Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
Read More
9
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Read More
8
Magnesium alloy inhibits cancer growth
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
Read More
Most Useful Reviews
9
Chemo support product
32 people found this helpful
Excellent for alleviating chemotherapy side effects! Chemotherapy can cause varied side effects, including constipation. Despite a healthy diet, my husband, a cancer patient, still faced constipation issues. Laxatives are often chemical-laden and slow to work. These magnesium tablets helped him regain regularity within days. They also contain B6, crucial for nutrient absorption. I've started taking them too, and my frequent leg cramps have vanished. A perfect product for older adults, being small and easy to swallow.
Read More
9
Helps with constipation
This is a wonderful supplement to ease the side effects of chemotherapy! Honestly, chemotherapy causes many side effects, including constipation. My husband is a cancer patient who, even with a great diet, struggled with side effects. Laxatives are often filled with chemicals and can take days to work. The key component in these laxatives is MAGNESIUM. After taking these, he returned to “normal” within a few days. As chemotherapy depletes vital vitamins, the combination of B6 and magnesium is excellent for absorption. I also take them now, and my leg cramps have gone. Many individuals do not consume enough magnesium, crucial for bone health. This product is perfect for seniors; the small tablets are smooth and easy to swallow.
Read More
6
Bone healing noted
I am taking this product due to my metastatic prostate cancer that has spread to my bones, alongside other medications. It’s difficult to determine its exact effectiveness, but I’ve noticed improvements in my bone health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
- All Researches
9.5
We studied how high-dose pyridoxine, also known as vitamin B6, influences the effectiveness of chemotherapy drugs like 5-fluorouracil (FUra) and folinic acid (FA) in patients with advanced-stage cancers. Our group of 50 patients included individuals with digestive tract and breast cancers, all characterized by poor prognoses.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
Read More
9
We looked into the question of how magnesium levels might affect cancer treatment outcomes, especially for patients receiving immune checkpoint blockers. The study pointed out that elevated serum magnesium levels corresponded with more favorable results in these patients, suggesting that magnesium could play a positive role in their treatment journey.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
Read More
9
We examined how magnesium plays a role in enhancing T cell-mediated cancer immunotherapy. The study focused on a unique magnesium peroxide-based nanoigniter designed to disrupt the tumors' defenses. By combating the challenging immunosuppressive environment surrounding tumors, this innovative treatment aims to allow T cells to attack more effectively.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
Read More
9
We investigated how magnesium might enhance the effectiveness of cytotoxic T lymphocytes (CTLs) in fighting glioblastoma, a particularly aggressive form of brain cancer. CTLs, although present in glioblastoma, often struggle to infiltrate tumors effectively and are hampered by various inhibitory markers, notably NK1.1.
This study introduced a novel method using a specially designed nanoeditor, named Mg@MK-8931@MPP. This editor combines magnesium with a specific drug that helps empower CTLs and encourages their infiltration into the tumor while addressing the challenges of delivering treatment safely in the brain.
We observed that once the magnesium-based nanoeditor localized within glioblastoma, it enabled the effective release of MK-8931. This release repolarized M2-like macrophages, promoting a more significant CTL presence within the tumor site. Furthermore, magnesium worked to amplify the immune response, boosting the production of crucial antitumor cytokines and proteins.
Additionally, we found that blocking the NK1.1 receptor on CTLs extended their cytotoxic activity, enhancing treatment outcomes. Research on both T-cell-deficient and standard mouse models validated the potential of this magnesium-driven metalloimmunotherapy approach in treating glioblastoma effectively.
Overall, this strategy not only broadens the application of metalloimmunotherapy to glioblastoma but also emphasizes the importance of ensuring the functionality of CTLs in the fight against cancer.
This study introduced a novel method using a specially designed nanoeditor, named Mg@MK-8931@MPP. This editor combines magnesium with a specific drug that helps empower CTLs and encourages their infiltration into the tumor while addressing the challenges of delivering treatment safely in the brain.
