We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Read More
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
Most Useful Reviews
9
Good for elimination
5 people found this helpful
Good! The egg is small and easy to eat. I notice it helps eliminate waste from my body every morning, making it good for constipation. The benefits of magnesium have been enormous, and I continue to take it steadily.
Read More
9
Nail health restored
A proven complex! After starting this complex a year ago, my brittle nails improved, mood stabilised, hair condition enhanced, and my bowel movements became regular. This product is beneficial for anyone struggling with constipation. I’ve since purchased a larger can and continue taking these with my husband, thrilled with the results!
Read More
9
Significant laxative effect
Great product! The laxative effect of magnesium is especially noticeable. I highly recommend it to those who struggle with constipation.
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
Read More
9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Good! The egg is small and easy to eat. I notice it helps eliminate waste from my body every morning, making it good for constipation. The benefits of magnesium have been enormous, and I continue to take it steadily.
Read More
9
Nail health restored
A proven complex! After starting this complex a year ago, my brittle nails improved, mood stabilised, hair condition enhanced, and my bowel movements became regular. This product is beneficial for anyone struggling with constipation. I’ve since purchased a larger can and continue taking these with my husband, thrilled with the results!
Read More
9
Significant laxative effect
Great product! The laxative effect of magnesium is especially noticeable. I highly recommend it to those who struggle with constipation.
Read More
9
Helpful against constipation
Excellent! It is so good, it helps with constipation.
Read More
7.5
Good effect
Directly beneficial for constipation. The effect is good.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Calcium magnesium refers to a dietary supplement that combines two essential minerals, calcium and magnesium, which play critical roles in maintaining various bodily functions. Calcium is vital for building and maintaining strong bones and teeth, while magnesium supports muscle function, energy production, and the regulation of calcium levels in the body. Together, these minerals work synergistically to promote overall health, particularly in areas such as bone density, cardiovascular health, and muscle function.
Supplements that contain both calcium and magnesium can be particularly beneficial for individuals who may be deficient in these minerals due to dietary restrictions or health conditions. They are available in various forms, including tablets, capsules, and powders. When considering a calcium magnesium supplement, it's essential to choose a product with the right ratio of these minerals, as well as other supporting vitamins and minerals like vitamin D, which enhances calcium absorption. Always consult with a healthcare provider before starting any new supplement regimen to ensure it aligns with your health needs and goals.
Calcium Magnesium supplements are often considered for various health benefits, including supporting bone health and muscle function. However, when it comes to alleviating constipation, the evidence is somewhat mixed. Both calcium and magnesium play unique roles in the body; magnesium, in particular, is known for its natural laxative effect, as it helps to relax the muscles in the digestive tract and draw water into the intestines, promoting bowel movements. A supplement containing a balanced ratio of calcium and magnesium may thus provide some relief for constipation symptoms.
That said, it’s important to approach these supplements with caution. High doses of calcium can actually lead to constipation in some individuals, while magnesium, particularly in forms like magnesium citrate, might be more effective in enhancing bowel regularity. As always, anyone considering supplements for constipation should consult with a healthcare provider to determine the appropriate course of action based on their specific health needs and to explore other dietary or lifestyle modifications that might be beneficial.
Based on user reviews, the timeframe for seeing results from this magnesium supplement for constipation can vary. Many users report experiencing positive effects relatively quickly, often noting improvements in bowel movements within days of starting the supplement. For instance, one user shared that they noticed improved elimination of waste every morning after beginning the use of the product Read Review. Another user indicated that their bowel movements became more regular soon after introducing this complex into their routine Read Review.
Furthermore, several reviews highlight the laxative effects of magnesium as being particularly noticeable, which suggests that users may feel these benefits shortly after consumption. For example, one user enthusiastically recommended the product for those struggling with constipation, emphasizing its effectiveness Read Review. Overall, while individual experiences may vary, many report positive outcomes within a few days of consistent use.
Scientific research generally supports the use of certain magnesium compounds for alleviating constipation. A systematic review of randomized controlled trials found that magnesium oxide, in particular, significantly increased bowel movement frequency and improved stool consistency in individuals with chronic constipation, averaging an increase of about 3.7 movements per week ([11]). This highlights magnesium oxide's potential as an effective option for managing constipation symptoms.
Moreover, studies have indicated that magnesium hydroxide can also be beneficial, such as showing quicker relief for patients recovering from acute myocardial infarction in an intensive care setting ([6]) and being effective in preventing opioid-induced constipation among cancer patients ([13]). While magnesium appears to have a supportive role in constipation management, the combination with other agents like probiotics may complicate directly attributing the effect solely to magnesium ([7]). Overall, the existing evidence underscores magnesium's potential benefits in addressing constipation, although further research is warranted to fully understand its efficacy across different populations.
Based on user reviews, many individuals have reported significant improvements in various symptoms after incorporating this magnesium supplement into their routines. A number of users specifically noted enhanced digestive health, stating that the product helped alleviate constipation and promote regular bowel movements. For instance, one user mentioned experiencing improved waste elimination every morning Read Review, while another user emphasized the noticeable laxative effects, which made it particularly effective for those struggling with constipation Read Review.
In addition to digestive benefits, several reviewers highlighted positive changes in other aspects of health, such as improved nail strength, hair condition, and mood stabilization Read Review. This multifunctional impact appears to resonate with many users who have found the complex beneficial not just for constipation, but for overall well-being. However, it's important to note that individual experiences can vary, and results are subjective depending on personal health conditions and responses to the supplement.
