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SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.6
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
Eicosapentaenoic Acid Reduces Obesity
EPA/DHA but Not ALA Reduces Visceral Adiposity and Adipocyte Size in High Fat Diet-Induced Obese Delta-6 Desaturase Knockout Mice.
Research directly applicable to obesity
In our exploration of omega-3 fatty acids, we aimed to understand how eicosapentaenoic acid (EPA), compared to α-linolenic acid (ALA), impacts obesity, particularly in a specific mouse model designed for this purpose. We fed both wildtype and delta-6 desaturase knockout (KO) mice a high-fat diet rich in different fats over a period of 21 weeks. These diets included lard, which contains no omega-3s, flaxseed (rich in ALA), and menhaden fish oil (rich in EPA and docosahexaenoic acid, DHA).
What we found was quite revealing. While the final body weights of the mice did not vary significantly, those fed menhaden oil experienced reduced epididymal white adipose tissue (eWAT) weight, smaller adipocyte sizes, and lower triacylglycerol (TAG) content compared to those on a lard diet. Interestingly, the eWAT of flaxseed-fed wildtype mice showed similar improvements as those on menhaden oil, but this positive effect did not extend to the KO mice, which exhibited characteristics more similar to the lard group.
It's important to note that despite these differences in adipose characteristics, we did not observe any changes in inflammatory markers between the different groups. This suggests that while a diet enriched in EPA/DHA may help reduce fat storage and cell size, it does not appear to influence inflammatory responses in this particular model of obesity. Overall, this study highlights the specific benefits of EPA/DHA in addressing obesity-related issues without exacerbating inflammation.
What we found was quite revealing. While the final body weights of the mice did not vary significantly, those fed menhaden oil experienced reduced epididymal white adipose tissue (eWAT) weight, smaller adipocyte sizes, and lower triacylglycerol (TAG) content compared to those on a lard diet. Interestingly, the eWAT of flaxseed-fed wildtype mice showed similar improvements as those on menhaden oil, but this positive effect did not extend to the KO mice, which exhibited characteristics more similar to the lard group.
It's important to note that despite these differences in adipose characteristics, we did not observe any changes in inflammatory markers between the different groups. This suggests that while a diet enriched in EPA/DHA may help reduce fat storage and cell size, it does not appear to influence inflammatory responses in this particular model of obesity. Overall, this study highlights the specific benefits of EPA/DHA in addressing obesity-related issues without exacerbating inflammation.
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8
Eicosapentaenoic acid benefits adipocytes
Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stress.
High relevance to obesity research
We explored the impact of eicosapentaenoic acid (EPA) on obesity by observing its effects on fat cells, specifically using 3T3-L1 cells as our model. This study aimed to understand how EPA, an omega-3 fatty acid, influences lipid storage and oxidative stress in comparison to palmitic acid, a saturated fatty acid known for its adverse effects.
Our findings revealed that EPA supplementation has a protective effect on fat cells. Unlike palmitic acid, which can lead to excessive lipid accumulation and promote inflammation, we observed that EPA reduces the size of fat droplets in the cells. Additionally, EPA appears to bring about favorable redox changes, highlighting its benefits in reducing oxidative stress.
These results emphasize the potential of EPA in managing obesity and improving metabolic health by supporting a healthier fatty acid profile in adipose tissue. Rather than contributing to fat storage, EPA may help mitigate the risks associated with weight gain and its related health issues.
Our findings revealed that EPA supplementation has a protective effect on fat cells. Unlike palmitic acid, which can lead to excessive lipid accumulation and promote inflammation, we observed that EPA reduces the size of fat droplets in the cells. Additionally, EPA appears to bring about favorable redox changes, highlighting its benefits in reducing oxidative stress.
These results emphasize the potential of EPA in managing obesity and improving metabolic health by supporting a healthier fatty acid profile in adipose tissue. Rather than contributing to fat storage, EPA may help mitigate the risks associated with weight gain and its related health issues.
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8
Docosahexaenoic acid reduces obesity
EPA/DHA but Not ALA Reduces Visceral Adiposity and Adipocyte Size in High Fat Diet-Induced Obese Delta-6 Desaturase Knockout Mice.
Studies effects on obesity treatment
We set out to evaluate how different types of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), compare to alpha-linolenic acid (ALA) in reducing obesity-related factors in genetically modified mice. Our research involved feeding male wildtype and delta-6 desaturase knockout mice a high-fat diet for 21 weeks, with dietary variations including lard (no omega-3s), flaxseed (rich in ALA), and menhaden fish oil (containing EPA and DHA).
