Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
CYP11A1, Autism Symptoms, Vitamin D3
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Read More
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
9
We explored how coal dust exposure leads to anxiety and depression-like behaviors in mice, using a pneumoconiosis model that was established after 28 days of exposure. This model allows us to closely observe the effects of environmental factors on mental health. Through treating the mice with Vitamin D3 for three months, we aimed to see if this treatment could alleviate anxiety symptoms.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Read More
Most Useful Reviews
10
Anxiety relief
After taking this dietary supplement, my anxiety disappeared. Therefore, I would recommend it.
Read More
9
Visible benefits
The benefits of taking magnesium are clear—it improves sleep and decreases anxiety. The quality is excellent; it’s a complex of glycinate and lysinate, both well-absorbed. I create product ratings based on the value of the active substance. This magnesium is of medium-low price, rated 7.3 against an average of 8.6.
Read More
7.5
Reduced anxiety
My calm. Thanks for the great pills! Anxiety and cravings for sweets have decreased.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
- All Researches
9
CYP11A1, Autism Symptoms, Vitamin D3
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Read More
9
We explored the effects of vitamin D3 on anxiety levels in rats subjected to chronic unpredictable mild stress. In our study, we used a total of 40 male Wistar rats, dividing them into five groups to analyze various treatments. These groups included a control group, a stress group, and groups receiving either vitamin D3, fluoxetine (an antidepressant), or a combination of both.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
Read More
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
9
We explored how coal dust exposure leads to anxiety and depression-like behaviors in mice, using a pneumoconiosis model that was established after 28 days of exposure. This model allows us to closely observe the effects of environmental factors on mental health. Through treating the mice with Vitamin D3 for three months, we aimed to see if this treatment could alleviate anxiety symptoms.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Read More
9
We examined the effects of vitamin D3 on anxiety in mice experiencing nicotine withdrawal. To conduct our research, we divided male C57/BL6 mice into four distinct groups: those receiving a vehicle, those receiving nicotine alone, those receiving vitamin D3 alone, and those receiving both nicotine and vitamin D3.
During the six-week study, the mice were given nicotine through their drinking water and vitamin D3 in their feed. When the withdrawal phase kicked in, we observed that mice treated with vitamin D3 demonstrated significantly reduced anxiety-like behaviors. This was measured using open-field tests and marble burying tests, where these mice spent more time in the central area and buried fewer marbles compared to those that did not receive vitamin D3.
Additionally, our study revealed that vitamin D3 supplementation reduced hippocampal NR2A expression, which may be linked to lowering anxiety during nicotine withdrawal. These findings suggest that vitamin D3 supplementation could be a promising dietary intervention for people dealing with anxiety related to quitting smoking.
During the six-week study, the mice were given nicotine through their drinking water and vitamin D3 in their feed. When the withdrawal phase kicked in, we observed that mice treated with vitamin D3 demonstrated significantly reduced anxiety-like behaviors. This was measured using open-field tests and marble burying tests, where these mice spent more time in the central area and buried fewer marbles compared to those that did not receive vitamin D3.
Additionally, our study revealed that vitamin D3 supplementation reduced hippocampal NR2A expression, which may be linked to lowering anxiety during nicotine withdrawal. These findings suggest that vitamin D3 supplementation could be a promising dietary intervention for people dealing with anxiety related to quitting smoking.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Anxiety relief
After taking this dietary supplement, my anxiety disappeared. Therefore, I would recommend it.
Read More
9
Visible benefits
The benefits of taking magnesium are clear—it improves sleep and decreases anxiety. The quality is excellent; it’s a complex of glycinate and lysinate, both well-absorbed. I create product ratings based on the value of the active substance. This magnesium is of medium-low price, rated 7.3 against an average of 8.6.
Read More
7.5
Reduced anxiety
My calm. Thanks for the great pills! Anxiety and cravings for sweets have decreased.
