Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.4
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
We explored the impact of a high omega-3, low omega-6 diet with fish oil on men with prostate cancer under active surveillance. In a year-long study involving 100 participants, those following the omega-rich regimen showed a notable 15% decrease in the Ki-67 index, a key marker for cancer progression.
In contrast, the control group experienced an increase in this index. While the diet showed promise in slowing down potential cancer growth, no significant differences were noted in other cancer-related measurements. Our findings encourage further research on dietary strategies in prostate cancer management.
In contrast, the control group experienced an increase in this index. While the diet showed promise in slowing down potential cancer growth, no significant differences were noted in other cancer-related measurements. Our findings encourage further research on dietary strategies in prostate cancer management.
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9
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Read More
8
Fish oil's preventive potential on cancer
We investigated how fish oil could help prevent skin cancer in mice exposed to specific carcinogens. The study included 70 Swiss albino mice divided into different groups, receiving fish oil either orally or topically, with some serving as controls.
While high doses of fish oil showed promising results, such as reduced cancer signs and decreased markers of oxidative stress, lower doses, notably 50 mg/kg/day, did not provide any benefits.
Overall, we found that fish oil has potential as a preventive treatment for skin cancer, especially at the right dosage.
While high doses of fish oil showed promising results, such as reduced cancer signs and decreased markers of oxidative stress, lower doses, notably 50 mg/kg/day, did not provide any benefits.
Overall, we found that fish oil has potential as a preventive treatment for skin cancer, especially at the right dosage.
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Most Useful Reviews
7.5
Antioxidant properties
122 people found this helpful
Omega-3 has been beneficial for various systems in the body, improving memory, and normalising metabolism. A shortage can lead to atherosclerosis and other health issues. These fatty acids also have antioxidant properties that may help prevent cancer. I find Omega-3 purifies blood vessels and improves conditions such as allergies, skin diseases, and diabetes. Overall, it's vital for maintaining good health.
Read More
7.5
Effective cancer prevention
32 people found this helpful
This Omega-3 preparation, rich in EPA and DHA, significantly reduces cholesterol. It serves as both a preventive measure and a treatment for various cardiovascular diseases while being noted by oncologists for its ability to slow tumour development. Additionally, Omega-3 contributes positively to skin health and aids in healing. Overall, it is essential for brain function and immunity.
Read More
7.5
Inflammation reduction
16 people found this helpful
I frequently order these omega-3 capsules and take 4-6 daily. They have proven to be effective in reducing inflammation and slowing down atherosclerotic plaque formation. These fatty acids support blood vessel health and may help prevent cancer. For those who struggle to consume oily fish regularly, these capsules are a fantastic alternative. I highly recommend them!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.4
- All Researches
9.5
Omega-3 fatty acids inhibit tumors
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
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9
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
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We investigated the role of alpha-linolenic acid (ALA), a plant-based omega-3 found in perilla seed oil, in preventing colitis-associated colorectal cancer (CRC) using a mouse model.
Mice were given different diets, while only the control group received soybean oil.
The results showed that those on a 5% perilla seed oil diet had fewer tumors and lower markers of inflammation compared to those on fish oil or soybean oil.
Overall, perilla seed oil appeared to help slow tumor progression and restore gut health.
Mice were given different diets, while only the control group received soybean oil.
The results showed that those on a 5% perilla seed oil diet had fewer tumors and lower markers of inflammation compared to those on fish oil or soybean oil.
Overall, perilla seed oil appeared to help slow tumor progression and restore gut health.
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9
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
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9
We focused our research on the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its derivatives known as specialized pro-resolving mediators (SPMs). These mediators have shown promise in playing a role in the resolution of inflammation, which is crucial in various health conditions, including cancer.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
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User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Antioxidant properties
122 people found this helpful
Omega-3 has been beneficial for various systems in the body, improving memory, and normalising metabolism. A shortage can lead to atherosclerosis and other health issues. These fatty acids also have antioxidant properties that may help prevent cancer. I find Omega-3 purifies blood vessels and improves conditions such as allergies, skin diseases, and diabetes. Overall, it's vital for maintaining good health.
Read More
7.5
Effective cancer prevention
32 people found this helpful
This Omega-3 preparation, rich in EPA and DHA, significantly reduces cholesterol. It serves as both a preventive measure and a treatment for various cardiovascular diseases while being noted by oncologists for its ability to slow tumour development. Additionally, Omega-3 contributes positively to skin health and aids in healing. Overall, it is essential for brain function and immunity.