We found that mice receiving menhaden oil exhibited noticeable benefits. They had lower weights of epididymal white adipose tissue (eWAT), smaller fat cells, and reduced triacylglycerol levels compared to those fed with lard. Notably, the white adipose tissue from mice fed flaxseed mimicked the outcomes of those consuming menhaden oil in wildtype mice, but not in knockout mice, suggesting a genetic component in the effectiveness of ALA.
Interestingly, despite the positive changes seen with EPA and DHA, we did not observe any impact on the inflammatory markers in eWAT, indicating that these omega-3s help with fat storage without triggering significant inflammatory responses. Ultimately, our findings suggest that while EPA and DHA effectively reduce fat accumulation, ALA does not yield the same benefits.
We found that mice receiving menhaden oil exhibited noticeable benefits. They had lower weights of epididymal white adipose tissue (eWAT), smaller fat cells, and reduced triacylglycerol levels compared to those fed with lard. Notably, the white adipose tissue from mice fed flaxseed mimicked the outcomes of those consuming menhaden oil in wildtype mice, but not in knockout mice, suggesting a genetic component in the effectiveness of ALA.
Interestingly, despite the positive changes seen with EPA and DHA, we did not observe any impact on the inflammatory markers in eWAT, indicating that these omega-3s help with fat storage without triggering significant inflammatory responses. Ultimately, our findings suggest that while EPA and DHA effectively reduce fat accumulation, ALA does not yield the same benefits.
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Most Useful Reviews
9.5
Skin improvement
I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!
Read More
8.3
Effective supplement
Omega is an excellent dietary supplement for tackling obesity. I consistently use it during my weight management efforts.
Read More
8.8
Improved hair growth
Omega-3 is primarily beneficial for reducing cardiovascular issues: it combats bad cholesterol, normalises blood pressure, and strengthens the heart. It has helped diminish my cholesterol levels, and after prolonged use, I noticed my hair quality improving. I’ve ordered this product four times, appreciating how it promotes hair growth and thins the blood, which is advantageous for heart health. My hair now shines more and splits less.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.6
9
Eicosapentaenoic Acid and Obesity
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice.
Key metabolite's role in obesity
We explored the benefits of eicosapentaenoic acid (EPA) in reducing obesity through a study involving ob/ob mice given various doses of Lingguizhugan Decoction (LGZGD) over eight weeks. This classic Chinese medicine formulation demonstrated a significant impact on weight loss and fat reduction.
Our observations revealed that treatment with LGZGD enhanced gut microbiota diversity, which is crucial for maintaining a healthy gut. Specifically, we noted that the reduced ratio of certain gut bacteria after LGZGD treatment correlated with improved metabolic pathways, particularly those related to energy and lipid metabolism.
Most excitingly, we identified that two metabolites, EPA and myristoleic acid, were notably affected by LGZGD treatment. This suggests that EPA may play a role in how the gut microbiota contributes to obesity management. Although our study does not directly test EPA as a standalone treatment, its involvement highlights a promising area for further research.
Our observations revealed that treatment with LGZGD enhanced gut microbiota diversity, which is crucial for maintaining a healthy gut. Specifically, we noted that the reduced ratio of certain gut bacteria after LGZGD treatment correlated with improved metabolic pathways, particularly those related to energy and lipid metabolism.
Most excitingly, we identified that two metabolites, EPA and myristoleic acid, were notably affected by LGZGD treatment. This suggests that EPA may play a role in how the gut microbiota contributes to obesity management. Although our study does not directly test EPA as a standalone treatment, its involvement highlights a promising area for further research.
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9
Eicosapentaenoic acid aids obesity
Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head.
Moderate relevance to findings
To explore the impact of eicosapentaenoic acid (EPA) on obesity, we conducted a study involving mice fed a high-fat diet. For eight weeks, we introduced different types of dietary phospholipids, including those enriched with EPA, DHA, and several others. This approach allowed us to assess how varying fatty acids and polar headgroups in these phospholipids influenced body weight and fat accumulation.
Our findings were promising; we observed that the phospholipids, especially those rich in EPA, led to decreased body weight and reduced fat storage. We also noted lower levels of circulating lipids in the blood, which are often associated with obesity. Interestingly, the phospholipids enriched with EPA showed the most significant effects, highlighting the importance of the specific fatty acids involved.
