NOW Supplements Vitamin D-3

Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial. Nutr Metab Cardiovasc Dis. 2015;25:287. doi:10.1016/j.numecd.2014.10.007

Based on 5 Researches

Vitamin D3 ineffective for CFS

We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.

Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.

In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.

9.5

Boosted immune system

Most Useful Review

Very good vitamins at a reasonable price. The whole family takes one small capsule daily with food. I've noticed a significant reduction in chronic fatigue syndrome and an improvement in my health, particularly after illnesses. Vitamin D3 supports recovery, strengthens bones, boosts muscle strength, and enhances mood. I've been taking it consistently and find it essential for my wellbeing, especially during the winter months.

Depression details

Vitamin D3 improves depressive symptoms

Kaviani M, Nikooyeh B, Etesam F, Behnagh SJ, Kangarani HM, et al. Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. BMC Psychiatry. 2022;22:694. doi:10.1186/s12888-022-04305-3

We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.

After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.

This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.

9.5

Boosted immunity

Most Useful Review

Good afternoon! These Vitamin D3 capsules are fantastic for boosting immunity in a digestible liquid form. Living in Siberia, we suffer from vitamin D deficiency. We've noticed a positive effect during the ARVI season, as we fell ill less frequently and more mildly. The whole family takes it, and I’ve been on this dosage for over a year. It helps alleviate depression due to the lack of sun, increases vitality, and without it in the morning, I don't feel like myself.

Diabetes details

Vitamin D3 shows no diabetes benefit

Based on 11 Researches

Virtanen JK, Hantunen S, Kallio N, Lamberg-Allardt C, Manson JE, et al. The effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial. Diabetologia. 2024. doi:10.1007/s00125-024-06336-9

We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.

Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.

Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.

9.5

Vitamin D recommendation

Most Useful Review

It appears that vitamin D deficiency occurs even in sunny countries like Italy and Mexico. The optimal level of vitamin D is between 60-100 ng/ml, ideally measured by mass spectrometry. Many labs use ELISA, which underestimates levels. Vitamin D, being a steroid hormone, when deficient can lead to conditions including diabetes. After taking 10,000 IU of vitamin D daily, my levels rose from 18 to 111 ng/ml. I believe everyone should consider having it in their home remedies.

Adenoiditis details

Improved health quality

I've been taking vitamin D 5000 IU and MK7 for 4 months, and my immunity has significantly improved! I used to get ill every month in winter, requiring antibiotics for throat infections, but now my health has dramatically enhanced. With Hashimoto’s, maintaining vitamin levels is crucial for me. My hair loss has stopped, and new growth has occurred. I've ordered a 2000 IU version for spring, hoping it will be equally effective. The capsules are small and easy to swallow—high-quality ingredients, with one per day recommended. Always monitor your blood levels to adjust your dosage. The packaging was perfect, and the effects have truly benefited my overall health, including my bones.

Anxiety details

CYP11A1, Autism Symptoms, Vitamin D3

Yin H, Zhang J, Chen Y, Guo J, Li Q, et al. Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. Brain Behav Immun. 2024;121:13. doi:10.1016/j.bbi.2024.07.012

We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.

Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.

Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.

9.5

Reduced anxiety

Most Useful Review

I have been taking this vitamin for over a month now, and I have noticed significant improvements in my quality of life. I used to frequently suffer from anxiety and depression, but since using this supplement, those symptoms have vanished.

Back Pain details

Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.

Vitamin D3 improves back pain

We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.

Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.

The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.

Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.

9.5

Eliminated back pain

Most Useful Review

Before taking this Vitamin D3, I had crippling pain in my joints, bones and muscles. After just one week, my deep aching pain has vanished. I now feel like an 18-year-old, with more energy than I’ve had in years. At 48, I previously felt like I was 88. This truly helps.

Celiac details

My family's hay fever symptoms dropped by 90% after starting vitamin D alongside a gluten-free diet. Previously, I faced severe symptoms. With vitamin D supplementation, I've been able to manage better without hospital visits or over-the-counter medications. I believe avoiding wheat flour is most effective, with vitamin D playing a significant supportive role.

Common Cold details

Shimizu Y, Ito Y, Yui K, Egawa K, Orimo H. Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. J Nutr Health Aging. 2018;22:491. doi:10.1007/s12603-017-0952-x

Based on 12 Researches

Vitamin D3 improves cold symptoms

We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.

Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.

Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.

9.5

Reduced illness frequency

Most Useful Review

This vitamin is essential for everyone, particularly for bolstering my immune system. I used to get sick frequently, especially from public transport. Since my daughter and I started taking vitamin D-3 regularly, we've both noticed a significant reduction in the common cold.

Pneumonia details

I began taking Now Foods Vitamin D-3 after a Covid infection. Within three weeks, I felt we quickly defeated the infection, with the acute phase lasting only about seven days and no pneumonia complications. I believe Vitamin D-3 significantly contributed to my recovery, and I plan to continue taking it for at least six months.

Tonsillitis details

Al-Rawashdeh BM, Altawil M, Khdair Ahmad F, Alharazneh A, Hamdan L, et al. Vitamin D Levels in Children with Recurrent Acute Tonsillitis in Jordan: A Case-Control Study. Int J Environ Res Public Health. 2022;19. doi:10.3390/ijerph19148744

Based on 9 Researches

Vitamin D may reduce tonsillitis

We aimed to understand the link between vitamin D deficiency and recurrent acute tonsillitis in children. In our study, we gathered data from 242 children suffering from repeated bouts of tonsillitis and compared it with a control group of 262 healthy children.

Our findings revealed that the average vitamin D levels were significantly lower in those with recurrent tonsillitis. Through detailed statistical analysis, we discovered that as vitamin D levels increased, the number of tonsillitis episodes decreased. Specifically, for every increase of one unit in vitamin D, we saw a 3.1% reduction in occurrences of tonsillitis each year.

These results strongly suggest that vitamin D deficiency may contribute to more frequent episodes of tonsillitis in children. To further enhance our understanding, we recommend future trials to explore the potential benefits of vitamin D supplementation for those frequently affected by this condition.