We observed that once the magnesium-based nanoeditor localized within glioblastoma, it enabled the effective release of MK-8931. This release repolarized M2-like macrophages, promoting a more significant CTL presence within the tumor site. Furthermore, magnesium worked to amplify the immune response, boosting the production of crucial antitumor cytokines and proteins.
Additionally, we found that blocking the NK1.1 receptor on CTLs extended their cytotoxic activity, enhancing treatment outcomes. Research on both T-cell-deficient and standard mouse models validated the potential of this magnesium-driven metalloimmunotherapy approach in treating glioblastoma effectively.
Overall, this strategy not only broadens the application of metalloimmunotherapy to glioblastoma but also emphasizes the importance of ensuring the functionality of CTLs in the fight against cancer.
Read More
9
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Chemo support product
32 people found this helpful
Excellent for alleviating chemotherapy side effects! Chemotherapy can cause varied side effects, including constipation. Despite a healthy diet, my husband, a cancer patient, still faced constipation issues. Laxatives are often chemical-laden and slow to work. These magnesium tablets helped him regain regularity within days. They also contain B6, crucial for nutrient absorption. I've started taking them too, and my frequent leg cramps have vanished. A perfect product for older adults, being small and easy to swallow.
Read More
9
Helps with constipation
This is a wonderful supplement to ease the side effects of chemotherapy! Honestly, chemotherapy causes many side effects, including constipation. My husband is a cancer patient who, even with a great diet, struggled with side effects. Laxatives are often filled with chemicals and can take days to work. The key component in these laxatives is MAGNESIUM. After taking these, he returned to “normal” within a few days. As chemotherapy depletes vital vitamins, the combination of B6 and magnesium is excellent for absorption. I also take them now, and my leg cramps have gone. Many individuals do not consume enough magnesium, crucial for bone health. This product is perfect for seniors; the small tablets are smooth and easy to swallow.
Read More
6
Bone healing noted
I am taking this product due to my metastatic prostate cancer that has spread to my bones, alongside other medications. It’s difficult to determine its exact effectiveness, but I’ve noticed improvements in my bone health.
Read More
7.5
Effective for cancer treatment
Excellent! I continuously order for my mother and generally favour this manufacturer. After her pancreatic cancer, she needed organic vitamins, and we chose Solgar, which has proven effective.
Read More
Frequently Asked Questions
9
Helps with constipation
This is a wonderful supplement to ease the side effects of chemotherapy! Honestly, chemotherapy causes many side effects, including constipation. My husband is a cancer patient who, even with a great diet, struggled with side effects. Laxatives are often filled with chemicals and can take days to work. The key component in these laxatives is MAGNESIUM. After taking these, he returned to “normal” within a few days. As chemotherapy depletes vital vitamins, the combination of B6 and magnesium is excellent for absorption. I also take them now, and my leg cramps have gone. Many individuals do not consume enough magnesium, crucial for bone health. This product is perfect for seniors; the small tablets are smooth and easy to swallow.
6
Bone healing noted
I am taking this product due to my metastatic prostate cancer that has spread to my bones, alongside other medications. It’s difficult to determine its exact effectiveness, but I’ve noticed improvements in my bone health.
7.5
Effective for cancer treatment
Excellent! I continuously order for my mother and generally favour this manufacturer. After her pancreatic cancer, she needed organic vitamins, and we chose Solgar, which has proven effective.
8
Magnesium alloy inhibits cancer growth
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
9
We looked into the question of how magnesium levels might affect cancer treatment outcomes, especially for patients receiving immune checkpoint blockers. The study pointed out that elevated serum magnesium levels corresponded with more favorable results in these patients, suggesting that magnesium could play a positive role in their treatment journey.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
8
We observed intriguing connections between magnesium levels and cancer treatment outcomes. Our focus was on how elevated serum magnesium might influence the effectiveness of immune checkpoint blockers, a promising class of cancer therapy.
