Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
USERS' SCORE
Good
Based on 10 Reviews
8.2
Supplement Facts
Serving Size: 1 Gummy
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
2 g
1%**
Dietary Fiber
<1 g
2%**
Total Sugars
1 g
***
Includes 1 g Added Sugars
2%**
Sodium
5 mg
0%
Probiotic Blend1 Billion CFU
10 mg
***
Bacillus coagulans SNZ 1969,Bacillus subtilis DE111®
Top Medical Research Studies
9.5
We evaluated how Bacillus coagulans Unique IS2 impacts functional constipation by conducting a double-blind, placebo-controlled study with 100 adults. Participants received either the probiotic or a placebo daily for four weeks.
By the end of the study, those taking the probiotic reported a significant increase in bowel movements and improved stool consistency. In fact, 98% of probiotic users achieved normal stool consistency, compared to just 74% in the placebo group.
Moreover, the probiotic group experienced relief from associated symptoms like painful defecation and abdominal pain. This shows Bacillus coagulans Unique IS2 is effective in treating constipation.
By the end of the study, those taking the probiotic reported a significant increase in bowel movements and improved stool consistency. In fact, 98% of probiotic users achieved normal stool consistency, compared to just 74% in the placebo group.
Moreover, the probiotic group experienced relief from associated symptoms like painful defecation and abdominal pain. This shows Bacillus coagulans Unique IS2 is effective in treating constipation.
Read More
9
Bacillus coagulans improves constipation
We explored the effects of Bacillus coagulans SNZ 1969 on mild intermittent constipation in healthy adults over an 8-week period. In this randomized controlled trial, participants received either the supplement or a placebo.
Results showed significant improvements in colonic transit time, increases in weekly bowel movements, and decreased bowel discomfort. Additionally, changes in gut microbiota composition were linked to these improvements.
Overall, our findings indicate that Bacillus coagulans can effectively enhance gut motility and relieve constipation symptoms in individuals with lower fruit and vegetable intake.
Results showed significant improvements in colonic transit time, increases in weekly bowel movements, and decreased bowel discomfort. Additionally, changes in gut microbiota composition were linked to these improvements.
Overall, our findings indicate that Bacillus coagulans can effectively enhance gut motility and relieve constipation symptoms in individuals with lower fruit and vegetable intake.
Read More
9
We investigated how Bacillus subtilis can help with constipation by treating mice with this specific bacteria. Over one week, the mice that received B. subtilis showed improved colonic motility and higher levels of tryptophan, a precursor for serotonin, compared to those that did not receive the treatment.
Notably, these effects were linked to enhanced serotonin signaling, as blocking serotonin receptors hindered this benefit. However, heat-inactivated bacteria or a different strain lacking tryptophan synthesis did not produce similar outcomes, indicating that live, active bacteria are crucial for this effect.
Notably, these effects were linked to enhanced serotonin signaling, as blocking serotonin receptors hindered this benefit. However, heat-inactivated bacteria or a different strain lacking tryptophan synthesis did not produce similar outcomes, indicating that live, active bacteria are crucial for this effect.
Read More
Most Useful Reviews
9
Successful daily use
6 people found this helpful
We love these! After months of searching for a remedy for my daughter's potty issues, we are thrilled to have found these. Frequent constipation in a four-year-old is dreadful. She takes them daily and has regular bowel movements without problems. We also noticed that her eczema has tremendously improved. I couldn't recommend these enough; they are wonderful.
Read More
10
Transformed bowel experience
1 people found this helpful
My daughter suffered from severe constipation, which was worsened by her reluctance to eat. This probiotic made a monumental difference in our lives; previously, she would call to go potty every 20 minutes without success. Now, she goes independently during the day, and her trips to the toilet are quick and painless, improving our quality of life significantly.
Read More
9
Remedied severe constipation
1 people found this helpful
My daughter suffered from severe constipation, making it difficult to encourage healthy eating habits. We tried these probiotic vitamins, which have been a godsend. She takes just one a day, and now she spends only 2 to 3 minutes on the toilet, compared to the previous struggle that lasted much longer. These vitamins have transformed her experience with probiotics positively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
- All Researches
9.5
We evaluated how Bacillus coagulans Unique IS2 impacts functional constipation by conducting a double-blind, placebo-controlled study with 100 adults. Participants received either the probiotic or a placebo daily for four weeks.
By the end of the study, those taking the probiotic reported a significant increase in bowel movements and improved stool consistency. In fact, 98% of probiotic users achieved normal stool consistency, compared to just 74% in the placebo group.
Moreover, the probiotic group experienced relief from associated symptoms like painful defecation and abdominal pain. This shows Bacillus coagulans Unique IS2 is effective in treating constipation.