9.5

Stopped infections

Most Useful Review

This Vitamin works! My child, aged 10, takes it daily as a prophylactic. Since starting vitamin D3, I have stopped getting sick, particularly with recurrent tonsillitis. I am very pleased with the results!

Angina details

Vitamin D3 alleviates angina symptoms

Based on 11 Researches

Andishmand A, Ansari Z, Soltani MH, Mirshamsi H, Raafat S. Vitamin D replacement therapy in patients with cardiac syndrome X. Perfusion. 2015;30:60. doi:10.1177/0267659114526629

We aimed to understand how vitamin D3 treatment might help reduce angina and exercise-related ischemia in patients suffering from cardiac syndrome X and low vitamin D levels.

In our study, we treated patients with a course of vitamin D3 injections, delivered intramuscularly every other week for two months. We monitored the number of angina episodes per day as well as various measures of exercise capacity before and after the treatment.

By the end of the two-month protocol, we observed a striking increase in serum vitamin D levels to within a normal range. Most importantly, patients reported a significant reduction in angina frequency. We also noted improvements in exercise duration, work capacity, and a reduction in ST-segment depression during stress tests, which suggests a decrease in ischemia.

These findings support the idea that vitamin D3 replacement can dramatically improve the symptoms experienced by patients suffering from angina linked to cardiac syndrome X.

Cured angina episodes

Most Useful Review

Wonderful vitamin D3! Angina used to be my major issue; I would get it even in summer. After trying Russian D3 with no effect, I switched to a foreign brand. Within three months, I noticed new hair growth, stronger nails, and I stopped suffering from colds or angina completely. This vitamin has greatly improved my health.

Arthritis details

Vitamin D aids rheumatoid arthritis

Based on 26 Researches

Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9

We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.

Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.

Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.

Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.

Resolved health issues

Most Useful Review

This vitamin is the best supplement! I was prescribed it for depression, and after a month, I noticed a significant difference. I feel more energetic. My partner suffered from stomach issues and arthritis, but after taking this supplement, he overcame these problems and saw further improvements.

Bone Pain details

Vitamin D3 correction improves pain

Based on 3 Researches

Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002

We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.

9.5

Restored bone health

Most Useful Review

Vitamin D3 effectively strengthened my bones and boosted immunity. I recommend taking it before the cold season to combat bone pain.

Cardiovascular Disease details

Vitamin D reduces foam cell formation

Based on 17 Researches

Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. doi:10.1530/JOE-24-0056

We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.

Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.

In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.

Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.

8.8

Vital supplement

Most Useful Review

I'm pleased with the high efficiency of this 2000 IU dosage of Vitamin D3. It’s essential for maintaining adequate levels, supporting immunity and preventing issues linked to cardiovascular disease. I feel energised and healthier since I started taking it.

Dizziness details

Talaat HS, Kabel AM, Khaliel LH, Abuhadied G, El-Naga HA, et al. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx. 2016;43:237. doi:10.1016/j.anl.2015.08.009

Vitamin D treatment reduces BPPV

We sought to understand the impact of severe vitamin D deficiency on benign paroxysmal positional vertigo (BPPV), a common cause of dizziness. Previous studies showed a connection between low vitamin D levels and both the onset and recurrence of BPPV, but none had conclusively demonstrated that addressing this deficiency could lessen the recurrence of symptoms.

To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.

Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.

This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.

9.5

No more dizziness

Most Useful Review

I’m not typically one for supplements, but after experiencing dizziness with a cold, I tried this vitamin. I’m pleased I did! After about two months, my colds have vanished and my energy levels are outstanding.

Headache details

Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial. Neurol Sci. 2020;41:1183. doi:10.1007/s10072-019-04220-8

Based on 22 Researches

Vitamin D3 aids migraine relief

We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.

After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.

Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.

9.5

Eliminated headaches

Most Useful Review

Great product! Due to my deficiency of vitamin D3, this supplement has been lifesaving. The small capsules are easy to take, with an excellent dosage. I've noticed my immunity improve, headaches have ceased, and heart pain has stopped. The quality is exceptional, with no additives. After a month, my deficiency resolved, and I take one pill daily as prescribed. My children also take it during winter. It's well absorbed, and I strongly recommend it.

Heartburn details

It’s convenient to select the dosage and number of capsules on the website. This company offers the largest selection of vitamin D3. The capsules are small and easy to swallow, with no heartburn or unpleasant aftertaste. I highly recommend buying them.

Insomnia details

Sharifan P, Khoshakhlagh M, Khorasanchi Z, Darroudi S, Rezaie M, et al. Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial. Food Sci Nutr. 2020;8:4484. doi:10.1002/fsn3.1750

Based on 6 Researches

Vitamin D benefits for insomnia

We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.

In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.

Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.

In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.

Improved mood

Most Useful Review

I decided to take vitamin D due to its positive effects on my body and my love for the sun. I often feel sluggish and down during autumn, and I've noticed significant improvements after taking these vitamins. I chose a dosage of 2000 IU, as I hardly go outside and suffer from poor mood in colder months. Taking one small capsule in the morning has really helped lift my spirits and combat insomnia.

We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.

From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.

However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.

Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.

9.5

Effective detox

Most Useful Review

I take 2000 IU of vitamin D for health and detox. I prefer supplements since I avoid sunbathing. Since I began taking this, I haven't been catching colds, and I'm feeling much better overall.

Fibromyalgia details

Vitamin D improves fibromyalgia symptoms

Based on 25 Researches

Ersoy S, Kesiktas FN, Sirin B, Bugdayci D, Paker N. The effect of vitamin D treatment on quality of life in patients with fibromyalgia. Ir J Med Sci. 2024;193:1111. doi:10.1007/s11845-023-03521-4

We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).

After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.

Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.

Significant health recovery

Most Useful Review

I discovered vitamin D, which saved my mother from severe pain caused by fibromyalgia and osteoporosis. Despite ineffective treatments, her condition drastically improved after her vitamin D levels rose from critical deficiency. After taking 2,000 units daily, her health greatly improved, allowing her to regain strength. I urge anyone with elderly loved ones to consider vitamin D for unexplained ailments, as it can be life-changing.

