Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid.
We investigated how dietary inulin can help manage constipation, particularly its role in alleviating related symptoms of depression and anxiety. To do this, we used male CD-1 mice and induced constipation through a specific medication.
With inulin incorporated into a standard diet, we observed a notable improvement in constipated mice. They experienced an increase in both the weight and moisture content of their feces, indicating better bowel function.
Beyond physical improvements, we also found that inulin treatment helped reduce behaviors associated with depression and anxiety. This was linked to a decrease in neuro-inflammation and protection against cellular damage in the brain's synapses. Importantly, inulin also supported gut health by enhancing the gut barrier and altering gut microbiota for the better.
While the gut microbiome reshaping was promising, we observed that when we depleted the gut microbiota with antibiotics, the benefits of inulin on mood were significantly diminished. Furthermore, inulin treatment boosted the levels of beneficial short-chain fatty acids (SCFAs), which were also shown to help improve depressive behavior when administered separately.
In conclusion, dietary inulin presents a valuable nutritional strategy for preventing depression linked to constipation by influencing both the gut microbiome and its metabolites.
Read More
9
Inulin alleviates constipation effectively
Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows.
We examined the effectiveness of inulin, a type of soluble dietary fiber, in alleviating constipation in pregnant sows. In our study, we divided 30 sows into three groups: one received a standard diet, while the others supplemented it with either 0.5% inulin or isomalto-oligosaccharide (IMO) starting on day 64 of their gestation.
What we discovered was quite promising. The sows that consumed inulin showed an increase in a hormone called substance P, known to aid in gastrointestinal movement. Simultaneously, levels of another hormone, vasoactive intestinal peptide, decreased, which suggests a potential reduction in constipation symptoms.
Furthermore, those on the inulin supplement exhibited changes in their gut health. Specifically, we found an increase in beneficial short-chain fatty acids and a positive shift in their fecal flora diversity. This suggests that inulin not only helps ease constipation but also promotes a healthier gut environment during pregnancy.
Overall, our findings indicate that including inulin in the diet of pregnant sows can effectively relieve constipation and enhance their reproductive performance, making it a valuable addition for managing gut health in these animals.
Read More
8
Kombucha improves IBS-C symptoms
Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study.
We set out to understand how inulin, particularly when combined with kombucha and vitamins, might help alleviate symptoms of constipation-predominant irritable bowel syndrome (IBS-C) in women. In a randomized pilot study involving 40 females, participants were given either 220 mL of this kombucha drink, which contained inulin and several vitamins, or simply water over a period of 10 days.
Throughout the study, we closely monitored key indicators such as stool frequency, stool consistency using the Bristol stool scale, and abdominal discomfort. The improvements were notable: those consuming the enriched kombucha experienced an increase in their stool frequency and a more favorable stool consistency score, alongside a reduction in the discomfort of feeling like their bowels weren't completely emptied.
Our findings suggest that incorporating inulin through this tasty kombucha may be a viable option for women dealing with IBS-C, making it easier for them to manage their symptoms. However, we acknowledge that further large-scale trials are necessary to solidify these results and better understand the long-term benefits.
Read More
Most Useful Reviews
9
Effective for constipation
190 people found this helpful
Great intestinal support! I bought this inulin to use with a probiotic from CGN. I drink the probiotic at night and inulin when I remember. Inulin nourishes beneficial intestinal flora. Previously, I suffered from constipation, sometimes going 4-5 days without a visit to the toilet, relying solely on Dufalac. Now, after combining the probiotic and inulin, my intestines are more active in the morning. Even while taking iron, which is known to cause constipation, this combination has worked wonders!
Read More
9
Chronic constipation help
16 people found this helpful
This product has been a lifesaver for my chronic idiopathic constipation. Despite eating a lot of fibre and trying Metamucil and Fiber One without success, I found that inulin greatly assists with my bowel movements. Initially, I did experience some gas, but that has decreased significantly. I mix it into my morning coffee, and it’s truly pleasant, keeping my bowels healthy.