Additionally, we found that certain inflammatory markers, like TNF-α and MCP-1, significantly decreased with the DHA-enriched phospholipids and phosphatidylserine groups. Mechanistically, the EPA-rich phospholipids helped reduce fat accumulation by promoting genes related to fat breakdown while inhibiting those that lead to fat production.
This study clearly indicates that EPA-PS phospholipids are particularly effective in fighting obesity, attributed to the combination of beneficial fatty acid composition and certain headgroups. Our exploration reinforces the potential of incorporating EPA into dietary strategies aimed at addressing obesity.
Our findings were promising; we observed that the phospholipids, especially those rich in EPA, led to decreased body weight and reduced fat storage. We also noted lower levels of circulating lipids in the blood, which are often associated with obesity. Interestingly, the phospholipids enriched with EPA showed the most significant effects, highlighting the importance of the specific fatty acids involved.
Additionally, we found that certain inflammatory markers, like TNF-α and MCP-1, significantly decreased with the DHA-enriched phospholipids and phosphatidylserine groups. Mechanistically, the EPA-rich phospholipids helped reduce fat accumulation by promoting genes related to fat breakdown while inhibiting those that lead to fat production.
This study clearly indicates that EPA-PS phospholipids are particularly effective in fighting obesity, attributed to the combination of beneficial fatty acid composition and certain headgroups. Our exploration reinforces the potential of incorporating EPA into dietary strategies aimed at addressing obesity.
Read More
9
Omega-3 may reverse diet effects
Western diet since adolescence impairs brain functional hyperemia at adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio.
Highly relevant to obesity research
In our exploration of how diet impacts brain function, we focused on the effects of a high-caloric Western Diet (WD) on obesity and brain health. We observed that feeding adolescent mice a WD leads to rapid changes in how their brain manages blood flow—specifically, the ability of their blood vessels to respond to increased brain activity was significantly impaired.
As early as three weeks into the WD, we noticed that essential mechanisms like functional hyperemia—the process that increases blood supply to active brain regions—were already compromised. This situation persisted into adulthood and middle age, raising concerns about the long-term effects of such dietary habits on brain health.
Interestingly, our study also identified that the imbalance between omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) contributed to the problem. By supplementing the diet with docosahexaenoic acid (DHA), an omega-3 fatty acid, we effectively restored normal blood flow responses and improved glucose management in these mice. This suggests that correcting dietary fat imbalances may offer a potential strategy to counteract the negative impacts of unhealthy eating patterns.
Overall, our findings highlight the serious effects of a Western Diet on brain blood flow and how omega-3 supplementation might serve as a beneficial intervention to support brain health in the face of obesity.
As early as three weeks into the WD, we noticed that essential mechanisms like functional hyperemia—the process that increases blood supply to active brain regions—were already compromised. This situation persisted into adulthood and middle age, raising concerns about the long-term effects of such dietary habits on brain health.
Interestingly, our study also identified that the imbalance between omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) contributed to the problem. By supplementing the diet with docosahexaenoic acid (DHA), an omega-3 fatty acid, we effectively restored normal blood flow responses and improved glucose management in these mice. This suggests that correcting dietary fat imbalances may offer a potential strategy to counteract the negative impacts of unhealthy eating patterns.
Overall, our findings highlight the serious effects of a Western Diet on brain blood flow and how omega-3 supplementation might serve as a beneficial intervention to support brain health in the face of obesity.
Read More
9
Krill oil aids obesity management
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
Krill oil offers cholesterol benefits
We explored how Antarctic krill oil, which is rich in docosahexaenoic acid (DHA), affects obesity and related health issues. This investigation focused on high-fat diets and their impact on mice, examining both liver health and cholesterol levels.
Our findings revealed that a high-fat diet could lead to increased oxidative stress and obesity indicators, which are concerning for overall health. However, by using Antarctic krill oil, we observed a notable reduction in the negative effects of this diet. The oil appeared to help decrease fat accumulation and improve metabolic parameters linked to cholesterol and fat metabolism.
Specifically, we found improvements in certain molecules responsible for cholesterol regulation that helped counteract obesity-related problems. Overall, this indicates that DHA from krill oil may be beneficial in managing obesity and its associated disorders. We believe these positive results could pave the way for further studies looking into krill oil as a potential treatment option for obesity.
