Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
9
We explored how coal dust exposure leads to anxiety and depression-like behaviors in mice, using a pneumoconiosis model that was established after 28 days of exposure. This model allows us to closely observe the effects of environmental factors on mental health. Through treating the mice with Vitamin D3 for three months, we aimed to see if this treatment could alleviate anxiety symptoms.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Read More
9
We examined the effects of vitamin D3 on anxiety in mice experiencing nicotine withdrawal. To conduct our research, we divided male C57/BL6 mice into four distinct groups: those receiving a vehicle, those receiving nicotine alone, those receiving vitamin D3 alone, and those receiving both nicotine and vitamin D3.
During the six-week study, the mice were given nicotine through their drinking water and vitamin D3 in their feed. When the withdrawal phase kicked in, we observed that mice treated with vitamin D3 demonstrated significantly reduced anxiety-like behaviors. This was measured using open-field tests and marble burying tests, where these mice spent more time in the central area and buried fewer marbles compared to those that did not receive vitamin D3.
Additionally, our study revealed that vitamin D3 supplementation reduced hippocampal NR2A expression, which may be linked to lowering anxiety during nicotine withdrawal. These findings suggest that vitamin D3 supplementation could be a promising dietary intervention for people dealing with anxiety related to quitting smoking.
During the six-week study, the mice were given nicotine through their drinking water and vitamin D3 in their feed. When the withdrawal phase kicked in, we observed that mice treated with vitamin D3 demonstrated significantly reduced anxiety-like behaviors. This was measured using open-field tests and marble burying tests, where these mice spent more time in the central area and buried fewer marbles compared to those that did not receive vitamin D3.
Additionally, our study revealed that vitamin D3 supplementation reduced hippocampal NR2A expression, which may be linked to lowering anxiety during nicotine withdrawal. These findings suggest that vitamin D3 supplementation could be a promising dietary intervention for people dealing with anxiety related to quitting smoking.
Read More
Most Useful Reviews
9
Life-changing vitamins
3 people found this helpful
Excellent Quality. I highly recommend these vitamins to anyone struggling with anxiety. After discovering my deficiencies in vitamins D3 and B12, which contributed to my anxiety and depression, I started taking them. Within a few months, I felt my life transform and was able to engage with society again.
Read More
9
Reduced anxiety
2 people found this helpful
I purchased it as it seemed to be made from cod liver oil. I take 2000-3000iu daily. After starting it, I found myself naturally becoming sleepy at night, and my sleep cycle improved. It appears beneficial for mental health, particularly in reducing anxiety and worries. Previously, I experienced dermatitis when increasing my dosage with another brand, believed to be due to lanolin. With Solger, I can take it confidently without any skin tingling.
Read More
9
Relaxation achieved
During a time of stress and anxiety, my doctor advised taking vitamin D. After starting with two pills a day, I regained my sanity and am now feeling more relaxed.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.7
- All Researches
9
We explored the effects of vitamin D3 on anxiety levels in rats subjected to chronic unpredictable mild stress. In our study, we used a total of 40 male Wistar rats, dividing them into five groups to analyze various treatments. These groups included a control group, a stress group, and groups receiving either vitamin D3, fluoxetine (an antidepressant), or a combination of both.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
Read More
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
9
We explored how coal dust exposure leads to anxiety and depression-like behaviors in mice, using a pneumoconiosis model that was established after 28 days of exposure. This model allows us to closely observe the effects of environmental factors on mental health. Through treating the mice with Vitamin D3 for three months, we aimed to see if this treatment could alleviate anxiety symptoms.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Read More
9
We examined the effects of vitamin D3 on anxiety in mice experiencing nicotine withdrawal. To conduct our research, we divided male C57/BL6 mice into four distinct groups: those receiving a vehicle, those receiving nicotine alone, those receiving vitamin D3 alone, and those receiving both nicotine and vitamin D3.
During the six-week study, the mice were given nicotine through their drinking water and vitamin D3 in their feed. When the withdrawal phase kicked in, we observed that mice treated with vitamin D3 demonstrated significantly reduced anxiety-like behaviors. This was measured using open-field tests and marble burying tests, where these mice spent more time in the central area and buried fewer marbles compared to those that did not receive vitamin D3.
