Solgar Solgar B-Complex &quot;100&quot;

Niacin helps alleviate anxiety symptoms

Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624

We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.

Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.

Highly recommended

Most Useful Review

340 people found this helpful

This fantastic product is recommended for those with anxiety or depression. I've been using it for about six years, having previously suffered from severe anxiety and panic attacks. After addressing deficiencies in vitamins D3 and B12, I was finally able to function. This is highly recommended for anyone experiencing anxiety or depression.

Rash details

Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111

Likely Very Effective

Based on 2 Researches

Vitamin B deficiency leads to rash

We explored the effects of riboflavin and biotin deficiencies in premature twins, who initially presented with skin rashes among other severe symptoms. After being diagnosed, one twin began supplementation with these vitamins.

Remarkably, this led to a quick improvement in clinical condition and laboratory findings within days. Though one twin experienced tragic complications resulting in death, the surviving twin went home in stable condition, highlighting the importance of addressing vitamin deficiencies early.

Skin cleared and improved

Most Useful Review

23 people found this helpful

Super vitamins! My hair has begun to grow more robustly, and my facial skin has cleared of rashes. My cycle has normalised, work efficiency has increased, headaches have subsided, and my overall well-being has improved. I took one tablet a day and will order again. If my feedback was helpful, please click YES.

Diabetes details

Myo-inositol aids diabetes management

Based on 11 Researches

Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009

We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.

Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.

Essential for diabetes

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2 people found this helpful

This product is essential for anyone, particularly those with diabetes, according to multiple doctors. It provides vital B vitamins necessary for health.

Insomnia details

Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.

Vitamin B12 aids sleep disorders

We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.

Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.

Improved sleep quality

Most Useful Review

203 people found this helpful

Capsules are of a manageable size for me, taken with breakfast. I noticed my insomnia has vanished, and I've felt a desire for more sleep, which is beneficial as I struggled with sleep for months. I've also become less irritable, much to my family's delight.

Knee Pain details

Niacin intake eases knee osteoarthritis pain

Based on 2 Researches

Zheng Z, Luo H, Xue Q. Association between niacin intake and knee osteoarthritis pain and function: a longitudinal cohort study. Clin Rheumatol. 2024;43:753. doi:10.1007/s10067-023-06860-w

We investigated how niacin intake impacts pain and function in individuals with knee osteoarthritis (OA).

Using data from the Osteoarthritis Initiative, we analyzed niacin consumption alongside pain and functional scores.

Our findings reveal a significant association between higher niacin intake and reduced knee pain, suggesting that boosting niacin levels might improve the quality of life for OA patients.

Notably, specific groups, including middle-aged individuals and women, experienced even greater benefits.

Reduced knee pain

Most Useful Review

11 people found this helpful

Great anti-inflammatory! I use this product primarily for my joints. Being overweight with arthritis, my joints often complain. This B complex from Solgar significantly reduces inflammation and pain, particularly in my knees! I'm not sure how it works, but combined with flaxseed oil, I almost feel no pain in my joints. I used to rely on OTC pain relief, but this B complex is a more natural alternative that lasts longer.

We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.

Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.

More research is needed to fully understand the potential of folate in preventing thrombosis in this population.

Cholesterol reduction

Most Useful Review

3 people found this helpful

Super remedy for blood cholesterol! My levels dropped from 7.9 to 6 after taking omega-3 for 1.5 months as advised by my cardiologist instead of statins. I’m amazed by the results and will continue taking it. The doctor recommends it for anyone over 32. It worked wonders for me!

Common Cold details

Zinc reduces diarrhea, colds in infants

Likely Very Effective

McDonald CM, Manji KP, Kisenge R, Aboud S, Spiegelman D, et al. Daily Zinc but Not Multivitamin Supplementation Reduces Diarrhea and Upper Respiratory Infections in Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2015;145:2153. doi:10.3945/jn.115.212308

We investigated the impact of daily multivitamin and zinc supplementation on the health of Tanzanian infants. In our randomized, double-blind study involving 2,400 infants, we compared the effects of these supplements against a placebo over 18 months.

Our findings revealed that while zinc significantly reduced occurrences of diarrhea and acute respiratory infections, multivitamins did not provide additional benefits. Ultimately, zinc supplementation starting at 6 weeks may be beneficial for reducing some common illnesses in infants, but multivitamins did not show any significant positive impact.

Enhances resilience

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1 people found this helpful

The B vitamins support the cardiovascular and nervous systems, bolster emotional health, and strengthen the immune system against diseases. They help improve bowel function and skin condition. A deficiency in B vitamins can lead to fatigue, irritability, and anaemia. I believe that taking a complex of these vitamins is essential for maintaining and enhancing our health.

