Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Read More
8
Docosahexaenoic acid and breast cancer
We conducted an exciting study to understand how docosahexaenoic acid (DHA), a type of n-3 fatty acid, affects women who are survivors of estrogen receptor and progesterone receptor negative (ERPR-) breast cancer. This particular molecular subtype of breast cancer is known for its unique challenges, and dietary fat choices may influence its progression.
Over the course of one year, participants in our clinical trial received different doses of EPA and DHA, ranging from about 1 to 5 grams per day. We gathered blood and breast fat tissue samples at various points during the study to analyze changes in fatty acids, specifically looking at how these doses affected fatty acid levels and related compounds called oxylipins, which are involved in inflammation and cancer processes.
Our findings revealed that the higher doses of EPA and DHA led to increased levels of these fatty acids in breast fat tissue. Moreover, we observed changes in the DNA methylation patterns related to metabolic pathways in breast cancer. This suggests that DHA and EPA may play a role beyond mere nutrition, potentially influencing genetic expression related to cancer risk.
Overall, our research highlights the metabolic and epigenetic effects of n-3 fatty acids in managing ERPR- breast cancer. The study opens up new avenues for exploring how dietary choices may help prevent this aggressive form of breast cancer.
Over the course of one year, participants in our clinical trial received different doses of EPA and DHA, ranging from about 1 to 5 grams per day. We gathered blood and breast fat tissue samples at various points during the study to analyze changes in fatty acids, specifically looking at how these doses affected fatty acid levels and related compounds called oxylipins, which are involved in inflammation and cancer processes.
Our findings revealed that the higher doses of EPA and DHA led to increased levels of these fatty acids in breast fat tissue. Moreover, we observed changes in the DNA methylation patterns related to metabolic pathways in breast cancer. This suggests that DHA and EPA may play a role beyond mere nutrition, potentially influencing genetic expression related to cancer risk.
Overall, our research highlights the metabolic and epigenetic effects of n-3 fatty acids in managing ERPR- breast cancer. The study opens up new avenues for exploring how dietary choices may help prevent this aggressive form of breast cancer.
Read More
9.5
DHA shows promise against neuroblastoma
We conducted a study to explore the effects of docosahexaenoic acid (DHA) on tumor formation, particularly in a mouse model of neuroblastoma—a type of aggressive cancer in children. By using a syngeneic model, we gavaged wildtype mice with high doses of omega-3 fatty acids, including DHA, and then injected cancerous cells to monitor tumor development.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
Read More
Most Useful Reviews
6
Support for cancer
10 people found this helpful
I took this to my mother, a cancer patient. I've read much praise for it concerning those on the keto diet. The packaging is large, and the fish monk is easy for her to swallow, suiting her dietary needs. The ingredients are excellent for a cancer patient, and my mother began today. The quality of this product is also highly esteemed. My mother is 72; I pray for her healing.
Read More
7.5
Brain activity support
Docosahexaenoic acid is a vital omega-3 fatty acid for health. Consuming at least 250 mg of DHA daily may lower the risk of cancer. I purchased this for my mother to support her brain function.
Read More
6
Cognitive benefits
I love this product! DHA is crucial for skin and eye health. Supplementing with DHA can improve children's vision and brain development, reducing future risks of issues like learning difficulties and ADHD. In older age, DHA may enhance brain function and lower Alzheimer's risk. It can also reduce the chances of cardiovascular disease and inflammation, helping in cancer prevention. Please support my review; I would be grateful.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.8
- All Researches
9.5
DHA shows promise against neuroblastoma
We conducted a study to explore the effects of docosahexaenoic acid (DHA) on tumor formation, particularly in a mouse model of neuroblastoma—a type of aggressive cancer in children. By using a syngeneic model, we gavaged wildtype mice with high doses of omega-3 fatty acids, including DHA, and then injected cancerous cells to monitor tumor development.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
Read More
9
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Read More
9
We assessed the effectiveness of docosahexaenoic acid (DHA) in treating cancer, specifically in various rodent models of hepatocellular carcinoma (HCC). The study utilized weighted amide proton transfer (APT) MRI to monitor tumor response in three different HCC models: diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft.
Our findings revealed that all HCC models exhibited a markedly higher APT signal compared to surrounding normal tissues. This increased signal allowed us to distinguish between malignant HCC lesions and benign nodules specifically in the DEN model.