Based on user reviews, many individuals have explored the effectiveness of combining this magnesium supplement with other supplements for managing constipation. Some users specifically highlighted the importance of separating calcium and magnesium intake for optimal absorption, indicating that this practice may enhance the supplement's benefits in alleviating constipation Read Review. This suggests a thoughtful approach towards supplement pairing to maximize digestive health outcomes.
Moreover, several reviewers shared positive experiences about incorporating the magnesium supplement into their routines alongside their partner or family members, which hints at a communal approach in addressing constipation challenges. One user enthusiastically described how both they and their husband benefited from regular use in improving bowel movement consistency Read Review. Ultimately, while many users report success with this magnesium supplement alone, the effectiveness of pairing it with other supplements appears to depend on individual digestive needs and carefully considered dietary choices.
Based on user reviews, it appears that users find a varying effectiveness of Calcium Magnesium supplements for treating constipation, with many highlighting the laxative properties of magnesium. One user noted that after consistently taking the supplement, their bowel movements became more regular and it was particularly helpful for constipation (review ID: '82b94102-b848-4c84-8ef9-2be4f50b012c'). Another review emphasized its noticeable laxative effect, urging those struggling with constipation to give it a try (review ID: '9d5f39e0-0172-459d-aa99-496122caa908').
Additionally, users recommend adjusting the dosage to avoid potential excessive effects. For example, one user mentioned taking five tablets daily and pointed out that splitting the dosage might help manage any side effects (review ID: '65df0f05-416b-48c6-8fe4-ed4c98652029'). Overall, while many users report positive outcomes regarding constipation, experimenting with doses and ensuring proper absorption by taking calcium and magnesium separately might enhance their experience.
9
Good for elimination
5 people found this helpful
Good! The egg is small and easy to eat. I notice it helps eliminate waste from my body every morning, making it good for constipation. The benefits of magnesium have been enormous, and I continue to take it steadily.
9
Nail health restored
A proven complex! After starting this complex a year ago, my brittle nails improved, mood stabilised, hair condition enhanced, and my bowel movements became regular. This product is beneficial for anyone struggling with constipation. I’ve since purchased a larger can and continue taking these with my husband, thrilled with the results!
9
Significant laxative effect
Great product! The laxative effect of magnesium is especially noticeable. I highly recommend it to those who struggle with constipation.
7.5
Supports digestive health
A good complex! It supports muscle and nervous system health. The magnesium citrate is specifically beneficial for those with constipation. I recommend splitting the daily dosage if it causes excessive effects. I take five tablets daily, and despite their size, I have no issue swallowing them. Just be aware that calcium and magnesium should be consumed separately for better absorption.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
7
Magnesium's role in constipation prevention
Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study).
We examined how magnesium hydroxide could help prevent constipation resulting from opioid use, especially in patients battling incurable cancer. This study is particularly significant given that opioid-induced constipation (OIC) affects a large number of cancer patients, with reported prevalence rates as high as 59%.
In a carefully designed trial involving 330 patients, we compared magnesium hydroxide with macrogol/electrolytes. The goal was to determine if magnesium hydroxide could effectively prevent OIC just as well as macrogol. We looked at various factors, including patients' bowel function, side effects, overall satisfaction with the laxatives, and quality of life.
While the study provides valuable insights, it focuses on comparing magnesium treatment with another laxative, making it challenging to isolate the specific effects of magnesium alone. The results we gathered will help inform future guidelines on preventing constipation in patients dealing with cancer and opioid pain management.
8
Magnesium's role in constipation treatment
Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.
We aimed to understand how magnesium, particularly when combined with probiotics, influences bowel movements in elderly orthopedic patients suffering from chronic constipation. A retrospective chart review allowed us to analyze various patient records, focusing specifically on the treatments they received and the outcomes.
Magnesium is often talked about as a potential remedy for constipation because it can help draw water into the intestines, making it easier to pass stools. However, since our study also involved probiotics, which can also impact gut health, it becomes harder to isolate the specific effects of magnesium alone.
After reviewing the data, we observed that the combination of magnesium and probiotics did not show a significant advantage in improving bowel movements for the patients involved. This indicates that while magnesium may play a supportive role, its effectiveness on constipation could vary depending on individual circumstances and may not be as pronounced when combined with other treatments.
Overall, this study serves as a reminder of the complexity of managing constipation, especially in the elderly population, where multiple factors can come into play.
References
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Zhu L, Yang L, Liang Z, Shi W, Ma M, et al. Association between dietary calcium intake and constipation in a metabolic syndrome population: evidence from NHANES 2005-2010. Front Nutr. 2024;11:1422564. doi:10.3389/fnut.2024.1422564
Rathi A, Pagare R. Efficacy and Safety of LBSC in Drug Induced Constipation Associated With Functional Gastrointestinal Disorder: A Double-Blind, Randomized, Interventional, Parallel, Controlled Trial a Clinical Study on LBSC for Drug Induced Constipation Associated With FGIDs. Glob Adv Integr Med Health. 2024;13:27536130241286511. doi:10.1177/27536130241286511
Wei CC, Harris MB, Ye M, Nicholls A, Alkhatib A, et al. Defecation after magnesium supplementation enhances cognitive performance in triathletes. Sports Med Health Sci. 2025;7:102. doi:10.1016/j.smhs.2024.04.001
Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. doi:10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. doi:10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. doi:10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. doi:10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. doi:10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. doi:10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. doi:10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. doi:10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. doi:10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. doi:10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. doi:10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. doi:10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. doi:10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. doi:10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. doi:10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. doi:10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. doi:10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. doi:10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.