NOW Supplements Magnesium Citrate

Magnesium improves elderly insomnia

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, et al. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17:1161.

We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.

Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.

The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.

Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.

9.5

Reduced insomnia

Most Useful Review

Excellent support for the nervous system. Since taking this magnesium supplement, I’m much calmer and my insomnia has improved significantly. Unlike other magnesium products that caused nausea, this one works perfectly. I continue to take it monthly.

Anxiety details

Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y

Magnesium treats anxiety in MS

We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.

8.8

Reduced anxiety

Most Useful Review

Magnesium citrate calms me effectively and helps soften stools. I take one tablet before bedtime, and my constipation has vanished, leaving me feeling much calmer. I highly recommend it!

Bone Pain details

CMT shows potential for pain relief

Based on 3 Researches

Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.

We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.

While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.

9.5

Night cramps resolved

Most Useful Review

Magnesium citrate effectively relieved my night cramps and joint pain. It has worked wonders, and I highly recommend it for those suffering from similar issues.

Cardiovascular Disease details

Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. doi:10.3390/nu16234223

Magnesium's impact on heart health

We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.

Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.

Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.

9.5

Essential for health

Most Useful Review

I recommend magnesium to all my patients as it is crucial for many bodily functions including those essential for cardiovascular disease. Deficiency can lead to several issues like fatigue and heartburn. It's best to use various forms for optimal benefits.

Celiac details

Magnesium is salvation

My salvation! After years of intestinal problems and constipation with no results from various treatments, this magnesium has been miraculous. I take 4 capsules daily—2 during meals and 2 before bed. Three weren't sufficient for me. The effect is fantastic; I have regular bowel movements now. The capsules are small and easy to swallow, and I am pleased with the product's quality. I will definitely order again.

Constipation details

Effective treatment for chronic constipation

Based on 22 Researches

Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. doi:10.14309/ajg.0000000000000942

We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.

Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.

Importantly, there were no severe treatment-related side effects reported during the trial.

9.5

Enhanced serenity

Most Useful Review

Calmness, only calmness. After a few weeks on 400 mg of magnesium daily, my psychosis improved. I observed various deficiency symptoms such as insomnia and cramps. I consulted an endocrinologist who confirmed my magnesium deficiency. Now, I feel much calmer and can communicate better with my child, resulting in happiness for both of us.

Anemia details

Significant health improvement

Working! An excellent supplement. I have anemia, low haemoglobin, and all the symptoms of magnesium deficiency. After starting this dietary supplement, my health improved significantly. My sleep returned to normal, I felt less fatigued and irritable, and my muscle pain disappeared. The dosage is good, quality high and the price reasonable. I trust this brand; I have used many of their products and have been satisfied.

Arthritis details

Magnesium protects against bone erosion

Based on 17 Researches

Li Y, Wang Y, Xu L, Liu C, Cui J, et al. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1375871. doi:10.3389/fendo.2024.1375871

We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.

Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.

Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.

9.5

Reduced arthritis pain

Most Useful Review

I stopped using calcium and now use Magnesium Citrate instead, which was recommended by a friend. My arthritis feels significantly better since I made the switch.

Atrial Flutter details

Effective for migraines

I've only read positive things about Mr. Fujikawa's blog and have been drinking this magnesium. It effectively alleviates migraines, eyelid spasms, arrhythmia, and leg cramps!

Autoimmune Disorder details

Magnesium shows promise for RA treatment

Based on 10 Researches

Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247

We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.

Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.

9.5

Improved sleep quality

Most Useful Review

I had wanted to order magnesium for a long time and this is the first company I've tried. I started taking it before bed and was pleasantly surprised to find I began to sleep well. I used to wake up feeling tired, but now I wake up before my alarm, full of energy. Additionally, it has helped with my constipation. I recommend it!

Chronic Fatigue Syndrome details

Magnesium potentially benefits CFS patients

Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet. 1991;337:757.

We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.

In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.

In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.

9.5

Better sleep

Most Useful Review

I struggled with chronic fatigue syndrome, often waking multiple times at night. However, after starting magnesium on my doctor’s advice, I now fall asleep quickly and wake refreshed. It also positively affects my cardiovascular system and helps with muscle cramps. Highly recommend it!

Depression details

Magnesium intake reduces depression risk

Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. doi:10.1093/nutrit/nuae056

We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.

Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.