By administering low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles directly to N1S1 xenografts, we observed a significant reduction in tumor APT signal within just 72 hours. Similarly, direct injections into HepG2 xenografts demonstrated comparable therapeutic effects. Overall, this study showcases the potential of APT imaging in the diagnostic and therapeutic management of HCC, particularly highlighting DHA's effectiveness delivered via nanoparticles.
Our findings revealed that all HCC models exhibited a markedly higher APT signal compared to surrounding normal tissues. This increased signal allowed us to distinguish between malignant HCC lesions and benign nodules specifically in the DEN model.
By administering low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles directly to N1S1 xenografts, we observed a significant reduction in tumor APT signal within just 72 hours. Similarly, direct injections into HepG2 xenografts demonstrated comparable therapeutic effects. Overall, this study showcases the potential of APT imaging in the diagnostic and therapeutic management of HCC, particularly highlighting DHA's effectiveness delivered via nanoparticles.
Read More
9
In our research, we looked into the potential benefits of docosahexaenoic acid, a type of omega-3 fatty acid, in treating pancreatic cancer. Utilizing a mouse model that closely mirrors the human disease, we examined how a diet rich in omega-3 fatty acids—specifically eicosapentaenoic acid and docosahexaenoic acid—affects tumor growth and metastasis.
We observed that mice on a diet supplemented with cod liver oil, which is high in omega-3s, exhibited a notable decrease in tumor size and lung and liver metastasis compared to control mice. The treatment seemed to enhance survival rates, suggesting that these fatty acids may help combat the growth of cancerous tumors.
Moreover, our findings indicated changes in the tumor's fatty acid profile and the release of eicosanoids, which are important signaling molecules in cancer. The intervention also reduced key histological features of malignancy and promoted apoptosis, or programmed cell death, without impacting the rate of cell proliferation. This indicates that omega-3 fatty acids might act in ways other than just slowing down cell division.
We noted a significant reduction in tumor fibrosis, which is often associated with aggressive cancer forms. This was linked to lower levels of Sonic Hedgehog, a protein playing a central role in tumor development. Overall, our study highlights the promise of docosahexaenoic acid and its fellow omega-3 fatty acids as potential dietary tools in pancreatic cancer treatment, paving the way for incorporating nutritional strategies into cancer care.
We observed that mice on a diet supplemented with cod liver oil, which is high in omega-3s, exhibited a notable decrease in tumor size and lung and liver metastasis compared to control mice. The treatment seemed to enhance survival rates, suggesting that these fatty acids may help combat the growth of cancerous tumors.
Moreover, our findings indicated changes in the tumor's fatty acid profile and the release of eicosanoids, which are important signaling molecules in cancer. The intervention also reduced key histological features of malignancy and promoted apoptosis, or programmed cell death, without impacting the rate of cell proliferation. This indicates that omega-3 fatty acids might act in ways other than just slowing down cell division.
We noted a significant reduction in tumor fibrosis, which is often associated with aggressive cancer forms. This was linked to lower levels of Sonic Hedgehog, a protein playing a central role in tumor development. Overall, our study highlights the promise of docosahexaenoic acid and its fellow omega-3 fatty acids as potential dietary tools in pancreatic cancer treatment, paving the way for incorporating nutritional strategies into cancer care.
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9
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
6
Support for cancer
10 people found this helpful
I took this to my mother, a cancer patient. I've read much praise for it concerning those on the keto diet. The packaging is large, and the fish monk is easy for her to swallow, suiting her dietary needs. The ingredients are excellent for a cancer patient, and my mother began today. The quality of this product is also highly esteemed. My mother is 72; I pray for her healing.
Read More
7.5
Brain activity support
Docosahexaenoic acid is a vital omega-3 fatty acid for health. Consuming at least 250 mg of DHA daily may lower the risk of cancer. I purchased this for my mother to support her brain function.
Read More
6
Cognitive benefits
I love this product! DHA is crucial for skin and eye health. Supplementing with DHA can improve children's vision and brain development, reducing future risks of issues like learning difficulties and ADHD. In older age, DHA may enhance brain function and lower Alzheimer's risk. It can also reduce the chances of cardiovascular disease and inflammation, helping in cancer prevention. Please support my review; I would be grateful.
Read More
Frequently Asked Questions
6
Support for cancer
10 people found this helpful
I took this to my mother, a cancer patient. I've read much praise for it concerning those on the keto diet. The packaging is large, and the fish monk is easy for her to swallow, suiting her dietary needs. The ingredients are excellent for a cancer patient, and my mother began today. The quality of this product is also highly esteemed. My mother is 72; I pray for her healing.
