We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Read More
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
Most Useful Reviews
9
Constipation relief
4 people found this helpful
After starting magnesium, I felt an improvement in my well-being. I even mixed it with my child's water, and she, too, experienced relief from constipation the same day! I hesitated to add nutrients to my diet, but I want to continue with this supplement.
Read More
9
Muscle spasms relief
4 people found this helpful
These magnesium tablets are small and easy to swallow, with no side effects. They effectively help with muscle spasms and constipation. The combination of B6 and magnesium may also aid against kidney stones. I take three daily with meals.
Read More
9
Chemotherapy relief
2 people found this helpful
My husband, a cancer patient, struggled with constipation from chemotherapy despite a healthy diet. Instead of chemical laxatives, we chose this magnesium supplement, and within days, his bowel movements improved. This product also helps with vitamins depletion from chemo, making it perfect for absorption. I've also found relief from leg cramps while taking it.
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
Read More
9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
After starting magnesium, I felt an improvement in my well-being. I even mixed it with my child's water, and she, too, experienced relief from constipation the same day! I hesitated to add nutrients to my diet, but I want to continue with this supplement.
Read More
9
Muscle spasms relief
4 people found this helpful
These magnesium tablets are small and easy to swallow, with no side effects. They effectively help with muscle spasms and constipation. The combination of B6 and magnesium may also aid against kidney stones. I take three daily with meals.
Read More
9
Chemotherapy relief
2 people found this helpful
My husband, a cancer patient, struggled with constipation from chemotherapy despite a healthy diet. Instead of chemical laxatives, we chose this magnesium supplement, and within days, his bowel movements improved. This product also helps with vitamins depletion from chemo, making it perfect for absorption. I've also found relief from leg cramps while taking it.
Read More
9
No bloating
1 people found this helpful
This product is fantastic, and my family loves it. My digestion has improved greatly, with no bloating or constipation since I began using it. I find everything I need in this shop, and the fast shipping is excellent. The product's quality is remarkable, and the taste is pleasant too.
Read More
9
Supports constipation relief
A must-have! Magnesium and vitamin B6 are essential for various bodily functions and work well together to alleviate chronic constipation. Magnesium supports muscle function and heart rhythm, while B6 aids metabolism and mood regulation. Together, they help reduce anxiety and enhance energy levels.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is often praised for its ability to support various bodily functions, and one of its lesser-known benefits is its potential to alleviate constipation. Magnesium acts as a natural laxative by attracting water into the intestines, which helps to soften stool and promote regular bowel movements. Various forms of magnesium supplements, such as magnesium citrate and magnesium hydroxide, are commonly used to relieve constipation. These forms are more bioavailable and have a reputation for being effective for those struggling with infrequent bowel movements.
That said, it's important to approach magnesium supplementation with care. While it can be beneficial, excessive magnesium intake can lead to adverse effects, including diarrhea and gastrointestinal discomfort. It’s always a good idea to consult with a healthcare provider or a dietitian before starting any supplementation, especially if you are considering magnesium as a treatment for constipation. They can help determine the appropriate dosage and form for your specific needs, ensuring that you reap the benefits while minimizing potential side effects.
Based on user reviews, many individuals report experiencing relief from constipation within a few days of starting the magnesium supplement. For instance, one user mentioned notable improvement in bowel movements within days for a cancer patient struggling with constipation due to chemotherapy Read Review. Another user found immediate relief for their child the same day the supplement was introduced Read Review. Several others noted a consistent timeline of improved digestion and decreased bloating or constipation within the first week of use Read Review, suggesting a short onset period for many users.
However, it's important to keep in mind that individual experiences may vary. While some users could feel results almost immediately, others reported gradual improvements or mixed results over a longer timeframe. For example, a user noted a 70% reduction in their constipation symptoms after three weeks Read Review, indicating that while quick relief is possible, it might take longer for others. Overall, most users seem to agree that noticeable benefits can be experienced relatively quickly following the introduction of magnesium into their routines.
Magnesium supplementation has garnered scientific support as a potential aid for managing constipation, particularly its various forms like magnesium oxide and magnesium hydroxide. Multiple studies, including a systematic review of randomized controlled trials, have indicated that magnesium can significantly increase bowel movement frequency and improve stool consistency. For instance, one study noted an average increase of about 3.7 additional bowel movements per week among participants taking magnesium oxide compared to those who weren’t [8]. Another trial revealed that patients using magnesium hydroxide syrup in an intensive care setting experienced quicker bowel movements than those receiving alternative treatments [3].
Despite these promising results, the effectiveness of magnesium can vary based on factors like dosage and individual patient circumstances. Research has shown that adjustments in magnesium dosage frequency didn't significantly impact its laxative effect [2], suggesting that while magnesium is effective, its use should be tailored to individual needs. Additionally, it's crucial to consider potential interactions with other medications, such as acid suppressants, which could compromise magnesium's effectiveness [12]. Overall, while magnesium is a well-supported option for alleviating constipation, further research is essential to optimize its use across different populations.
Based on user reviews, many individuals have reported significant improvements in their symptoms after starting a magnesium supplement. Users frequently mention enhanced well-being and immediate relief from constipation, with some even finding that their children's digestive issues improved the same day they started using the product Read Review. Others have noted that their constipation symptoms have diminished considerably; one user reported a 70% improvement after three weeks, while another found that their symptoms completely disappeared Read Review. Additionally, several reviewers highlighted improvements in related areas, such as reduced leg cramps and enhanced sleep quality alongside better digestive health Read ReviewRead Review.