Read More
7.5
Helps with independence
12 people found this helpful
This low-cost prebiotic is simple to consume and blends into a variety of foods. We’re using it for my daughter, who is on the spectrum. Initially, it caused gas, bloating, and constipation, but after a few months, she's now able to use the toilet independently without fear. It is a useful product for helping children.
Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study.
We explored how synbiotic treatment, which included inulin and probiotics, could improve constipation and non-motor symptoms in patients with stable Parkinson's Disease (PD). In a study involving patients diagnosed with functional constipation, we administered a synbiotic product that contained the prebiotic fiber inulin for 12 weeks.
Throughout the study, we observed significant enhancements in various symptoms. On the neurological side, patients displayed better results in scales that measure non-motor symptoms, like mood and cognitive function. The gastroenterological evaluations, which specifically looked at constipation, showed notable improvements too. For instance, there was a measurable increase in the number of complete bowel movements and enhancements in patients’ overall comfort.
While our focus was on the synbiotic mixture, the role of inulin as a fiber source cannot be underestimated. It appears to contribute substantially to the observed gastrointestinal benefits. The evidence suggests that while synbiotics may help alleviate constipation and improve general well-being, we cannot make any definitive claims solely based on inulin's effects, as it was part of a combined formulation. Overall, our findings indicate that synbiotic supplementation can be beneficial for PD patients, especially those suffering from constipation.
Read More
9
Inulin aids constipation and depression
Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid.
We investigated how dietary inulin can help manage constipation, particularly its role in alleviating related symptoms of depression and anxiety. To do this, we used male CD-1 mice and induced constipation through a specific medication.
With inulin incorporated into a standard diet, we observed a notable improvement in constipated mice. They experienced an increase in both the weight and moisture content of their feces, indicating better bowel function.
Beyond physical improvements, we also found that inulin treatment helped reduce behaviors associated with depression and anxiety. This was linked to a decrease in neuro-inflammation and protection against cellular damage in the brain's synapses. Importantly, inulin also supported gut health by enhancing the gut barrier and altering gut microbiota for the better.
While the gut microbiome reshaping was promising, we observed that when we depleted the gut microbiota with antibiotics, the benefits of inulin on mood were significantly diminished. Furthermore, inulin treatment boosted the levels of beneficial short-chain fatty acids (SCFAs), which were also shown to help improve depressive behavior when administered separately.
In conclusion, dietary inulin presents a valuable nutritional strategy for preventing depression linked to constipation by influencing both the gut microbiome and its metabolites.
Read More
9
Kombucha with inulin aids constipation
[Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome].
We explored the effects of a new kombucha drink enriched with inulin on individuals suffering from constipation-predominant irritable bowel syndrome (IBS). The study involved two groups: one received the kombucha drink and the other a placebo of water for 10 days. By assessing changes in stool frequency, consistency, and feelings of incomplete bowel emptying, we aimed to see whether inulin could help alleviate symptoms of constipation.
Participants who drank the kombucha showed a noticeable improvement. After 10 days, their stool frequency increased, indicating better bowel regularity. We observed that people consuming the kombucha reported fewer feelings of incomplete bowel emptying, which is often a bothersome symptom for those with constipation. The drink also improved the consistency of stools, making them easier to pass.
However, it's worth noting that the control group did not experience any significant changes during the study period. This finding strongly suggests that the kombucha drink with inulin has potential benefits for treating constipation, highlighting the role of inulin as a dietary fiber that can improve digestive regularity.
Read More
9
Inulin alleviates constipation effectively
Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows.
We examined the effectiveness of inulin, a type of soluble dietary fiber, in alleviating constipation in pregnant sows. In our study, we divided 30 sows into three groups: one received a standard diet, while the others supplemented it with either 0.5% inulin or isomalto-oligosaccharide (IMO) starting on day 64 of their gestation.
What we discovered was quite promising. The sows that consumed inulin showed an increase in a hormone called substance P, known to aid in gastrointestinal movement. Simultaneously, levels of another hormone, vasoactive intestinal peptide, decreased, which suggests a potential reduction in constipation symptoms.