Additionally, our study revealed that vitamin D3 supplementation reduced hippocampal NR2A expression, which may be linked to lowering anxiety during nicotine withdrawal. These findings suggest that vitamin D3 supplementation could be a promising dietary intervention for people dealing with anxiety related to quitting smoking.
During the six-week study, the mice were given nicotine through their drinking water and vitamin D3 in their feed. When the withdrawal phase kicked in, we observed that mice treated with vitamin D3 demonstrated significantly reduced anxiety-like behaviors. This was measured using open-field tests and marble burying tests, where these mice spent more time in the central area and buried fewer marbles compared to those that did not receive vitamin D3.
Additionally, our study revealed that vitamin D3 supplementation reduced hippocampal NR2A expression, which may be linked to lowering anxiety during nicotine withdrawal. These findings suggest that vitamin D3 supplementation could be a promising dietary intervention for people dealing with anxiety related to quitting smoking.
Read More
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing vitamins
3 people found this helpful
Excellent Quality. I highly recommend these vitamins to anyone struggling with anxiety. After discovering my deficiencies in vitamins D3 and B12, which contributed to my anxiety and depression, I started taking them. Within a few months, I felt my life transform and was able to engage with society again.
Read More
9
Reduced anxiety
2 people found this helpful
I purchased it as it seemed to be made from cod liver oil. I take 2000-3000iu daily. After starting it, I found myself naturally becoming sleepy at night, and my sleep cycle improved. It appears beneficial for mental health, particularly in reducing anxiety and worries. Previously, I experienced dermatitis when increasing my dosage with another brand, believed to be due to lanolin. With Solger, I can take it confidently without any skin tingling.
Read More
9
Relaxation achieved
During a time of stress and anxiety, my doctor advised taking vitamin D. After starting with two pills a day, I regained my sanity and am now feeling more relaxed.
Read More
7.5
Improved well-being
Necessary! After watching Dr. Oz, I began taking these vitamins alongside Omega-3 and B-complex for their anti-anxiety benefits. I don't know the exact cause, but I feel significantly better! I highly recommend these products.
Read More
7.5
Effective for anxiety
I've used these vitamins for about three years and highly recommend them for anxiety, depression, and bone issues. They are of very good quality.
Read More
Frequently Asked Questions
7.5
Mood improvement
After just a few days of taking D3, I felt a notable improvement in my mood, increased energy and a reduction in anxiety. The capsule size is convenient and easy to swallow.
9
Life-changing vitamins
3 people found this helpful
Excellent Quality. I highly recommend these vitamins to anyone struggling with anxiety. After discovering my deficiencies in vitamins D3 and B12, which contributed to my anxiety and depression, I started taking them. Within a few months, I felt my life transform and was able to engage with society again.
9
Relaxation achieved
During a time of stress and anxiety, my doctor advised taking vitamin D. After starting with two pills a day, I regained my sanity and am now feeling more relaxed.
7.5
Improved well-being
Necessary! After watching Dr. Oz, I began taking these vitamins alongside Omega-3 and B-complex for their anti-anxiety benefits. I don't know the exact cause, but I feel significantly better! I highly recommend these products.
9
Reduced anxiety
2 people found this helpful
I purchased it as it seemed to be made from cod liver oil. I take 2000-3000iu daily. After starting it, I found myself naturally becoming sleepy at night, and my sleep cycle improved. It appears beneficial for mental health, particularly in reducing anxiety and worries. Previously, I experienced dermatitis when increasing my dosage with another brand, believed to be due to lanolin. With Solger, I can take it confidently without any skin tingling.
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
7
We investigated whether vitamin D levels during pregnancy could predict anxiety symptoms in new mothers. In a large cohort study involving over 2,400 participants, we measured maternal serum vitamin D and C-reactive protein (CRP) levels around the 13-week mark of gestation. After giving birth, we checked in on the mothers three months later to assess their levels of depression and anxiety using standardized questionnaires.
Our findings suggest that insufficient vitamin D, particularly in women who did not take supplements, is linked to increased anxiety symptoms post-delivery. Specifically, a deficiency in vitamin D was associated with a noticeable rise in these symptoms, hinting that proper vitamin D levels might play a protective role. However, we found that CRP did not seem to mediate this relationship.
Overall, our research indicates that ensuring adequate vitamin D levels during pregnancy may be beneficial for reducing anxiety, especially for those not using supplements. Still, further clinical trials are needed to confirm whether vitamin D supplementation can actively mitigate postpartum affective disorders.
