Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
The product is found useful for the following medical conditions
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.8
10
Drastic improvement
Most Useful Review
I did a blood test, revealing that methylfolate could be beneficial due to my lifelong heartburn issues. This pill has transformed my life—just one a day has dramatically reduced my heartburn symptoms. I highly recommend it for others with similar issues. It’s high quality, small, and effective.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9
Reduced homocysteine levels
Most Useful Review
221 people found this helpful
My blood tests revealed elevated homocysteine, which can indicate poor lifestyle choices and heightens the risk of heart and vascular issues. I discovered I have folic acid malabsorption, so I was prescribed Methylfolate instead. After 2 weeks of taking 4000 mcg daily, my homocysteine dropped from 14 to 5.8. I now take 800 mcg per day.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
9
Improved sleep quality
Most Useful Review
145 people found this helpful
My doctor recommended 5-MTHF due to high homocysteine levels that link to inflammation and insomnia. After just three days of taking it, I was sleeping through the night.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Reduced leg swelling
Most Useful Review
I purchased this on a doctor's recommendation. I follow a regimen including biorutin, horse chestnut, and vitamin C to support my veins. The combination has proven effective—my legs feel lighter and the swelling has subsided.
Neuropathy details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Effective methylfolate
Most Useful Review
133 people found this helpful
This works for me. I have MTHFR and peripheral neuropathy. Many medications worsen my condition. This methylfolate is effective without fillers that aggravate my neuropathy. I take 2-3 daily and am tolerating it well.
Back Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
9
Deficiency solved!
Most Useful Review
34 people found this helpful
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.3
USERS' SCORE
Good
Based on 8 Reviews
8.5
9
Folate alleviates dizziness symptoms
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
10
Dizziness gone
Most Useful Review
1 people found this helpful
I used to experience slight dizziness when standing, but after using this product, it completely disappeared. Thank goodness, I have requested it several times.
Abscess details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Discomfort alleviated
Most Useful Review
Excellent shape and effect. During ovulation, I experienced unpleasant sensations in my lower abdomen, feeling full. An ultrasound revealed an ovarian cyst. The gynaecologist suggested hormonal pills, but due to previous side effects, I chose not to follow this advice. I learned that folic acid could help, and after completing the course, the discomfort vanished, and my menstruation became more regular. I highly recommend it to women facing similar issues! There are no overdoses from methylfolate, and it seems to have no side effects, so I believe it can be taken without prior consultation.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
9
Decreased acne spots
Most Useful Review
1 people found this helpful
Very good. Excellent for the skin; since I started using it, I have noticed a decrease in acne spots. Additionally, my hair feels shinier, falls out less, and my hair and nails have grown faster.
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Effective relief noted
Most Useful Review
At the first signs of the illness, such as perspiration and sore throat, I give the child 3-4 pieces a day after meals. It helps immensely and quickly alleviates discomfort. No side effects were noted.
Adrenal Gland Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
7.5
Increased energy
Most Useful Review
17 people found this helpful
Great! Initially, I was taking one tiny capsule per day, but recently I learned about my MTHFR issue, which could be impacting me. I tried taking 10 of these (4 mg) over two consecutive days to see if it would help. Remarkably, I felt energetic for five days and found it easier to wake in the mornings. Even after a heavy drinking weekend, I didn't suffer from my usual severe hangovers. Normally, I require 12 hours of sleep due to adrenal fatigue, yet during this period, I managed to get by on just 9 hours. After five days, the effects diminished, so I plan to increase my intake.
Diabetes details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.4
7
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
9
Improves feline health
Most Useful Review
I purchased methylfolate for my diabetic cat, which developed diabetic neuropathy. After four months on a regimen of methylcobalamin and methylfolate, the improvement was noticeable within a month. I plan to continue this treatment for my cat's ongoing health.
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We explored the effectiveness of a special combination of micronutrients, including folate, in helping patients who suffer from recurrent upper respiratory tract infections, commonly known as colds. Our study involved 192 participants over 16 weeks in a randomized, placebo-controlled, double-blind trial that allowed us to compare results objectively.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
7.5
Effective cold relief
Most Useful Review
The doctor recommended this product to me for when I have a common cold. I usually take two tablets, which act like a dose of folic acid. It's very helpful for those who struggle to absorb B vitamins.
Hot Flashes details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
We conducted a study with 70 menopausal women, randomly assigning them to receive either folic acid or a placebo for four weeks. Through questionnaires and hot flash diaries, we monitored changes in the severity, duration, and frequency of hot flashes.
