We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
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9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
We engaged in a double-blind study involving 478 young adults to explore the effects of high-dose Vitamin B6 and B12 supplementation on anxiety levels. Over a month of treatment, we compared these vitamin supplements against a placebo, focusing on their potential to balance neural inhibition and excitation—two processes crucial for emotional regulation.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
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Most Useful Reviews
9
Improved mental stability
33 people found this helpful
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
Read More
9
Dramatic changes noticed
6 people found this helpful
This medication has greatly improved my sleep and has eliminated the persistent feeling of anxiety that troubled me in the dark. Since taking it, I feel a sense of calm, and both friends and family have noticed significant changes in my behaviour, such as reduced aggression. Additionally, 5-HTP enhances serotonin production, contributing to an overall feeling of joy. I highly recommend it.
Read More
9
Soothes anxiety
3 people found this helpful
This vitamin B6 is in its most effective form—pyridoxal-5-phosphate—which the body absorbs well. It works remarkably with magnesium to calm anxiety and improve emotional well-being.
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
Read More
9
Vitamin B6 potentially reduces anxiety
Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study.
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
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9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
8
Vitamin B6 aids postpartum depression
Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
We conducted a clinical trial that looked into whether vitamin B6 could help prevent postpartum depression (PPD) among mothers at risk. This single-blind, placebo-controlled study involved 81 pregnant women in Isfahan, Iran, who were divided into two groups—one group received 80 mg of vitamin B6, while the other received a placebo.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
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8
Magnesium and B6 improve anxiety
Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
Read More
9
Dramatic changes noticed
6 people found this helpful
This medication has greatly improved my sleep and has eliminated the persistent feeling of anxiety that troubled me in the dark. Since taking it, I feel a sense of calm, and both friends and family have noticed significant changes in my behaviour, such as reduced aggression. Additionally, 5-HTP enhances serotonin production, contributing to an overall feeling of joy. I highly recommend it.
Read More
9
Soothes anxiety
3 people found this helpful
This vitamin B6 is in its most effective form—pyridoxal-5-phosphate—which the body absorbs well. It works remarkably with magnesium to calm anxiety and improve emotional well-being.
Read More
9
Improved stress handling
3 people found this helpful
I’ve been taking this for a few weeks, and it works really well! I take it with magnesium at bedtime. My sleep has improved, and it positively impacts my stress management; my anxiety levels have decreased. I'm using another medication, but I notice positive changes linked to this form of vitamin B. No side effects observed. Good product, highly recommended!
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7.5
Supports nervous system
1 people found this helpful
I’ve purchased multiple bottles of this supplement and find the quality and effects satisfactory. The packaging is convenient, and the formulation includes magnesium glycinate, which greatly benefits my nervous system and helps with anxiety and depression, all without any taste.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
B6, also known as pyridoxine, is a water-soluble vitamin that plays a vital role in numerous physiological functions within the body. It is essential for the metabolism of proteins, carbohydrates, and fats, and is involved in the synthesis of neurotransmitters, which are critical for proper brain function and mood regulation. B6 also contributes to the production of hemoglobin, which is necessary for transporting oxygen in the blood, and aids in the maintenance of healthy immune function.
Most people can obtain sufficient B6 through a balanced diet that includes foods like poultry, fish, potatoes, chickpeas, bananas, and fortified cereals. However, some individuals may benefit from supplementation, particularly those with specific health conditions, dietary restrictions, or higher nutritional needs. The recommended dietary allowance (RDA) varies by age and gender, so it’s important to pay attention to your individual needs. Although B6 is generally safe, high doses from supplements can lead to side effects, so it’s always best to consult with a healthcare provider if you’re considering adding pyridoxine to your regimen.
Pyridoxine, commonly known as Vitamin B6, plays a crucial role in neurotransmitter synthesis and overall brain health, which has led some research to explore its potential benefits for anxiety. Some studies suggest that adequate levels of Vitamin B6 may promote better mood regulation and reduce feelings of anxiety. This is largely attributed to its involvement in the production of serotonin, a neurotransmitter that helps stabilize mood.
However, while some individuals report feeling calmer and more balanced with sufficient B6 intake, it's important to note that the evidence is not robust enough to conclusively recommend Vitamin B6 as a standalone treatment for anxiety. If you’re considering using B6 supplements, it’s advisable to consult with a healthcare provider first, as they can provide personalized advice based on your specific health needs and conditions.
Based on user reviews, it appears that individuals may start to notice improvements in their anxiety levels within a week to several weeks of taking the supplement. For instance, one user reported feeling a decrease in anxiety after just one week of use Read Review. Others have mentioned positive changes at the two to three weeks mark, with reviews indicating that significant benefits, like improved mood and reduced anxiety, can be observed over this timeframe Read Review.
Moreover, some users suggest that continued use for a more extended period, such as several weeks or even months, can contribute to enhanced emotional well-being Read Review. Overall, while some may find relief relatively quickly, others recommend allowing time for the supplement to build efficacy in managing anxiety symptoms.