Read More
7.5
Inflammation reduction
16 people found this helpful
I frequently order these omega-3 capsules and take 4-6 daily. They have proven to be effective in reducing inflammation and slowing down atherosclerotic plaque formation. These fatty acids support blood vessel health and may help prevent cancer. For those who struggle to consume oily fish regularly, these capsules are a fantastic alternative. I highly recommend them!
Read More
7.5
Improved quality of life
1 people found this helpful
I have been taking this product for years along with vitamin D3. At 74 years old, I have not been ill. I give 1-2 capsules daily (pierce cap and mix with food) with homemade kefir to my cat, who has cancer in the jaw and has gone blind in one eye. He is improving; he is more active and has gained weight. I believe everyone should take an omega oil supplement, and this one is my choice.
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7.5
Breast cancer support
After years on Omega 3-6-9, I switched to this omega-3 product while on Tamoxifen after my breast cancer diagnosis. This substitute works nearly as well, and I plan to return to 3-6-9 after my treatment. I appreciate the focus on my health during this period.
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Frequently Asked Questions
7.5
Breast cancer support
After years on Omega 3-6-9, I switched to this omega-3 product while on Tamoxifen after my breast cancer diagnosis. This substitute works nearly as well, and I plan to return to 3-6-9 after my treatment. I appreciate the focus on my health during this period.
7.5
Effective cancer prevention
32 people found this helpful
This Omega-3 preparation, rich in EPA and DHA, significantly reduces cholesterol. It serves as both a preventive measure and a treatment for various cardiovascular diseases while being noted by oncologists for its ability to slow tumour development. Additionally, Omega-3 contributes positively to skin health and aids in healing. Overall, it is essential for brain function and immunity.
7.5
Antioxidant properties
122 people found this helpful
Omega-3 has been beneficial for various systems in the body, improving memory, and normalising metabolism. A shortage can lead to atherosclerosis and other health issues. These fatty acids also have antioxidant properties that may help prevent cancer. I find Omega-3 purifies blood vessels and improves conditions such as allergies, skin diseases, and diabetes. Overall, it's vital for maintaining good health.
7.5
Inflammation reduction
16 people found this helpful
I frequently order these omega-3 capsules and take 4-6 daily. They have proven to be effective in reducing inflammation and slowing down atherosclerotic plaque formation. These fatty acids support blood vessel health and may help prevent cancer. For those who struggle to consume oily fish regularly, these capsules are a fantastic alternative. I highly recommend them!
0
Cancer concern
1 people found this helpful
I was disappointed to find synthetic vitamin E in this product. Evidence suggests that it has been linked to cancer since the 1970s. Hence, I had to discard this item and recommend being vigilant about ingredients that may pose health risks.
7.5
Cancer link
Omega-3 fatty acids play a crucial role in cardiovascular and nervous system health. Some oncologists believe that deficiencies can lead to cancer, including breast and prostate. I ensure to consume them with fatty meals for better absorption, and for children, the recommended intake is vital for their growth and health.
9
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
7
Omega-3s benefit weight and well-being
We evaluated the impact of omega-3 fatty acids, particularly eicosapentaenoic acid, on patients with advanced non-small cell lung cancer who are experiencing cancer cachexia. The study analyzed various clinical trials and found that participants who received omega-3 supplements experienced significant weight gain and improved health-related quality of life scores, specifically in areas related to global health and physical functioning.
However, when it came to lean body or skeletal mass, the results were less promising; no significant changes were observed in this area. In total, six trials were included in our analysis, focusing on different aspects, but the overall takeaway is that while omega-3 fatty acids seem to be beneficial for improving weight and quality of life, they do not significantly affect muscle mass in these patients.
This indicates that although eicosapentaenoic acid can play a helpful role in supporting nutrition and wellness in those battling advanced lung cancer, it should be viewed as part of a broader treatment strategy rather than a standalone solution.
However, when it came to lean body or skeletal mass, the results were less promising; no significant changes were observed in this area. In total, six trials were included in our analysis, focusing on different aspects, but the overall takeaway is that while omega-3 fatty acids seem to be beneficial for improving weight and quality of life, they do not significantly affect muscle mass in these patients.
This indicates that although eicosapentaenoic acid can play a helpful role in supporting nutrition and wellness in those battling advanced lung cancer, it should be viewed as part of a broader treatment strategy rather than a standalone solution.
8
We examined the impact of omega-3 fish oil on chemotherapy-induced peripheral neuropathy (CIPN) in mice. Our findings indicate that this fish oil supplementation effectively prevented hypersensitivity caused by common chemotherapy drugs.
Over 30 days, it reduced neuroinflammation, which seems to be a key factor in mitigating pain and discomfort linked to treatments like paclitaxel and oxaliplatin.