Our findings revealed that folic acid treatment significantly reduced all three measures of hot flashes compared to the placebo, particularly in the later weeks of the treatment. This suggests that folic acid could be a valuable, low-risk option for managing menopausal hot flashes.
Our findings revealed that folic acid treatment significantly reduced all three measures of hot flashes compared to the placebo, particularly in the later weeks of the treatment. This suggests that folic acid could be a valuable, low-risk option for managing menopausal hot flashes.
9
Reduced flushing
Most Useful Review
As I have considerable white hair, I tried active folic acid for the first time. After a week, I feel fine. I no longer experience the redness and hot flashes that came with niacin. The price is reasonable, though the packaging is somewhat basic. If it proves effective, I will purchase it again.
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
Folic Acid Improves Cognitive Function
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
9
Highly absorbable
Most Useful Review
Highly absorbable and well tolerated, I am taking this supplement following a vitamin B9 deficiency linked to my hypothyroidism. Methylfolate is the active form of folic acid, directly assimilated by the body and crossing the blood-brain barrier. This product is of good quality and easy to take.
Polycystic Ovary Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.3
7.5
Effective treatment
Most Useful Review
6 people found this helpful
I recommend this drug; it was effective in combination with inositol for treating Polycystic ovary syndrome.
Psoriasis details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 4 Reviews
8.3
8
Folate's role in psoriasis management
We explored the relationship between homocysteine levels and psoriasis, with particular attention on how folate treatment may influence this chronic skin condition. Recent findings have shown that individuals suffering from psoriasis typically have elevated serum homocysteine levels. This condition, known as hyperhomocysteinaemia, can be associated with deficiencies in essential nutrients like folic acid and vitamin B12.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
9
Notable skin improvement
Most Useful Review
It was prescribed by a naturopath to enhance skin condition in psoriasis. I noticed a significant improvement within one month.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
USERS' SCORE
Good
Based on 17 Reviews
8.3
7
Folic acid linked to OSA severity
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
9
Improved sleep quality
Most Useful Review
21 people found this helpful
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Allergies details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 13 Reviews
8.2
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
9
Improved tolerance
Most Useful Review
27 people found this helpful
Do you know your homocysteine levels? For women planning a pregnancy, this indicator is crucial. My levels were about 9, too high. I ordered this supplement due to my severe allergies to folic acid. After a month, my levels dropped to 7, indicating effectiveness. I tolerate it well, with no allergies. I took one capsule daily after meals, and notably, I felt clearer-headed and more cheerful, which likely improved my performance as well. I highly recommend it!
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 16 Reviews
8.2
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
9
Lowered homocysteine level
Most Useful Review
27 people found this helpful
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Good
Based on 19 Reviews
8.2
8
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
9
Significant improvement
Most Useful Review
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.2
9
Ideal vegan supplement
Most Useful Review
Jarrow Formulas Vegan Methylfolate is a high-quality supplement, ideal for those seeking a natural source of active folic acid. With an extra concentration of 400 mcg per capsule, it supports metabolism and the nervous system. This vegan option is perfect for plant-based diets, with 60 capsules ensuring a long-term supply. It improves energy without causing niacin flush, making it convenient for daily use. I highly recommend it for overall well-being!
Low Libido details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
Increased libido
Most Useful Review
Great product! Methyl Folate, unlike folic acid, has an excellent formula for absorption. The quality is high, and I trust this company. The ingredients are natural, the capsules are small, and the taste is neutral, packaged in plastic. I noticed results after the first month of taking it. Personally, my libido increased. I recommend buying it.
Autism details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.1
7.5
Improved focus
Most Useful Review
8 people found this helpful
Works great! I've been using these for my ADD symptoms, and they help me focus. My 12-year-old daughter, who has autism and ADHD, has been given them too. She is now able to focus and express herself more effectively. Great product!
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.1
8
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9
Guaranteed regularity
Most Useful Review
1 people found this helpful
After starting folate on my doctor's advice, my menstrual cycle became regular and my pain disappeared, which is quite pleasing.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 14 Reviews
8.1
7
We formulated a functional food product designed specifically for elderly individuals with Parkinson's disease, focusing on the common issue of constipation. Our approach involved creating a muffin recipe enriched with inulin, cacao, and Moringa, all of which play a role in supporting digestive health.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
9
Convenient to consume
Most Useful Review
1 people found this helpful
Very straightforward! It's really convenient to take. Other folic acids cause constipation, but this one does not. I'm preparing for pregnancy, so I'm taking it with my husband!