Our findings suggest that insufficient vitamin D, particularly in women who did not take supplements, is linked to increased anxiety symptoms post-delivery. Specifically, a deficiency in vitamin D was associated with a noticeable rise in these symptoms, hinting that proper vitamin D levels might play a protective role. However, we found that CRP did not seem to mediate this relationship.
Overall, our research indicates that ensuring adequate vitamin D levels during pregnancy may be beneficial for reducing anxiety, especially for those not using supplements. Still, further clinical trials are needed to confirm whether vitamin D supplementation can actively mitigate postpartum affective disorders.
8
We examined if there is a connection between vitamin D levels and anxiety among US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012. The study included over 12,000 participants and employed sophisticated statistical methods to determine the relationship between serum vitamin D and anxiety.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
8
We examined how vitamin D3 levels influence anxiety and overall quality of life in older adults, specifically those aged 65 and above. In a study involving 273 participants, we analyzed vital health markers like calcium and phosphorus, alongside vitamin D3 levels, to see how these relate to mental and physical well-being.
Our findings were noteworthy: about 90% of the participants were found to be either vitamin D deficient or insufficient. We observed that those with higher levels of vitamin D3 reported significantly fewer instances of anxiety or depression. After adjusting for other factors, there was a clear connection between elevated serum vitamin D3 and reduced feelings of anxiety, indicating that maintaining adequate vitamin D levels could play a role in enhancing mental health.
Additionally, participants with better vitamin D levels also showed improved muscle strength. This leads us to believe that vitamin D not only positively influences mood but could also contribute to better physical health and mobility in older adults. Ultimately, our data suggest that by focusing on vitamin D3 supplementation, we could help improve quality of life and reduce anxiety among the elderly.
Our findings were noteworthy: about 90% of the participants were found to be either vitamin D deficient or insufficient. We observed that those with higher levels of vitamin D3 reported significantly fewer instances of anxiety or depression. After adjusting for other factors, there was a clear connection between elevated serum vitamin D3 and reduced feelings of anxiety, indicating that maintaining adequate vitamin D levels could play a role in enhancing mental health.
Additionally, participants with better vitamin D levels also showed improved muscle strength. This leads us to believe that vitamin D not only positively influences mood but could also contribute to better physical health and mobility in older adults. Ultimately, our data suggest that by focusing on vitamin D3 supplementation, we could help improve quality of life and reduce anxiety among the elderly.
8
Vitamin D3 improves anxiety in diabetes
We investigated the potential benefits of vitamin D3 supplementation on anxiety levels in women diagnosed with type 2 diabetes and suffering from vitamin D deficiency. This research involved a randomized controlled trial with 51 participants who were divided into two groups. One group received a high dose of vitamin D3, while the other was given a placebo over a period of 16 weeks.
At the end of the study, we noticed some significant changes among the women who received vitamin D3. Their anxiety scores dropped markedly compared to the placebo group, which indicates a positive impact on their mental well-being. Additionally, there was a notable reduction in markers of inflammation, while other mood indicators, such as depression, improved as well.
Our findings suggest that vitamin D3 supplementation might be a valuable tool in improving mood and reducing anxiety for women with diabetes who are also facing vitamin D deficiency. This combination of physical health and mental well-being is crucial, especially for managing diabetes more effectively.
At the end of the study, we noticed some significant changes among the women who received vitamin D3. Their anxiety scores dropped markedly compared to the placebo group, which indicates a positive impact on their mental well-being. Additionally, there was a notable reduction in markers of inflammation, while other mood indicators, such as depression, improved as well.
Our findings suggest that vitamin D3 supplementation might be a valuable tool in improving mood and reducing anxiety for women with diabetes who are also facing vitamin D deficiency. This combination of physical health and mental well-being is crucial, especially for managing diabetes more effectively.
