' 
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.1
USERS' SCORE
Good
Based on 11 Reviews
8.6
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Strong relevance to anxiety treatment
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
7
Vitamin B6 reduces anxiety levels
High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.
Study is highly relevant
We engaged in a double-blind study involving 478 young adults to explore the effects of high-dose Vitamin B6 and B12 supplementation on anxiety levels. Over a month of treatment, we compared these vitamin supplements against a placebo, focusing on their potential to balance neural inhibition and excitation—two processes crucial for emotional regulation.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Read More
9
Vitamin B6 potentially reduces anxiety
Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study.
Mentions importance of vitamin B6
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
Most Useful Reviews
8.8
Normalised blood pressure
Magnesium B6 was prescribed by a neurologist for my mother to combat stress. After just two months, she became calm, positive, and the pressure stabilised. This supplement helped eliminate anxiety and insomnia, normalising her condition without needing additional medications. Cardiologists suggest a daily intake of 400-600 mg of magnesium, which I found beneficial for managing hypertension.
Read More
8.8
Alleviated symptoms
I ordered Solgar's Magnesium and vitamin B6 after a cardiologist suggested they could alleviate my chest pain linked to deficiencies. This supplement is essential for muscle and nerve functions and helped reduce my anxiety and stress. Over two months, I felt calmer and my symptoms improved significantly, with no adverse effects.
Read More
9.5
Improved comfort
Suffering from VSD and magnesium B6 deficiency, I faced chronic issues like dizziness and anxiety. However, after taking this supplement, my symptoms virtually disappeared, my sleep improved, and I felt rejuvenated. The quality of this brand is exceptional, and I always choose the best for my health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.1
9
Vitamin B6 potentially reduces anxiety
Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study.
Mentions importance of vitamin B6
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Strong relevance to anxiety treatment
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
9
Initial findings suggest potential benefits
Magnesium-ibogaine therapy in veterans with traumatic brain injuries.
Combination treatment lacks isolation benefit
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
Read More
8
Vitamin B6 aids postpartum depression
Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
Limited relevance for anxiety context
We conducted a clinical trial that looked into whether vitamin B6 could help prevent postpartum depression (PPD) among mothers at risk. This single-blind, placebo-controlled study involved 81 pregnant women in Isfahan, Iran, who were divided into two groups—one group received 80 mg of vitamin B6, while the other received a placebo.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Read More
8
Magnesium and B6 improve anxiety
Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Vitamin B6's impact unclear
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.6
9.5
Improved comfort
Suffering from VSD and magnesium B6 deficiency, I faced chronic issues like dizziness and anxiety. However, after taking this supplement, my symptoms virtually disappeared, my sleep improved, and I felt rejuvenated. The quality of this brand is exceptional, and I always choose the best for my health.
Read More
8.8
Normalised blood pressure
Magnesium B6 was prescribed by a neurologist for my mother to combat stress. After just two months, she became calm, positive, and the pressure stabilised. This supplement helped eliminate anxiety and insomnia, normalising her condition without needing additional medications. Cardiologists suggest a daily intake of 400-600 mg of magnesium, which I found beneficial for managing hypertension.
Read More
8.8
Alleviated symptoms
I ordered Solgar's Magnesium and vitamin B6 after a cardiologist suggested they could alleviate my chest pain linked to deficiencies. This supplement is essential for muscle and nerve functions and helped reduce my anxiety and stress. Over two months, I felt calmer and my symptoms improved significantly, with no adverse effects.
Read More
8.8
Stress relief
This superb supplement has been crucial for combating stress, especially for those with anxiety disorders or panic attacks. I even found it helpful after a night of drinking; it really aids in recovery.
8.8
Effective for anxiety
This supplement effectively combats stress and is particularly helpful for people with anxiety disorders or panic attacks, as our bodies often remain under stress.