Menopause details

Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. doi:10.1007/s13770-025-00709-w

Based on 8 Researches

Investigating T-MSCs for menopause

We investigated if small extracellular vesicles (sEVs) derived from tonsil stem cells could improve myo-inositol production, which is often disrupted by inflammation in menopausal women.

Over two weeks, mice received treatments mimicking this condition. Our results indicated that those receiving sEVs showed a restoration of myo-inositol levels and healthier muscle profiles compared to those that did not.

This research suggests that sEVs could be a promising option to improve metabolic health during menopause.

Improved concentration

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2 people found this helpful

I began using this product daily based on a recommendation for menopausal women's health. It significantly improved my memory and concentration, allowing me to maintain my usual routine. Additionally, I experienced fewer migraines, both in frequency and intensity, particularly alongside a magnesium supplement from the same company.

Psoriasis details

5 people found this helpful

Very happy with this complex. My spouse has psoriasis, and during autumn and spring, it usually worsens with facial rashes, which is quite embarrassing for him. The dermatologist advised adding B vitamins. After reading the reviews, we decided to try this product, and it was the right choice! The rashes appeared less frequently, and the facial ones completely disappeared. We will order more.

Shingles details

Maintains health post-shingles

My health friend maintains my condition well, and I continue taking it after experiencing shingles.

Sleep Apnea details

203 people found this helpful

The capsules are a manageable size for me, and I take them during breakfast. Since I began this treatment, my insomnia has improved significantly, and I find myself wanting to sleep more, which is a positive change after months of poor sleep. I've also become less irritable and nervous, much to my family's relief.

Ulcer details

Benfotiamine improves ulcer healing

Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x

We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.

Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.

However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.

Effectively treats ulcer

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3 people found this helpful

Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!

Anemia details

Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x

Based on 11 Researches

Case study: Vitamin B12 efficacy

We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.

Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.

Improved vitamin levels

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16 people found this helpful

An excellent B vitamin complex. After being diagnosed with anaemia, I took one tablet daily for six months. My vitamin levels have returned to normal, and my hair and nails are growing remarkably well. There were no side effects, just bright yellow urine, but who else pays attention to that?

Cardiovascular Disease details

Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413

Vitamin B6 aids heart recovery

We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.

Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.

Reduced migraine symptoms

Most Useful Review

18 people found this helpful

Trims my migraine attacks significantly. I have a classic migraine and was sceptical about B-Complex being effective, but the results were striking: my seizure frequency dropped. When I stopped taking it, my attacks increased. With this complex, I consume one pack of triptans a month instead of six to seven.

Celiac details

Improved overall well-being

**Review of Solgar B-Complex 100**—This quality supplement aids in maintaining health and energy. I began taking these vitamins on my doctor's advice to enhance my well-being, and noticed positive changes within weeks. The B-complex vitamins support energy metabolism crucially and improve nervous system functionality. I've significantly reduced fatigue, enjoying more energy throughout the day. This is especially vital for those living under continual stress needing extra nervous system support. Additionally, I noticed improvements in my skin, hair, and nails, making me feel healthier and fresher. The trustworthy Solgar brand offers high-quality products, free from gluten, dairy, and preservatives, essential for those with allergies. I highly recommend it to active individuals or anyone requiring extra support during stressful times.

Migraine details

Vitamin B2 significantly reduces migraines

Based on 15 Researches

Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542

In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.

Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.

Migraine reduction

Most Useful Review

18 people found this helpful

Trims migraine attacks. This has been my salvation! As a doctor, I initially doubted that migraine is a metabolic disease. However, the effect was significant: my episodes reduced significantly. When I tried to stop taking this complex, the migraines returned. With this supplement, I use only 1 pack of triptans monthly, compared to 6-7 packs without it.

Pelvic Pain details

Gokhale LB. Curative treatment of primary (spasmodic) dysmenorrhoea. Indian J Med Res. 1996;103:227.

Based on 4 Researches

Vitamin B1 shows promising results

We assessed how effective oral vitamin B1 could be in treating primary dysmenorrhea, which causes significant pelvic pain in young women. In a robust study involving 556 participants aged 12-21 years, we administered 100 mg of vitamin B1 daily for 90 days.

The results were promising, with 87% of participants reportedly completely cured, while 8% experienced some relief. Notably, these positive outcomes persisted for two months after treatment ended, showcasing vitamin B1 as a safe and cost-effective approach to address the root cause of pelvic pain.