Hashimoto details

Chahardoli R, Robat-Jazi B, Azizi F, Amouzegar A, Khalili D, et al. Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial. Endocr Metab Immune Disord Drug Targets. 2024;24:1454. doi:10.2174/0118715303273297231226153751

Based on 16 Researches

Vitamin D3 shows limited effect

We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.

Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.

On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.

This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.

9.5

Improved immunity

Most Useful Review

I've been taking vitamin D 5000 ui + MK7 for four months and my immunity has improved significantly! I previously fell ill every month during winter due to Hashimoto’s, but now my health has greatly benefited. My hair has stopped falling out, and new growth has started. I ordered the 2000 ui version for spring, when sunlight is limited. The capsules are small, easy to swallow, and tasteless. The product seems of high quality, and I appreciate the positive effects on my overall health, particularly my bones.

Heart Disease details

Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. doi:10.30476/ijms.2024.101112.3372

Based on 19 Researches

Vitamin D's role in heart health

We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.

The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.

Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.

9.5

Improved immunity

Most Useful Review

Excellent! Vitamin D3 promotes muscle tone, aids immunity, is crucial for thyroid function, and helps regulate blood pressure and heart rate. It may prevent the growth of cancerous cells. I take 2,000 to 5,000 IU during winter as a precaution.

Influenza details

Vitamin D3 may reduce influenza severity

Hayashi H, Okamatsu M, Ogasawara H, Tsugawa N, Isoda N, et al. Oral Supplementation of the Vitamin D Metabolite 25(OH)D Against Influenza Virus Infection in Mice. Nutrients. 2020;12. doi:10.3390/nu12072000

We aimed to understand how oral supplementation of 25-hydroxyvitamin D, a key metabolite of vitamin D3, influences influenza A virus infection in mice. In our study, mice were given a diet enriched with a high dose of 25(OH)D before they were exposed to the influenza virus.

The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.

These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.

9.5

Improves immunity

Most Useful Review

Vitamin D3 is essential for everyone. I recommend this manufacturer to my friends. It's particularly important for office workers living in areas with limited sunlight. It enhances immunity, supports bone health, and lowers the risk of ARVI and influenza. My family takes it for prevention with 2,000 IU every other day, and daily when ill.

Leg Cramps details

Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. doi:10.1002/14651858.CD010655.pub3

Very Likely Ineffective

Based on 2 Researches

Minimal effects of vitamin D

We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.

In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.

Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.

9.5

Reduced sweet cravings

Most Useful Review

I’ve struggled with cravings for sweets, particularly pies. After starting D3, I noticed a decrease in these cravings over time. My vitamin D levels rose from 16 to 28 after four months of taking D3 and selenium during the autumn-winter period, which has truly worked wonders for me, including reducing leg cramps.

Low Libido details

Enhances reproductive function

Maintaining a proper level of vitamin D is vital for many aspects, including immunological strength, healthy bones and muscles, preventing depression, and normalising reproductive functions, which encompasses increasing libido and rectifying erectile dysfunction. It also plays a role in heart health and enhances skin condition, resolving issues such as hyperpigmentation and dermatitis.

Menopause details

G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. doi:10.52225/narra.v4i1.452

Based on 11 Researches

Vitamin D supports bone health

We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.

9.5

Improves menopause symptoms

Most Useful Review

I absolutely love this vitamin product. It effectively enhances both my physical and mental well-being, helps maintain a healthy weight, and alleviates menopause symptoms. It has even won FDA approval.

Osteoporosis details

Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. doi:10.1016/j.jot.2024.10.011

Vitamin D's impact on osteoporosis

We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.

The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.

Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.

This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.

9.5

Supports healthy bones

Most Useful Review

We take vitamin D3 as a family. It is essential for preventing osteoporotic changes and supports growth, immunity, and other bodily functions. It's particularly important given the current health climate with Covid.

Rheumatoid Arthritis details

Vitamin D3 reduces rheumatoid arthritis inflammation

Zhu W, Zhu Y, Zhang S, Zhang W, Si Z, et al. 1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. J Steroid Biochem Mol Biol. 2023;228:106251. doi:10.1016/j.jsbmb.2023.106251

We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.

We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.

In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.

By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.

Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.

9.5

Improved energy levels

Most Useful Review

I was sceptical about the claims but decided to give this vitamin a try for health benefits. I fully recovered from some serious illnesses like rheumatoid arthritis and bronchitis, which had plagued me. I now have more energy, an improved mood, and greater vitality, which is amazing.

Sinusitis details

Vitamin D helps alleviate CRS symptoms

Baruah B, Gupta A, Kumar A, Kumar A. The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency. J Family Med Prim Care. 2020;9:2877. doi:10.4103/jfmpc.jfmpc_448_20

We explored the potential benefits of vitamin D supplementation for individuals suffering from Chronic Rhinosinusitis (CRS), a common condition marked by inflammation of the nose and sinus linings. In a study involving 200 patients with vitamin D deficiency, we divided participants into two groups: one receiving oral vitamin D supplements and the other receiving a placebo.

Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.

This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.

9.5

Sinusitis relief

Most Useful Review

In today's world, money is tight, so this company's vitamin D3 is both economical and effective. I have been taking it for two years, and thanks to it, my chronic sinusitis has ceased. Whenever I feel unwell, I supplement with zinc from the same brand, and I haven't been ill in about two years, which is fantastic for a postpartum mother.

Tinnitus details

Excellent! Since I began taking D3 2000 IU daily, I’ve not experienced sunburn, and remarkably, my tinnitus ceased after half a year. I had endured tinnitus since I was five, and now, at 63, I can finally enjoy peace without the ringing in my ears. This supplement has made a significant difference in my life.

Uterine Fibroids details

Vitamin D is vital for maintaining calcium and phosphorus levels in the blood, supporting musculoskeletal tissue health. It significantly influences the immune, cardiovascular, endocrine, hormonal, and nervous systems. A deficiency can lead to various health issues, including endometriosis and uterine fibroids. I take vitamin D from November to March, which has alleviated my chronic fatigue and headaches, increasing my vitality.

