Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications.
Our exploration into the management of diabetes and its complications led us to develop a unique beverage formulation. This drink combines stevia glycoside, mogroside V, and sodium hyaluronate, known as SMH-B, which offers a sweet taste without affecting blood sugar levels.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
Read More
9
Fermented soy improves constipation relief
Incremental effects of fermentation of soybean on its nutrients, flavor profile and laxative regulation in experimental constipated rats.
We investigated how protein from probiotic-fermented soybean powder affects constipation, particularly in an experimental setting. Rats were used to test both fermented and non-fermented soybean powders for their laxative effects.
After eight days of fermentation, we noticed significant changes in various nutrients. While the polysaccharides in the soy decreased, the flavonoid levels first went up before swiftly dropping later. Importantly, we found that the fermented soybean resulted in higher levels of isoflavone aglycones, which showed promise for digestive health.
The fermented soybean powder outperformed its non-fermented counterpart in relieving constipation symptoms in rats treated with diphenoxylate. This was largely due to alterations in specific proteins and factors in the colon that help manage water and mucus in the digestive system.
Additionally, our metabolomic analyses suggested that several compounds, including linoleic acid and bile acids, might play roles in regulating constipation. Our findings reveal that fermentation not only enhances the nutritional quality of soybeans but also strengthens their ability to aid digestive health.
Read More
8
Bacillus subtilis improves sow health
Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows.
We conducted a study to explore how dietary supplementation with Bacillus subtilis QST 713 can influence reproductive performance, perinatal constipation, and the growth of piglets. By analyzing two groups of multiparous Landrace-Yorkshire sows—one on a standard diet and the other receiving Bacillus subtilis—we aimed to understand the broader effects of this probiotic on sow health and offspring.
Our findings revealed that the sows receiving Bacillus subtilis had shorter parturition times and lower stillbirth rates. Interestingly, sows on this diet showed improvements in their fecal scores, which suggests a reduction in constipation during the perinatal period. Moreover, the supplementation significantly boosted the protein level and IgM content in colostrum, enhancing the nourishment quality available to piglets.
Although the study primarily focused on the beneficial effects of Bacillus subtilis, the increase in protein levels in colostrum may have played a role in addressing constipation. It’s important to note that these outcomes are part of a multi-faceted intervention, making it challenging to pinpoint protein's standalone influence on constipation precisely. Overall, the supplementation showed promise in improving sow health and promoting the growth of healthy piglets.
Read More
Most Useful Reviews
9
Highly beneficial
5 people found this helpful
I first ordered pumpkin seeds and found them excellent in quality. They’re not large but very clean, and the package was impressive in volume. My family enjoys eating them, and I give them a bit each day as they're beneficial for health. They are said to aid in fighting constipation and boosting immunity. Plus, they contain valuable nutrients like zinc and magnesium. The benefits of pumpkin seeds are immense, and I will certainly purchase them again.
Read More
9
Relieves constipation
It tastes delightful and is of great quality. It's rich in health benefits and effectively alleviates constipation. I highly recommend using it.
Read More
9
Eliminates constipation
I find this product very effective. It has a pleasant scent, and my children love it. It's easy to use and moisturises well. Importantly, it effectively eliminates constipation, so I will buy it again.
We investigated how protein from probiotic-fermented soybean powder affects constipation, particularly in an experimental setting. Rats were used to test both fermented and non-fermented soybean powders for their laxative effects.
After eight days of fermentation, we noticed significant changes in various nutrients. While the polysaccharides in the soy decreased, the flavonoid levels first went up before swiftly dropping later. Importantly, we found that the fermented soybean resulted in higher levels of isoflavone aglycones, which showed promise for digestive health.
The fermented soybean powder outperformed its non-fermented counterpart in relieving constipation symptoms in rats treated with diphenoxylate. This was largely due to alterations in specific proteins and factors in the colon that help manage water and mucus in the digestive system.
Additionally, our metabolomic analyses suggested that several compounds, including linoleic acid and bile acids, might play roles in regulating constipation. Our findings reveal that fermentation not only enhances the nutritional quality of soybeans but also strengthens their ability to aid digestive health.
