' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
High relevance to glioblastoma research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
Read More
9
Vitamin B6 deficiency impacts cancer
Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila.
Direct link to cancer research
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Read More
8
Magnesium alloy inhibits cancer growth
Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer.
Significant effects on cervical cancer
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
Read More
Most Useful Reviews
9.5
Chemo support product
Excellent for alleviating chemotherapy side effects! Chemotherapy can cause varied side effects, including constipation. Despite a healthy diet, my husband, a cancer patient, still faced constipation issues. Laxatives are often chemical-laden and slow to work. These magnesium tablets helped him regain regularity within days. They also contain B6, crucial for nutrient absorption. I've started taking them too, and my frequent leg cramps have vanished. A perfect product for older adults, being small and easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
9.5
Vitamin B6 enhances chemotherapy effectiveness
Treatment of patients with carcinomas in advanced stages with 5-fluorouracil, folinic acid and pyridoxine in tandem.
Some benefit, but complex interplay
We studied how high-dose pyridoxine, also known as vitamin B6, influences the effectiveness of chemotherapy drugs like 5-fluorouracil (FUra) and folinic acid (FA) in patients with advanced-stage cancers. Our group of 50 patients included individuals with digestive tract and breast cancers, all characterized by poor prognoses.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
Read More
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
High relevance to glioblastoma research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
Read More
9
Vitamin B6 deficiency impacts cancer
Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila.
Direct link to cancer research
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Read More
9
Magnesium and Cancer Treatment Outcomes
Letter Re: Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers.
Magnesium correlation, not causation
We looked into the question of how magnesium levels might affect cancer treatment outcomes, especially for patients receiving immune checkpoint blockers. The study pointed out that elevated serum magnesium levels corresponded with more favorable results in these patients, suggesting that magnesium could play a positive role in their treatment journey.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
Read More
9
Magnesium enhances cancer immunotherapy
Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy.
Magnesium's effect not fully isolated
We examined how magnesium plays a role in enhancing T cell-mediated cancer immunotherapy. The study focused on a unique magnesium peroxide-based nanoigniter designed to disrupt the tumors' defenses. By combating the challenging immunosuppressive environment surrounding tumors, this innovative treatment aims to allow T cells to attack more effectively.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Chemo support product
Excellent for alleviating chemotherapy side effects! Chemotherapy can cause varied side effects, including constipation. Despite a healthy diet, my husband, a cancer patient, still faced constipation issues. Laxatives are often chemical-laden and slow to work. These magnesium tablets helped him regain regularity within days. They also contain B6, crucial for nutrient absorption. I've started taking them too, and my frequent leg cramps have vanished. A perfect product for older adults, being small and easy to swallow.
Read More