Yeast Infection details

Vitamin D exhibits antifungal activity

Based on 9 Researches

Lei J, Xiao W, Zhang J, Liu F, Xin C, et al. Antifungal activity of vitamin D against Candida albicans in vitro and in vivo. Microbiol Res. 2022;265:127200. doi:10.1016/j.micres.2022.127200

We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.

Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.

Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.

These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.

9.5

Reduced infections

Most Useful Review

Good vitamin D at a reasonable price. I store it in the fridge and take it with Omega in the mornings. We consume it all year round. Since starting vitamin D, my children's frequent acute respiratory viral infections have significantly decreased, and they rarely miss school. Even when they catch colds, they recover easily without complications. I highly recommend it!

Abscess details

I'm truly an inositol beneficiary. The polycystic cysts that had persisted for many years vanished after I used myo-inositol for two months. The results from my latest examination revealed no signs of polycystic cysts anymore, allowing me to prepare for pregnancy normally. Sisters, go for it; it's really beneficial!

Atrial Flutter details

Boosted energy levels

I had low vitamin D levels, leading to constant fatigue and atrial flutter, which left me feeling overwhelmed by the end of the day. After trying this vitamin with shock doses of 10,000, I felt a surge of strength and my heart didn’t trouble me anymore. I highly recommend this excellent vitamin D, but always consult your doctor before use.

Benign Tumor details

Crucial for hormone balance

No vitamin enhances health or well-being like vitamin D. No organ in the endocrine system can function properly without adequate vitamin D. Its deficiency is a leading cause of infertility in both men and women. Vitamin D regulates various hormones, particularly testosterone, which influences energy, fat burning, and sexual motivation. It also plays a role in maintaining the body's anti-tumour immunity from birth. Furthermore, lower mortality rates from cardiovascular diseases in summer highlight the importance of vitamin D. Deficiencies in vitamin D and zinc can lead to depression, thus demonstrating its significance for mental health.

Bruise details

Excellent vitamin D in a suitable dosage for children! My child swallows the capsule easily. I've noticed an improvement in mood, the bruises under their eyes have vanished, and they are very active now! I highly recommend it!

Chemotherapy details

Vital during treatment

Excellent vitamin D! I took it consistently throughout the year as a cancer patient receiving chemotherapy. The chemical treatments drained my vitamin D levels, and my doctor recommended this supplement. After testing, my levels improved significantly, and I've since reduced my dose to once a week. Vitamin D is truly essential in our lives.

Cholecystitis details

Vitamin D is essential for maintaining mineral levels like calcium and phosphorus, crucial for strong bones and overall musculoskeletal health. It supports correct posture and enhances immune, cardiovascular, and nervous systems. Moreover, it helps regulate metabolism and can aid in weight loss. Adequate levels of vitamin D are particularly vital for women, especially during pregnancy and postpartum, as it affects both maternal and fetal health. I noticed significant improvements after taking vitamin D, including a decrease in chronic fatigue and headaches, resulting in increased vitality. I highly recommend it.

Chronic Cough details

Improved immune response

Impressive! I believe vitamin D has significant immunomodulatory effects. My older brother had urticaria due to an overactive immune reaction, but he no longer suffers from it after taking this supplement. My younger brother frequently felt tired due to low vitamin D levels linked to a thyroid autoimmune condition. He’s much better now. It's advised to take a moderate dose throughout winter for optimum absorption, and it's best taken with a fat-rich meal rather than before bedtime, as it can interfere with melatonin levels.

Knee Pain details

Vitamin D3 shows promise for knee OA

Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0

We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.

Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.

Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.

Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.

9.5

Eliminated knee pain

Most Useful Review

Before taking this Vitamin D3, I suffered from crippling knee pain. After just one week of taking it and Coral Calcium Plus, the deep aching pain disappeared, and I have more energy than ever.

Lung Cancer details

Liang Y, Zhang X, Peng J, Liu J, Chen H, et al. Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL. J Cancer Res Clin Oncol. 2024;150:51. doi:10.1007/s00432-023-05586-1

Based on 19 Researches

Vitamin D's role in lung cancer

We explored the impact of vitamin D treatment on non-small cell lung cancer (NSCLC) and how it may influence mitochondrial functions in cancer cells. By utilizing small RNA sequencing, we identified various tRNA-derived small RNAs (tsRNAs) that were differentially expressed in lung cancer cells treated with vitamin D.

Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.

Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.

Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.

9.5

Vital for survival

Most Useful Review

I am consistently taking this vitamin D due to late-stage lung cancer. It’s crucial as I cannot access sunlight much.

Lupus details

Vitamin D enhances immune response in lupus

Based on 16 Researches

Mariz HA, Sato EI, Cardoso PRG, Gonçalves R, Duarte ALBP, et al. Vitamin D Presented In Vitro Immunomodulatory Property on T Lymphocyte-Related Cytokines in Systemic Lupus Erythematosus. Inflammation. 2023;46:730. doi:10.1007/s10753-022-01768-0

We explored how vitamin D influences immune responses in women with systemic lupus erythematosus (SLE). Blood samples from 27 patients were used to isolate immune cells and examine the impact of 1,25 dihydroxyvitamin D3 on various cytokines.

Our findings revealed that this form of vitamin D significantly reduced certain pro-inflammatory cytokines while simultaneously increasing beneficial ones, suggesting its potential to improve immune regulation in lupus. However, not all cytokine levels were affected.

Overall, vitamin D shows promise in helping manage inflammatory responses related to SLE.

9.5

Improved energy levels

Most Useful Review

I have been taking this vitamin D3 for a few months, and I have noticed a significant improvement in my energy and mood. I highly recommend it for anyone looking for a vegan-friendly option. The quality is excellent, and the size is suitable. I was advised to take this 2000 IU dosage, which has greatly enhanced my immunity as I cannot be out in the sun due to my lupus. The packaging is also good.

Stroke details

Vitamin D3 protects neurons from stroke

Qiao J, Ma H, Chen M, Bai J. Vitamin D alleviates neuronal injury in cerebral ischemia-reperfusion via enhancing the Nrf2/HO-1 antioxidant pathway to counteract NLRP3-mediated pyroptosis. J Neuropathol Exp Neurol. 2023;82:722. doi:10.1093/jnen/nlad047

We explored the potential benefits of vitamin D3 (specifically, 1,25-vitamin D3) for protecting the brain during events such as strokes caused by impaired blood flow, known as cerebral ischemia-reperfusion injury (CIRI). In this study, rats received vitamin D3 supplementation for a week before undergoing a procedure that mimicked a stroke. The results were striking; those treated with vitamin D3 showed significant improvements in neurological function, with reduced areas of brain damage and more surviving neurons.