Read More
8
Bacillus subtilis improves sow health
Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows.
We conducted a study to explore how dietary supplementation with Bacillus subtilis QST 713 can influence reproductive performance, perinatal constipation, and the growth of piglets. By analyzing two groups of multiparous Landrace-Yorkshire sows—one on a standard diet and the other receiving Bacillus subtilis—we aimed to understand the broader effects of this probiotic on sow health and offspring.
Our findings revealed that the sows receiving Bacillus subtilis had shorter parturition times and lower stillbirth rates. Interestingly, sows on this diet showed improvements in their fecal scores, which suggests a reduction in constipation during the perinatal period. Moreover, the supplementation significantly boosted the protein level and IgM content in colostrum, enhancing the nourishment quality available to piglets.
Although the study primarily focused on the beneficial effects of Bacillus subtilis, the increase in protein levels in colostrum may have played a role in addressing constipation. It’s important to note that these outcomes are part of a multi-faceted intervention, making it challenging to pinpoint protein's standalone influence on constipation precisely. Overall, the supplementation showed promise in improving sow health and promoting the growth of healthy piglets.
Read More
7
Diabetes management beverage study
Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications.
Our exploration into the management of diabetes and its complications led us to develop a unique beverage formulation. This drink combines stevia glycoside, mogroside V, and sodium hyaluronate, known as SMH-B, which offers a sweet taste without affecting blood sugar levels.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
All Reviews
Positive Reviews
Negative Reviews
9
Highly beneficial
5 people found this helpful
I first ordered pumpkin seeds and found them excellent in quality. They’re not large but very clean, and the package was impressive in volume. My family enjoys eating them, and I give them a bit each day as they're beneficial for health. They are said to aid in fighting constipation and boosting immunity. Plus, they contain valuable nutrients like zinc and magnesium. The benefits of pumpkin seeds are immense, and I will certainly purchase them again.
Read More
9
Relieves constipation
It tastes delightful and is of great quality. It's rich in health benefits and effectively alleviates constipation. I highly recommend using it.
Read More
9
Eliminates constipation
I find this product very effective. It has a pleasant scent, and my children love it. It's easy to use and moisturises well. Importantly, it effectively eliminates constipation, so I will buy it again.
Read More
7.5
Effective for constipation
From my experience, this product is useful for constipation and tastes quite good. It's effective for both children and adults dealing with this issue.
Read More
7.5
Delicious aid
This is a wonderful product. The taste is palatable and the quality excellent. It’s particularly good for those struggling with constipation. I suggest a quarter cup for use.
Read More
Frequently Asked Questions
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Pumpkin seeds, often referred to as pepitas, are the edible seeds of certain types of pumpkins and squash. Unlike the traditional hull-on pumpkin seeds that are frequently roasted and consumed as a snack, pepitas are the flat, green seeds that have had their outer shell removed. Not only are they a popular ingredient in various cuisines, particularly in Mexican dishes, but they also pack a significant nutritional punch.
Rich in protein, healthy fats, and a variety of antioxidants, pepitas are a great addition to a balanced diet. They are a good source of magnesium, zinc, and iron, making them an excellent choice for anyone looking to enhance their overall nutrient intake. Pepitas can be enjoyed in numerous ways—sprinkled on salads, added to granola, or blended into smoothies for a boost in nutrition and flavor. Whether eaten raw, roasted, or seasoned, pumpkin seeds are an easy way to incorporate more plant-based goodness into your meals.
Pumpkin seeds, also known as pepitas, may indeed help alleviate constipation due to their high fiber content. A serving of pumpkin seeds can provide a substantial amount of dietary fiber, which is essential for promoting healthy digestion and regular bowel movements. Fiber adds bulk to stool, making it easier to pass through the intestines. Furthermore, pumpkin seeds contain magnesium, a mineral that supports muscular contractions in the digestive tract, which can also aid in relieving constipation.
