. It is easy to swallow and helps with heart function and regulating blood pressure, thereby reducing the risk of heart attacks.
8.8
Heart protection
This Cod Liver Oil is beneficial for my family aged 12 to 40. The lemon taste reduces the fishy smell, and it has helped to protect our hearts and lower cholesterol, thus reducing the risk of heart attacks.