We also tested the effects of vitamin D3 on rat cortical neurons in a laboratory setting, specifically observing its influence on cell survival during oxygen-glucose deprivation and reoxygenation (a model for stroke). The vitamin D3 treatment not only improved cell viability but also appeared to reduce cell death and inflammation. Our analyses revealed that vitamin D3 boosts important protective proteins in the brain, which help combat oxidative stress and inhibit pathways linked to inflammatory cell death.

Overall, our findings strongly suggest that vitamin D3 could be a valuable resource in stroke management by protecting neurons through its antioxidant actions and reduction of harmful inflammation.

9.5

Cognitive protection

Most Useful Review

For those over 50 or recovering from a stroke, this Vitamin D3 is excellent. It boosts digestibility and is effective against strokes, dementia, and various cancers. I've felt improvements since starting it!

Swollen Lymph Nodes details

Wonderful! Effective! Initially, I took Ukrainian Vit. D3, then switched to this one, consumed it for three months, and repeated the analysis. The result after taking 78 is normal—I raised my levels twofold! I have problems with the thyroid gland (swollen lymph nodes), and I’m considering purchasing iodine here instead of Iodomarin. Overall, Vit. D3 is good and effective.

Tuberculosis details

Vitamin D improves EPTB treatment outcomes

Based on 12 Researches

Eletreby R, Elsharkawy A, Mohamed R, Hamed M, Kamal Ibrahim E, et al. Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis. BMC Infect Dis. 2024;24:681. doi:10.1186/s12879-024-09367-0

We assessed vitamin D levels in patients with extrapulmonary tuberculosis (EPTB) and evaluated the effects of vitamin D3 supplementation on their treatment.

In our study, 47 EPTB patients received vitamin D3 or standard anti-TB treatment alone. We found that vitamin D levels were much lower in EPTB patients compared to healthy controls.

Those receiving vitamin D3 showed improvements, such as better weight gain, higher albumin and hemoglobin levels, and reduced inflammation markers, suggesting that vitamin D supplementation can enhance anti-TB therapy.

9.5

Antidepressant effects

Most Useful Review

These vitamins are well absorbed and enhance immunity, improving calcium and phosphorus metabolism. They serve as excellent antidepressants and possess both anti-tuberculosis and antifungal effects. Our entire family has benefited from these during the off-season, with a practical preventive dosage.

Ulcer details

Halschou-Jensen PM, Sauer J, Bouchelouche P, Fabrin J, Brorson S, et al. Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial. Int J Low Extrem Wounds. 2023;22:466. doi:10.1177/15347346211020268

Vitamin D3 improves ulcer healing

We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.

Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.

In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.

9.5

Stronger immunity

Most Useful Review

I regularly take vitamin D3, which is vital for my immune system and overall health. After taking 2000 units daily, I haven't faced respiratory issues in over a year, and my ulcer problems have improved significantly.

Breast Cancer details

Schömann-Finck M, Vogt T, Reichrath J. Umbrella Review on the Relationship Between Vitamin D Intake and Cancer. Anticancer Res. 2025;45:855. doi:10.21873/anticanres.17474

Vitamin D and breast cancer link

We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.

While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.

Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.

Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.

8.3

Reduces cancer risk

Most Useful Review

Vitamin D (D3) is key for overall health and may protect against breast cancer and other conditions. I take it daily with food, and I appreciate its small, easy-to-swallow tablets, which have reassured me during these challenging times.

Bronchitis details

Vitamin D3 improves immune function

Based on 4 Researches

Babarykin DA, Vasipa SB, Gintere GB, Bigestan VIa. [Immunocorrecting properties and effect on the phosphorus-calcium metabolism of oxidevit (1 alpha-hydroxyvitamin D3)]. Vopr Med Khim. 1988;34:104.

We explored the impact of 1 alpha-hydroxyvitamin D3, commonly known as vitamin D3, on patients with chronic bronchitis, focusing on its potential benefits for the immune system and calcium-phosphorus metabolism. In this study, 45 patients received doses of either 2 or 4 micrograms of the vitamin over a period of 1 to 2 weeks.

Our findings revealed that the treatment led to observable changes in the metabolism of calcium and phosphorus. The alterations depended on the specific dose and duration of the treatment. Notably, the higher dose of 4 micrograms daily over two weeks was identified as excessive.

We also assessed various immune system components, such as total and rosette-forming cells, T-lymphocyte helpers and suppressors, and B lymphocytes. All these immune parameters showed significant normalization, regardless of the patients' initial levels. Elevated values tended to decrease, while those that were low increased back towards normal. It’s essential to note that despite these positive changes, the immune patterns remained stable throughout the treatment period.

Interestingly, we found a correlation between blood inorganic phosphorus levels and the dynamics of leukocytes, suggesting an interaction between immune responses and mineral metabolism. Overall, vitamin D3 treatment demonstrates a noteworthy effect on improving immune system function in chronic bronchitis patients, supporting its role as an adjunct therapy in managing this condition.

9.5

Quick recovery

Most Useful Review

This vitamin D has had a positive effect on my well-being: no spring blues or vitamin deficiency, and I caught bronchitis but recovered quickly without antibiotics. Cuts heal faster now, which is wonderful.

Chest Pain details

Vitamin D deficiency affects symptoms

Based on 8 Researches

Khater WA, Alfarkh MA, Allnoubani A. The Association Between Vitamin D Level and Chest Pain, Anxiety, and Fatigue in Patients With Coronary Artery Disease. Clin Nurs Res. 2023;32:639. doi:10.1177/10547738221126325

We aimed to understand how vitamin D deficiency (VDD) might influence symptoms like chest pain, anxiety, and fatigue in people living with coronary artery disease (CAD). In our investigation, we collected data from 90 CAD patients, focusing on their vitamin D levels and experiences with these symptoms.