9.5

Mood enhancer

Most Useful Review

I wholeheartedly endorse magnesium citrate! It lifted me from deep depression and calmed my PMS. I take two capsules daily and feel significantly better.

Gout details

Magnesium may protect against bone erosion

Based on 2 Researches

We examined the relationship between magnesium levels and the occurrence of bone erosion in patients with gouty arthritis. In our analysis, we observed that 769 gout patients were studied, allowing us to classify them into groups based on their serum ionized magnesium levels.

The results were striking: those with lower magnesium levels had a significantly higher rate of bone erosion. Specifically, patients in the lowest magnesium group showed a bone erosion prevalence rate of over 60%, compared to less than 45% in those with higher magnesium levels.

Our findings suggest that maintaining adequate levels of magnesium might offer a protective effect against bone deterioration in gout arthritis. This points to the possibility that magnesium supplementation could be beneficial for preventing or slowing down bone erosion in these patients.

9.5

Pain relief

Most Useful Review

Very effective in lowering uric acid. The price is reasonable. I take one pill after each meal, and the pain from gout disappears. Taking 3-5 pills a day improves my body and urine's pH value, effectively reducing uric acid. This medicine works well for gout.

Irritable Bowel Syndrome details

Magnesium boosts colonic activity

Harvey RF, Read AE. Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome. Gut. 1973;14:983.

We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.

Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.

Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.

9.5

Improved bowel function

Most Useful Review

A restful sleep is guaranteed. It improves bowel function, reduces stress and irritability, and regulates blood sugar and oxygen levels. You will feel more rested and resilient to stress.

Kidney Stones details

Magnesium reduces kidney stone risk

Based on 9 Researches

Taheri M, Jalali S, Borumandnia N, Tavasoli S, Basiri A, et al. Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial. Magnes Res. 2024;37:12. doi:10.1684/mrh.2024.0524

We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.

9.5

Improved blood pressure

Most Useful Review

Magnesium citrate is easily absorbed and has significantly helped my husband and me. After consuming three bottles, I've noticed reduced soreness and stable blood pressure. It aids in activating vitamin D in the kidneys and is beneficial for muscle and bone health, as well as energy production.

Migraine details

Magnesium reduces migraine symptoms

Based on 21 Researches

Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. doi:10.3390/nu17040725

We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.

9.5

Life-changing experience

Most Useful Review

This changed my life. I have suffered from daily migraines since puberty, trying every preventative available. Surprisingly, these pills have drastically reduced my migraines to just one per week, especially after eliminating certain foods.

Reflux details

Magnesium alginate effectively treats LPR

Based on 11 Researches

Ciprandi G, Damiani V, Passali FM, Crisanti A, Motta G, et al. Magnesium alginate in patients with laryngopharyngeal reflux. J Biol Regul Homeost Agents. 2021;35:61. doi:10.23812/21-1supp2-12

We examined the role of magnesium alginate in treating laryngopharyngeal reflux (LPR), which causes symptoms like voice issues, swallowing difficulties, and coughing. In a study involving 100 outpatients, patients were treated with alginate for two months, visiting at the start and then at 15, 30, and 60 days.

The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.

9.5

Reduced reflux discomfort

Most Useful Review

Good evening, we are from Ukraine! I wish you all the best in this challenging time. This magnesium was prescribed by my doctor, so I take three capsules before bedtime as directed. The capsules are large, necessitating plenty of water. My gastrointestinal tract has improved, and the reflux gastritis has ceased to trouble me. My nervousness during PMS has also disappeared.

Athlete’s Foot details

My legs no longer hurt. I began taking magnesium for cramps and pain in my feet, and within an hour, I noticed relief. It appears that my leg cramps were due to a magnesium deficiency. I'm surprised by how effective the supplement is, and I appreciate that it’s chelated for better absorption.

Back Pain details

Magnesium reduces postoperative back pain

Based on 7 Researches

Celenlioglu AE, Sir E, Ors-Yildirim N, Yildirim AK, Ince ME, et al. Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting. J Vasc Surg Venous Lymphat Disord. 2023;11:517. doi:10.1016/j.jvsv.2022.09.008

We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.

9.5

Knee pain resolved

Most Useful Review

My left knee issue has resolved, allowing me to go down stairs without pain. After trying various supplements, magnesium proved to be the missing link in treating my back pain and knee discomfort.