7.5
Brain activity support
Docosahexaenoic acid is a vital omega-3 fatty acid for health. Consuming at least 250 mg of DHA daily may lower the risk of cancer. I purchased this for my mother to support her brain function.
6
Cognitive benefits
I love this product! DHA is crucial for skin and eye health. Supplementing with DHA can improve children's vision and brain development, reducing future risks of issues like learning difficulties and ADHD. In older age, DHA may enhance brain function and lower Alzheimer's risk. It can also reduce the chances of cardiovascular disease and inflammation, helping in cancer prevention. Please support my review; I would be grateful.
7
DHA's potential in cancer therapy
In our exploration of liver cancer treatment, we found that combinations of Lenvatinib—an established first-line therapy—and docosahexaenoic acid (DHA) can uniquely influence outcomes. The focus was on understanding how Lenvatinib resistance develops in hepatocellular carcinoma (HCC) and the potential role of DHA in this context.
Through comprehensive studies, including CRISPR screening in liver cancer cells, we discovered that a protein called DTX2 strongly contributes to Lenvatinib resistance. This protein helps protect the cancer cells from a type of cell death known as ferroptosis, which Lenvatinib usually triggers. Interestingly, we learned that DTX2 does this by reducing DHA levels, a fatty acid that plays a crucial role in cellular health.
In our findings, when we added DHA to Lenvatinib treatment, it appeared to counteract DTX2's protective effect against ferroptosis. The study emphasized that using DHA in combination with Lenvatinib could potentially offer a new therapeutic pathway for patients facing drug resistance in liver cancer.
Overall, the relationship between DTX2, DHA production, and Lenvatinib resistance presents an exciting avenue for further exploration in cancer treatment strategies.
Through comprehensive studies, including CRISPR screening in liver cancer cells, we discovered that a protein called DTX2 strongly contributes to Lenvatinib resistance. This protein helps protect the cancer cells from a type of cell death known as ferroptosis, which Lenvatinib usually triggers. Interestingly, we learned that DTX2 does this by reducing DHA levels, a fatty acid that plays a crucial role in cellular health.
In our findings, when we added DHA to Lenvatinib treatment, it appeared to counteract DTX2's protective effect against ferroptosis. The study emphasized that using DHA in combination with Lenvatinib could potentially offer a new therapeutic pathway for patients facing drug resistance in liver cancer.
Overall, the relationship between DTX2, DHA production, and Lenvatinib resistance presents an exciting avenue for further exploration in cancer treatment strategies.
9
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
9.5
DHA shows promise against neuroblastoma
We conducted a study to explore the effects of docosahexaenoic acid (DHA) on tumor formation, particularly in a mouse model of neuroblastoma—a type of aggressive cancer in children. By using a syngeneic model, we gavaged wildtype mice with high doses of omega-3 fatty acids, including DHA, and then injected cancerous cells to monitor tumor development.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
8
Docosahexaenoic acid reduces cancer risk
We examined the relationship between docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and colorectal cancer risk using data from the UK Biobank study. This study included over 234,000 participants and tracked health outcomes over a mean follow-up of 13.4 years, focusing specifically on blood levels of DHA and overall n-3 polyunsaturated fatty acids (PUFAs).
Our findings showed that higher levels of plasma n-3 PUFAs and DHA were linked to a decreased risk of developing colorectal cancer. The analysis suggested a non-linear relationship, meaning that while increasing levels of these fatty acids generally led to lower cancer risk, the beneficial effects plateaued at higher concentrations. This trend was particularly noteworthy for cancers located in the proximal colon and was more pronounced among male participants.
While the study highlights the potential protective effects of DHA against colorectal cancer, it's important to acknowledge that the relationship varied based on tumor location and participant sex. This insight could help shape nutrition guidelines, should these findings hold true across broader populations.
Our findings showed that higher levels of plasma n-3 PUFAs and DHA were linked to a decreased risk of developing colorectal cancer. The analysis suggested a non-linear relationship, meaning that while increasing levels of these fatty acids generally led to lower cancer risk, the beneficial effects plateaued at higher concentrations. This trend was particularly noteworthy for cancers located in the proximal colon and was more pronounced among male participants.
While the study highlights the potential protective effects of DHA against colorectal cancer, it's important to acknowledge that the relationship varied based on tumor location and participant sex. This insight could help shape nutrition guidelines, should these findings hold true across broader populations.