Furthermore, those on the inulin supplement exhibited changes in their gut health. Specifically, we found an increase in beneficial short-chain fatty acids and a positive shift in their fecal flora diversity. This suggests that inulin not only helps ease constipation but also promotes a healthier gut environment during pregnancy.
Overall, our findings indicate that including inulin in the diet of pregnant sows can effectively relieve constipation and enhance their reproductive performance, making it a valuable addition for managing gut health in these animals.
Read More
8
Inulin improves constipation in Parkinson's
Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease.
We examined the potential benefits of inulin for managing constipation, particularly in individuals with Parkinson's disease. Our research focused on creating a functional muffin recipe enhanced with inulin, cocoa, and Moringa—ingredients that could provide additional fiber and nutrients.
With quality assessments like physical-chemical analysis and sensory evaluations, we found a significant increase in both soluble and insoluble fiber in muffins with inulin compared to control samples. This is important because fiber plays a crucial role in promoting digestive health and alleviating constipation.
Notably, the muffins enriched with inulin plus cocoa not only improved fiber content but also offered better antioxidant properties. Participants expressed a strong preference for muffins containing inulin, especially those with cocoa, showcasing a purchase intention of 78%.
Our findings suggest that incorporating inulin into baked goods like muffins can enhance their nutritional profile while also providing an appealing option for those struggling with constipation due to Parkinson's disease. Overall, this enriched bakery product could serve as a beneficial dietary strategy in improving digestive health.
Great intestinal support! I bought this inulin to use with a probiotic from CGN. I drink the probiotic at night and inulin when I remember. Inulin nourishes beneficial intestinal flora. Previously, I suffered from constipation, sometimes going 4-5 days without a visit to the toilet, relying solely on Dufalac. Now, after combining the probiotic and inulin, my intestines are more active in the morning. Even while taking iron, which is known to cause constipation, this combination has worked wonders!
Read More
9
Chronic constipation help
16 people found this helpful
This product has been a lifesaver for my chronic idiopathic constipation. Despite eating a lot of fibre and trying Metamucil and Fiber One without success, I found that inulin greatly assists with my bowel movements. Initially, I did experience some gas, but that has decreased significantly. I mix it into my morning coffee, and it’s truly pleasant, keeping my bowels healthy.
Read More
7.5
Helps with independence
12 people found this helpful
This low-cost prebiotic is simple to consume and blends into a variety of foods. We’re using it for my daughter, who is on the spectrum. Initially, it caused gas, bloating, and constipation, but after a few months, she's now able to use the toilet independently without fear. It is a useful product for helping children.
Read More
9
Improved regularity
10 people found this helpful
Helped with constipation. I was diagnosed with dysbiosis and the doctor prescribed Inulin along with probiotics and vitamins. Initially, I experienced strong flatulence, but this subsided. Over the month, my bowel movements improved significantly, becoming regular. I am now finishing my first jar and will continue as prescribed for better intestinal microflora. I enjoy the taste, reminiscent of childhood cotton candy, mixing it with yogurt, kefir, or simply water. I suggest consulting a doctor before starting Inulin as they may recommend complementary treatments for better results.
Read More
10
Child's relief
7 people found this helpful
It helped! I bought this for a child with developmental disabilities. The child had constipation since birth, but with inulin, we’ve managed to forget about this problem. We take it regularly.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Prebiotic fiber inulin is a naturally occurring carbohydrate found in a variety of plants, particularly in roots and tubers such as chicory, garlic, leeks, and onions. As a soluble fiber, it is not digested in the small intestine but rather fermented by beneficial gut bacteria in the large intestine. This fermentation process helps promote the growth of beneficial bacteria, which can support gut health, improve digestion, and enhance the absorption of certain nutrients. Increasing dietary intake of prebiotic fibers like inulin can contribute to a healthier microbiome.
In addition to its benefits for gut health, inulin can also help to enhance feelings of fullness and reduce appetite, making it a popular ingredient in weight management products. It is often added to food and beverage items as a texturizer or sweetener because it offers a mildly sweet flavor without contributing significant calories. Given its numerous health benefits, inulin is frequently emphasized in discussions about dietary fiber and overall nutrition, making it a valuable component of a balanced diet.