While our findings suggest a potential benefit of higher magnesium levels in conjunction with these treatments, it’s important to note that isolating the effects of magnesium alone was challenging. We found that patients who had elevated magnesium levels experienced more favorable outcomes, yet we must remain cautious in interpreting these results as definitive proof of magnesium's standalone effectiveness.
Overall, the investigation into magnesium's impact on cancer treatment highlights an interesting avenue for future research. Understanding how our bodies' minerals interact with innovative therapies like immune checkpoint blockers could open new doors in the fight against cancer.
While our findings suggest a potential benefit of higher magnesium levels in conjunction with these treatments, it’s important to note that isolating the effects of magnesium alone was challenging. We found that patients who had elevated magnesium levels experienced more favorable outcomes, yet we must remain cautious in interpreting these results as definitive proof of magnesium's standalone effectiveness.
Overall, the investigation into magnesium's impact on cancer treatment highlights an interesting avenue for future research. Understanding how our bodies' minerals interact with innovative therapies like immune checkpoint blockers could open new doors in the fight against cancer.
7
Vitamin B6 may reduce CIPN severity
In our research, we delved into how vitamin B6 might affect chronic chemotherapy-induced peripheral neuropathy (CIPN) among patients with non-metastatic colorectal cancer undergoing treatment with oxaliplatin. This type of neuropathy can persist long after chemotherapy has finished, often impacting patients' quality of life. We aimed to uncover any links between vitamin B6 levels in the blood and the severity and occurrence of chronic CIPN among these individuals.
We observed a cohort of 242 patients and collected their blood samples at three key points: before treatment, during treatment, and a year after diagnosis. We measured specific markers of vitamin B6, such as pyridoxal 5'-phosphate (PLP), to gauge their vitamin B6 status. Our analyses took into account various factors, including age, sex, and lifestyle choices, ensuring a comprehensive understanding of the situation.
Interestingly, our findings revealed that while having normal levels of PLP was important, higher vitamin B6 levels during chemotherapy were associated with a lower occurrence and severity of chronic CIPN. This suggests that maintaining adequate vitamin B6 levels could potentially benefit patients experiencing this uncomfortable side effect. However, further research is needed to establish a clear cause-and-effect relationship and determine the optimal levels of vitamin B6 for managing side effects during cancer treatment.
We observed a cohort of 242 patients and collected their blood samples at three key points: before treatment, during treatment, and a year after diagnosis. We measured specific markers of vitamin B6, such as pyridoxal 5'-phosphate (PLP), to gauge their vitamin B6 status. Our analyses took into account various factors, including age, sex, and lifestyle choices, ensuring a comprehensive understanding of the situation.
Interestingly, our findings revealed that while having normal levels of PLP was important, higher vitamin B6 levels during chemotherapy were associated with a lower occurrence and severity of chronic CIPN. This suggests that maintaining adequate vitamin B6 levels could potentially benefit patients experiencing this uncomfortable side effect. However, further research is needed to establish a clear cause-and-effect relationship and determine the optimal levels of vitamin B6 for managing side effects during cancer treatment.
8
We explored the relationship between serum levels of vitamin B6, specifically pyridoxal 5'-phosphate (PLP), and survival rates in colorectal cancer patients. The study involved 1,286 colorectal cancer patients from the Guangdong Colorectal Cancer Cohort, tracked for their overall and cancer-specific mortality until December 2023.
Our findings revealed that higher levels of PLP were linked to better overall survival and colorectal cancer-specific survival. In contrast, the pyridoxic acid ratio (PAr) did not show a significant association with survival outcomes. We observed that PLP levels correlated positively with longevity in patients, as evidenced by improved survival rates. Moreover, the impact of vitamin B6 varied based on alcohol consumption among patients.
While these results suggest that maintaining adequate vitamin B6 levels may benefit those with colorectal cancer, it is essential to note that the correlation does not establish a definitive cause-and-effect relationship. Thus, while vitamin B6 shows promising signs in enhancing survival, further research is needed to confirm its efficacy.