8
We examined the relationship between docosahexaenoic acid (DHA) and the risk of developing non-small cell lung cancer (NSCLC) through an extensive analysis of 249,132 participants over an average of 12 years. This large-scale, prospective study aimed to shed light on how different fatty acids, particularly DHA, might influence cancer risk.
During the follow-up, we learned that 1,460 participants were diagnosed with NSCLC. Our findings revealed that higher levels of DHA, along with linoleic acid (LA) and omega-3 fatty acids, were linked to a lower risk of developing this form of cancer. We found that increased concentrations of both DHA and LA appeared to significantly delay the onset of NSCLC.
Additionally, our analysis suggested that the relationship between these fatty acids and cancer risk varied among different groups based on factors like smoking status, gender, and body mass index. These findings provide promising insights into how dietary adjustments involving specific fatty acids could potentially lower the risk of NSCLC.
During the follow-up, we learned that 1,460 participants were diagnosed with NSCLC. Our findings revealed that higher levels of DHA, along with linoleic acid (LA) and omega-3 fatty acids, were linked to a lower risk of developing this form of cancer. We found that increased concentrations of both DHA and LA appeared to significantly delay the onset of NSCLC.
Additionally, our analysis suggested that the relationship between these fatty acids and cancer risk varied among different groups based on factors like smoking status, gender, and body mass index. These findings provide promising insights into how dietary adjustments involving specific fatty acids could potentially lower the risk of NSCLC.
References
- Zhang Z, Zhou Q, Li Z, Huang F, Mo K, et al. DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. Drug Resist Updat. 2025;81:101224. doi:10.1016/j.drup.2025.101224
- Babaeenezhad E, Khosravi P, Moradi Sarabi M. Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines. Genes Nutr. 2025;20:2. doi:10.1186/s12263-025-00764-x
- Patel V, Li YN, Benhamou LE, Park HG, Raleigh M, et al. Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model. Cancers (Basel). 2025;17. doi:10.3390/cancers17030362
- Teng Y, Luo C, Qiu X, Mu J, Sriwastva MK, et al. Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites. Nat Commun. 2025;16:1295. doi:10.1038/s41467-025-56498-2
- Wang X, Ishimatsu K, Li J, Wen X, Ou W, et al. APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage. Hepat Oncol. 2024;11:2389031. doi:10.1080/20450923.2024.2389031
- Olkhovik DM, Silkina MO, Razumovskaya AV, Klycheva KV, Fatkulin AA, et al. Omega-3 Docosahexaenoic Acid as a Promising Inducer of Ferroptosis: Dynamics of Action in Prostate and Colorectal Cancer Models. Dokl Biochem Biophys. 2025. doi:10.1134/S160767292460132X
- Garay MI, Mazo T, Ferrero V, Barotto NN, Lagares C, et al. Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression. Carcinogenesis. 2025;46. doi:10.1093/carcin/bgae081
- Aldoori J, Zulyniak MA, Toogood GJ, Hull MA. Plasma n-3 Polyunsaturated Fatty Acid Levels and Colorectal Cancer Risk in the UK Biobank: Evidence of Nonlinearity, as Well as Tumor Site- and Sex-Specificity. Cancer Epidemiol Biomarkers Prev. 2025;34:394. doi:10.1158/1055-9965.EPI-24-1154
- Lin HL, Lin QY, Feng JN, Zheng WE, Yang C, et al. Plasma fatty acid levels and risk of non-small cell lung cancer: a large-scale prospective cohort study. Front Nutr. 2024;11:1462300. doi:10.3389/fnut.2024.1462300
- Frankhouser DE, DeWess T, Snodgrass IF, Cole RM, Steck S, et al. Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns. medRxiv. 2024. doi:10.1101/2024.09.16.24313691
- Ormiston K, Fitzgerald J, Andridge R, Lustberg MB, DeVries AC, et al. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutr Res. 2024;131:39. doi:10.1016/j.nutres.2024.09.004
- Ormiston K, Melink Z, Andridge R, Lustberg M, Courtney DeVries A, et al. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behav Immun. 2025;123:370. doi:10.1016/j.bbi.2024.09.021
- La Vecchia S, Fontana S, Salaroglio IC, Anobile DP, Digiovanni S, et al. Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy. Cancer Lett. 2024;604:217221. doi:10.1016/j.canlet.2024.217221
- Huang J, Li J, He L, Miao J, Zhu M, et al. The association between plasma fatty acids and risk of lung cancer: a prospective cohort study of the UK Biobank. J Clin Endocrinol Metab. 2024. doi:10.1210/clinem/dgae609
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