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.1
USERS' SCORE
Good
Based on 26 Reviews
8.1
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
9
Potential depression aid
Most Useful Review
86 people found this helpful
Methylfolate, or (6S)-5-MTHF, is the most effective form of folate, easily absorbed and critical for human health. It helps control homocysteine levels, supports cell growth, and reduces risks of developmental defects in infants. Methylfolate also positively influences cognitive functions, making it valuable for depression treatment. Studies show it can lower homocysteine levels, which, when elevated, is linked to cardiovascular diseases. It's crucial to choose methylfolate over standard folic acid, which is poorly absorbed and can hinder essential nutrient absorption from food.
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
USERS' SCORE
Good
Based on 14 Reviews
8.1
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
9
Reduced heart disease risk
Most Useful Review
221 people found this helpful
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
Liver Disease details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 7 Reviews
8.1
9
Folate treatment aids liver fat reduction
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
9
Supports liver function
Most Useful Review
1 people found this helpful
Methylfolate is an easily absorbed, active form of folate that is essential, especially for women during pregnancy. It aids liver function and detoxification, while positively influencing my skin and hair. I take it due to folate cycle mutations and use it alongside B12 for better absorption. Dosage varies based on B9 levels and mutation type. I take it with food, but it's also fine on its own.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 26 Reviews
8
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
9
Hormonal balance restored
Most Useful Review
115 people found this helpful
My wife, who has an autoimmune disorder related to hormonal imbalance, was prescribed folic acid and vitamin E. After trying a "pharmacy course", we sought a better quality supplement from iHerb, which proved beneficial, resulting in her improved health.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 50 Reviews
8
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
9
Reduces homocysteine levels
Most Useful Review
301 people found this helpful
Fully active folate helped lower my homocysteine level from 10 to 7, which is crucial for reducing heart disease risk. My mother’s level was 15, and now she takes folate with me. If you found this helpful, please like!
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8
7
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
9
Natural formulation
Most Useful Review
3 people found this helpful
This product contains a natural formulation of folic acid and does not cause stomach discomfort, making it a good option for my needs, particularly regarding my knee pain.
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8
9
Increased energy boost
Most Useful Review
This is vitamin E (folic acid), vitamin B9 in an easily digestible methyl form. An essential vitamin for the nervous system and vital for blood formation, its deficiency can lead to dementia in the elderly. It's especially beneficial for pregnant women and athletes. I take it alongside B vitamins to support my nervous system and combat anaemia. I feel a rush of energy almost immediately!
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 37 Reviews
8
9
Reduced PMS pain
Most Useful Review
1 people found this helpful
Initially concerned about skin issues and PMS pain, I consulted my gynecologist who diagnosed multifollicular ovaries and prescribed inositol with folic acid. I chose the active form, methylfolate, for its effectiveness. Remarkably, I felt relief from PMS pain within the first month, and my skin cleared significantly.
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.9
8
We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
7.5
Improved cold tolerance
Most Useful Review
47 people found this helpful
I have suffered from Chronic Fatigue Syndrome for many years. I tried a comparable product from Solgar, Metafolin, which worked but upset my stomach. This product does the same without causing any discomfort. It essentially alters my perception and tolerance to cold; I no longer feel it penetrating my bones as I did before. While it hasn't completely removed my brain fog, it has subtly improved my ability to focus, allowing me to concentrate better without the haze I previously experienced.
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Moderately Good
Based on 46 Reviews
7.9
8
Folic acid treatment shows promise
We explored the effects of folic acid on hair loss in a three-week-old Charolais calf showing signs typical of folic acid deficiency. After starting daily folic acid therapy at a dose of 1 mg/kg, we observed that the crusts and patches diminished within two weeks. Remarkably, hair growth resumed, and within two months, the calf returned to a normal state. This indicates that folic acid could be an effective treatment for certain types of alopecia related to deficiencies in this essential nutrient.
7.5
Reduced hair loss
Most Useful Review
33 people found this helpful
My research led me to this better form of folic acid. The small pill is easy to take, and since using it, my hair loss has significantly decreased and I sleep more soundly.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
8
Improved PMS symptoms
Most Useful Review
20 people found this helpful
Folic acid is crucial for women's health, especially after 30 and during menopause. It's also beneficial when combined with MyoInositol for those planning a pregnancy. The tablets are small and easy to take. Since starting this supplement on my doctor's advice, I've noticed an improvement in my PMS symptoms.
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.7
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
9
Effective for Alzheimer’s
Most Useful Review
This is folic acid at its finest! It can help with Alzheimer’s! I have been taking it for a long time and will continue to do so!
