Overview
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Pancreatin 10X (porcine) (Equivalent to 2,000 mg)
200 mg
**
Amylase
50,000 USP units
**
Protease
50,000 USP units
**
Lipase
4,000 USP units
**
Top Medical Research Studies
8
We conducted a randomized double-blind trial to see if pancreatin could help prevent weight loss in patients with unresectable cancer of the pancreatic head region.
Over eight weeks, 21 patients received either pancreatin or a placebo, alongside dietary counseling.
Those on pancreatin gained weight, while placebo patients lost weight. The results showed a significant difference, suggesting that pancreatin may effectively counteract weight loss during this critical period.
Over eight weeks, 21 patients received either pancreatin or a placebo, alongside dietary counseling.
Those on pancreatin gained weight, while placebo patients lost weight. The results showed a significant difference, suggesting that pancreatin may effectively counteract weight loss during this critical period.
Read More
2
We assessed the effectiveness of pancreatic exocrine replacement therapy (PERT) in preventing weight loss for patients with unresectable pancreatic cancer through a double-blind, randomized trial involving 67 participants.
Each patient received either pancreatin capsules or a placebo for eight weeks. However, the results showed no significant difference in weight loss between the two groups.
Additionally, there was no notable improvement in quality of life or overall survival rates, suggesting that PERT may not be beneficial in this context. Further research is needed to explore who might benefit from PERT.
Each patient received either pancreatin capsules or a placebo for eight weeks. However, the results showed no significant difference in weight loss between the two groups.
Additionally, there was no notable improvement in quality of life or overall survival rates, suggesting that PERT may not be beneficial in this context. Further research is needed to explore who might benefit from PERT.
Read More
9
We explored the potential cancer-fighting properties of lunasin, a peptide found in Soy Bowman Birk Inhibitor Concentrate (BBIC). Our research revealed that lunasin, alongside BBI, plays a significant role in preventing breast cancer.
When administered to mice with human breast cancer, lunasin showed a remarkable capability to reduce tumor rates by up to 49%. In contrast, BBI did not demonstrate any significant effect on tumor development.
This suggests lunasin is the key player in BBIC’s cancer-preventive properties, with BBI primarily serving to protect lunasin from being digested.
When administered to mice with human breast cancer, lunasin showed a remarkable capability to reduce tumor rates by up to 49%. In contrast, BBI did not demonstrate any significant effect on tumor development.
This suggests lunasin is the key player in BBIC’s cancer-preventive properties, with BBI primarily serving to protect lunasin from being digested.
Read More
Most Useful Reviews
9
Improved well-being
4 people found this helpful
As a pancreatic cancer survivor who underwent the Whipple Procedure and has Crohn's disease, my digestive system has been poor. This product has helped immensely and is far more affordable than the prescription alternatives. After losing considerable weight, I now feel much better and encourage anyone with digestive issues to try this.
Read More
9
Preventative measure
2 people found this helpful
This product should be taken by everyone to prevent cancer or to help lessen its effects.
Read More
7.5
Digestive aid success
2 people found this helpful
This product serves as a great Creon substitute. I have neuroendocrine cancer and struggle with digestion. I take it with every meal and it truly aids in my digestion. The lower price compared to Creon, classified as tier 4 by my insurance, is a significant advantage.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
- All Researches
9
We explored the potential cancer-fighting properties of lunasin, a peptide found in Soy Bowman Birk Inhibitor Concentrate (BBIC). Our research revealed that lunasin, alongside BBI, plays a significant role in preventing breast cancer.
When administered to mice with human breast cancer, lunasin showed a remarkable capability to reduce tumor rates by up to 49%. In contrast, BBI did not demonstrate any significant effect on tumor development.
This suggests lunasin is the key player in BBIC’s cancer-preventive properties, with BBI primarily serving to protect lunasin from being digested.
When administered to mice with human breast cancer, lunasin showed a remarkable capability to reduce tumor rates by up to 49%. In contrast, BBI did not demonstrate any significant effect on tumor development.
This suggests lunasin is the key player in BBIC’s cancer-preventive properties, with BBI primarily serving to protect lunasin from being digested.
Read More
9
We examined the impact of porcine pancreatic enzyme extracts (PPE) on human pancreatic cancer in mice. Mice with transplanted cancer cells received PPE in their drinking water. The results showed that those treated with PPE lived significantly longer and had smaller tumors compared to untreated mice.
Interestingly, while PPE helped improve survival and reduced tumor size, the study found no notable differences in certain tumor growth factors or cell death rates between the two groups. This suggests that the nutritional benefits of PPE contributed to the observed outcomes.
Interestingly, while PPE helped improve survival and reduced tumor size, the study found no notable differences in certain tumor growth factors or cell death rates between the two groups. This suggests that the nutritional benefits of PPE contributed to the observed outcomes.
Read More
9
We examined how pancreatin and other treatments affect fat absorption in patients suffering from pancreatic steatorrhoea. Over 45 patients were divided into four groups and treated with various medications for two to four weeks.
