Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.2
USERS' SCORE
Good
Based on 39 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%

Top Medical Research Studies

9.5
Pyridoxine deficiency linked to anxiety
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
Read More
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.

Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.

To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.

Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
We engaged in a double-blind study involving 478 young adults to explore the effects of high-dose Vitamin B6 and B12 supplementation on anxiety levels. Over a month of treatment, we compared these vitamin supplements against a placebo, focusing on their potential to balance neural inhibition and excitation—two processes crucial for emotional regulation.

Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.

Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Read More

Most Useful Reviews

9
Improved mental stability
33 people found this helpful
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
Read More
9
Dramatic changes noticed
6 people found this helpful
This medication has greatly improved my sleep and has eliminated the persistent feeling of anxiety that troubled me in the dark. Since taking it, I feel a sense of calm, and both friends and family have noticed significant changes in my behaviour, such as reduced aggression. Additionally, 5-HTP enhances serotonin production, contributing to an overall feeling of joy. I highly recommend it.
Read More
9
Soothes anxiety
3 people found this helpful
This vitamin B6 is in its most effective form—pyridoxal-5-phosphate—which the body absorbs well. It works remarkably with magnesium to calm anxiety and improve emotional well-being.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.2
  • All Researches
9.5
Pyridoxine deficiency linked to anxiety
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
Read More
9
Vitamin B6 potentially reduces anxiety
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.

Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.

Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.

However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.

Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.

To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.

Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
We conducted a clinical trial that looked into whether vitamin B6 could help prevent postpartum depression (PPD) among mothers at risk. This single-blind, placebo-controlled study involved 81 pregnant women in Isfahan, Iran, who were divided into two groups—one group received 80 mg of vitamin B6, while the other received a placebo.

Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.

The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Read More
8
Magnesium and B6 improve anxiety
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.

Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.

Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Read More

User Reviews

USERS' SCORE
Good
Based on 39 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved mental stability
33 people found this helpful
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
Read More
9
Dramatic changes noticed
6 people found this helpful
This medication has greatly improved my sleep and has eliminated the persistent feeling of anxiety that troubled me in the dark. Since taking it, I feel a sense of calm, and both friends and family have noticed significant changes in my behaviour, such as reduced aggression. Additionally, 5-HTP enhances serotonin production, contributing to an overall feeling of joy. I highly recommend it.
Read More
9
Soothes anxiety
3 people found this helpful
This vitamin B6 is in its most effective form—pyridoxal-5-phosphate—which the body absorbs well. It works remarkably with magnesium to calm anxiety and improve emotional well-being.
Read More
9
Improved stress handling
3 people found this helpful
I’ve been taking this for a few weeks, and it works really well! I take it with magnesium at bedtime. My sleep has improved, and it positively impacts my stress management; my anxiety levels have decreased. I'm using another medication, but I notice positive changes linked to this form of vitamin B. No side effects observed. Good product, highly recommended!
Read More
7.5
Supports nervous system
1 people found this helpful
I’ve purchased multiple bottles of this supplement and find the quality and effects satisfactory. The packaging is convenient, and the formulation includes magnesium glycinate, which greatly benefits my nervous system and helps with anxiety and depression, all without any taste.
Read More

Frequently Asked Questions

9
Improved sleep quality
These capsules have greatly enhanced my sleep. After a week, I felt a decrease in anxiety, and my nervous system truly benefits from these.
9
Improved stress handling
3 people found this helpful
I’ve been taking this for a few weeks, and it works really well! I take it with magnesium at bedtime. My sleep has improved, and it positively impacts my stress management; my anxiety levels have decreased. I'm using another medication, but I notice positive changes linked to this form of vitamin B. No side effects observed. Good product, highly recommended!
7.5
Long-term anxiety relief
I have been using it for a long time, and it effectively relieves my anxiety.
9
Improved mental stability
33 people found this helpful
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
9
Focus and calmness
After starting P-5-P, I noticed positive changes in my anxiety levels, which allowed me to feel more focused and calm, enhancing my training.
9
Great sleep improvement
Excellent drug. It reduces anxiety and helps me sleep deeply at night.
9
Soothes anxiety
3 people found this helpful
This vitamin B6 is in its most effective form—pyridoxal-5-phosphate—which the body absorbs well. It works remarkably with magnesium to calm anxiety and improve emotional well-being.
9
Stronger sleep achieved
This vitamin B6, when taken with magnesium, worked wonders; my sleep improved significantly, and my anxiety diminished. It’s effective!
9
Helps with anxiety
I’ve been experiencing anxiety and have discovered that zinc, magnesium, vitamin B6, and inositol are particularly beneficial for depression. Currently, I'm taking zinc alongside other supplements and traditional Chinese medicine, which seems to alleviate my anxiety.
9
Reduces stress anxiety
Excellent! I took P5P (pyridoxal-5-phosphate), the active form of vitamin B6, for my nervous system and overall well-being. I found I was more focused and less stressed after starting it. P5P is effective in reducing anxiety and enhancing mood.
7.5
Calmed anxiety
3 people found this helpful
Since entering menopause, my anxiety has intensified, prompting me to purchase this active type. The capsule size suits me perfectly. I've only finished half the bottle, yet I feel my anxiety has subsided considerably. I'm hopeful it will also assist with my sleep, as some reviews suggest.
7.5
Promotes calmness
4 people found this helpful
P-5-P is a vital form of vitamin B6 that needs to be replenished as it is water-soluble and quickly excreted. This nutrient aids metabolic processes, enhances protein and fat assimilation, and positively impacts skin health. Additionally, pyridoxine supports the nervous system, combats depression, reduces anxiety, and promotes calmness while bolstering the immune system and normalising blood sugar levels.
9.5
Pyridoxine deficiency linked to anxiety
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
We explored the relationship between dietary B6 intake and psychological disorders in Iranian women. Our cross-sectional study involved 447 participants, using a Food Frequency Questionnaire and a validated anxiety scale.