Incorporating pumpkin seeds into your diet can be simple and delicious. You can sprinkle them on salads, blend them into smoothies, or enjoy them as a crunchy snack. However, it's important to consume them in moderation alongside a balanced diet rich in fruits, vegetables, and whole grains for optimal digestive health. If you're experiencing chronic constipation, it's always a good idea to consult with a healthcare professional for personalized advice. Overall, while pumpkin seeds can be a beneficial addition to your diet, they work best when combined with other healthy lifestyle practices.
Based on user reviews, the timeline for experiencing relief from constipation when using this supplement can vary. Many users report finding the product effective in alleviating constipation relatively quickly. For instance, one reviewer mentions improved results after incorporating the supplement into their routine, indicating that it works well for both children and adults Read Review. Another reviewer describes them as effective in managing constipation and highlights the immediate benefits they experienced Read Review.
While individual responses may differ, the consensus suggests that most users see positive results shortly after starting the supplement. In several reviews, customers appreciated the combination of quality and taste, which further motivated their consistent use, potentially leading to quicker relief Read Review. However, it is essential to remember that results can vary based on personal health conditions and adherence to dosage recommendations. Ultimately, for those seeking a solution to constipation, this supplement has garnered favorable feedback for its quick efficacy.
Based on the available studies, there is scientific support for certain supplements in addressing constipation. For example, a study involving probiotic-fermented soybean powder showed considerable promise in relieving constipation symptoms in an experimental rat model. The research indicated that the fermented soybean exhibited better laxative effects compared to its non-fermented counterpart, largely due to beneficial changes in the colon that help manage water and mucus, ultimately promoting digestive health [1].
Additionally, another study highlighted the impact of the probiotic Bacillus subtilis on improving fecal scores in sows, which suggests a reduction in constipation during the perinatal period [2]. Furthermore, a beverage formulated with natural sweeteners and additives demonstrated potential for alleviating constipation alongside managing diabetes, indicating a multifaceted approach to digestive health [3]. Overall, these findings point towards the beneficial effects of specific supplements and probiotics in relieving constipation, warranting further exploration within human applications.
Based on user reviews, many individuals have reported significant improvements in symptoms related to constipation when using this product. One user emphasized that the product not only tastes delightful but also effectively alleviates constipation, highlighting its health benefits Read Review. Another reviewer noted that it works well for children and adults alike, making it a versatile solution for families Read Review.
Overall, users appreciate the combination of quality, taste, and effectiveness, with several reporting it as a beneficial addition to their dietary routine. The pleasant smell and ease of use also seem to enhance the overall experience, prompting some to continue purchasing the product for consistent results Read Review. However, as with any supplement, individual results may vary, and it’s essential to consider personal health conditions when assessing potential benefits.
Based on user reviews, there are varied experiences regarding combining this supplement with other products for managing constipation. One user highlighted the benefits of pumpkin seeds, stating they contribute to alleviating constipation, while also providing valuable nutrients such as zinc and magnesium Read Review. Other users have noted that the supplement is effective on its own, with several reviewers praising its taste and quality. For instance, one noted its effectiveness and ease of use, making it a friendly option for children as well Read Review.
The consensus suggests that, while users primarily focused on the supplement's individual benefits, some might combine it with other dietary options, benefitting from the additional nutrients. Overall, many users found the product effective and recommended it for constipated individuals without explicit mentions of combining it with other supplements for optimal effects Read Review. Thus, most feedback implies a reliance on this supplement as a standalone remedy rather than as part of a broader supplement strategy.
Based on user reviews, many customers have reported positive outcomes from using Pumpkin Seeds Pepitas for treating constipation. Users highlight the product's health benefits and effectiveness in alleviating constipation for both children and adults. One user specifically noted that while the seeds provide numerous benefits, including boosting immunity, they recommend a daily serving of around a quarter cup for optimal results in combating constipation Read Review.
Additionally, reviewers consistently praised the product for its pleasant taste and high quality, which seems to encourage regular consumption. Overall, the consensus suggests that incorporating a moderate amount of pumpkin seeds into one's diet can be a helpful natural remedy for constipation Read Review.