Blurred Vision details

This is because the land is being degraded by pesticides. Due to the extensive use of chemical fertilisers such as nitrogen, the mineral content in vegetables and other foods is diminishing. It's vital to take supplements. Magnesium is involved in over 300 metabolic processes, and its ability to prevent cramps is significant. When I began taking it, I was astonished as my vision suddenly became focused. Magnesium has an effect on stabilising blood flow in the retina. The dose is 133 mg/cp, which differs from medical magnesium oxide. Thank you for reading to the end.

Bruise details

Magnesium reduces bruising post-surgery

Likely Very Effective

Zou P, Zhang K, Jin Y, Liu G. The Efficacy of Magnesium Sulfate (MgSO4) Wet Dressing in Reducing Eyelid Swelling and Bruising after Blepharoplasty: A Randomized, Controlled, and Observer-Blinded Assessment Study. Facial Plast Surg. 2024;40:46. doi:10.1055/s-0043-1767768

We explored the impact of magnesium sulfate (MgSO4) wet dressings on bruising and swelling following blepharoplasty, a common eyelid surgery. In our study, fifty-eight patients were evenly split between two treatments: one side received a magnesium sulfate solution, while the other was cooled with ice packs. This setup allowed us to compare the effectiveness of these two methods objectively.

Over the recovery period, we observed that the eyelid swelling was similar in both groups initially but notably reduced over time. However, by the fifth day after surgery, we found that those treated with the magnesium solution experienced significantly less swelling compared to the cooling method. Additionally, bruising—measured by both area and incidence—was also lower in the magnesium group, highlighting its effectiveness.

Interestingly, a significant majority of patients preferred the magnesium treatment over ice cooling, with many appreciating the convenience and results of the wet dressing. This suggests that magnesium sulfate is not only effective in reducing bruising and swelling but is also a patient-favored option for recovery after eyelid surgery.

9.5

Helps with bruises

Most Useful Review

A year ago, I switched from pharmacy Magnelis B6 to this magnesium, which cost a fortune. The endless bruises I had were a real concern. I now understand that citrate is the most absorbable form of magnesium, helping with constipation, acting as an antispasmodic, alleviating gastrointestinal spasms, alkalising the body, and addressing deficiencies. I take it 2 hours before bedtime, though it can also be consumed in the morning and afternoon.

Chest Pain details

Magnesium improves chest pain outcomes

Based on 19 Researches

Shechter M, Bairey Merz CN, Stuehlinger HG, Slany J, Pachinger O, et al. Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease. Am J Cardiol. 2003;91:517.

We examined how oral magnesium might enhance quality of life and reduce exercise-induced chest pain for those with coronary artery disease (CAD). In an impressive multicenter trial, 187 patients were randomly assigned to receive either magnesium supplements or a placebo for six months.

Our findings show that magnesium therapy improved exercise duration and decreased chest pain during exertion. Participants receiving magnesium reported both enhanced exercise tolerance and better quality of life compared to those on a placebo. This suggests that magnesium supplementation could play an important role in managing CAD symptoms.

9.5

Eliminated chest pain

Most Useful Review

My beloved magnesium! The issue with my left knee pain has substantially improved, allowing me to navigate stairs with ease. After trying various supplements, including omega 3 and collagen, the addition of magnesium seemed crucial for my recovery. I deeply appreciate its benefits and plan to continue its use forever, God willing.

Cholecystitis details

Great! I take it to support gallbladder function, and the results are fantastic.

Dizziness details

Magnesium's role in Meniere's treatment

Based on 7 Researches

Abouzari M, Abiri A, Djalilian HR. Successful treatment of a child with definite Meniere's disease with the migraine regimen. Am J Otolaryngol. 2019;40:440. doi:10.1016/j.amjoto.2019.02.004

We observed the intriguing connection between Meniere's disease (MD) and migraine-related dizziness in our study of a 5-year-old girl. She experienced a six-month struggle with left-sided hearing loss, which evolved into daily bouts of vertigo, headaches, and vomiting, fulfilling the criteria for definite MD.

After implementing a specialized six-week migraine diet and lifestyle plan that included riboflavin and magnesium, we noted a remarkable transformation. The child became symptom-free and achieved nearly normal hearing levels, leading us to consider that MD symptoms might be linked to vestibular migraine triggers.

This suggests that young patients with MD could greatly benefit from lifestyle and dietary adjustments aimed at managing migraine symptoms. While magnesium was part of this regimen, it’s essential to look at it as one component of a broader approach. The results invite further exploration into how dietary interventions may alleviate both cochlear and vestibular symptoms in Meniere's disease.