The findings were quite revealing. A significant 80% of the participants were found to have low vitamin D levels. Interestingly, we discovered that lower vitamin D levels were linked to increased chest pain and heightened anxiety and fatigue. Specifically, there were strong negative relationships noted: as vitamin D levels dropped, chest pain, anxiety, and fatigue scores rose.

This suggests that addressing vitamin D deficiency might be an important step for managing cardiac-related symptoms in patients with CAD. As this connection unfolds, it seems valuable for healthcare providers to monitor vitamin D levels in CAD patients and consider interventions to correct deficiencies.

9.5

Eliminated chest pain

Most Useful Review

After discovering the link between vitamin D deficiency and my severe lower back pain, I took 5000 IU and was amazed—my pain vanished overnight. It was enlightening to see how this deficiency played a role in my condition.

Eczema details

Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128

Vitamin D reduces eczema severity

We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.

Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.

Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.

9.5

Eczema improvement

Most Useful Review

A fantastic supplement that everyone needs. I order it for my 11-year-old daughter, and it's been effective; her eczema on her hands has disappeared.

Frozen Shoulder details

Significant improvement

After taking vitamin D3, my frozen shoulder pain improved remarkably. I had been suffering from back pain for nearly a month, and within two days of starting the supplement, my pain disappeared. It also helped lift my spirits during a period of depression.

High Cholesterol details

Vitamin D lowers cholesterol levels

Based on 20 Researches

Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. doi:10.1615/CritRevImmunol.2024052129

We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.

Improved metabolism

Most Useful Review

Excellent vitamin D. As many know, we often lack it, and it aids calcium absorption, supports the immune system, and promotes bone and muscle function. Additionally, it enhances metabolism and lowers high cholesterol levels. We take a preventive dose of 2,000 IU. The soft capsules are small and easy to swallow with water. It is advisable to avoid coffee and strong tea for optimal vitamin absorption.

Mild Cognitive Impairment details

Comprehensive benefits

Taking Vitamin D3 is paramount as it aids in bone development and absorption of key minerals like phosphorus and calcium. It's suitable for vegetarians and contributes to skin health, metabolic improvements, and immune support. Regular intake is essential to prevent osteoporosis and rickets. It also normalises hormone production and could aid in preventing cancer and dementia.

Prostate Cancer details

Vitamin D may reduce prostate cancer mortality

Based on 25 Researches

Vaselkiv JB, Shui IM, Grob ST, Ericsson CI, Giovannucci I, et al. Intratumoral vitamin D signaling and lethal prostate cancer. Carcinogenesis. 2024;45:735. doi:10.1093/carcin/bgae055

We set out to understand how vitamin D signaling within prostate cancer tumors might impact patient outcomes, particularly the risk of developing lethal forms of the disease. In our exploration, we analyzed data from 404 men with primary prostate cancer over a long follow-up period, assessing specific gene expressions linked to vitamin D in their tumor tissues.

Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.

Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.

8.8

Increased energy

Most Useful Review

I've been taking this vitamin since my prostate cancer diagnosis on my doctor's recommendation. After nearly 3 months, I've noticed an increase in energy and mood, along with a significant decrease in fatigue. The overall quality of life is still being assessed, but there has been a notable improvement thus far.

Reflux details

Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056

Based on 2 Researches

Vitamin D3 may aid inflammation

We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.

The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.

Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.

8.3

Effective alternative treatment

Most Useful Review

I was recently informed that Vitamin D is preferable to Vitamin C. Since I occasionally suffer from reflux, Vitamin D has been a remarkable alternative for me.

Whooping Cough details

Whenever I sense I'm getting a cold with a slight runny nose or cough, I immediately take this vitamin, and the next day, the symptoms vanish. It’s been a true godsend, and I've ordered it for myself and my family multiple times.

Anemia details

Ahmad Fuzi SF, Su Peng L, Zabaha Zalbahar N, Ab Manan N, Mohamad Alwi MN. Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial. PLoS One. 2022;17:e0265772. doi:10.1371/journal.pone.0265772

Based on 10 Researches

Vitamin D3's role in anemia

We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.

Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.

Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.

As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.

9.5

Effective treatment

Most Useful Review

I was vitamin D deficient and took this supplement. I checked my levels afterward, and to my surprise, they improved. I took it consistently before meals, though some may require higher dosages.

Autoimmune Disorder details

Vitamin D3 modulates autoimmune response

Zhang Q, He X, Chen W, Jiu J, Gao C, et al. Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis. Immunol Lett. 2024;269:106890. doi:10.1016/j.imlet.2024.106890

We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.

Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.

Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.

9.5

Immunomodulatory effects

Most Useful Review

I believe that vitamin D has excellent effects on the immune system. My older brother’s urticaria caused by an overactive immune reaction has resolved after taking it. My younger brother’s fatigue, linked to an autoimmune disorder, improved with vitamin D as well. I've learned that a moderate dose over several months is more beneficial than a high dose for a short period. It's best taken with a rich-fat meal and not before sleep as it can disrupt melatonin levels.

Bloating details

Sanaei M, Banasiri M, Shafiee G, Rostami M, Alizad S, et al. Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction. J Diabetes Metab Disord. 2015;15:9. doi:10.1186/s40200-016-0231-0

Likely Very Effective

Based on 4 Researches

Vitamin D3 may reduce bloating

We aimed to assess how the supplement OsteoCalVitFort, which includes 500 mg of calcium and 400 I.U. of vitamin D3, affects bloating and overall satisfaction among users. In our study, 186 participants aged between 18 and 65 were invited to take two tablets daily—one after breakfast and one after dinner—over a period defined by the contents of a single pack.

After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.

With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.

9.5

No more bloating

Most Useful Review

I was recommended by a doctor to take vitamin D3, 2000 IU. I previously tried a different D3 vitamin which caused bloating and stomach pain. However, since taking Now Foods' vitamin D3, I feel much better and my digestion is fine. I'm now on my third or fourth bottle and will definitely continue taking it.