By normalizing certain biochemical parameters, omega-3 fish oil holds potential to enhance the quality of life for cancer survivors facing CIPN.
Over 30 days, it reduced neuroinflammation, which seems to be a key factor in mitigating pain and discomfort linked to treatments like paclitaxel and oxaliplatin.
By normalizing certain biochemical parameters, omega-3 fish oil holds potential to enhance the quality of life for cancer survivors facing CIPN.
8
We explored the relationship between docosahexaenoic acid (DHA) and its effects on cancer treatment, particularly focusing on its role alongside anti-PD-L1 therapy for melanoma. The study employed a humanized gnotobiotic mouse model to better understand how dietary components influence gut microbiota and their metabolites in the context of cancer immunotherapy.
Our findings revealed that ginger-derived exosome-like nanoparticles (GELN) specifically targeted certain gut bacteria, enhancing their function. Notably, we discovered that the incorporation of GELN into treatment increased levels of DHA. Elevated DHA levels were found to inhibit PD-L1 expression in tumor cells by binding to its promoter, thus disrupting a process that often leads to cancer proliferation.
Furthermore, we observed that germ-free mice colonized with gut bacteria from individuals who did not respond to anti-PD-L1 therapy showed improved treatment responses when supplemented with DHA. This suggests that manipulating gut microbiota and metabolites could bolster cancer immunotherapy efforts.
Overall, our study shines a light on the significant role that dietary elements like DHA play in enhancing the efficacy of immunotherapies in cancer treatment, offering promising avenues for future research and therapeutic strategies.
Our findings revealed that ginger-derived exosome-like nanoparticles (GELN) specifically targeted certain gut bacteria, enhancing their function. Notably, we discovered that the incorporation of GELN into treatment increased levels of DHA. Elevated DHA levels were found to inhibit PD-L1 expression in tumor cells by binding to its promoter, thus disrupting a process that often leads to cancer proliferation.
Furthermore, we observed that germ-free mice colonized with gut bacteria from individuals who did not respond to anti-PD-L1 therapy showed improved treatment responses when supplemented with DHA. This suggests that manipulating gut microbiota and metabolites could bolster cancer immunotherapy efforts.
Overall, our study shines a light on the significant role that dietary elements like DHA play in enhancing the efficacy of immunotherapies in cancer treatment, offering promising avenues for future research and therapeutic strategies.
References
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- Melato J, Goldoni FC, Benvenutti L, Corrêa TP, Remor AP, et al. Omega-3-Enriched Fish oil reduces the chemotherapy-induced peripheral neuropathy in mice. Neuropharmacology. 2025;271:110384. doi:10.1016/j.neuropharm.2025.110384
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- Aronson WJ, Grogan T, Liang P, Jardack P, Liddell AR, et al. High Omega-3, Low Omega-6 Diet With Fish Oil for Men With Prostate Cancer on Active Surveillance: The CAPFISH-3 Randomized Clinical Trial. J Clin Oncol. 2025;43:800. doi:10.1200/JCO.24.00608
- Korsirikoon C, Techaniyom P, Kettawan A, Rungruang T, Metheetrairut C, et al. Cold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis in the AOM/DSS mice model of colitis-associated colorectal cancer. PLoS One. 2024;19:e0315172. doi:10.1371/journal.pone.0315172
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16223960
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. doi:10.1016/j.clnesp.2024.11.014
- Głowacka K, Ibanez S, Renoult O, Vermonden P, Giolito MV, et al. Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources. Nat Commun. 2024;15:10107. doi:10.1038/s41467-024-54435-3
- Machuca J, Wirkus J, Ead AS, Vahmani P, Matsukuma KE, et al. Dietary ω-3 Fatty Acids Mitigate Intestinal Barrier Integrity Alterations in Mice Fed a High-Fat Diet: Implications for Pancreatic Carcinogenesis. J Nutr. 2025;155:197. doi:10.1016/j.tjnut.2024.10.054
- Zhang Y, Sun Y, Song S, Khankari NK, Brenna JT, et al. Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: A population-based cohort study in UK Biobank. Int J Cancer. 2025;156:1154. doi:10.1002/ijc.35226
- Lam CS, Hua R, Loong HH, Chung VC, Cheung YT. Association between fish oil and glucosamine use and mortality in patients diagnosed with cancer: the role of the Life Essential 8 score and cancer prognosis. Nutr J. 2024;23:124. doi:10.1186/s12937-024-01032-1
- Elçi MP, Fatsa T, Ören S, Miser Salihoğlu E, Akaydın S. Investigation of the Effects of Polyunsaturated Fatty Acid Ratios in Human SH-SY5Y Cells by Methods. Turk J Pharm Sci. 2025;22:10. doi:10.4274/tjps.galenos.2024.40583
- Babaeenezhad E, Khosravi P, Moradi Sarabi M. Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines. Genes Nutr. 2025;20:2. doi:10.1186/s12263-025-00764-x
- Patel V, Li YN, Benhamou LE, Park HG, Raleigh M, et al. Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model. Cancers (Basel). 2025;17. doi:10.3390/cancers17030362
- Alharthy FH, Alsughayyir J, Alfhili MA. Eicosapentaenoic Acid Triggers Phosphatidylserine Externalization in the Erythrocyte Membrane through Calcium Signaling and Anticholinesterase Activity. Physiol Res. 2024;73:1075.