9.5

Reduced dizziness

Most Useful Review

I take magnesium in courses as recommended by my cardiologist to manage dizziness of unclear origin. I noticed a reduction in dizziness a couple of weeks after starting the intake while taking it with a vitamin B complex. I take 1 tablet three times a day.

Hashimoto details

Reliable magnesium source

My best friend magnesium citrate has been my steadfast ally. It effectively addresses my primary concerns regarding Hashimoto disease, and its other benefits are of lesser importance to me. With its support, I feel completely fine. Thank you for your attention.

Hypothyroidism details

Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, et al. Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021;199:4074. doi:10.1007/s12011-020-02548-3

Magnesium shows potential benefits

We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.

In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.

However, no noteworthy changes were observed in the control group regarding thyroid hormones.

Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.

9.5

Indispensable supplement

Most Useful Review

Magnesium citrate is irreplaceable for my hypothyroidism treatment. It’s non-constipating and soothing, and I take at least three capsules daily. I've now introduced it to my daughter; it’s particularly beneficial during menopause when sleep can be elusive. It works wonderfully with estrogens.

Osteoporosis details

Magnesium's role in osteoporosis therapy

Based on 19 Researches

Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. doi:10.1186/s12944-024-02083-3

We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.

9.5

Alleviates constipation

Most Useful Review

I purchased magnesium citrate for my mother’s constipation, which laxatives didn't help. After taking magnesium citrate, her long-term constipation resolved. It also aids her osteoporosis, and I hope it improves her bone density.

Pelvic Pain details

Magnesium alleviates primary dysmenorrhea

Based on 10 Researches

Benassi L, Barletta FP, Baroncini L, Bertani D, Filippini F, et al. Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea. Clin Exp Obstet Gynecol. 1992;19:176.

We evaluated how magnesium pidolate impacts primary dysmenorrhea in 30 young women. Over six menstrual cycles, we tracked their pain levels using a visual scale. Initially, no treatment was given, and subsequently, magnesium was administered just before menstruation.

The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.

9.5

Knee pain relief

Most Useful Review

My beloved heart 😍 The problem with my left knee and the accompanying pain that prevented me from going down stairs has been resolved. I used various supplements, and with magnesium, my knee returned to normal, as if it were the final treatment missing link. I truly love this and will continue taking it forever, God willing.

This study looks into how mesoporous magnesium carbonate (MMC) can help with acne by reducing bacteria that thrive on our skin. We used a specific Gram-positive bacterium considered a common culprit in acne lesions. To ensure our results were reliable, we measured bacterial activity using a metabolic assay.

Our findings revealed that MMC exhibits a strong antibacterial effect against this acne-related bacterium. A significant factor contributing to its effectiveness is the material's alkalinity. This suggests that MMC could be developed further as a skincare ingredient aimed at inhibiting bacterial growth, providing an alternative to traditional antibiotic treatments.

Overall, we see promising potential for MMC in topical applications, especially for those looking for non-antibiotic solutions to manage acne and maintain skin health.

9.5

Improved skin quality

Most Useful Review

It may not work for everyone, but I have battled adult acne for years. I took Vitamin A on a whim to see if it would help, and it has. Although it takes time, this product significantly improved my skin quality and reduced my acne. I highly recommend it!

Adrenal Gland Disorder details

Excellent addition for the complex treatment of adrenal fatigue! I've observed a visible result: a sense of calm, improved mood, and no more mood swings.

Asthma details

Magnesium sulfate aids pediatric asthma

Based on 4 Researches

Rower JE, Johnson MD, Zorc JJ, Shihabuddin B, Dai M, et al. Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. J Clin Pharmacol. 2025. doi:10.1002/jcph.6179

We explored how intravenous magnesium sulfate (IVMg) can help children facing severe asthma attacks. The study included 49 pediatric patients who were treated with IVMg after presenting to the emergency department. Some received a placebo, while others were given either 50 or 75 mg/kg of magnesium.

Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.

Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.

9.5

Effective for asthma

Most Useful Review

I purchased this product based on recommendations for its effectiveness in treating asthma. Recently, I’ve noticed improvements, confirming that it is indeed effective. Thank you!