However, it's essential to acknowledge that individual experiences can differ widely. While some users experienced quick relief, others reported varying degrees of success, with some finding the product less effective Read Review. Despite these mixed reviews, the overall consensus suggests that magnesium supplementation can lead to positive results for many, particularly concerning constipation and digestive health. This may serve as a promising option for those seeking relief from similar issues.
Based on user reviews, many individuals report positive experiences when combining magnesium supplements with other supplements to alleviate constipation. For example, one user specifically mentioned giving their child magnesium along with milk thistle, resulting in immediate relief from constipation Read Review. Another user noted the benefits of taking magnesium with vitamin B6, both for reducing constipation symptoms and enhancing overall well-being, highlighting the synergistic effects these nutrients may provide Read Review.
Users also shared that combining magnesium with their diets or other supplements contributed to better digestive health. One review praises the magnesium and vitamin B6 combination for its role in relieving chronic constipation and providing general support for bodily functions such as muscle and heart rhythm Read Review. However, responses to supplementation can vary; some users experienced discomfort or less effective results when using certain forms of magnesium, indicating a need for personal experimentation to find the right combination Read Review.
Based on user reviews, the right dose of magnesium for treating constipation appears to vary among individuals, but some common recommendations can be extracted. Users report taking between 2 to 3 tablets daily as effective doses. For instance, one user noted that they take three magnesium tablets daily with meals, which helped alleviate constipation symptoms Read Review. Another user mentioned taking two tablets at night as a successful approach to combatting their constipation Read Review.
Additionally, parents have reported giving their children specific doses, such as two tablets, and have noted quick relief from constipation issues Read Review. Overall, while user experiences may differ, dosage within this range seems to be commonly effective for those seeking relief from constipation.
9
Chemotherapy relief
2 people found this helpful
My husband, a cancer patient, struggled with constipation from chemotherapy despite a healthy diet. Instead of chemical laxatives, we chose this magnesium supplement, and within days, his bowel movements improved. This product also helps with vitamins depletion from chemo, making it perfect for absorption. I've also found relief from leg cramps while taking it.
9
Constipation relief
4 people found this helpful
After starting magnesium, I felt an improvement in my well-being. I even mixed it with my child's water, and she, too, experienced relief from constipation the same day! I hesitated to add nutrients to my diet, but I want to continue with this supplement.
9
No bloating
1 people found this helpful
This product is fantastic, and my family loves it. My digestion has improved greatly, with no bloating or constipation since I began using it. I find everything I need in this shop, and the fast shipping is excellent. The product's quality is remarkable, and the taste is pleasant too.
7.5
Relieves constipation symptoms
1 people found this helpful
After three weeks of use, I've seen a 70% reduction in eyelid tremors and my constipation symptoms have improved, although it hasn't helped with insomnia yet.
9
No constipation
3 people found this helpful
I prefer to take magnesium on an empty stomach. Since starting this supplement, I no longer experience constipation, and I appreciate that the tablets are smaller than typical magnesium ones, making them easier to swallow.
0
Caused intestinal issues
This was not the right form of magnesium for me; my intestines reacted poorly, though it may benefit others with constipation.
9
Kid's constipation remedy
This worked wonders for my 5-year-old son who frequently experiences constipation. I give him 2 tablets of this magnesium and 1 tablet of milk thistle, and it leads to immediate relief.
7.5
Reduced constipation
4 people found this helpful
Since taking magnesium and B6 together, my constipation has improved. I'm not entirely sure if it has fully prevented leg cramps, but I have noticed they have decreased. The smoother bowel movements suggest magnesium is beneficial for my situation, and I intend to buy it again.
9
Supports constipation relief
A must-have! Magnesium and vitamin B6 are essential for various bodily functions and work well together to alleviate chronic constipation. Magnesium supports muscle function and heart rhythm, while B6 aids metabolism and mood regulation. Together, they help reduce anxiety and enhance energy levels.
9
Muscle spasms relief
4 people found this helpful
These magnesium tablets are small and easy to swallow, with no side effects. They effectively help with muscle spasms and constipation. The combination of B6 and magnesium may also aid against kidney stones. I take three daily with meals.
9
Recommended for constipation
If you're struggling with constipation, I recommend this magnesium. I take 2 tablets at night, and it really helps.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
4
Magnesium laxative effectiveness diminished
Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System.
We investigated how magnesium oxide interacts with acid suppressant medications in treating opioid-induced constipation.
Using a vast database of over 14 million reports, we found that combining magnesium with acid suppressants, particularly proton pump inhibitors, can actually increase the incidence of constipation in opioid users.
This suggests that while magnesium is generally a helpful laxative, its effectiveness may be compromised when used alongside acid suppressants, necessitating caution among healthcare providers.
References
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Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. 10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. 10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. 10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. 10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. 10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. 10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. 10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. 10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. 10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. 10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. 10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. 10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. 10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. 10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. 10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. 10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. 10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. 10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. 10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. 10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.
Liu X, Liu Y, Shu Y, Tao H, Sheng Z, et al. Association between dietary vitamin B6 intake and constipation: a population-based study. Front Nutr. 2024;11:1483515. 10.3389/fnut.2024.1483515
Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. 10.3390/nu11040886