Hives details

Vitamin D may alleviate chronic hives

Yuan I, Katari P, Shaker M. Vitamin D treatment for chronic urticaria: a case report. J Med Case Rep. 2019;13:193. doi:10.1186/s13256-019-2121-9

We explored the intriguing connection between vitamin D and chronic hives, also known as chronic urticaria. This condition involves recurring itchy welts that can be quite frustrating, especially when the triggers are often elusive. In this case, we observed a 14-year-old boy suffering from persistent hives that weren’t responding to conventional treatments. Thankfully, during his medical evaluation, we discovered he had a vitamin D deficiency.

The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.

Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.

9.5

Chronic hives relief

Most Useful Review

This excellent product helped me eliminate chronic hives that were unresponsive to other medications.

Hypothyroidism details

Vitamin D improves thyroid function

Based on 18 Researches

Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. doi:10.1097/MD.0000000000036759

We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.

The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.

Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.

Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.

9.5

Improved mood

Most Useful Review

The supplement effectively boosted my vitamin D levels, improving my immune function significantly. Since taking it, I’ve experienced fewer relapses of herpes and a general uplift in my mood. My previous apathy has dissipated, and I'm no longer feeling close to depressive. I've been using this for several months with breaks, cautiously managing the dosage to avoid complications.

Irritable Bowel Syndrome details

Huang H, Lu L, Chen Y, Zeng Y, Xu C. The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Nutr J. 2022;21:24. doi:10.1186/s12937-022-00777-x

Based on 27 Researches

Vitamin D benefits IBS patients

We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.

Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.

Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.

9.5

Promotes immunity

Most Useful Review

Vitamin D3 is vital for everyone, reducing the risk of viral diseases and respiratory tract infections. It's essential for immunity and addresses irritable bowel syndrome. D3 controls the absorption of key minerals and supports bone health. Due to limited sunlight, many lack sufficient D3, so supplementation is beneficial. I recommend D3 from NOW; it's high quality and reasonably priced. Almost everyone needs this vitamin!

Multiple Sclerosis details

Robat-Jazi B, Oraei M, Bitarafan S, Mesbah-Namin SA, Noori-Zadeh A, et al. Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice. Iran J Allergy Asthma Immunol. 2023;22:452. doi:10.18502/ijaai.v22i5.13995

Based on 30 Researches

Vitamin D3 alleviates MS symptoms

We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.

We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.

Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.

Boosts immunity

Most Useful Review

Solar cell D3 is essential for everyone. It enhances immunity, reduces the risk of viral diseases, and is vital for various bodily functions. In our area, sunlight is limited, making D3 supplementation crucial. I prefer NOW Vitamin D3, as it offers excellent quality at a reasonable price.

Psoriasis details

Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. doi:10.1038/s41598-024-72951-6

Based on 14 Researches

Vitamin D3 ethosomes for psoriasis

We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.

In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.

Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.

9.5

Reduced psoriasis impact

Most Useful Review

I prefer NOW brand vitamins for my family. Vitamin D3 is essential. My brother benefited greatly from it for his psoriasis, which has improved significantly. I take it regularly, and it's advisable to test for the right dosage, as deficiency is common.

Blood Clot details

Vitamin D counteracts blood clotting

Based on 18 Researches

Cimmino G, Conte S, Morello M, Pellegrino G, Marra L, et al. Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?. J Cardiovasc Dev Dis. 2022;9. doi:10.3390/jcdd9010027

Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.

Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.

Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.

9.5

Improved blood clotting

Most Useful Review

Vitamin D3 helps normalise blood clotting, enhances insulin sensitivity, and prevents cholesterol buildup in blood vessels. It significantly boosted my immune system, and after just six months of taking D3 and K2, my previously bumpy nails improved.

Cancer details

Vitamin D3 offers anti-cancer benefits

Based on 14 Researches

Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. doi:10.3389/fimmu.2025.1529007

We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.

8.8

Increased energy

Most Useful Review

I’ve been taking this vitamin since my cancer diagnosis as recommended by my doctor. It’s been nearly three months, and I’ve noticed a boost in energy and mood, along with a decrease in fatigue. The impact on my quality of life is still uncertain, but the improvement has been promising so far.

Hypertension details

Calcitriol reduces age-related hypertension

Based on 6 Researches

Hua R, Liu B, He W, Zhang H, Liu Y, et al. Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function. Clin Exp Hypertens. 2023;45:2277653. doi:10.1080/10641963.2023.2277653

We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.

Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.

Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.

Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.

8.3

Vital for hypertension

Most Useful Review

Good composition of lanolin. Vitamin D (D3) is vital for health, possibly preventing serious ailments. Studies show that optimal vitamin D levels can lower the risk of heart attacks and hypertension. I took 2000 units during the pandemic with food.

Ovarian Cancer details

Recommended by doctor

Under medical advice, I've started taking this vitamin due to my daughter's polycystic ovary issue. The doctor mentioned its role in preventing ovarian cancer and colorectal cancer. My family has a history of autonomic nervous system disorders, and this vitamin has been included in our supplement plan. I intend to continue using it and will recommend it warmly.

Pelvic Pain details

Pelvic pain alleviated

Great. I suffered from terrible pelvic pain, thinking it was a spine issue. Luckily, after watching Dr. Berg's video, I realised it might be due to vitamin D deficiency. I took 5000 iu, and the next day, the pain disappeared.

Sleep Apnea details

Vitamin D3 improves mild sleep apnea

Based on 10 Researches

Ayyıldız F, Yıldıran H, Afandiyeva N, Gülbahar Ö, Köktürk O. The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome. Turk J Med Sci. 2021;51:2524. doi:10.3906/sag-2101-83

We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.

By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.

Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.

9.5

Improved sleep quality

Most Useful Review

It effectively addressed my husband's nocturia and my own sleep issues. Previously, I would wake at least twice nightly, feeling exhausted. After taking this vitamin D supplement daily, I noticed immediate improvements in my sleep quality, allowing me to rest through the night. It's considerably cheaper than other products I tried, and I’m grateful for NOW Foods and iHerb.

Acne details

Hasamoh Y, Thadanipon K, Juntongjin P. Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis. Dermatology. 2022;238:404. doi:10.1159/000517514

Vitamin D's effect on acne

We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.

Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.

This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.