Bacterial Infection details

Excellent magnesium in citrate form. Although I've only been taking this magnesium for a short period, I've already observed a boost in my immune system. After catching a viral infection, I recovered rapidly with only mild symptoms, which vanished in two days! Previously, common colds would last longer. I increased my magnesium intake during this period and was pleased to find that my strength remained intact, without any lingering weakness. Perhaps it’s just a coincidence, but I’m satisfied with this supplement.

Frozen Shoulder details

Stiff shoulders and neck have been cured. I take one capsule in the morning and at night. I had suffered from stiff neck, shoulders, and headaches for years, but now I am free of pain. I don't exercise, and it's all thanks to magnesium citrate. It feels reasonably priced compared to massages and acupuncture treatments.

Gastritis details

Improved gastrointestinal work

Good evening, we are from Ukraine!🏠💛💙 I wish you all the best during this challenging time. This magnesium was prescribed by my doctor, and I take 3 large capsules before bed as directed, which necessitates plenty of water. My gastrointestinal tract has improved, and reflux gastritis no longer troubles me. Additionally, my nervousness during PMS has ceased.

Heart Disease details

Magnesium supplements lower heart failure risk

Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870

We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.

In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.

Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.

9.5

Normalises heartbeat

Most Useful Review

Magnesium citrate has been a lifesaver for my VSD, reducing my heart rate and normalising blood pressure. I've noticed significant improvements in muscle cramps and eye twitching after just two weeks of intake, and I maintain regularity with my bowel movements.

Hypertension details

Magnesium intake linked to reduced hypertension

Han M, Zhang Y, Fang J, Sun M, Liu Q, et al. Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia. Hypertens Res. 2024;47:331. doi:10.1038/s41440-023-01439-z

We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.

We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.

These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.

9.5

Supports overall wellbeing

Most Useful Review

I'm not feeling as hungry and I'm sleeping well! Magnesium plays a key role in supporting good sleep and relieving stress, which is helpful for those with hypertension. It has notably improved my daily activities and reduced menstrual cramps, and I often share it with my family. Just remember, moderation is crucial to avoid overdose.

Indigestion details

Excellent for indigestion

The quality is excellent with sweet, easy ingredients, and the quantity is good. Magnesium is beneficial for constipation issues; it has helped my mother with her indigestion. I’ve noticed improvements in her stomach health, for which I am grateful.

Knee Pain details

Magnesium sulfate alleviates postoperative pain

Zhao C, Wang L, Chen L, Wang Q, Kang P. Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2023;18:301. doi:10.1186/s13018-023-03790-w

We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.

Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.

Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.

9.5

Relieved joint pain

Most Useful Review

Magnesium citrate is an excellent remedy; it alleviated my night cramps and joint pain.

Menopause details

Magnesium aids menopause-related issues

Based on 8 Researches

Zhang J, Mai CL, Xiong Y, Lin ZJ, Jie YT, et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021;14:6633. doi:10.2147/JIR.S330894

We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.

9.5

Less irritable feeling.

Most Useful Review

I recommend it! I purchased magnesium for its benefits on depression and irritability during menopause. After starting it, I felt less depressed and irritable, enabling me to live more comfortably. My mother had severe menopausal symptoms, but if taking magnesium can alleviate my fears about menopause, I’m delighted! I appreciate the capsule size as well, making it easy to take.

Sciatica details

I have been suffering from sciatica pain for a year. After numerous yoga sessions, stretching, and acupuncture, I've managed to maintain my hiking and workout routine weekly. I researched remedies and learned that magnesium could potentially help with sciatica, so I decided to try it. It truly works! After about two weeks of taking magnesium, I've noticed a gradual reduction in pain. I am immensely grateful!

Toothache details

I love this magnesium form; it alleviates pain effectively, helping with headaches and toothaches. Additionally, it has a laxative effect, which I consider beneficial. If this was helpful, please click yes.

Autism details

Magnesium linked to autism levels

Almalki AH, Bamaga AK, Alharbi A, Abduljabbar MH, Alnemari RM, et al. Exploring the association between serum magnesium level and autism spectrum disorder using validated spectrofluorimetric method. Anal Biochem. 2025;699:115755. doi:10.1016/j.ab.2024.115755

We aimed to understand the relationship between magnesium levels and autism spectrum disorder (ASD), shedding light on a critical nutrient’s role in brain health. To do this, we developed a unique analytical method to measure magnesium levels in the serum of both autistic and healthy children. Our approach used innovative technology involving fluorescent graphene quantum dots to detect magnesium, ensuring accuracy in our measurements.