Our findings revealed that a high-fat diet could lead to increased oxidative stress and obesity indicators, which are concerning for overall health. However, by using Antarctic krill oil, we observed a notable reduction in the negative effects of this diet. The oil appeared to help decrease fat accumulation and improve metabolic parameters linked to cholesterol and fat metabolism.
Specifically, we found improvements in certain molecules responsible for cholesterol regulation that helped counteract obesity-related problems. Overall, this indicates that DHA from krill oil may be beneficial in managing obesity and its associated disorders. We believe these positive results could pave the way for further studies looking into krill oil as a potential treatment option for obesity.
Read More
8
Eicosapentaenoic Acid Enhances Insulin Sensitivity
Fish Oil and EPA Improve Insulin Sensitivity, in Part Through Adipocyte mTORC2 Activation in Diet-Induced Obese Male Mice.
Strong relevance to obesity research
We investigated how eicosapentaenoic acid (EPA), a key component of fish oil, affects insulin sensitivity and glucose metabolism, especially in the context of high-fat diets. The study involved male mice that either had or lacked a specific protein called Rictor, associated with a pathway known to influence cellular functions.
Our findings revealed that a diet rich in fish oil significantly enhanced glucose tolerance and insulin sensitivity in these mice. Moreover, the intake of fish oil resulted in better glucose uptake in both adipose (fat) tissues and skeletal muscle, all while reducing the liver's glucose production. This improvement was marked by lower levels of insulin in the bloodstream and an increase in the phosphorylation of a protein called Akt in the fat tissues, suggesting a key role for mTORC2 activation.
Interestingly, when the mice were fed a high-fat diet supplemented with EPA, we noticed an increase in insulin sensitivity and Akt phosphorylation, although this supplementation did not significantly improve overall glucose tolerance. This suggests that while EPA promotes insulin sensitivity via mTORC2, the enhancement of glucose tolerance observed with fish oil seems to arise from other mechanisms in the body, particularly in the muscles and liver.
Our study highlights how EPA can contribute to better metabolic health by improving how the body manages insulin and glucose, particularly for those consuming high-fat diets.
Our findings revealed that a diet rich in fish oil significantly enhanced glucose tolerance and insulin sensitivity in these mice. Moreover, the intake of fish oil resulted in better glucose uptake in both adipose (fat) tissues and skeletal muscle, all while reducing the liver's glucose production. This improvement was marked by lower levels of insulin in the bloodstream and an increase in the phosphorylation of a protein called Akt in the fat tissues, suggesting a key role for mTORC2 activation.
Interestingly, when the mice were fed a high-fat diet supplemented with EPA, we noticed an increase in insulin sensitivity and Akt phosphorylation, although this supplementation did not significantly improve overall glucose tolerance. This suggests that while EPA promotes insulin sensitivity via mTORC2, the enhancement of glucose tolerance observed with fish oil seems to arise from other mechanisms in the body, particularly in the muscles and liver.
Our study highlights how EPA can contribute to better metabolic health by improving how the body manages insulin and glucose, particularly for those consuming high-fat diets.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
9.5
Combats obesity
This omega-3 supplement offers excellent value for money. With 200 capsules in a jar, it lasts a long time. Taking one tablet twice daily suits adults well. Omega-3s lower harmful fats in the blood and reduce the risk of heart attacks. They also help in tackling obesity by stimulating fat metabolism. Regular intake has a positive impact on mood and cognitive function, greatly benefiting mental health.
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9.5
Skin improvement
I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!
9
Preventive effects
Omega-3 from Nau is an invaluable dietary supplement with unique properties: it reduces bad cholesterol, improves circulation, and supports the heart. It effectively combats obesity and slows skin ageing, benefiting both the nervous system and brain function. The price is quite reasonable.
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8.8
Improved hair growth
Omega-3 is primarily beneficial for reducing cardiovascular issues: it combats bad cholesterol, normalises blood pressure, and strengthens the heart. It has helped diminish my cholesterol levels, and after prolonged use, I noticed my hair quality improving. I’ve ordered this product four times, appreciating how it promotes hair growth and thins the blood, which is advantageous for heart health. My hair now shines more and splits less.
Read More
8.8
Supports weight loss
Omega-3 helps lower bad cholesterol and normalise blood pressure, significantly reducing the risk of obesity-related diseases. The price is reasonable, and the packaging lasts a long time.