Interestingly, patients receiving high-lipase pancreatin had a notable reduction in fat excretion, showing it was more effective than sodium bicarbonate and proton pump inhibitors. However, all treatments were beneficial for mild cases. For more severe conditions, a greater dose of pancreatin paired with an acid-reducing agent could be necessary.
Interestingly, patients receiving high-lipase pancreatin had a notable reduction in fat excretion, showing it was more effective than sodium bicarbonate and proton pump inhibitors. However, all treatments were beneficial for mild cases. For more severe conditions, a greater dose of pancreatin paired with an acid-reducing agent could be necessary.
Read More
8
We evaluated the effects of protein hydrolysates from three medicinal plants—Matricaria chamomilla, Ziziphora clinopodioides, and Cressa cretica—on cancer cells. Our methodology involved extracting and partially purifying the proteins, followed by treatment with pancreatin.
We found that these hydrolysates displayed both cytotoxic and antioxidant properties. Particularly, C. cretica showed cytotoxic activity against breast cancer cells, although it did not affect healthy cells significantly.
While the results are promising, especially for M. chamomilla in terms of cancer cell suppression, we must note that further research is needed before we can consider these findings as concrete breakthroughs in cancer therapy.
We found that these hydrolysates displayed both cytotoxic and antioxidant properties. Particularly, C. cretica showed cytotoxic activity against breast cancer cells, although it did not affect healthy cells significantly.
While the results are promising, especially for M. chamomilla in terms of cancer cell suppression, we must note that further research is needed before we can consider these findings as concrete breakthroughs in cancer therapy.
Read More
8
We designed a study to evaluate if porcine pancreatic extract could help manage pancreatic cancer in hamsters. The hamsters were put on a high-fat diet, and after developing insulin resistance, one group received the extract while the other group drank plain water.
After 43 weeks, we found that the hamsters treated with the extract had fewer pancreatic tumors and lower insulin levels compared to the control group. However, there was no significant difference in blood glucose levels. Overall, these findings suggest that porcine pancreatic extract may inhibit the growth of pancreatic cancer.
After 43 weeks, we found that the hamsters treated with the extract had fewer pancreatic tumors and lower insulin levels compared to the control group. However, there was no significant difference in blood glucose levels. Overall, these findings suggest that porcine pancreatic extract may inhibit the growth of pancreatic cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved well-being
4 people found this helpful
As a pancreatic cancer survivor who underwent the Whipple Procedure and has Crohn's disease, my digestive system has been poor. This product has helped immensely and is far more affordable than the prescription alternatives. After losing considerable weight, I now feel much better and encourage anyone with digestive issues to try this.
Read More
9
Preventative measure
2 people found this helpful
This product should be taken by everyone to prevent cancer or to help lessen its effects.
Read More
7.5
Digestive aid success
2 people found this helpful
This product serves as a great Creon substitute. I have neuroendocrine cancer and struggle with digestion. I take it with every meal and it truly aids in my digestion. The lower price compared to Creon, classified as tier 4 by my insurance, is a significant advantage.
Read More
7.5
Affordable choice
25 people found this helpful
This product closely resembles the prescription Creon, needed for my fiancée who has pancreatic cancer to aid her digestion. We selected this due to the high cost of Creon, making it much more affordable as we required it for meals and snacks.
Read More
6
Digestive control gained
10 people found this helpful
Pancreon was very expensive for my Stage IV Pancreatic Cancer, diagnosed after persistent diarrhoea. I am now undergoing chemotherapy with Gemzar and Abraxane. A friend suggested Pancreatin, which I have been using for over a year, and I’m still alive 18 months post-diagnosis! I take two capsules every eight hours. While it hasn’t cured my diarrhoea, it is much more manageable. I am grateful for my porcine friends for their pancreatic enzymes.
Read More
Frequently Asked Questions
7
We explored the potential of peptides derived from soybean and cowpea proteins to inhibit breast and prostate cancer cell growth. After hydrolyzing these proteins with pancreatin, the resulting peptides showed promise in laboratory tests. Notably, one peptide, VIPAAY, demonstrated a strong ability to interact with the Bcl-2 protein, similar to a popular cancer drug called Venetoclax. However, while initial findings are encouraging, further research is necessary to confirm these results and understand their true impact on cancer treatment.
7
Jackfruit leaf hydrolysates reduce cancer cell viability
We evaluated how jackfruit leaf protein hydrolysates, produced using pepsin and pancreatin, affect cancer cells and oxidative stress. Our analysis revealed that these hydrolysates had peptide sizes ranging from 20 to 25 kDa. While we didn't observe significant toxicity on normal cells, the hydrolysates showed promising results in reducing cancer cell viability. Specifically, the 240-minute pancreatin hydrolysate reduced cervical cancer cell viability by 23%, along with notable reductions in ovarian and liver cancer cells. The hydrolysates also protected against oxidative stress, showcasing their potential for safe use in plant-based therapies.
9
We explored the potential cancer-fighting properties of lunasin, a peptide found in Soy Bowman Birk Inhibitor Concentrate (BBIC). Our research revealed that lunasin, alongside BBI, plays a significant role in preventing breast cancer.