Prebiotic fiber inulin can be a helpful addition to your diet if you're looking to alleviate constipation. As a soluble fiber, inulin adds bulk to your stool and helps retain water, which can improve the overall consistency and ease of passage. This fermentation process in the gut promotes the growth of beneficial bacteria, potentially enhancing your digestive health. However, it's essential to introduce inulin gradually into your diet to minimize any gastrointestinal discomfort, such as bloating or gas.
In addition to its role in promoting regular bowel movements, inulin can help support gut health. However, results can vary from person to person, and while some may experience significant relief from constipation, others might not see the same benefits. If constipation persists, it may be wise to consult a healthcare professional for personalized advice. Overall, incorporating inulin-rich foods like chicory root, garlic, onions, or even taking a fiber supplement could contribute positively to your digestive system.
Based on user reviews, the time it takes to see results from taking inulin for constipation varies widely among individuals. Many users report significant improvements within just a week of starting to use the supplement. For instance, one user states that their bowel movements improved significantly after just one week of using two teaspoons of inulin daily Read Review. Another reviewed that they felt relief within an hour of taking inulin, indicating that it could potentially work quickly for some Read Review.
However, for others, the results took a bit longer to manifest. Some users mention a gradual improvement over the course of a month, suggesting that consistent daily intake is key for optimal results Read Review. Ultimately, individual responses can differ widely, making it important to monitor how your body reacts and consult with a healthcare provider for personalized advice.
Inulin, a soluble dietary fiber, has gathered attention in the realm of constipation relief, supported by various studies over the years. Research indicates that inulin administration can significantly enhance bowel movements and improve stool consistency. For instance, a clinical trial highlighted that inulin could boost the frequency of defecation and overall gastrointestinal comfort, indicating its potential efficacy in managing constipation symptoms [6]. Moreover, a study involving patients with functional constipation and Parkinson's disease also found substantial improvements in bowel movement frequency when using synbiotic treatments that included inulin [2].
While inulin appears to contribute positively to gastrointestinal health, it may not stand out as the most potent fiber compared to other soluble options [1]. Several studies have suggested that while inulin can be beneficial, the overall effectiveness may be influenced by various factors, including its delivery method or the presence of other dietary components [4]. Despite this variance, the accumulating evidence points toward inulin being a viable supplemental option for those seeking to manage constipation, especially when incorporated into enjoyable dietary forms, such as enriched baked goods or drinks [3][14].
Many users report significant improvements in their symptoms of constipation after taking inulin, highlighting its effectiveness in promoting regular bowel movements. For instance, one user experienced a transformation from suffering constipation for years to achieving daily regularity after just one use Read Review. Another noted a remarkable response, as their child, who had battled constipation their whole life, began eliminating that issue after introducing inulin into their diet Read Review. Users have indicated experiences ranging from relief within a few minutes of consumption Read Review to more gradual but significant improvements over a month, suggesting varied responses that seem to depend on individual circumstances and dietary integrations Read Review.
Further, the overall feedback emphasizes not just symptomatic relief but also improved gut health and associated benefits, such as a decrease in bloating and an enhanced sense of lightness after use. Users have found inulin to be a pleasant addition to their diets, often enjoying its cotton candy-like flavor when mixed with beverages Read Review. However, it’s essential to note that while many report positive outcomes, individual results can vary; some users experienced confusion about its efficacy and noted unsuccessful experiences with constipation following its use Read Review. Therefore, as with any supplement, it's wise to consult with a healthcare provider to find the dosage and regimen suited to your needs.
Users have reported positive experiences when combining inulin with other supplements, particularly probiotics. One user noted that taking inulin alongside a probiotic led to significant improvements in their bowel movements, even while also taking iron, which is known to cause constipation Read Review. Another review highlighted that inulin was prescribed by a doctor along with probiotics and vitamins, resulting in improved regularity after an initial period of flatulence Read Review.
