' 
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
The product is found useful for the following medical conditions
Anemia
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
USERS' SCORE
Good
Based on 72 Reviews
8.9
9
Folate supplementation improves anemia
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
Most Relevant Research
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
9.5
Combatting folate deficiency
Most Useful Review
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
Depression
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 26 Reviews
8.8
8
Folate's role in depression treatment
Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
Most Relevant Research
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
9.5
Potential depression aid
Most Useful Review
Methylfolate, or (6S)-5-MTHF, is the most effective form of folate, easily absorbed and critical for human health. It helps control homocysteine levels, supports cell growth, and reduces risks of developmental defects in infants. Methylfolate also positively influences cognitive functions, making it valuable for depression treatment. Studies show it can lower homocysteine levels, which, when elevated, is linked to cardiovascular diseases. It's crucial to choose methylfolate over standard folic acid, which is poorly absorbed and can hinder essential nutrient absorption from food.
Heart Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 50 Reviews
8.8
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Reduces homocysteine levels
Most Useful Review
Fully active folate helped lower my homocysteine level from 10 to 7, which is crucial for reducing heart disease risk. My mother’s level was 15, and now she takes folate with me. If you found this helpful, please like!
Sleep Apnea
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 17 Reviews
8.8
8
Folate may protect against OSA
The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study.
Most Relevant Research
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
9.5
Improved sleep quality
Most Useful Review
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 16 Reviews
8.7
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Lowered homocysteine level
Most Useful Review
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
Heart Attack
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.3
USERS' SCORE
Good
Based on 14 Reviews
8.7
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Most Relevant Research
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
9.5
Reduced heart disease risk
Most Useful Review
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.7
7
Folic acid reduces cholesterol risk
Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis.
Most Relevant Research
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9.5
Reduced homocysteine levels
Most Useful Review
My blood tests revealed elevated homocysteine, which can indicate poor lifestyle choices and heightens the risk of heart and vascular issues. I discovered I have folic acid malabsorption, so I was prescribed Methylfolate instead. After 2 weeks of taking 4000 mcg daily, my homocysteine dropped from 14 to 5.8. I now take 800 mcg per day.
Insomnia
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Folic acid combats insomnia effects
Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP).
Most Relevant Research
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
9.5
Improved sleep quality
Most Useful Review
My doctor recommended 5-MTHF due to high homocysteine levels that link to inflammation and insomnia. After just three days of taking it, I was sleeping through the night.
Neuropathy
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
Effective methylfolate
Most Useful Review
This works for me. I have MTHFR and peripheral neuropathy. Many medications worsen my condition. This methylfolate is effective without fillers that aggravate my neuropathy. I take 2-3 daily and am tolerating it well.
Back Pain
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.6
9
Methotrexate reduces epidural fibrosis
Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway.
Most Relevant Research
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
9.5
Deficiency solved!
Most Useful Review
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 70 Reviews
8.6
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Most Relevant Research
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
8
Reduced risk
Most Useful Review
Methylfolate is more easily absorbed than regular folic acid and acts quickly. It helps maintain normal homocysteine levels and reduces the risk of cardiovascular disease. It also addresses folic acid deficiency during pregnancy to prevent neural tube defects.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.4
USERS' SCORE
Good
Based on 19 Reviews
8.6
9
Folinic acid improves CFS symptoms
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
Most Relevant Research
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
9.5
Significant improvement
Most Useful Review
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
Hypothyroidism
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 10 Reviews
8.6
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Most Relevant Research
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
9.5
Highly absorbable
Most Useful Review
Highly absorbable and well tolerated, I am taking this supplement following a vitamin B9 deficiency linked to my hypothyroidism. Methylfolate is the active form of folic acid, directly assimilated by the body and crossing the blood-brain barrier. This product is of good quality and easy to take.
Menopause
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
USERS' SCORE
Good
Based on 16 Reviews
8.6
7
Folic acid positively affects sexual health
Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial.
Most Relevant Research
We aimed to understand how folic acid might influence sexual function in postmenopausal women, a group that often experiences sexual dysfunction. For this investigation, we conducted a solid triple-blind randomized controlled trial in Tehran, Iran, involving 100 participants recruited from health centers. Each woman in the study received either 5 mg of folic acid or a placebo daily for eight weeks, always on an empty stomach.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
9
Improved PMS symptoms
Most Useful Review
Folic acid is crucial for women's health, especially after 30 and during menopause. It's also beneficial when combined with MyoInositol for those planning a pregnancy. The tablets are small and easy to take. Since starting this supplement on my doctor's advice, I've noticed an improvement in my PMS symptoms.