Our findings revealed that children with ASD had significantly lower serum magnesium levels compared to their healthy peers. Specifically, they averaged 2.03 mg/dl of magnesium, while the healthy group had an average of 2.28 mg/dl. This noteworthy difference suggests a potential link between magnesium deficiency and ASD, indicating that enhancing magnesium levels might benefit autistic children.

Overall, our study emphasizes the importance of considering micronutrients like magnesium when addressing autism. While further research is necessary to fully understand the implications, our results provide a foundation for exploring magnesium supplementation as a supportive approach for those with autism spectrum disorder.

9.5

Improves bowel issues

Most Useful Review

This is not the first time I have purchased this drug for my son with autism, as magnesium citrate suits him according to genetic analysis. This form of magnesium effectively regulates nervous excitement and has a relaxing effect on the colon, helping him with stool problems. Previously, he required laxatives. The dosage is quite convenient—I give him one large capsule in the afternoon alongside GABA from the same manufacturer.

Blood Clot details

Magnesium scaffold shows promising results

Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study. EuroIntervention. 2023;19:e414. doi:10.4244/EIJ-D-23-00326

We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.

Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.

Overall, our findings support its potential use in heart treatments.

9.5

Normalised heart rate

Most Useful Review

Excellent help from VSD Magnesium citrate has been a lifesaver for my VSD, nervousness, high heart rate, and blood pressure issues. It has brought my blood pressure to normal and reduced my pulse from 90-110 beats per minute to 70-75. The heart palpitations have ceased, and I no longer experience muscle cramps or eye twitches. I take three pills a day after meals, and it has also improved my bowel regularity.

Cancer details

Magnesium alloy inhibits cancer growth

Ouyang Y, Cao L, Zhao Q, Yang W, Lin C. Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer. Biomed Mater. 2025. doi:10.1088/1748-605X/adb2cc

We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.

In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.

Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.

With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.

8.8

Relieves constipation

Most Useful Review

I've just started using it, and it seems to be effective for my constipation due to colon cancer.

Eczema details

Great! I have purchased this product several times and am very satisfied. During an exacerbation of my eczema, I take five capsules a day, reducing to three once it improves. This regimen was prescribed by my doctor. I experience no side effects from this magnesium.

High Cholesterol details

Magnesium chloride reduces liver stress

Based on 9 Researches

Mohammed KA, Goji ADT, Tanko Y, Muhammed A, Salisu IA. Protective Effects of Magnesium Chloride on Liver Enzymes and Biomarkers of Oxidative Stress in high fat diet fed Rats. Niger J Physiol Sci. 2019;34:149.

We aimed to find out how magnesium chloride influences liver health and oxidative stress in rats on a high-fat diet.

In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.

We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.

This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.

8.3

Eliminates bad cholesterol

Most Useful Review

Magnesium is vital for the nervous system and heart muscle. It has a vasodilator effect, normalises blood pressure, and promotes the elimination of bad cholesterol from the body.

Sleep Apnea details

Magnesium's role in sleep apnea

Luo X, Tang M, Wei X, Peng Y. Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study. J Affect Disord. 2024;358:105. doi:10.1016/j.jad.2024.05.002

We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.

We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.

Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.

While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.

9.5

Improved sleep quality

Most Useful Review

Sleep has returned to normal after a week of taking magnesium. I fall asleep quickly and no longer wake during the night, helping me feel more cheerful. My depressive state began to improve from week three, and now I no longer experience tantrums, making me feel like a happy, functioning person.

Swollen Lymph Nodes details

Has relaxed my pregnancy cramps. The quality of this product is excellent; the benefits are felt immediately. It has helped with leg swelling and muscle cramps due to pregnancy. The only downside is the large pill size. My sleep and mood have improved, and it is tasteless, which is great for pregnancy.

Adenoiditis details

Relieves cramps and anxiety

I was prescribed magnesium by my doctor to take almost permanently, alternating between different forms but not oxide. Regular intake prevents cramps and reduces anxiety. These capsules are easy to swallow, unlike many other magnesium tablets that can irritate the throat.

Allergies details

Magnesium enhances postoperative recovery

Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. doi:10.2147/DDDT.S444896

We conducted a study to see how magnesium sulfate could influence recovery after total knee arthroplasty in older patients. Using a double-blind, randomized control design, 148 patients were split into two groups: one received magnesium sulfate while the other got saline.