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
References
- Charoenporn V, Tungsukruthai P, Teacharushatakit P, Hanvivattanakul S, Sriyakul K, et al. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial. Psychiatry Clin Neurosci. 2024;78:595. doi:10.1111/pcn.13716
- Yin H, Zhang J, Chen Y, Guo J, Li Q, et al. Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. Brain Behav Immun. 2024;121:13. doi:10.1016/j.bbi.2024.07.012
- Domacassé D, de Rooij SR, Vrijkotte T, de Jonge A, Henrichs J. Associations Between Early-Pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosom Med. 2024;86:648. doi:10.1097/PSY.0000000000001328
- Wen Z, Bai L, Wu S, Chen J, Jama HA, et al. Association of serum vitamin D with anxiety in US adults: a cross-sectional study. Front Nutr. 2024;11:1371170. doi:10.3389/fnut.2024.1371170
- Zhao W, Zhu DM, Shen Y, Zhang Y, Chen T, et al. The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial. Psychol Med. 2024;54:2403. doi:10.1017/S0033291724000539
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. doi:10.23736/S2724-5985.24.03581-2
- Renteria KM, Constantine E, Teoh CM, Cooper A, Lozano N, et al. Combination of vitamin D and fructooligosaccharides upregulates colonic vitamin D receptor in C57BL/6J mice and affects anxiety-related behavior in a sex-specific manner. Nutr Res. 2024;125:16. doi:10.1016/j.nutres.2024.02.003
- Gammoh O, Ibrahim A, Yehya A, Alqudah A, Qnais E, et al. Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. Int J Mol Sci. 2024;25. doi:10.3390/ijms25041960
- Gizzi G, Fiorani F, Cataldi S, Mandarano M, Delvecchio E, et al. Exploring the Influence of / Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines. Genes (Basel). 2024;15. doi:10.3390/genes15070913
- Al-Ramadhan FR, Abulmeaty MMA, Alquraishi M, Razak S, Alhussain MH. Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress. Biomedicines. 2023;11. doi:10.3390/biomedicines11082112
- Lapmanee S, Bhubhanil S, Sriwong S, Yuajit C, Wongchitrat P, et al. Oral calcium and vitamin D supplements differentially alter exploratory, anxiety-like behaviors and memory in male rats. PLoS One. 2023;18:e0290106. doi:10.1371/journal.pone.0290106
- Pereira ADS, Miron VV, Castro MFV, Bottari NB, Assmann CE, et al. Neuromodulatory effect of the combination of metformin and vitamin D triggered by purinergic signaling in type 1 diabetes induced-rats. Mol Cell Endocrinol. 2023;563:111852. doi:10.1016/j.mce.2023.111852
- Zaromytidou E, Koufakis T, Dimakopoulos G, Drivakou D, Konstantinidou S, et al. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study. Metabolites. 2022;12. doi:10.3390/metabo12100884
- Tokarchuk A, Abenavoli L, Kobyliak N, Khomenko M, Revun M, et al. Nutrition program, physical activity and gut microbiota modulation: a randomized controlled trial to promote a healthy lifestyle in students with vitamin D3 deficiency. Minerva Med. 2022;113:683. doi:10.23736/S0026-4806.22.07992-7
- Zou Y, Mu M, Zhang S, Li C, Tian K, et al. Vitamin D3 suppresses astrocyte activation and ameliorates coal dust-induced mood disorders in mice. J Affect Disord. 2022;303:138. doi:10.1016/j.jad.2022.02.026
- Guzek D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, et al. Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review. Nutrients. 2021;13. doi:10.3390/nu13113678
- Wu B, Tao X, Liu C, Li H, Jiang T, et al. Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice. Transl Neurosci. 2021;12:273. doi:10.1515/tnsci-2020-0166
- Tsoukalas D, Zlatian O, Mitroi M, Renieri E, Tsatsakis A, et al. A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals. J Clin Med. 2021;10. doi:10.3390/jcm10040624
- Lang F, Ma K, Leibrock CB. 1,25(OH)D in Brain Function and Neuropsychiatric Disease. Neurosignals. 2019;27:40. doi:10.33594/000000182
- Verde Z, Giaquinta A, Sainz CM, Ondina MD, Araque AF. Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People. Nutrients. 2019;11. doi:10.3390/nu11112748
- Fedotova JO. Vitamin D treatment differentially affects anxiety-like behavior in the old ovariectomized female rats and old ovariectomized female rats treated with low dose of 17β-estradiol. BMC Med Genet. 2019;20:49. doi:10.1186/s12881-019-0774-2
- Fazelian S, Amani R, Paknahad Z, Kheiri S, Khajehali L. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial. Int J Prev Med. 2019;10:17. doi:10.4103/ijpvm.IJPVM_174_18