When administered to mice with human breast cancer, lunasin showed a remarkable capability to reduce tumor rates by up to 49%. In contrast, BBI did not demonstrate any significant effect on tumor development.
This suggests lunasin is the key player in BBIC’s cancer-preventive properties, with BBI primarily serving to protect lunasin from being digested.
When administered to mice with human breast cancer, lunasin showed a remarkable capability to reduce tumor rates by up to 49%. In contrast, BBI did not demonstrate any significant effect on tumor development.
This suggests lunasin is the key player in BBIC’s cancer-preventive properties, with BBI primarily serving to protect lunasin from being digested.
9
We examined the impact of porcine pancreatic enzyme extracts (PPE) on human pancreatic cancer in mice. Mice with transplanted cancer cells received PPE in their drinking water. The results showed that those treated with PPE lived significantly longer and had smaller tumors compared to untreated mice.
Interestingly, while PPE helped improve survival and reduced tumor size, the study found no notable differences in certain tumor growth factors or cell death rates between the two groups. This suggests that the nutritional benefits of PPE contributed to the observed outcomes.
Interestingly, while PPE helped improve survival and reduced tumor size, the study found no notable differences in certain tumor growth factors or cell death rates between the two groups. This suggests that the nutritional benefits of PPE contributed to the observed outcomes.
References
- Philadelpho BO, Santiago VG, Santos JEMD, Silva MBCE, De Grandis RA, et al. Soybean β-Conglycinin and Cowpea β-Vignin Peptides Inhibit Breast and Prostate Cancer Cell Growth: An In Silico and In Vitro Approach. Foods. 2024;13. doi:10.3390/foods13213508
- CalderĂłn-Chiu C, Ragazzo-Sánchez JA, Ordaz-Hernández A, Herrera-MartĂnez M. Jackfruit Leaf Protein Hydrolysates Obtained by Enzymatic Hydrolysis of Leaf Protein Concentrate with Pepsin and Pancreatin: Molecular Weight, Cytotoxicity, Antiproliferative Activity, and Oxidative Stress. Plant Foods Hum Nutr. 2024;79:685. doi:10.1007/s11130-024-01203-9
- Akbarmehr A, Peighambardoust SH, Ghanbarzadeh B, Sarabandi K. Physicochemical, antioxidant, antimicrobial, and in vitro cytotoxic activities of corn pollen protein hydrolysates obtained by different peptidases. Food Sci Nutr. 2023;11:2403. doi:10.1002/fsn3.3252
- Nag D, Goel A, Padwad Y, Singh D. In Vitro Characterisation Revealed Himalayan Dairy Kluyveromyces marxianus PCH397 as Potential Probiotic with Therapeutic Properties. Probiotics Antimicrob Proteins. 2023;15:761. doi:10.1007/s12602-021-09874-5
- Taghizadeh MS, Niazi A, Moghadam A, Afsharifar AR. The potential application of the protein hydrolysates of three medicinal plants: cytotoxicity and functional properties. J Food Sci. 2020;85:3160. doi:10.1111/1750-3841.15379
- Kim H, Yoon YS, Han Y, Kwon W, Kim SW, et al. Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized Trial. Clin Gastroenterol Hepatol. 2020;18:926. doi:10.1016/j.cgh.2019.08.061
- Woo SM, Joo J, Kim SY, Park SJ, Han SS, et al. Efficacy of pancreatic exocrine replacement therapy for patients with unresectable pancreatic cancer in a randomized trial. Pancreatology. 2016;16:1099. doi:10.1016/j.pan.2016.09.001
- Nozawa F, Yalniz M, Saruc M, Standop J, Egami H, et al. Effects of porcine pancreatic enzymes on the pancreas of hamsters. Part 2: carcinogenesis studies. JOP. 2012;13:482. doi:10.6092/1590-8577/663
- Saruc M, Nozawa F, Yalniz M, Itami A, Pour PM. Effects of porcine pancreatic enzymes on the pancreas of hamsters. Part 1: basic studies. JOP. 2012;13:476. doi:10.6092/1590-8577/522
- Hsieh CC, Hernández-Ledesma B, Jeong HJ, Park JH, de Lumen BO. Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable. PLoS One. 2010;5:e8890. doi:10.1371/journal.pone.0008890
- Saruc M, Standop S, Standop J, Nozawa F, Itami A, et al. Pancreatic enzyme extract improves survival in murine pancreatic cancer. Pancreas. 2004;28:401.
- Kriváchy P, Bálint A, Máté M, Ihász M. [Result of Panzytrat 25000 therapy following total gastrectomy]. Orv Hetil. 1999;140:2107.
- Bruno MJ, Haverkort EB, Tijssen GP, Tytgat GN, van Leeuwen DJ. Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region. Gut. 1998;42:92.
- Nakamura T, Takebe K, Kudoh K, Ishii M, Imamura K, et al. Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases. J Int Med Res. 1995;23:37.
- Zavadova E, Desser L, Mohr T. Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation. Cancer Biother. 1995;10:147.