We found that magnesium sulfate not only reduced early postoperative pain but also enhanced the quality of recovery. This suggests that incorporating magnesium into pain management could be beneficial for older adults undergoing knee surgery, improving their overall recovery experience.

9.5

Reduced anxiety

Most Useful Review

I initially left a negative review due to tachycardia and tremors. However, after stopping the chelated vitamins, I realised the allergy was to them. Taking magnesium alone has made me 99% calmer. It’s excellent for anyone with anxiety disorders!

Diabetes details

Magnesium intake benefits diabetes patients

Based on 19 Researches

Huang R, Kong X, Geng R, Wu J, Li J, et al. Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank. Diabetes Metab. 2024;50:101554. doi:10.1016/j.diabet.2024.101554

We investigated the link between dietary magnesium intake and the risk of heart disease and death in over 149,000 individuals, including those with type 2 diabetes. Through careful analysis over a median of 12 years, we found that higher magnesium intake was associated with significantly lower risks of heart disease and mortality in individuals with diabetes.

However, this benefit wasn't seen in those without diabetes. Our findings highlight the potential for magnesium to play a crucial role in health management for people living with type 2 diabetes, signaling the need for tailored dietary guidance.

9.5

Supports pancreatic function

Most Useful Review

An excellent product! It normalises mood, dilates blood vessels, reduces pressure, and maintains heart health. It's vital for pregnant women for child development and aids in improving pancreatic beta cell function in diabetes when combined with selenium, chromium, and zinc.

Pneumonia details

Big package! I often take magnesium, and its large packaging is very convenient. It's excellent for supporting the heart and the body. I particularly relied on magnesium, exceeding the recommended dosage as my doctor advised, while suffering from pneumonia.

Stroke details

Magnesium shows neuroprotective promise

Based on 15 Researches

Zhang Y, Zhang H, Jiang M, Cao X, Ge X, et al. Neuroprotection on ischemic brain injury by Mg/H released from endovascular Mg implant. Bioact Mater. 2024;42:124. doi:10.1016/j.bioactmat.2024.08.019

We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.

To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.

Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.

In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.

7.5

Doctor's advice

Most Useful Review

I bought magnesium citrate for my mother, following her doctor's recommendation. Magnesium is known to lessen the risks associated with ischemic heart disease, hypertension, and stroke while normalising blood pressure and preventing muscle contractions.

Common Cold details

No longer catch colds

Since I began taking it with zinc, I no longer catch a common cold.

Heartburn details

Magnesium alginate offers heartburn relief

Based on 6 Researches

Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.

We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.

9.5

Effective absorption

Most Useful Review

Most people are magnesium deficient due to poor digestion or medication. Magnesium deficiency may lead to various conditions including heartburn. Magnesium Citrate, a popular form, is easily absorbed, but high dosages can cause laxative effects. I find it helpful for my heartburn. Please put "Yes" 💜.

Tinnitus details

Magnesium's role in tinnitus explored

Based on 6 Researches

Uluyol S, Kılıçaslan S, Yağız Ö. Relationship between serum magnesium level and subjective tinnitus. Kulak Burun Bogaz Ihtis Derg. 2016;26:225. doi:10.5606/kbbihtisas.2016.87094

We explored the connection between serum magnesium levels and the occurrence of severe bilateral subjective tinnitus. This study involved 76 patients suffering from this distressing condition and compared them to 86 healthy participants.

By measuring and analyzing the magnesium levels in both groups, we observed that those with tinnitus had significantly lower magnesium concentrations—1.8 mg/dL compared to 2.3 mg/dL in the control group. This difference suggests that magnesium may play a role in the body’s response to tinnitus.

Our findings indicate that magnesium could be an important factor in understanding the pathophysiology of subjective tinnitus. While this doesn’t confirm that magnesium treatment will alleviate tinnitus symptoms, it certainly opens up avenues for further research in this area.

9.5

Prevented tinnitus convulsions

Most Useful Review

Excellent! I experienced symptoms of magnesium deficiency, including sleep disturbances and convulsions, which alarmed me. After consulting my doctor, I’ve been taking magnesium citrate. I start with six capsules daily due to my high physical activity, gradually reducing it when feeling better. My symptoms, including tinnitus, have normalised, and the packaging is convenient.