Our findings revealed that higher levels of PLP were linked to better overall survival and colorectal cancer-specific survival. In contrast, the pyridoxic acid ratio (PAr) did not show a significant association with survival outcomes. We observed that PLP levels correlated positively with longevity in patients, as evidenced by improved survival rates. Moreover, the impact of vitamin B6 varied based on alcohol consumption among patients.
While these results suggest that maintaining adequate vitamin B6 levels may benefit those with colorectal cancer, it is essential to note that the correlation does not establish a definitive cause-and-effect relationship. Thus, while vitamin B6 shows promising signs in enhancing survival, further research is needed to confirm its efficacy.
9.5
We studied how high-dose pyridoxine, also known as vitamin B6, influences the effectiveness of chemotherapy drugs like 5-fluorouracil (FUra) and folinic acid (FA) in patients with advanced-stage cancers. Our group of 50 patients included individuals with digestive tract and breast cancers, all characterized by poor prognoses.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
References
- Ouyang Y, Cao L, Zhao Q, Yang W, Lin C. Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer. Biomed Mater. 2025. doi:10.1088/1748-605X/adb2cc
- Wang Z, Wang Z. Letter Re: Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers. Eur J Cancer. 2025;216:115187. doi:10.1016/j.ejca.2024.115187
- Kitapli S, Alkan A, Tanriverdi O. Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers. Eur J Cancer. 2025;216:115188. doi:10.1016/j.ejca.2024.115188
- Hao H, Sun S, Fu Y, Wen S, Wen Y, et al. Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy. Biomaterials. 2025;317:123043. doi:10.1016/j.biomaterials.2024.123043
- Li W, Tian H, Yan Z, Yu X, Li B, et al. Magnesium-Phenolic Nanoeditor Refining Gliomatous T Cells for Metalloimmunotherapy. ACS Nano. 2025;19:1222. doi:10.1021/acsnano.4c13388
- Renting L, Zwart NRK, Ueland PM, McCann A, Ulvik A, et al. Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy. BMJ Oncol. 2024;3:e000462. doi:10.1136/bmjonc-2024-000462
- Li X, Xu L, Ou QJ, Xu H, Chen YY, et al. Serum Pyridoxal 5'-Phosphate and Pyridoxic Acid Ratio Index with Prognosis of Colorectal Cancer: A Prospective Cohort Study. Nutrients. 2024;16. doi:10.3390/nu16213685
- Moosa NY, Azeem SA, Lodge JK, Cheung W, Ahmed SU. Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910428
- Alroba AAN, Aazam ES, Zaki M. Metal complexes containing vitamin B6-based scaffold as potential DNA/BSA-binding agents inducing apoptosis in hepatocarcinoma (HepG2) cells. Mol Divers. 2024. doi:10.1007/s11030-024-10986-7
- Wang J, Liang Y, Xue A, Xiao J, Zhao X, et al. Intratumoral CXCL13 CD160 CD8 T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer. J Immunother Cancer. 2024;12. doi:10.1136/jitc-2024-009603
- Inoue-Choi M, Freedman ND, Etemadi A, Hashemian M, Brennan P, et al. One-carbon metabolism biomarkers and upper gastrointestinal cancer in the Golestan Cohort Study. Int J Cancer. 2024;155:1944. doi:10.1002/ijc.35115
- Pilesi E, Tesoriere G, Ferriero A, Mascolo E, Liguori F, et al. Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila. Cell Death Dis. 2024;15:388. doi:10.1038/s41419-024-06787-3
- Machover D, Almohamad W, Castagné V, Desterke C, Gomez L, et al. Treatment of patients with carcinomas in advanced stages with 5-fluorouracil, folinic acid and pyridoxine in tandem. Sci Rep. 2024;14:12054. doi:10.1038/s41598-024-62860-z
