We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Read More
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
Most Useful Reviews
9
Relieves constipation
19 people found this helpful
This product, containing magnesium and potassium, supports heart function but has unexpectedly helped with my autoimmune disease treatment. It combats cramps, constipation, and sleep disturbances caused by prednisolone. I take two capsules at night, and the quality is excellent. It’s now a permanent fixture in my orders.
Read More
10
Constipation issues gone
10 people found this helpful
I'm so happy! This product did absolute wonders for my stomach issues. After taking it for the first time, I relieved a lot of gas. I now take it daily and have found that all my constipation issues have completely disappeared; I now have a daily movement. I'm absolutely thrilled!
Read More
8
Helps greatly
3 people found this helpful
Here's to your health! I suffer from constipation, and this supplement genuinely helps me go!
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
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9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
This product, containing magnesium and potassium, supports heart function but has unexpectedly helped with my autoimmune disease treatment. It combats cramps, constipation, and sleep disturbances caused by prednisolone. I take two capsules at night, and the quality is excellent. It’s now a permanent fixture in my orders.
Read More
10
Constipation issues gone
10 people found this helpful
I'm so happy! This product did absolute wonders for my stomach issues. After taking it for the first time, I relieved a lot of gas. I now take it daily and have found that all my constipation issues have completely disappeared; I now have a daily movement. I'm absolutely thrilled!
Read More
8
Helps greatly
3 people found this helpful
Here's to your health! I suffer from constipation, and this supplement genuinely helps me go!
Read More
9
Cramps and constipation
2 people found this helpful
Magnesium and potassium support heart functions but have also helped me significantly with cramps, constipation, and sleep issues caused by my medication. I take two capsules at night, and the quality is excellent. This product is now a staple in my routine.
Read More
9
Pain relief
1 people found this helpful
This product is essential after exercise for pain relief and provides my magnesium needs. It calms the nerves, helps me relax before bed, and effectively treats constipation. The quality is high, and there’s enough quantity for months.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is often praised for its ability to support various bodily functions, and one of its lesser-known benefits is its potential to alleviate constipation. Magnesium acts as a natural laxative by attracting water into the intestines, which helps to soften stool and promote regular bowel movements. Various forms of magnesium supplements, such as magnesium citrate and magnesium hydroxide, are commonly used to relieve constipation. These forms are more bioavailable and have a reputation for being effective for those struggling with infrequent bowel movements.
That said, it's important to approach magnesium supplementation with care. While it can be beneficial, excessive magnesium intake can lead to adverse effects, including diarrhea and gastrointestinal discomfort. It’s always a good idea to consult with a healthcare provider or a dietitian before starting any supplementation, especially if you are considering magnesium as a treatment for constipation. They can help determine the appropriate dosage and form for your specific needs, ensuring that you reap the benefits while minimizing potential side effects.
Based on user reviews, the time frame to experience relief from constipation while using this supplement can vary. Many users report that taking the supplement before bed leads to noticeable results by the next day. For example, one reviewer stated, "This product works wonders. I take two capsules before bed, and it helps me sleep soundly while also preventing constipation" Read Review. Similarly, another user highlighted that it has enabled them to have regular bowel movements every day Read Review.
However, experiences can differ, with some individuals needing a bit more time to see their desired results. One reviewer mentioned that it was effective during a specific diet, aiding in regularity regarding constipation Read Review. Overall, if used consistently, many users seem to achieve significant improvements within a day or two, but the optimal results may vary based on individual circumstances.
Magnesium has garnered attention as a potential remedy for constipation, and recent scientific research supports its efficacy in various forms. For instance, a systematic review of randomized controlled trials indicated that magnesium oxide could lead to an increase in bowel movements, showing an average improvement of about 3.7 extra movements per week and enhanced stool consistency [8]. Additionally, studies have demonstrated that magnesium hydroxide syrup aids in quickening bowel movements in specific populations, such as ICU patients recovering from heart issues [3].