Fibromyalgia details

Magnesium potentially aids fibromyalgia

Based on 6 Researches

Macian N, Dualé C, Voute M, Leray V, Courrent M, et al. Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial. Nutrients. 2022;14. doi:10.3390/nu14102088

We conducted a randomized, controlled, double-blind study to determine the effects of magnesium on fibromyalgia symptoms. Our findings showed that magnesium supplementation did not lead to a significant reduction in overall stress levels compared to placebo.

However, we did find that magnesium significantly reduced mild to moderate stress and pain severity among participants. These results suggest that including magnesium in treatment could help alleviate some of the burdens fibromyalgia patients face.

This research indicates further exploration of magnesium’s potential should take place in larger studies.

8.8

Migraine relief

Most Useful Review

I feel the effects of fibromyalgia and migraines, but since I began taking this, I have not experienced severe migraine attacks. It seems to also benefit my family's fibromyalgia. The capsules are somewhat large, so I take them with plenty of water. My stomach has become a bit loose, but that is manageable.

Headache details

Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. doi:10.3390/nu17040725

Magnesium aids migraine management

We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.

A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.

This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.

9.5

Headache relief

Most Useful Review

This magnesium is one of the most affordable online. It is a great aid for the body, addressing magnesium deficiency which many people suffer from. It relieves headaches, improves bowel function, and enhances sleep quality. I feel more energetic and balanced after two years of use.

Rash details

Magnesium affects rash treatment efficacy

Based on 2 Researches

Neckermann G, Bavandi A, Meingassner JG. Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981. Br J Dermatol. 2000;142:669.

We investigated how magnesium deficiency affects rash in hairless rats, which develop a severe, itchy rash resembling atopic dermatitis. In our study, we tested a derivative called SDZ ASM 981, given either systemically or topically. Remarkably, oral treatment with SDZ ASM 981 significantly cleared the rash within just one day.

Furthermore, this treatment reduced several inflammatory markers, showing promising results for both prevention and therapy. This indicates that magnesium's role might be crucial in managing similar skin conditions in humans, reinforcing the value of this rat model for effective treatment evaluation.

9.5

Rash disappearance

Most Useful Review

This form of magnesium has considerably aided in resolving my sluggish intestines, leading to regular bowel movements. Additionally, magnesium enhances the absorption of various beneficial components. My condition has markedly improved after two months of usage. I've experienced an increase in energy and an uplifted mood. When combined with Taurine, psyllium, lecithin, probiotics, and enzymes, I optimised my gastrointestinal tract's function, making this a crucial first step in my recovery! The rashes on my face have vanished, the itching in my calves has ceased, a healthy blush has returned, and the dark circles under my eyes have diminished. Even my body odour has improved.

Nausea details

Hua X, Chen Y, Wu Z, Zheng G, Yang D, et al. Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial. Heliyon. 2024;10:e30342. doi:10.1016/j.heliyon.2024.e30342

Based on 4 Researches

Magnesium effectively reduces PONV

We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.

We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.

Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.

This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.

Nausea free

Most Useful Review

This product excellently supports my nervous system. Since taking it, I've overcome insomnia and feel much calmer. Unlike other magnesium supplements, I have experienced no nausea. I continue to take it regularly as it’s effective for me.

Heart Attack details

Magnesium implantation improves heart recovery

Based on 23 Researches

Wang B, Pan S, Nie C, Zou R, Liu J, et al. Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats. Sci Rep. 2024;14:10959. doi:10.1038/s41598-024-60609-2

We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.

9.5

Heart attack relief

Most Useful Review

Great magnesium in good shape! This magnesium citrate works best for me; it has alleviated my heart attack symptoms and calmed my leg cramps. Previously, I struggled to stretch my legs due to discomfort, but now this issue has disappeared. I tried other supplements, but they didn't help.

Diarrhea details

Magnesium shows potential for diarrhea

Based on 7 Researches

de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, et al. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024;134. doi:10.1172/JCI171249

We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.

We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.

Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.

9.5

Reduced diarrhea

Most Useful Review

Very nice mineral! I found that my legs drank in the middle of the night, and they felt lighter. My heart feels better, and I move more easily. Surprisingly, magnesium citrate is easy to absorb and doesn’t cause diarrhea.

Chronic Cough details

Helps with deficiency

I continuously take this for chronic magnesium deficiency, and it really helps. The effect is outstanding; I highly recommend it to everyone.

Bloating details