- Sun R, Zhang Y, Zhao X, Tang T, Cao Y, et al. Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer. Adv Sci (Weinh). 2025. doi:10.1002/advs.202412551
- Luo J, Peng S, Jiang Z, Wang Q, Zhang M, et al. Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer. iScience. 2025;28:111601. doi:10.1016/j.isci.2024.111601
- Frankhouser DE, DeWess T, Snodgrass IF, Cole RM, Steck S, et al. Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns. medRxiv. 2024. doi:10.1101/2024.09.16.24313691
- Ormiston K, Fitzgerald J, Andridge R, Lustberg MB, DeVries AC, et al. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutr Res. 2024;131:39. doi:10.1016/j.nutres.2024.09.004
- Ormiston K, Melink Z, Andridge R, Lustberg M, Courtney DeVries A, et al. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behav Immun. 2025;123:370. doi:10.1016/j.bbi.2024.09.021
- Chua AV, Hernandez ARB, Mendoza MJL, San Juan MD. Omega-3 Fatty Acids Increase Weight and Quality of Life Scores in Patients With Advanced Non-Small Cell Lung Cancer and Cancer Cachexia: A Meta-Analysis. Integr Cancer Ther. 2024;23:15347354241275052. doi:10.1177/15347354241275052
- Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, et al. The Impact of Dietary Unsaturated Fat or the Mediterranean Diet on Women Diagnosed With Breast Cancer: A Systematic Review. Cureus. 2024;16:e65362. doi:10.7759/cureus.65362
- Gholamalizadeh M, Tajadod S, Majidi N, Aghakhaninejad Z, Mahmoudi Z, et al. Associations between diet and nutritional supplements and colorectal cancer: A systematic review. JGH Open. 2024;8:e13108. doi:10.1002/jgh3.13108
- Chen X, Jiang T, Li Y, Zhang Y, Chen J, et al. Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis. Int J Biol Macromol. 2024;276:133942. doi:10.1016/j.ijbiomac.2024.133942
- Babar MU, Nassar AF, Nie X, Zhang T, He J, et al. Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer. Metabolites. 2024;14. doi:10.3390/metabo14060314
- Zhang Z, Zhou Q, Li Z, Huang F, Mo K, et al. DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. Drug Resist Updat. 2025;81:101224. doi:10.1016/j.drup.2025.101224
- Teng Y, Luo C, Qiu X, Mu J, Sriwastva MK, et al. Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites. Nat Commun. 2025;16:1295. doi:10.1038/s41467-025-56498-2
- Wang X, Ishimatsu K, Li J, Wen X, Ou W, et al. APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage. Hepat Oncol. 2024;11:2389031. doi:10.1080/20450923.2024.2389031
- Olkhovik DM, Silkina MO, Razumovskaya AV, Klycheva KV, Fatkulin AA, et al. Omega-3 Docosahexaenoic Acid as a Promising Inducer of Ferroptosis: Dynamics of Action in Prostate and Colorectal Cancer Models. Dokl Biochem Biophys. 2025. doi:10.1134/S160767292460132X
- Lin HL, Lin QY, Feng JN, Zheng WE, Yang C, et al. Plasma fatty acid levels and risk of non-small cell lung cancer: a large-scale prospective cohort study. Front Nutr. 2024;11:1462300. doi:10.3389/fnut.2024.1462300
- La Vecchia S, Fontana S, Salaroglio IC, Anobile DP, Digiovanni S, et al. Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy. Cancer Lett. 2024;604:217221. doi:10.1016/j.canlet.2024.217221
- Huang J, Li J, He L, Miao J, Zhu M, et al. The association between plasma fatty acids and risk of lung cancer: a prospective cohort study of the UK Biobank. J Clin Endocrinol Metab. 2024. doi:10.1210/clinem/dgae609
- Lin SC, Tsai YC, Chen YL, Lin HK, Huang YC, et al. Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer. Drug Resist Updat. 2024;77:101144. doi:10.1016/j.drup.2024.101144