While these findings present a favorable view of magnesium’s role in alleviating constipation, the research also suggests that its effectiveness can vary based on individual circumstances and treatment combinations. For example, magnesium's impact can be influenced when used alongside probiotics, and its combination with lactulose has shown promising results in enhancing bowel health [4]. Overall, although magnesium is supported by a body of research as a helpful option for managing constipation, further studies are warranted to fully understand its benefits in varied contexts and to investigate the mechanisms at play.
Based on user reviews, many individuals report notable improvements in symptoms related to constipation and sleep disturbances after using this magnesium and potassium supplement. Several users have highlighted that they experience relief from constipation, with one reviewer noting that the product has enabled them to have regular daily bowel movements, particularly after menopause Read Review. Another user mentioned that it has significantly improved their digestive system function, alleviating chronic constipation that they had been suffering from Read Review.
In addition to digestive benefits, users have also observed enhancements in sleep quality. For instance, one reviewer shared that taking two capsules before bed not only facilitates sound sleep but also combats constipation effectively Read Review. Others have reported similar experiences, indicating that this supplement can help relax the body and calm nerves before sleep, thus enhancing overall wellbeing Read Review. However, it's important to note that individual results can vary, and some users have experienced issues with constipation themselves when adjusting their dosages Read Review. Overall, consistent use appears to yield positive outcomes for many.
Based on user reviews, many individuals report successful combinations of this magnesium and potassium supplement with other supplements and dietary practices to help manage constipation. Multiple users highlighted that integrating this supplement into their routine significantly alleviated their symptoms. For instance, one user noted, "I take two capsules before bed, and it helps me sleep soundly while also preventing constipation" Read Review. Another reviewer mentioned that while on a specific diet, this supplement boosted their energy and aided regularity concerning constipation, suggesting that it works well when paired with dietary changes Read Review.
However, not all experiences were positive, as some users reported challenges when combining this with other supplements. One reviewer experienced constipation when adjusting their dosage, hinting that care should be taken when combining potassium and magnesium, as "I realized potassium should be taken separately" to avoid an imbalance Read Review. Therefore, while many users find this supplement effective for constipation relief either alone or in conjunction with dietary adjustments, individual responses can vary significantly based on dosage and supplement combinations.
According to user reviews, many consumers report that taking two capsules of magnesium at night appears to be an effective dose for addressing constipation. For instance, one user noted, "I take two capsules at night, and it helps me sleep soundly while also preventing constipation" Read Review. Similarly, another reviewer shared that this dosage has become a staple in their nightly routine, effectively alleviating constipation and related issues Read Review.
However, it's essential to be cautious, as some users reported adverse effects when the dosage was not managed properly. One reviewer mentioned that they experienced constipation after starting the product, realizing they needed to take potassium separately to avoid an overdose of magnesium Read Review. Therefore, while a nightly dosage of two capsules is commonly reported as effective, individual responses may vary, and adjustments might be necessary based on personal health conditions and dietary needs.
7.5
Helps with constipation
22 people found this helpful
Cathy from Texas: This product works wonders. I take two capsules before bed, and it helps me sleep soundly while also preventing constipation. I’ll continue using it and have even started both my daughters on it.
9
Daily relief
2 people found this helpful
After menopause, I experienced increased constipation, so I began using this product. It has enabled me to have regular bowel movements every day, and I feel much better.
7.5
Constipation relief
3 people found this helpful
I found this product after reading about it online. Despite not being available locally, I received my order quickly. It has been highly effective while I was on the HCG diet, boosting my energy and aiding regularity, particularly regarding constipation. I highly recommend it.
7.5
Effective constipation
1 people found this helpful
Value for money, this product visibly improved my digestive system's function and alleviated chronic constipation that I was suffering from. I initially aimed to improve my sleep but got positive results for both issues.
9
Pain relief
1 people found this helpful
This product is essential after exercise for pain relief and provides my magnesium needs. It calms the nerves, helps me relax before bed, and effectively treats constipation. The quality is high, and there’s enough quantity for months.
0
Caused constipation
Initially, I was pleased with this product, but it caused constipation after I began taking it. I realised potassium should be taken separately as the dosage I need leads to an overdose of magnesium.