By the end of the study, those taking the probiotic reported a significant increase in bowel movements and improved stool consistency. In fact, 98% of probiotic users achieved normal stool consistency, compared to just 74% in the placebo group.
Moreover, the probiotic group experienced relief from associated symptoms like painful defecation and abdominal pain. This shows Bacillus coagulans Unique IS2 is effective in treating constipation.
Read More
9
We investigated the effects of BIOVITA 3, a blend of three probiotic bacteria, on constipation in Sprague-Dawley rats. Using loperamide to induce constipation, we observed that those given BIOVITA 3 showed significant improvements in fecal volume, moisture, and gastrointestinal transit time. Additionally, we noted positive changes in gut health markers, including short chain fatty acids and microbial diversity. This promising research indicates that BIOVITA 3 could be a beneficial ingredient in foods aimed at relieving constipation.
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9
We investigated how Bacillus subtilis can help with constipation by treating mice with this specific bacteria. Over one week, the mice that received B. subtilis showed improved colonic motility and higher levels of tryptophan, a precursor for serotonin, compared to those that did not receive the treatment.
Notably, these effects were linked to enhanced serotonin signaling, as blocking serotonin receptors hindered this benefit. However, heat-inactivated bacteria or a different strain lacking tryptophan synthesis did not produce similar outcomes, indicating that live, active bacteria are crucial for this effect.
Notably, these effects were linked to enhanced serotonin signaling, as blocking serotonin receptors hindered this benefit. However, heat-inactivated bacteria or a different strain lacking tryptophan synthesis did not produce similar outcomes, indicating that live, active bacteria are crucial for this effect.
Read More
9
We sought to understand how Bacillus subtilis affects slow transit constipation (STC) and its underlying mechanics. Using a mouse model, we treated STC with Bacillus subtilis and observed notable improvements.
Our findings showed that Bacillus subtilis significantly increased defecation rates and improved colon health. It also stimulated the release of serotonin from intestinal cells via the bile acid TGR5 receptor pathway, enhancing intestinal activity. Overall, this treatment appears beneficial for managing STC.
Our findings showed that Bacillus subtilis significantly increased defecation rates and improved colon health. It also stimulated the release of serotonin from intestinal cells via the bile acid TGR5 receptor pathway, enhancing intestinal activity. Overall, this treatment appears beneficial for managing STC.
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9
We investigated how the probiotic Bacillus Coagulans (BC01) affects constipation in a mouse model. Mice were divided into groups receiving either saline, the constipation-inducing agent loperamide, a control laxative, or BC01 at low and high doses.
After treatment, BC01 significantly improved intestinal movement and increased fecal water content, helping relieve constipation symptoms. It also positively influenced gut motility and overall health by restoring intestinal microbiota balance and regulating related gene expression.
Notably, the high-dose BC01 treatment showed the greatest effectiveness.
After treatment, BC01 significantly improved intestinal movement and increased fecal water content, helping relieve constipation symptoms. It also positively influenced gut motility and overall health by restoring intestinal microbiota balance and regulating related gene expression.
Notably, the high-dose BC01 treatment showed the greatest effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Successful daily use
6 people found this helpful
We love these! After months of searching for a remedy for my daughter's potty issues, we are thrilled to have found these. Frequent constipation in a four-year-old is dreadful. She takes them daily and has regular bowel movements without problems. We also noticed that her eczema has tremendously improved. I couldn't recommend these enough; they are wonderful.
Read More
10
Transformed bowel experience
1 people found this helpful
My daughter suffered from severe constipation, which was worsened by her reluctance to eat. This probiotic made a monumental difference in our lives; previously, she would call to go potty every 20 minutes without success. Now, she goes independently during the day, and her trips to the toilet are quick and painless, improving our quality of life significantly.
Read More
9
Remedied severe constipation
1 people found this helpful
My daughter suffered from severe constipation, making it difficult to encourage healthy eating habits. We tried these probiotic vitamins, which have been a godsend. She takes just one a day, and now she spends only 2 to 3 minutes on the toilet, compared to the previous struggle that lasted much longer. These vitamins have transformed her experience with probiotics positively.
Read More
9
Consistent health improvement
1 people found this helpful
I don't know if it's genetics or this probiotic, but since our 4-year-old started taking it, she hasn’t fallen ill. It has also resolved her constipation issues, similar to our neighbour's son. We use Amazon's autoship feature, ensuring we never run out, and it's more economical than drugstore prices. She enjoys the taste, making it an easy addition to her routine.