In addition, users have remarked on the success of mixing inulin with various food and beverage options. For instance, one user mentioned the efficacy of inulin when mixed with yogurt or kefir, which enhanced the relief from their constipation issues Read Review. Another user experienced substantial relief within minutes of combining inulin with lactic acid bacteria Read Review. Overall, the consensus among users is that inulin can be effectively combined with probiotics and other dietary items, amplifying its benefits for digestive health and regular bowel movements.
Based on user reviews, the right dosage for Prebiotic Fiber Inulin in treating constipation seems to vary, with many users suggesting starting with a smaller amount and gradually increasing it. For instance, one user reported success with a teaspoon daily, indicating a routine that has worked to eliminate their long-standing constipation issues (Read Review). Another user mentioned that two teaspoons led to significant improvement within a week, providing regular bowel movements (Read Review).
Several users also highlighted the importance of adjusting the dosage to individual tolerance. One review noted that excessive inulin intake could lead to flatulence, recommending that users monitor their consumption closely (Read Review). Overall, it appears that users advocate starting with lower doses, increasing gradually as needed, and combining inulin with other dietary components like probiotics for enhanced effects (Read Review). This tailored approach may provide the best results for alleviating constipation while minimizing potential side effects.
9
Improved bowel movements
5 people found this helpful
This is a great prebiotic! I suffered from constipation, but after a week of using two teaspoons, my bowel movements improved significantly. I also give it to my child, and after introducing olive and fish oils, all constipation issues were resolved, leaving the child more settled and calmer.
9
Effective for constipation
2 people found this helpful
I suffer from constipation ... When coffee, Saccharomycetes of Boulardia, or Regulax fail, I take a teaspoon of inulin. Its effects are felt within 30 minutes. It aids significantly in restoring my intestinal health. I highly recommend it!
9
Improved regularity
10 people found this helpful
Helped with constipation. I was diagnosed with dysbiosis and the doctor prescribed Inulin along with probiotics and vitamins. Initially, I experienced strong flatulence, but this subsided. Over the month, my bowel movements improved significantly, becoming regular. I am now finishing my first jar and will continue as prescribed for better intestinal microflora. I enjoy the taste, reminiscent of childhood cotton candy, mixing it with yogurt, kefir, or simply water. I suggest consulting a doctor before starting Inulin as they may recommend complementary treatments for better results.
10
Life-changing results
4 people found this helpful
After long struggles with constipation, which no diet, liquid intake, or fibre could resolve, I took Inulin before bed. After an hour and with probiotics, my bowel movements improved to daily. I felt a sense of lightness. Extremely satisfied and would thoroughly recommend it!
10
Child's relief
7 people found this helpful
It helped! I bought this for a child with developmental disabilities. The child had constipation since birth, but with inulin, we’ve managed to forget about this problem. We take it regularly.
10
Quickly alleviates constipation
2 people found this helpful
Whoa, this product is brilliant. My 10-year-old daughter took it, and her constipation vanished. I also consume it with lactic acid bacteria, but after combining lactic acid bacteria, dietary fibre, and inulin, she was 'relieved' merely 5 minutes later. It tastes delightful (cotton candy) and is now her favourite supplement.
9
Effective solution
3 people found this helpful
Effective for constipation and tastes like cotton candy. I simply add it to my coffee in the morning, and it helps improve my gut health without overwhelming me with extra fibre.
0
Worsened constipation
2 people found this helpful
After consuming this product, I experienced constipation and was unable to use the bathroom for over three days. I'm disappointed and have decided not to consume it again.
9
Effective for constipation
190 people found this helpful
Great intestinal support! I bought this inulin to use with a probiotic from CGN. I drink the probiotic at night and inulin when I remember. Inulin nourishes beneficial intestinal flora. Previously, I suffered from constipation, sometimes going 4-5 days without a visit to the toilet, relying solely on Dufalac. Now, after combining the probiotic and inulin, my intestines are more active in the morning. Even while taking iron, which is known to cause constipation, this combination has worked wonders!