We found that women who consumed more vitamin B6 had a lower likelihood of experiencing depression. Conversely, higher intake of vitamin B12 was linked to increased odds of depression and psychological distress.

Overall, while B6 showed promise in reducing anxiety, the effects of B12 were concerning, indicating potential complexity in dietary B-vitamin effects on mental health.
We looked into whether vitamin B6 supplementation could help with irritability caused by the antiseizure medication levetiracetam in male Veterans with epilepsy. By reviewing 26 patient charts, we tracked changes in irritability and anxiety scores before and after vitamin B6 use.

Our findings suggest that vitamin B6 may indeed help reduce irritability for these Veterans. However, we acknowledge that more rigorous studies are necessary to confirm these results and understand which patients may benefit the most.
7
Vitamin B6 alleviates anxiety symptoms
We explored how vitamin B6 might help reduce anxiety in women using hormonal contraceptives. Over the past 15 years, studies indicated that these contraceptives could lead to a deficiency in vitamin B6, resulting in symptoms like anxiety and depression. When women received 40 mg of vitamin B6 daily, their biochemical levels normalized, and anxiety symptoms improved. This suggests that vitamin B6 could play an important role in managing anxiety and other mood-related issues in hormonal contraceptive users, pointing to the need for further investigation into its benefits during different hormonal phases.
8
Magnesium and B6 improve anxiety
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.

Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.

Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
7
B6 not superior; magnesium essential
We conducted a study to explore if magnesium and vitamin B6 together can reduce stress more effectively than magnesium alone. Through a clinical trial involving adults with low magnesium levels and high stress, we found that both combinations led to significant improvements in perceived stress levels.

However, the addition of vitamin B6 did not show a major advantage over magnesium alone for most participants. Yet, those with severe stress saw a notable benefit from the combination treatment, indicating that magnesium paired with vitamin B6 could be helpful in specific situations.

References

  1. Sousou JM, Griffith EM, Marsalisi C, Reddy P. Pyridoxine Deficiency and Neurologic Dysfunction: An Unlikely Association. Cureus. 2023;15:e47647. 10.7759/cureus.47647
  2. Dreischmeier E, Zuloaga A, Kotloski RJ, Karasov AO, Gidal BE. Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy. Epilepsy Behav Rep. 2021;16:100452. 10.1016/j.ebr.2021.100452
  3. Mozaffari H, Darooghegi Mofrad M, Surkan PJ, Askari M, Azadbakht L. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study. Public Health Nutr. 2021;24:1787. 10.1017/S1368980020002943
  4. Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13:e0208454. 10.1371/journal.pone.0208454
  5. De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000;9:131.
  6. Bermond P. Therapy of side effects of oral contraceptive agents with vitamin B6. Acta Vitaminol Enzymol. 1982;4:45.
  7. Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. 10.3390/nu15234981
  8. Ding X, Wen Y, Ma X, Zhang Y, Cheng Y, et al. Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring. Environ Sci Ecotechnol. 2023;13:100224. 10.1016/j.ese.2022.100224
  9. Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
  10. Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. 10.3390/nu14091863
  11. Rizzo R, Prato A, Scerbo M, Saia F, Barone R, et al. Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients. 2022;14. 10.3390/nu14040852
  12. Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. 10.4103/ijpvm.IJPVM_240_19
  13. Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, et al. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021;37:1000. 10.1002/smi.3051
  14. Walia V, Garg C, Garg M. Lithium potentiated, pyridoxine abolished and fluoxetine attenuated the anxiolytic effect of diazepam in mice. Brain Res Bull. 2019;150:343. 10.1016/j.brainresbull.2019.06.008
  15. Kafeshani M, Feizi A, Esmaillzadeh A, Keshteli AH, Afshar H, et al. Higher vitamin B intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study. Int J Vitam Nutr Res. 2020;90:484. 10.1024/0300-9831/a000589
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