7.5
Effective for constipation
From my experience, this product is useful for constipation and tastes quite good. It's effective for both children and adults dealing with this issue.
9
Eliminates constipation
I find this product very effective. It has a pleasant scent, and my children love it. It's easy to use and moisturises well. Importantly, it effectively eliminates constipation, so I will buy it again.
9
Relieves constipation
It tastes delightful and is of great quality. It's rich in health benefits and effectively alleviates constipation. I highly recommend using it.
9
Highly beneficial
5 people found this helpful
I first ordered pumpkin seeds and found them excellent in quality. They’re not large but very clean, and the package was impressive in volume. My family enjoys eating them, and I give them a bit each day as they're beneficial for health. They are said to aid in fighting constipation and boosting immunity. Plus, they contain valuable nutrients like zinc and magnesium. The benefits of pumpkin seeds are immense, and I will certainly purchase them again.
7.5
Delicious aid
This is a wonderful product. The taste is palatable and the quality excellent. It’s particularly good for those struggling with constipation. I suggest a quarter cup for use.
9
Fermented soy improves constipation relief
Incremental effects of fermentation of soybean on its nutrients, flavor profile and laxative regulation in experimental constipated rats.
We investigated how protein from probiotic-fermented soybean powder affects constipation, particularly in an experimental setting. Rats were used to test both fermented and non-fermented soybean powders for their laxative effects.
After eight days of fermentation, we noticed significant changes in various nutrients. While the polysaccharides in the soy decreased, the flavonoid levels first went up before swiftly dropping later. Importantly, we found that the fermented soybean resulted in higher levels of isoflavone aglycones, which showed promise for digestive health.
The fermented soybean powder outperformed its non-fermented counterpart in relieving constipation symptoms in rats treated with diphenoxylate. This was largely due to alterations in specific proteins and factors in the colon that help manage water and mucus in the digestive system.
Additionally, our metabolomic analyses suggested that several compounds, including linoleic acid and bile acids, might play roles in regulating constipation. Our findings reveal that fermentation not only enhances the nutritional quality of soybeans but also strengthens their ability to aid digestive health.
8
Bacillus subtilis improves sow health
Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows.
We conducted a study to explore how dietary supplementation with Bacillus subtilis QST 713 can influence reproductive performance, perinatal constipation, and the growth of piglets. By analyzing two groups of multiparous Landrace-Yorkshire sows—one on a standard diet and the other receiving Bacillus subtilis—we aimed to understand the broader effects of this probiotic on sow health and offspring.
Our findings revealed that the sows receiving Bacillus subtilis had shorter parturition times and lower stillbirth rates. Interestingly, sows on this diet showed improvements in their fecal scores, which suggests a reduction in constipation during the perinatal period. Moreover, the supplementation significantly boosted the protein level and IgM content in colostrum, enhancing the nourishment quality available to piglets.
Although the study primarily focused on the beneficial effects of Bacillus subtilis, the increase in protein levels in colostrum may have played a role in addressing constipation. It’s important to note that these outcomes are part of a multi-faceted intervention, making it challenging to pinpoint protein's standalone influence on constipation precisely. Overall, the supplementation showed promise in improving sow health and promoting the growth of healthy piglets.
7
Diabetes management beverage study
Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications.
Our exploration into the management of diabetes and its complications led us to develop a unique beverage formulation. This drink combines stevia glycoside, mogroside V, and sodium hyaluronate, known as SMH-B, which offers a sweet taste without affecting blood sugar levels.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
References
Yang C, Chen X, Niu P, Yang X, Lu Y. Incremental effects of fermentation of soybean on its nutrients, flavor profile and laxative regulation in experimental constipated rats. Food Funct. 2025. 10.1039/d4fo06067a
Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. 10.1016/j.anireprosci.2025.107785
Lei P, Yu H, Jiang T, Ma J, Du J, et al. Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications. Int J Biol Macromol. 2025;293:139487. 10.1016/j.ijbiomac.2025.139487