9.5

Cleared acne

Most Useful Review

Great for acne! I started taking this for my health, but it significantly improved my acne. After about two weeks, my facial acne had completely disappeared. If you struggle with rough skin, I highly recommend this.

Alzheimer details

Vitamin D may aid Alzheimer treatment

Based on 22 Researches

Kang J, Park M, Kim T. Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2024;97:1939. doi:10.3233/JAD-231033

We aimed to understand how vitamin D influences the progression of Alzheimer’s disease (AD) by examining its effects on the brain. Our study involved male 5xFAD mice that underwent various dietary regimes and received vitamin D injections. This allowed us to investigate both vitamin D deficiency and supplementation in relation to AD symptoms.

Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.

This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.

Improved mood

Most Useful Review

I discovered Vitamin D through Anton's videos, noting its importance in regulating various bodily functions. Despite its fat-soluble nature, I learned that high dosages are safe and beneficial. After ordering this supplement, I found that it alleviated my autumn blues and helped me recover quickly from illnesses. Vitamin D appears crucial in combating Alzheimer’s and other conditions, emphasising its role in overall health.

Asthma details

Niu H, He H, Zhao Z, Lu X, Zhao G. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference. Technol Health Care. 2024;32:3985. doi:10.3233/THC-231462

Based on 31 Researches

Vitamin D improves asthma outcomes

We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.

To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.

Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.

9.5

Effective under supervision

Most Useful Review

A child with bronchial asthma was found to have low vitamin D levels. Under the allergist’s supervision, we followed a treatment plan with this vitamin. Now, the child is in remission, which could be due to the treatment and vitamin D. It’s a good medication, but it must be taken with medical oversight.

Blurred Vision details

Vision improvement confirmed

Good quality vitamin D3 with beneficial ingredients. I’ve noticed eye benefits and improvement in my vision, and it tastes good too.

Indigestion details

I purchased vitamin D capsules from the pharmacy and experienced indigestion. I found it difficult to drink them. Consequently, I ordered NOW vitamin D3 (2000 IU) - the soft capsules are easy to swallow with no issues with my stool. The dosage is fantastic, with just 1 capsule required per day!

Liver Disease details

Derogar Kasmaei SR, Parastouei K, Hosseini Ahangar B, Saberifiroozi M, Taghdir M. Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial. BMJ Nutr Prev Health. 2024;7:e000938. doi:10.1136/bmjnph-2024-000938

Vitamin D improves liver health

We explored the effects of vitamin D supplementation in patients with liver cirrhosis—a progressive disease that often manifests alongside vitamin D deficiency. In a carefully designed study, we involved sixty patients who participated in a double-blind, randomized controlled trial. Each patient received either a weekly dose of 50,000 IU of vitamin D or a placebo over 12 weeks.

Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.

Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.

8.8

Reduced inflammation

Most Useful Review

I have had rheumatoid arthritis for more than 27 years, and because of my condition, I struggle with movement and joint inflammation. Since taking NOW Foods vitamin D-3, 50 micrograms (2,000 IU), the inflammation and pain from my joints have reduced considerably. I find this product effective, and my children also take it. If you find my sharing helpful, please give me a thumbs up.

Nausea details

Vitamin D and nausea in gastroparesis

Based on 2 Researches

Koch KL, Parkman HP, Yates KP, Van Natta ML, Grover M, et al. Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity. Dig Dis Sci. 2024;69:2904. doi:10.1007/s10620-024-08520-8

We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.

Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.

While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.

9.5

No nausea

Most Useful Review

I avoided the vaccine and started taking it to prevent corona. It seems effective in preventing upper respiratory inflammation, as I'm now less prone to colds. Previously, when I took 5000 IU, I experienced nausea and loss of appetite from side effects, but this caused none.

Obesity details

Vitamin D reduces triglycerides effectively

Based on 12 Researches

Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226

We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.

Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.

Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.

Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.

8.8

Improved well-being

Most Useful Review

Since I started taking vitamin D, I've noticed improvements such as reduced drowsiness and increased energy. This vitamin is essential not only for bones but also for metabolic health. Adequate vitamin D intake reportedly lowers the risk of obesity and metabolic syndromes. I recommend consulting a doctor before starting.

Autism details

For my 6-year-old son with autism, this Vitamin D3 has been perfect amid deficiency. After just a month, his levels doubled, and he swallows it easily. Our doctor has recommended regular use, and I plan to continue ordering it.

Heart Attack details

Yang S, Wang C, Ruan C, Chen M, Cao R, et al. Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction. Cells. 2022;11. doi:10.3390/cells11101676

Calcitriol aids heart recovery

We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.

Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.

We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.

6.8

Improved mental clarity

Most Useful Review

While I didn’t feel less tired, my stamina improved. After a good night’s sleep, I wake up alert. This supplement hasn't dramatically changed my life, but I haven’t suffered from headaches or high blood pressure for three months. Panic attacks and anxiety have also diminished.

Migraine details

Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. doi:10.1016/j.ajem.2021.07.062

Based on 34 Researches

Vitamin D helps reduce migraines

We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.

9.5

No more migraines

Most Useful Review

Now Foods offers an excellent product. I adore Vitamin D3, especially as I rarely go out, even pre-pandemic. I used to suffer from migraines, but since taking these capsules, I no longer experience headaches or joint pain. My sleep has significantly improved.

Rash details

Relieves itching effectively

Good way to meet your daily vitamin D intake. Since quarantine, it's been difficult to go out often, and I found my vitamin D levels had dropped, causing some skin issues. I started taking this, and it helps relieve the itch and rashes.

Diarrhea details

No significant benefit from vitamin D3

Based on 14 Researches

Aluisio AR, Maroof Z, Chandramohan D, Bruce J, Mughal MZ, et al. Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial. Pediatrics. 2013;132:e832. doi:10.1542/peds.2012-3986

We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.

Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.

However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.

Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.

Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.

9.5

Vitamin D importance

Most Useful Review

A deficiency of vitamin D can lead to gastrointestinal disruptions like belching, bloating, and diarrhea. It's vital to take vitamin D for better health. NOW's vitamin D is a fantastic choice with 240 capsules at 2000 IU.

Kidney Stones details