Read More
9
Improved condition
I felt a severe shortage of magnesium: anxiety, insomnia, irritability, and leg cramps appeared. I purchased this dietary supplement as it contains calcium and vitamin D3. I'm not fond of many containers, but this one is effective. My condition has vastly improved, and the cramps have entirely vanished.
Read More
7.5
Helpful for sleep
It is challenging to find vitamins that absorb correctly. I take four before bed each night and can definitely tell when I don’t. They assist with sleep, anxiety, bowel movements, and much more. A quality product.
Read More
Frequently Asked Questions
10
Anxiety relief
After taking this dietary supplement, my anxiety disappeared. Therefore, I would recommend it.
7.5
Reduced anxiety
My calm. Thanks for the great pills! Anxiety and cravings for sweets have decreased.
9
Improved condition
I felt a severe shortage of magnesium: anxiety, insomnia, irritability, and leg cramps appeared. I purchased this dietary supplement as it contains calcium and vitamin D3. I'm not fond of many containers, but this one is effective. My condition has vastly improved, and the cramps have entirely vanished.
7.5
Good for sleep
Great quality. This product is beneficial for the third time; I recommend it to everyone. It aids nails, joints, muscles, bones, and teeth. Excellent packaging, magnesium helps with anxiety and regulates sleep.
7.5
Helpful for sleep
It is challenging to find vitamins that absorb correctly. I take four before bed each night and can definitely tell when I don’t. They assist with sleep, anxiety, bowel movements, and much more. A quality product.
9
Visible benefits
The benefits of taking magnesium are clear—it improves sleep and decreases anxiety. The quality is excellent; it’s a complex of glycinate and lysinate, both well-absorbed. I create product ratings based on the value of the active substance. This magnesium is of medium-low price, rated 7.3 against an average of 8.6.
4
Vitamin D3 and adolescent anxiety response
We aimed to understand how vitamin D3 might influence anxiety and depressive symptoms among adolescents in central Italy. Our study examined the relationship between specific genetic variants of the vitamin D receptor (VDR) and anxious or depressive traits in young individuals. Despite our thorough approach, we found no significant difference in the genetic makeup of those experiencing symptoms and those who did not.
Our investigation involved HN9.10e cell lines representing different genetic variations, which showed varied responses to vitamin D3 treatment. Notably, certain cell lines with the AA genotype responded positively to vitamin D3, while others did not show any response at all. Interestingly, this suggests that the effectiveness of vitamin D3 in treating potential mental health issues may depend on the specific genetic variants present in individuals.
Ultimately, while the study explored important genetic influences, we did not find strong evidence that vitamin D3 treatment has a meaningful effect on anxiety symptoms in the adolescent population we studied. This highlights the complexity of mental health treatments and the need for further research to better understand these interactions.
Our investigation involved HN9.10e cell lines representing different genetic variations, which showed varied responses to vitamin D3 treatment. Notably, certain cell lines with the AA genotype responded positively to vitamin D3, while others did not show any response at all. Interestingly, this suggests that the effectiveness of vitamin D3 in treating potential mental health issues may depend on the specific genetic variants present in individuals.
Ultimately, while the study explored important genetic influences, we did not find strong evidence that vitamin D3 treatment has a meaningful effect on anxiety symptoms in the adolescent population we studied. This highlights the complexity of mental health treatments and the need for further research to better understand these interactions.