10
Regularity achieved
5 people found this helpful
It helped to relieve my constipation. Despite daily yogurt and natto, I struggled until I tried inulin. Now I have daily regular bowel movements! I take a teaspoon before meals, and it suits me well without any stomach pain. However, excessive inulin may cause flatulence, so adjusting the dosage is essential.
8
Inulin shows promise for constipation
Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence.
We evaluated the potential of inulin, a popular prebiotic, in alleviating constipation symptoms based on a thorough review of existing studies. The research examined both animal models and clinical trials, uncovering that inulin appears to be one of the most effective prebiotics for promoting regular bowel movements.
Specifically, the findings suggest that inulin supplementation can enhance defecation frequency and improve stool consistency, making it a viable option for those grappling with constipation. Participants taking inulin reported positive changes in their gastrointestinal functions, leading to more comfortable and regular bowel habits.
However, while the results are promising, some critical questions around inulin's long-term effectiveness and the ideal dosage remain unanswered. We need further high-quality research to determine the best practices for using inulin in managing constipation more effectively.
In summary, while inulin shows significant potential as a remedy, ongoing investigation is essential to fine-tune our understanding and application in clinical settings.
9
Synbiotic treatment benefits constipation
Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study.
We explored how synbiotic treatment, which included inulin and probiotics, could improve constipation and non-motor symptoms in patients with stable Parkinson's Disease (PD). In a study involving patients diagnosed with functional constipation, we administered a synbiotic product that contained the prebiotic fiber inulin for 12 weeks.
Throughout the study, we observed significant enhancements in various symptoms. On the neurological side, patients displayed better results in scales that measure non-motor symptoms, like mood and cognitive function. The gastroenterological evaluations, which specifically looked at constipation, showed notable improvements too. For instance, there was a measurable increase in the number of complete bowel movements and enhancements in patients’ overall comfort.
While our focus was on the synbiotic mixture, the role of inulin as a fiber source cannot be underestimated. It appears to contribute substantially to the observed gastrointestinal benefits. The evidence suggests that while synbiotics may help alleviate constipation and improve general well-being, we cannot make any definitive claims solely based on inulin's effects, as it was part of a combined formulation. Overall, our findings indicate that synbiotic supplementation can be beneficial for PD patients, especially those suffering from constipation.
7
Examining inulin's laxative effects
Different Efficacy of Five Soluble Dietary Fibers on Alleviating Loperamide-Induced Constipation in Mice: Influences of Different Structural Features.
We aimed to understand how different types of soluble dietary fibers, including inulin, help with constipation. Over a 14-day period, we tested the effects of five different fibers on mice that were induced with constipation using loperamide. Our findings showed that while inulin was one of the fibers tested, it did not significantly stand out compared to the others in improving gastrointestinal (GI) transit rates.
However, we observed that inulin did have a positive effect on increasing fecal weight, alongside other fibers. The study highlighted that the unique structures of each fiber, including the monosaccharide composition and glycosidic bonds, played a crucial role in their effectiveness. Inulin, for instance, was connected with the proliferation of certain beneficial bacteria that promote gut health.
Overall, the results indicate that while inulin contributes to constipation relief, it might not be as effective as some other soluble fibers. This research gives us valuable insights into how different fibers can impact gut health and constipation management.
9
Inulin aids constipation and depression
Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid.
We investigated how dietary inulin can help manage constipation, particularly its role in alleviating related symptoms of depression and anxiety. To do this, we used male CD-1 mice and induced constipation through a specific medication.
With inulin incorporated into a standard diet, we observed a notable improvement in constipated mice. They experienced an increase in both the weight and moisture content of their feces, indicating better bowel function.
Beyond physical improvements, we also found that inulin treatment helped reduce behaviors associated with depression and anxiety. This was linked to a decrease in neuro-inflammation and protection against cellular damage in the brain's synapses. Importantly, inulin also supported gut health by enhancing the gut barrier and altering gut microbiota for the better.
While the gut microbiome reshaping was promising, we observed that when we depleted the gut microbiota with antibiotics, the benefits of inulin on mood were significantly diminished. Furthermore, inulin treatment boosted the levels of beneficial short-chain fatty acids (SCFAs), which were also shown to help improve depressive behavior when administered separately.