The research surrounding vitamin B6 (pyridoxine) and its potential impact on anxiety is promising yet nuanced. Studies have indicated that individuals with vitamin B6 deficiencies may experience elevated anxiety levels; for instance, a study highlighted that a 57-year-old man with a deficiency saw his anxiety symptoms resolve after receiving vitamin B6 treatment [1]. Similarly, another investigation suggested an association between higher dietary B6 intake and decreased anxiety symptoms, specifically in women [3]. However, despite these encouraging findings, the need for more rigorous research is evident, particularly to identify which demographic groups may benefit the most from supplementation [2].
While vitamin B6 has shown potential in several contexts—such as improving anxiety in women using hormonal contraceptives [6] or mitigating anxiety from stress [13]—the evidence points to a need for further investigation. For example, studies indicate that structuring vitamin B6 in combination with other treatments, like magnesium, may produce more significant effects, although the isolated role of B6 remains unclear [4]. Overall, while there is a foundational basis for considering vitamin B6 in managing anxiety, more controlled studies are required to solidify these claims.
Users have reported a broad range of improvements in anxiety symptoms after incorporating vitamin B6, particularly in its active form pyridoxal-5-phosphate (P-5-P), into their daily routines. Many individuals have noted a significant reduction in anxiety levels, which in some cases led to the alleviation of panic disorders and anticipation anxiety Read Review. One user describes feeling markedly calmer and more focused, crediting the supplement with enhancing their emotional well-being and daily functioning Read Review.
Additionally, users have highlighted the positive effects on their sleep quality, with many stating that they experienced deeper, more restorative sleep after beginning supplementation Read Review. Some reviews suggest that combining P-5-P with magnesium further amplifies its calming effects, contributing to an overall enhanced sense of calm and well-being Read Review. While numerous users have found relief, individual experiences may vary, and it is crucial for each person to assess how the supplement affects their unique circumstances.
Users have reported various experiences when combining this supplement with others to manage anxiety. Notably, many have highlighted the benefits of pairing vitamin B6, particularly in its active form pyridoxal-5-phosphate (P-5-P), with magnesium. Several users noted that this combination significantly enhances the calming effects, which leads to improved emotional well-being and reduced anxiety Read Review, Read Review. One user specifically mentioned that taking P-5-P with magnesium not only helped diminish anxiety but also improved sleep quality Read Review.
Additionally, other supplements like zinc have been reported to complement this regimen effectively. One review indicated that taking zinc alongside traditional Chinese medicine and magnesium appeared to alleviate anxiety symptoms Read Review. While many users found success in mixing these supplements for enhanced anxiety management, individual results may vary, making it important for each person to assess their unique combination of supplements for optimal benefits.
According to user reviews, many individuals have found success in managing their anxiety with vitamin B6, particularly its active form, pyridoxal-5-phosphate (P5P). Users reported that combining B6 with magnesium has significantly reduced their anxiety levels while improving sleep quality. For instance, one user indicated that taking P5P resulted in a calmer demeanor and enhanced focus without any noticeable side effects Read Review. Another noted that this combination worked well at bedtime, leading to improvements in their stress management and overall peace of mind Read Review.
When it comes to the right dosage, users have pointed out that consistently taking these supplements has led to diminishing anxiety symptoms. The feedback suggests that a regular intake of P5P might be effective for many, as one user mentioned their anxiety subsided considerably after only half a bottle Read Review. Additionally, another review emphasized the need to replenish B6 due to its water-soluble nature, indicating that continual use is necessary for optimal effects in managing anxiety Read Review. Overall, while specific dosages weren't explicitly stated, consistent use of B6 in conjunction with magnesium appears to be a common thread among successful user experiences.
9
Improved sleep quality
These capsules have greatly enhanced my sleep. After a week, I felt a decrease in anxiety, and my nervous system truly benefits from these.
9
Improved stress handling
3 people found this helpful
I’ve been taking this for a few weeks, and it works really well! I take it with magnesium at bedtime. My sleep has improved, and it positively impacts my stress management; my anxiety levels have decreased. I'm using another medication, but I notice positive changes linked to this form of vitamin B. No side effects observed. Good product, highly recommended!
7.5
Long-term anxiety relief
I have been using it for a long time, and it effectively relieves my anxiety.
9
Improved mental stability
33 people found this helpful
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
9
Focus and calmness
After starting P-5-P, I noticed positive changes in my anxiety levels, which allowed me to feel more focused and calm, enhancing my training.
9
Great sleep improvement
Excellent drug. It reduces anxiety and helps me sleep deeply at night.
9
Soothes anxiety
3 people found this helpful
This vitamin B6 is in its most effective form—pyridoxal-5-phosphate—which the body absorbs well. It works remarkably with magnesium to calm anxiety and improve emotional well-being.
9
Stronger sleep achieved
This vitamin B6, when taken with magnesium, worked wonders; my sleep improved significantly, and my anxiety diminished. It’s effective!
9
Helps with anxiety
I’ve been experiencing anxiety and have discovered that zinc, magnesium, vitamin B6, and inositol are particularly beneficial for depression. Currently, I'm taking zinc alongside other supplements and traditional Chinese medicine, which seems to alleviate my anxiety.