Freedom of movement

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1 people found this helpful

The basis of health. For years, I suffered from back pain, especially due to pelvic pain from a hernia in my spine. Only the consistent use of this complex has given me freedom of movement without pain, restoring my cheerfulness and confidence.

Stroke details

Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. doi:10.1016/j.ajcnut.2023.12.021

Based on 9 Researches

B-vitamins may reduce stroke risk

We investigated the impact of combined B-vitamin supplementation—specifically folic acid, vitamin B12, and vitamin B6—on stroke prevention. Through a thorough analysis of 14 randomized controlled trials, we found that these vitamins significantly reduced stroke risk, especially in areas lacking folic acid fortification.

Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.

7.5

Blood vessel elasticity

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2 people found this helpful

I’m pleased! The brown bottle is effective for proper storage. It has no odour. As a stroke survivor, I take four a day and hope it aids in improving elasticity in my blood vessels.

Autoimmune Disorder details

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

Pernicious anemia case in Uganda

We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.

Decreased psoriasis rashes

Most Useful Review

5 people found this helpful

We are delighted with this complex. My husband suffers from psoriasis, which flares up during autumn and spring. After consulting a dermatologist, we introduced B vitamins and decided to try this product. It helped reduce rashes, particularly those on his face. We will continue to order this.

Bloating details

Essential supplement with high quality; unlike Russian vitamins, there's no bloating or diarrhoea when consumed.

Blurred Vision details

Blurred vision relief

After childbirth, I felt persistently fatigued, and upon testing, I discovered my vitamin levels were quite low. I decided to try these B vitamins based on positive reviews. Within a week, I noticed a significant improvement; my mind was clear, and I no longer experienced the blurred vision I had been troubled with for years. Now, after a month of use, I feel wonderful, and I plan to retest my vitamin levels soon to confirm the benefits.

Cold Sores details

I take it daily. It’s excellent for recovery from colds and helps with cold sores.

Depression details

Vitamin B may alleviate depression symptoms

Based on 12 Researches

Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608

Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.

We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.

The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.

Improved mood significantly

Most Useful Review

4 people found this helpful

These vitamins are excellent! I suggested them to my husband when he was feeling depressed and dissatisfied. After taking one capsule daily, his mood and energy improved noticeably within days!

Flu details

I've been taking this vitamin complex for two years during spring and autumn. As a result, seasonal illnesses like ARVI and influenza either bypass me or occur mildly. Previously, any runny nose would lead to bronchitis, but since taking these vitamins, I've noticed a significant improvement in my health.

Heart Attack details

Vitamin B6 aids heart recovery

We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.

We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.

Reduced migraine attacks

Most Useful Review

18 people found this helpful

Trims migraine attacks significantly. As a doctor, I initially doubted that migraine was a metabolic disease. However, after taking a B-Complex, the results were striking: my seizures decreased considerably. Attempting to discontinue resulted in frequent attacks. I now consume just one pack of triptans per month with this complex, compared to 6-7 packs without it.

High Cholesterol details

Niacin reduces cholesterol and oxidative stress

Based on 10 Researches

Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28

We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.

The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.

Significant cholesterol reduction

Most Useful Review

3 people found this helpful

I’m amazed at the results from taking omega-3 for my high cholesterol. My cholesterol levels decreased from 7.9 to 6 after just 1.5 months, as advised by my cardiologist, who suggested omega instead of statins. I’m really pleased with the outcome and will continue using it. It's recommended for everyone over 32, and it has certainly worked wonders for me.

Multiple Sclerosis details

2 people found this helpful

I've experienced fatigue issues due to multiple sclerosis, but since taking Solgar B-Complex for three months, I feel much better.

Cold details

I consume this daily as it's the best for my condition and aids in immune recovery. It's a vital aid for colds and stomatitis.

Hair Loss details

Cicaria shows promise against hair loss

Jo H, Kim SY, Kang BH, Baek C, Kwon JE, et al. Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules. 2022;27. doi:10.3390/molecules27165136

We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.

Improved calmness

Most Useful Review

8 people found this helpful

I purchased this complex for my dad, who has been irritable and fatigued. After just over a week on the capsules, there was a noticeable improvement in his nervous system, and he slept better. I previously used it for hair loss, and it helped me significantly.

Heart Disease details

VB6 helps heart recovery post-AMI

We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.

Improved heart health

Most Useful Review

18 people found this helpful

EXCELLENT COMPLEX OF VITAMINS OF GROUP B. After the corona, I experienced heart issues, fatigue, hair loss, and low energy. At 47, I began taking a B complex and felt invigorated. My eyesight slightly improved, and my heart symptoms diminished. This complex contains essential B vitamins, which I believe are vital for treating heart disease.