In conclusion, dietary inulin presents a valuable nutritional strategy for preventing depression linked to constipation by influencing both the gut microbiome and its metabolites.
8
Inulin improves constipation in Parkinson's
Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease.
We examined the potential benefits of inulin for managing constipation, particularly in individuals with Parkinson's disease. Our research focused on creating a functional muffin recipe enhanced with inulin, cocoa, and Moringa—ingredients that could provide additional fiber and nutrients.
With quality assessments like physical-chemical analysis and sensory evaluations, we found a significant increase in both soluble and insoluble fiber in muffins with inulin compared to control samples. This is important because fiber plays a crucial role in promoting digestive health and alleviating constipation.
Notably, the muffins enriched with inulin plus cocoa not only improved fiber content but also offered better antioxidant properties. Participants expressed a strong preference for muffins containing inulin, especially those with cocoa, showcasing a purchase intention of 78%.
Our findings suggest that incorporating inulin into baked goods like muffins can enhance their nutritional profile while also providing an appealing option for those struggling with constipation due to Parkinson's disease. Overall, this enriched bakery product could serve as a beneficial dietary strategy in improving digestive health.
8
Inulin improves constipation effectively
Chemical stability of fructans in apple beverages and their influence on chronic constipation.
We explored the potential of inulin, a Dietary Fiber, as a remedy for constipation by analyzing beverages made from apple juice enriched with inulin. In our study, we utilized a well-structured design, including a placebo-controlled, randomized approach involving 20 participants aged 20-29 who exhibited chronic constipation symptoms.
Each participant consumed a drink boosted with highly polymerized inulin, providing 12 grams of inulin in a 300 mL serving. Our research revealed substantial findings: over a 120-day period, pasteurized apple juice beverages containing inulin retained their chemical integrity, as the fructans did not break down into reducing sugars. Notably, the addition of inulin didn't compromise the juice's taste, smell, or overall enjoyment.
Most importantly, we observed a significant increase in bowel movement frequency among the participants consuming these inulin-enriched drinks. The results indicated a quite effective way of managing constipation without any adverse effects on sensory qualities of the beverages. Our findings suggest that fructans in apple juice drinks could offer a chemically stable and enjoyable option for individuals looking to alleviate constipation symptoms.
References
Zhang Z, Liu B, Liu W, Liu X, Zhang C, et al. Different Efficacy of Five Soluble Dietary Fibers on Alleviating Loperamide-Induced Constipation in Mice: Influences of Different Structural Features. Int J Mol Sci. 2025;26. doi:10.3390/ijms26031236
Andreozzi V, Cuoco S, Balestrieri M, Fierro F, Ferrara N, et al. Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study. Sci Rep. 2024;14:23095. doi:10.1038/s41598-024-74400-w
García-Milla P, Peñalver R, Nieto G. Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13060683
Zou H, Gao H, Liu Y, Zhang Z, Zhao J, et al. Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid. Int J Biol Macromol. 2024;259:129420. doi:10.1016/j.ijbiomac.2024.129420
Isakov VA, Pilipenko VI, Vlasova AV, Kochetkova AA. Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study. Curr Dev Nutr. 2023;7:102037. doi:10.1016/j.cdnut.2023.102037
Araújo MM, Botelho PB. Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Front Nutr. 2022;9:935830. doi:10.3389/fnut.2022.935830
Pilipenko VI, Isakov VA, Morozov SV, Vlasova AV, Kochetkova AA. [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]. Vopr Pitan. 2022;91:95. doi:10.33029/0042-8833-2022-91-5-95-104
Liao W, Su M, Zhang D. A study on the effect of symbiotic fermented milk products on human gastrointestinal health: Double-blind randomized controlled clinical trial. Food Sci Nutr. 2022;10:2947. doi:10.1002/fsn3.2890
Bărboi OB, Chirilă I, Ciortescu I, Anton C, Drug VL. Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study. J Clin Med. 2022;11. doi:10.3390/jcm11082248
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