9
We explored the effects of vitamin D3 on anxiety levels in rats subjected to chronic unpredictable mild stress. In our study, we used a total of 40 male Wistar rats, dividing them into five groups to analyze various treatments. These groups included a control group, a stress group, and groups receiving either vitamin D3, fluoxetine (an antidepressant), or a combination of both.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
9
CYP11A1, Autism Symptoms, Vitamin D3
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
References
- Gizzi G, Fiorani F, Cataldi S, Mandarano M, Delvecchio E, et al. Exploring the Influence of / Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines. Genes (Basel). 2024;15. doi:10.3390/genes15070913
- Yin H, Zhang J, Chen Y, Guo J, Li Q, et al. Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. Brain Behav Immun. 2024;121:13. doi:10.1016/j.bbi.2024.07.012
- Renteria KM, Constantine E, Teoh CM, Cooper A, Lozano N, et al. Combination of vitamin D and fructooligosaccharides upregulates colonic vitamin D receptor in C57BL/6J mice and affects anxiety-related behavior in a sex-specific manner. Nutr Res. 2024;125:16. doi:10.1016/j.nutres.2024.02.003
- Al-Ramadhan FR, Abulmeaty MMA, Alquraishi M, Razak S, Alhussain MH. Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress. Biomedicines. 2023;11. doi:10.3390/biomedicines11082112
- Lapmanee S, Bhubhanil S, Sriwong S, Yuajit C, Wongchitrat P, et al. Oral calcium and vitamin D supplements differentially alter exploratory, anxiety-like behaviors and memory in male rats. PLoS One. 2023;18:e0290106. doi:10.1371/journal.pone.0290106
- Pereira ADS, Miron VV, Castro MFV, Bottari NB, Assmann CE, et al. Neuromodulatory effect of the combination of metformin and vitamin D triggered by purinergic signaling in type 1 diabetes induced-rats. Mol Cell Endocrinol. 2023;563:111852. doi:10.1016/j.mce.2023.111852
- Zaromytidou E, Koufakis T, Dimakopoulos G, Drivakou D, Konstantinidou S, et al. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study. Metabolites. 2022;12. doi:10.3390/metabo12100884
- Tokarchuk A, Abenavoli L, Kobyliak N, Khomenko M, Revun M, et al. Nutrition program, physical activity and gut microbiota modulation: a randomized controlled trial to promote a healthy lifestyle in students with vitamin D3 deficiency. Minerva Med. 2022;113:683. doi:10.23736/S0026-4806.22.07992-7
- Zou Y, Mu M, Zhang S, Li C, Tian K, et al. Vitamin D3 suppresses astrocyte activation and ameliorates coal dust-induced mood disorders in mice. J Affect Disord. 2022;303:138. doi:10.1016/j.jad.2022.02.026
- Guzek D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, et al. Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review. Nutrients. 2021;13. doi:10.3390/nu13113678
- Wu B, Tao X, Liu C, Li H, Jiang T, et al. Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice. Transl Neurosci. 2021;12:273. doi:10.1515/tnsci-2020-0166
- Tsoukalas D, Zlatian O, Mitroi M, Renieri E, Tsatsakis A, et al. A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals. J Clin Med. 2021;10. doi:10.3390/jcm10040624
- Lang F, Ma K, Leibrock CB. 1,25(OH)D in Brain Function and Neuropsychiatric Disease. Neurosignals. 2019;27:40. doi:10.33594/000000182
- Verde Z, Giaquinta A, Sainz CM, Ondina MD, Araque AF. Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People. Nutrients. 2019;11. doi:10.3390/nu11112748
- Fedotova JO. Vitamin D treatment differentially affects anxiety-like behavior in the old ovariectomized female rats and old ovariectomized female rats treated with low dose of 17β-estradiol. BMC Med Genet. 2019;20:49. doi:10.1186/s12881-019-0774-2
- Fazelian S, Amani R, Paknahad Z, Kheiri S, Khajehali L. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial. Int J Prev Med. 2019;10:17. doi:10.4103/ijpvm.IJPVM_174_18
- Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. doi:10.1016/j.neuroscience.2025.01.003
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
- Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. doi:10.3390/microorganisms12071429
- Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. doi:10.7759/cureus.59317
- Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. doi:10.5152/alphapsychiatry.2024.231342
- Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. doi:10.23736/S0375-9393.24.17868-6
- Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. doi:10.1080/01616412.2024.2352234
- Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. doi:10.3390/life14030306
- Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. doi:10.1038/s41591-023-02705-w
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. doi:10.3389/fnut.2023.1211321
- Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. doi:10.1080/1354750X.2023.2246104
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. doi:10.3390/metabo13010073