9
Cramps and constipation
2 people found this helpful
Magnesium and potassium support heart functions but have also helped me significantly with cramps, constipation, and sleep issues caused by my medication. I take two capsules at night, and the quality is excellent. This product is now a staple in my routine.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
8
Magnesium's role in constipation treatment
Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.
We aimed to understand how magnesium, particularly when combined with probiotics, influences bowel movements in elderly orthopedic patients suffering from chronic constipation. A retrospective chart review allowed us to analyze various patient records, focusing specifically on the treatments they received and the outcomes.
Magnesium is often talked about as a potential remedy for constipation because it can help draw water into the intestines, making it easier to pass stools. However, since our study also involved probiotics, which can also impact gut health, it becomes harder to isolate the specific effects of magnesium alone.
After reviewing the data, we observed that the combination of magnesium and probiotics did not show a significant advantage in improving bowel movements for the patients involved. This indicates that while magnesium may play a supportive role, its effectiveness on constipation could vary depending on individual circumstances and may not be as pronounced when combined with other treatments.
Overall, this study serves as a reminder of the complexity of managing constipation, especially in the elderly population, where multiple factors can come into play.
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Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. doi:10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. doi:10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. doi:10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. doi:10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. doi:10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. doi:10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. doi:10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. doi:10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. doi:10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. doi:10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. doi:10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. doi:10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. doi:10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. doi:10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. doi:10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. doi:10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. doi:10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. doi:10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.
Imamura T, Kinugawa K. Successful Conversion from Conventional Potassium Binder to Sodium Zirconium Cyclosilicate in a Patient with Refractory Constipation. Medicina (Kaunas). 2022;58. doi:10.3390/medicina58050635
Narita Y, Fukumoto K, Fukunaga M, Kondo Y, Ishitsuka Y, et al. Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model. Int J Mol Sci. 2020;21. doi:10.3390/ijms21072491
Lambert K, Bird L, Borst AC, Fuller A, Wang Y, et al. Safety and Efficacy of Using Nuts to Improve Bowel Health in Hemodialysis Patients. J Ren Nutr. 2020;30:462. doi:10.1053/j.jrn.2019.10.002
Dehghani SM, Bahroloolomifard MS, Yousefi G, Pasdaran A, Hamedi A. A randomized controlled double blinded trial to evaluate efficacy of oral administration of black strap molasses (sugarcane extract) in comparison with polyethylene glycol on pediatric functional constipation. J Ethnopharmacol. 2019;238:111845. doi:10.1016/j.jep.2019.111845
Kim JH, Lee YP, Suh KW. Changes in anorectal physiology following injection sclerotherapy using aluminum potassium sulfate and tannic acid versus transanal repair in patients with symptomatic rectocele; a retrospective cohort study. BMC Surg. 2018;18:34. doi:10.1186/s12893-018-0363-x
Souli A, Sebai H, Rtibi K, Chehimi L, Sakly M, et al. Effects of dates pulp extract and palm sap (Phoenix dactylifera L.) on gastrointestinal transit activity in healthy rats. J Med Food. 2014;17:782. doi:10.1089/jmf.2013.0112
Wu D, Wang X, Zhou J, Yuan J, Cui B, et al. Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. J Ethnopharmacol. 2010;130:347. doi:10.1016/j.jep.2010.05.018
Iida R, Otsuka Y, Matsumoto K, Kuriyama S, Hosoya T. Pseudoaldosteronism due to the concurrent use of two herbal medicines containing glycyrrhizin: interaction of glycyrrhizin with angiotensin-converting enzyme inhibitor. Clin Exp Nephrol. 2006;10:131.
Jo HG, Kim MJ, Moon BY, Cheong SH. Antioxidant and laxative effects of taurine-xylose, a synthetic taurine-carbohydrate derivative, in loperamide-induced constipation in Sprague-Dawley rats. J Exerc Nutrition Biochem. 2019;23:6. doi:10.20463/jenb.2019.0025
Lee DS, Jo HG, Kim MJ, Lee H, Cheong SH. Laxative Effects of Taurine on Loperamide-Induced Constipation in Rats. Adv Exp Med Biol. 2019;1155:261. doi:10.1007/978-981-13-8023-5_25