Read More
7.5
Eased constipation issues
11 people found this helpful
My daughter, who has chronic constipation due to a genetic condition, has benefited immensely from this probiotic. She takes miralax daily but was still struggling with hard stool. Since starting this product, her bowel movements have improved from once a week to every other day and then to daily. She doesn't mind the taste or texture, and I hope it continues to work as it has already brought us remarkable results.
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Frequently Asked Questions
8
We examined how dietary supplementation with Bacillus subtilis QST 713 could impact constipation in sows, along with their reproductive success and the growth of their piglets.
The study included 78 sows split into two groups—one on a standard diet and another receiving the B. subtilis supplement.
Results indicated that the supplemented group experienced less postpartum constipation and better fecal quality. Furthermore, the treatment improved reproductive outcomes and nutrient levels in colostrum, benefiting piglet growth.
Overall, Bacillus subtilis appears effective in addressing constipation in sows while enhancing other important aspects of reproductive health.
The study included 78 sows split into two groups—one on a standard diet and another receiving the B. subtilis supplement.
Results indicated that the supplemented group experienced less postpartum constipation and better fecal quality. Furthermore, the treatment improved reproductive outcomes and nutrient levels in colostrum, benefiting piglet growth.
Overall, Bacillus subtilis appears effective in addressing constipation in sows while enhancing other important aspects of reproductive health.
7
We conducted a double-blind, randomized controlled trial to see if a specific probiotic strain, BG01-4™, could help with constipation and other gastrointestinal issues.
Over four weeks, 67 participants received either BG01-4™ or a placebo. While 33% of those taking BG01-4™ reported improvements in constipation, this was a noticeable difference over the 15% seen in the placebo group.
The results suggest that BG01-4™ might offer relief from symptoms of constipation in people with functional gastrointestinal disorders, though more extensive studies are needed for confirmation.
Over four weeks, 67 participants received either BG01-4™ or a placebo. While 33% of those taking BG01-4™ reported improvements in constipation, this was a noticeable difference over the 15% seen in the placebo group.
The results suggest that BG01-4™ might offer relief from symptoms of constipation in people with functional gastrointestinal disorders, though more extensive studies are needed for confirmation.
8
We explored the effectiveness of different treatments for chronic constipation, focusing on probiotics like Bacillus subtilis. Our analysis included numerous studies showing that while lactulose and synbiotics effectively increased weekly stool movements, Bacillus subtilis as part of certain mixes did not show significant benefits on its own. Overall, there were some positive outcomes, but we found only moderate to low-quality evidence supporting these interventions.
4
Bacillus subtilis shows limited effect
We explored the effectiveness of a combination of Bacillus subtilis, Enterococcus faecium capsules, and lactulose in treating functional constipation. In a study involving 216 patients across nine hospitals, participants were split into two groups: one received the treatment while the other received a placebo.
Although both groups showed improvement, the differences in effectiveness were not statistically significant. This suggests that while many reported benefits, the combined treatment with B. subtilis does not provide significantly better results compared to a placebo for overall constipation relief.
Although both groups showed improvement, the differences in effectiveness were not statistically significant. This suggests that while many reported benefits, the combined treatment with B. subtilis does not provide significantly better results compared to a placebo for overall constipation relief.
References
- Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. 10.1016/j.anireprosci.2025.107785
- Deng X, Liang C, Zhou L, Shang X, Hui X, et al. Network meta-analysis of probiotics, prebiotics, and synbiotics for the treatment of chronic constipation in adults. Eur J Nutr. 2024;63:1999. 10.1007/s00394-024-03410-1
- Jang YJ, Moon JS, Kim JE, Kim D, Choi HS, et al. Blending Three Probiotics Alleviates Loperamide-Induced Constipation in Sprague-Dawley (SD)-Rats. Food Sci Anim Resour. 2024;44:119. 10.5851/kosfa.2023.e61