Leg Cramps details

Vitamin B complex effective for cramps

Based on 2 Researches

Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharmacol. 1998;38:1151.

We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.

The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.

Vitamin B recovery

Most Useful Review

For those suffering from leg cramps, a deficiency in Vitamin B can cause serious symptoms. My family and I consistently use these high-potency B vitamin supplements. They are ideal for replenishing our Vitamin B levels.

Chronic Fatigue Syndrome details

B12 and folic acid show variability

Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

7.5

Increased energy

Most Useful Review

211 people found this helpful

The bright yellow capsules are large but easy to swallow. After taking them for two months, I experienced increased energy, reduced irritability, and less mood fluctuation, which greatly helped with my chronic fatigue syndrome. I felt more strength to engage in activities and noticed a gradual improvement in my overall mood. It's important to take a break of six months after a two-month course.

Frozen Shoulder details

Significant improvement

3 people found this helpful

The effect is quite impressive! I'm feeling much better in the mornings after previously struggling with frozen shoulder during night shifts. Since starting this product a month ago, the heaviness in my shoulder has disappeared, and I'm no longer fatigued!

Heartburn details

There is no heartburn even when taken on an empty stomach. This is a product I use regularly.

Diarrhea details

This essential supplement is of high quality and does not cause diarrhoea or bloating as seen with some Russian vitamins.

Nausea details

Cariban effectively relieves pregnancy nausea

Based on 4 Researches

Saz-Leal P, Zamorano-Domínguez L, Frías J, Guerra P, Saura-Valls M, et al. Bioavailability of Cariban Capsules: A Modified-Release Fixed-Dose Combination of Doxylamine and Pyridoxine to Relieve Nausea and Vomiting During Pregnancy. Drugs R D. 2023;23:185. doi:10.1007/s40268-023-00425-7

We examined how Cariban, a combination of doxylamine and pyridoxine, helps alleviate nausea and vomiting during pregnancy. Using a controlled study involving 12 healthy women, we looked at how the modified-release capsules perform in the body compared to other forms.

Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.

No discomfort

Most Useful Review

This is the first B complex I’ve used without experiencing nausea. I highly recommend it.

Yeast Infection details

Although this may be the best vitamin B complex, I developed a yeast infection soon after taking it. I believe it's better to consume vitamin B separately rather than in a complex. I noticed my urine became darker, highlighting the need for increased water intake. I have decided to discontinue these vitamins and will instead take each one separately, as Solgar’s vitamins are usually effective, which is why I initially chose this B vitamin.

Headache details

Pediatric migraine treatment with riboflavin

Based on 15 Researches

Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009

Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.

Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.

Headache relief

Most Useful Review

23 people found this helpful

Fantastic vitamins! My hair improved, facial skin cleared, and my cycle adjusted. I felt more efficient, and the headache disappeared. I took one tablet daily and will definitely order more.

Allergies details

Pinitol may reduce allergy symptoms

You X, Sun X, Kong J, Tian J, Shi Y, et al. D-Pinitol Attenuated Ovalbumin-induced Allergic Rhinitis in Experimental Mice via Balancing Th1/Th2 Response. Iran J Allergy Asthma Immunol. 2021;20:672. doi:10.18502/ijaai.v20i6.8017

We evaluated how D-Pinitol affects allergic rhinitis (AR) in a controlled study using mice.

By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.

Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.

Calmer husband

Most Useful Review

I give these vitamins to my husband, who has a stressful job. He has become calmer and sleeps better, and I’m glad they did not cause any allergies. However, I did notice his urine is brightly coloured.

Dizziness details

Gabapentin and B vitamins reduce dizziness

Mimenza Alvarado A, Aguilar Navarro S. Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy. J Diabetes Res. 2016;2016:4078695. doi:10.1155/2016/4078695

We evaluated the effects of gabapentin combined with B vitamins (B1 and B12) against pregabalin for painful diabetic neuropathy. In this multicenter, randomized, and blind study, 270 patients participated over 12 weeks.

Both treatments reduced pain without a significant statistical difference. However, our findings indicated that the gabapentin plus B vitamin group experienced fewer cases of dizziness, highlighting a potential advantage in managing side effects compared to pregabalin. This could lead to a more comfortable treatment experience for patients.

Improved concentration

Most Useful Review

I absolutely love these vitamins, which I take once every year and a half. They help with dizziness and loss of concentration. The B vitamins have supported me in addressing neuroses, memory loss, and low hemoglobin as part of my therapy. Additionally, I’ve noticed an improvement in my hair quality.

Liver Disease details