9
Reduces stress anxiety
Excellent! I took P5P (pyridoxal-5-phosphate), the active form of vitamin B6, for my nervous system and overall well-being. I found I was more focused and less stressed after starting it. P5P is effective in reducing anxiety and enhancing mood.
7.5
Calmed anxiety
3 people found this helpful
Since entering menopause, my anxiety has intensified, prompting me to purchase this active type. The capsule size suits me perfectly. I've only finished half the bottle, yet I feel my anxiety has subsided considerably. I'm hopeful it will also assist with my sleep, as some reviews suggest.
7.5
Promotes calmness
4 people found this helpful
P-5-P is a vital form of vitamin B6 that needs to be replenished as it is water-soluble and quickly excreted. This nutrient aids metabolic processes, enhances protein and fat assimilation, and positively impacts skin health. Additionally, pyridoxine supports the nervous system, combats depression, reduces anxiety, and promotes calmness while bolstering the immune system and normalising blood sugar levels.
9.5
Pyridoxine deficiency linked to anxiety
Pyridoxine Deficiency and Neurologic Dysfunction: An Unlikely Association.
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
7
B6 may reduce anxiety symptoms
Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
We explored the relationship between dietary B6 intake and psychological disorders in Iranian women. Our cross-sectional study involved 447 participants, using a Food Frequency Questionnaire and a validated anxiety scale.
We found that women who consumed more vitamin B6 had a lower likelihood of experiencing depression. Conversely, higher intake of vitamin B12 was linked to increased odds of depression and psychological distress.
Overall, while B6 showed promise in reducing anxiety, the effects of B12 were concerning, indicating potential complexity in dietary B-vitamin effects on mental health.
7
B6 may ease medication-related irritability
Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy.
We looked into whether vitamin B6 supplementation could help with irritability caused by the antiseizure medication levetiracetam in male Veterans with epilepsy. By reviewing 26 patient charts, we tracked changes in irritability and anxiety scores before and after vitamin B6 use.
Our findings suggest that vitamin B6 may indeed help reduce irritability for these Veterans. However, we acknowledge that more rigorous studies are necessary to confirm these results and understand which patients may benefit the most.
7
Vitamin B6 alleviates anxiety symptoms
Therapy of side effects of oral contraceptive agents with vitamin B6.
We explored how vitamin B6 might help reduce anxiety in women using hormonal contraceptives. Over the past 15 years, studies indicated that these contraceptives could lead to a deficiency in vitamin B6, resulting in symptoms like anxiety and depression. When women received 40 mg of vitamin B6 daily, their biochemical levels normalized, and anxiety symptoms improved. This suggests that vitamin B6 could play an important role in managing anxiety and other mood-related issues in hormonal contraceptive users, pointing to the need for further investigation into its benefits during different hormonal phases.
8
Magnesium and B6 improve anxiety
Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
7
B6 not superior; magnesium essential
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
We conducted a study to explore if magnesium and vitamin B6 together can reduce stress more effectively than magnesium alone. Through a clinical trial involving adults with low magnesium levels and high stress, we found that both combinations led to significant improvements in perceived stress levels.
However, the addition of vitamin B6 did not show a major advantage over magnesium alone for most participants. Yet, those with severe stress saw a notable benefit from the combination treatment, indicating that magnesium paired with vitamin B6 could be helpful in specific situations.
References
Sousou JM, Griffith EM, Marsalisi C, Reddy P. Pyridoxine Deficiency and Neurologic Dysfunction: An Unlikely Association. Cureus. 2023;15:e47647. 10.7759/cureus.47647
Dreischmeier E, Zuloaga A, Kotloski RJ, Karasov AO, Gidal BE. Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy. Epilepsy Behav Rep. 2021;16:100452. 10.1016/j.ebr.2021.100452
Mozaffari H, Darooghegi Mofrad M, Surkan PJ, Askari M, Azadbakht L. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study. Public Health Nutr. 2021;24:1787. 10.1017/S1368980020002943
Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13:e0208454. 10.1371/journal.pone.0208454
De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000;9:131.
Bermond P. Therapy of side effects of oral contraceptive agents with vitamin B6. Acta Vitaminol Enzymol. 1982;4:45.
Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. 10.3390/nu15234981
Ding X, Wen Y, Ma X, Zhang Y, Cheng Y, et al. Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring. Environ Sci Ecotechnol. 2023;13:100224. 10.1016/j.ese.2022.100224
Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. 10.3390/nu14091863
Rizzo R, Prato A, Scerbo M, Saia F, Barone R, et al. Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients. 2022;14. 10.3390/nu14040852
Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. 10.4103/ijpvm.IJPVM_240_19
Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, et al. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021;37:1000. 10.1002/smi.3051
Walia V, Garg C, Garg M. Lithium potentiated, pyridoxine abolished and fluoxetine attenuated the anxiolytic effect of diazepam in mice. Brain Res Bull. 2019;150:343. 10.1016/j.brainresbull.2019.06.008
Kafeshani M, Feizi A, Esmaillzadeh A, Keshteli AH, Afshar H, et al. Higher vitamin B intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study. Int J Vitam Nutr Res. 2020;90:484. 10.1024/0300-9831/a000589