- Patch C, Pearce AJ, Cheng M, Boyapati R, Brenna JT. Bacillus Subtilis (BG01-4) Improves Self-Reported Symptoms for Constipation, Indigestion, and Dyspepsia: A Phase 1/2A Randomized Controlled Trial. Nutrients. 2023;15. 10.3390/nu15214490
- Legan TB, Lavoie B, Norberg E, Ley IC, Tack S, et al. Tryptophan-synthesizing bacteria enhance colonic motility. Neurogastroenterol Motil. 2023;35:e14629. 10.1111/nmo.14629
- Chen Z, Feng J, Hu S, Hua Y, Ma S, et al. Bacillus Subtilis Promotes the Release of 5-HT to Regulate Intestinal Peristalsis in STC Mice via Bile Acid and Its Receptor TGR5 Pathway. Dig Dis Sci. 2022;67:4410. 10.1007/s10620-021-07308-4
- Wang C, Wei S, Xu B, Hao L, Su W, et al. Bacillus subtilis and Enterococcus faecium co-fermented feed regulates lactating sow's performance, immune status and gut microbiota. Microb Biotechnol. 2021;14:614. 10.1111/1751-7915.13672
- Choi CH, Kwon JG, Kim SK, Myung SJ, Park KS, et al. Efficacy of combination therapy with probiotics and mosapride in patients with IBS without diarrhea: a randomized, double-blind, placebo-controlled, multicenter, phase II trial. Neurogastroenterol Motil. 2015;27:705. 10.1111/nmo.12544
- Liu YP, Liu X, Dong L. [Lactulose plus live binary Bacillus subtilis in the treatment of elders with functional constipation]. Zhonghua Yi Xue Za Zhi. 2012;92:2961. 10.3760/cma.j.issn.0376-2491.2012.42.003
- Li SR, Wang HH, Wu ZY, Liu RH, Tong MH, et al. [Efficacies of lactulose plus live combined Bacillus subtilis and Enterococcus faecium capsules in the treatment of functional constipation: a multicenter, randomized, double blind, controlled trial]. Zhonghua Yi Xue Za Zhi. 2012;92:2955. 10.3760/cma.j.issn.0376-2491.2012.42.002
- Lee H, Kim YH, Kim JH, Chang DK, Kim JY, et al. A feasibility study of probiotics pretreatment as a bowel preparation for colonoscopy in constipated patients. Dig Dis Sci. 2010;55:2344. 10.1007/s10620-009-1011-1
- Kim YG, Moon JT, Lee KM, Chon NR, Park H. [The effects of probiotics on symptoms of irritable bowel syndrome]. Korean J Gastroenterol. 2006;47:413.
- Rathi A, Pagare R. Efficacy and Safety of LBSC in Drug Induced Constipation Associated With Functional Gastrointestinal Disorder: A Double-Blind, Randomized, Interventional, Parallel, Controlled Trial a Clinical Study on LBSC for Drug Induced Constipation Associated With FGIDs. Glob Adv Integr Med Health. 2024;13:27536130241286511. 10.1177/27536130241286511
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. 10.3390/jcm12144838
- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. 10.1016/j.clnu.2022.10.015
- Zhou X, Chen Y, Ma X, Yu Y, Yu X, et al. Efficacy of BC01 on loperamide hydrochloride-induced constipation model in Kunming mice. Front Nutr. 2022;9:964257. 10.3389/fnut.2022.964257
- Jung SM, Ha AW, Choi SJ, Kim SY, Kim WK. Effect of SNZ 1969 on the Improvement of Bowel Movement in Loperamide-Treated SD Rats. Nutrients. 2022;14. 10.3390/nu14183710
- Li L, Liu B, Cao J, Zhang H, Tian F, et al. Different effects of vegetative cells and spore isolates on constipation-induced gut microbiota dysbiosis in mice. Food Funct. 2022;13:9645. 10.1039/d2fo01668k
- Venkataraman R, Shenoy R, Ahire JJ, Neelamraju J, Madempudi RS. Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study. Probiotics Antimicrob Proteins. 2023;15:379. 10.1007/s12602-021-09855-8
- Kang S, Park MY, Brooks I, Lee J, Kim SH, et al. Spore-forming Bacillus coagulans SNZ 1969 improved intestinal motility and constipation perception mediated by microbial alterations in healthy adults with mild intermittent constipation: A randomized controlled trial. Food Res Int. 2021;146:110428. 10.1016/j.foodres.2021.110428
- Gupta AK, Maity C. Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]. Medicine (Baltimore). 2021;100:e23641. 10.1097/MD.0000000000023641
- Chang CW, Chen MJ, Shih SC, Chang CW, Chiau JC, et al. Bacillus coagulans (PROBACI) in treating constipation-dominant functional bowel disorders. Medicine (Baltimore). 2020;99:e20098. 10.1097/MD.0000000000020098
- Madempudi RS, Neelamraju J, Ahire JJ, Gupta SK, Shukla VK. Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020;12:335. 10.1007/s12602-019-09542-9
- Minamida K, Nishimura M, Miwa K, Nishihira J. Effects of dietary fiber with Bacillus coagulans lilac-01 on bowel movement and fecal properties of healthy volunteers with a tendency for constipation. Biosci Biotechnol Biochem. 2015;79:300. 10.1080/09168451.2014.972331
- Rogha M, Esfahani MZ, Zargarzadeh AH. The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Gastroenterol Hepatol Bed Bench. 2014;7:156.