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.8
USERS' SCORE
Moderately Good
Based on 72 Reviews
7.8
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
9
Combatting folate deficiency
Most Useful Review
113 people found this helpful
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.8
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
9
Controls anxiety effectively
Most Useful Review
112 people found this helpful
This supplement has been instrumental in maintaining my anxiety levels. Its effects were subtle at first, but when I skipped several days, the anxiety returned, reminding me of its efficacy. I ensure I take it daily as it helps manage my anxiety better than anything else I've tried, alongside a balanced diet.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Moderately Good
Based on 40 Reviews
7.8
8
We explored the impact of folic acid combined with ferrous bisglycinate on nausea in pregnant women facing iron deficiency. In a controlled trial involving 120 participants, we discovered that the group taking ferrous bisglycinate with folinic acid reported significantly fewer instances of nausea and other discomforts compared to those receiving a standard iron supplement.
Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.
Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.
10
Light on stomach
Most Useful Review
Excellent! It is very easy on the stomach, does not cause nausea, and the pill is small and simple to swallow. I liked the product 🤍
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
8
We explored the impact of folic acid supplementation on stroke risk by analyzing data from 21 randomized clinical trials involving over 115,000 participants.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
9
Effective for stroke
Most Useful Review
1 people found this helpful
This methyl folate is from a reputable firm, with adequate dosage. Though capsules are larger than tablets, they’re manageable to swallow. This form is better absorbed, benefiting those with absorption issues. Methyl folate can help lower the risk of strokes.
Uterine Fibroids details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
7.5
Support for pregnancy
Most Useful Review
We are planning a pregnancy soon, but I have Uterine Fibroids and endometriosis. The doctor suggested this easily absorbed medication. The capsules are small and easy to swallow, which makes it convenient for us.
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.7
7.5
Increased energy levels
Most Useful Review
Excellent product! It's gluten-free and increases energy levels due to its high bioactive form of folate. Methylfolate is effective as the body struggles to convert synthetic folic acid, making (6S)-5-MTHF essential. I recommend it!
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Moderately Good
Based on 70 Reviews
7.6
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
7.5
Enhanced sleep
Most Useful Review
240 people found this helpful
I've been taking methylfolate for two months to support my haemoglobin levels and cardiovascular health. Since starting, my sleep has deepened, and my haemoglobin has improved. This digestible form of folic acid is crucial for women planning pregnancy, as it does not cause side effects.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.5
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9
Has anticancer properties
Most Useful Review
Methylfolate, the active form of folic acid, crosses the blood-brain barrier to promote a healthy nervous system. It supports cardiovascular health by managing homocysteine levels, which are linked to heart disease. Methylfolate aids in the production of essential neurotransmitters and improves mood. It positively affects cognitive functions and has been shown to have anticancer effects against various tumours, including cervical and colorectal cancers.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.5
8
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
9
Supports health benefits
Most Useful Review
1 people found this helpful
I take folate even when not planning a pregnancy. It’s helped my health immensely and might have reduced the risk of hereditary diseases. I've noticed an improvement in my restless legs syndrome, which is likely linked to my nerves and blood vessels. The attacks have lessened since I started taking methylfolate, and I hope they won't return after I stop. This is a helpful vitamin, especially for treating irritable bowel syndrome.
Pelvic Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.4
9
We explored an innovative treatment for chronic bacterial prostatitis (CBP) by creating antibiotic-loaded nanoparticles modified with folic acid. These nanoparticles can effectively target and penetrate the prostate tissues where inflammation and pain occur.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
9
Cycle regularity
Most Useful Review
1 people found this helpful
Following my doctor's recommendation, I take this folate regularly and have experienced pleasing results: my cycle is now regular, and my pelvic pain has disappeared.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.1
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
10
Headache relief
Most Useful Review
Good quality. After a month, I started feeling better as my headaches stopped. I definitely recommend this manufacturer.
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.1
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
10
Migraine relief
Most Useful Review
I take inositol, 4000mg daily, with my husband, and the migraines that tormented me for six years have vanished. I'm amazed by this response to the medication; it has given me a surge of energy. I'm delighted I eventually tried it for my migraines, although it was originally recommended by my gynecologist for pregnancy planning.
Rash details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 13 Reviews
7
7
We reviewed numerous studies to understand the skin reactions stemming from Methotrexate (MTX). Our analysis included data from over 8,000 papers, ultimately focusing on 31 relevant studies involving 38 patients.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
7
Cell growth support
Most Useful Review
14 people found this helpful
High-quality, strong methylfolate. It promotes cell growth and renewal, enhances the functioning of the brain, heart, and blood vessels, while also preventing fatty infiltration of the liver. This supplement helps women maintain their youth and beauty by renewing hair follicles, slowing down wrinkle formation, and cleansing the skin of rashes, especially beneficial for those pregnant or planning a pregnancy.