Urinary Tract Infection
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.3
USERS' SCORE
Good
Based on 1 Review
8.6
8
Folate may enhance UTI treatment
Using Functional Annotations to Study Pairwise Interactions in Urinary Tract Infection Communities.
Most Relevant Research
We devised a computational approach to examine how certain compounds, specifically folate, influence microbial communities involved in urinary tract infections (UTIs). By analyzing 66 genomes from various UTI-related bacteria, we looked closely at their metabolic interactions to predict if supplementary folate could enhance bacterial growth.
Our findings suggested that some bacterial species could indeed benefit from folate, particularly when supplied alongside other community members that produce complementary metabolites. To put our predictions to the test, we experimented with folate supplementation, which resulted in an impressive increase in the population density of UTI isolates.
This study indicates a promising link between folate and UTI treatment, revealing how beneficial interactions between different bacteria can be harnessed for improved health outcomes. While additional studies will be needed for further validation, our method offers a quick and effective way to explore and understand these microbial partnerships.
Our findings suggested that some bacterial species could indeed benefit from folate, particularly when supplied alongside other community members that produce complementary metabolites. To put our predictions to the test, we experimented with folate supplementation, which resulted in an impressive increase in the population density of UTI isolates.
This study indicates a promising link between folate and UTI treatment, revealing how beneficial interactions between different bacteria can be harnessed for improved health outcomes. While additional studies will be needed for further validation, our method offers a quick and effective way to explore and understand these microbial partnerships.
9.5
Resolved infections
Most Useful Review
My experience with folate before pregnancy led to dryness in my vagina and urinary tract infections. Thankfully, these issues cleared up, thanks to this product. The amount of folate lasts for three months, and it does not upset my stomach like some other products.
Asthma
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
5.6
USERS' SCORE
Good
Based on 1 Review
8.6
8
Maternal Folate and Child Asthma
Interaction of maternal asthma history and plasma folate levels on child asthma risk in the Boston Birth Cohort.
Most Relevant Research
We examined the link between maternal folate levels and the risk of asthma in children, particularly focusing on whether this relationship varies according to whether the mother has a history of asthma. In a comprehensive study involving 1,948 mother-child pairs from the Boston Birth Cohort, we found that both maternal asthma history and lower levels of folate together increased the risk for childhood asthma.
Interestingly, for children whose mothers had asthma, there was a notable L-shaped relationship with folate levels. This means that those with low maternal folate levels had a dramatically higher risk of asthma, presenting an odds ratio of 5.93 compared to kids with asthma-free mothers and sufficient folate levels. Our findings suggest that when a mother has asthma, ensuring adequate folate during pregnancy could be crucial for reducing the chance of developing asthma in their children.
If further research supports our findings, optimizing maternal folate levels could serve as an important step in asthma prevention, especially for moms with a history of the condition.
Interestingly, for children whose mothers had asthma, there was a notable L-shaped relationship with folate levels. This means that those with low maternal folate levels had a dramatically higher risk of asthma, presenting an odds ratio of 5.93 compared to kids with asthma-free mothers and sufficient folate levels. Our findings suggest that when a mother has asthma, ensuring adequate folate during pregnancy could be crucial for reducing the chance of developing asthma in their children.
If further research supports our findings, optimizing maternal folate levels could serve as an important step in asthma prevention, especially for moms with a history of the condition.
9.5
Immediate relief
Most Useful Review
This product was great for my asthma! Within 30 minutes of taking it, my lungs felt open. I'm grateful for a solution that addresses nutrient deficiencies rather than relying on pharmaceutical drugs.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 30 Reviews
8.5
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Most Relevant Research
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
9.5
Controls anxiety effectively
Most Useful Review
This supplement has been instrumental in maintaining my anxiety levels. Its effects were subtle at first, but when I skipped several days, the anxiety returned, reminding me of its efficacy. I ensure I take it daily as it helps manage my anxiety better than anything else I've tried, alongside a balanced diet.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 26 Reviews
8.5
7
PANS/PANDAS and folate treatment
Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population.
Most Relevant Research
We aimed to understand how folate receptor alpha autoantibodies (FRAAs) relate to symptoms in children diagnosed with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). We analyzed serum samples from 47 children, aged 6 to 18, who carried these diagnoses.
Our results showed that a significant number of these children—about 63.8%—had binding or blocking FRAAs. Additionally, certain symptoms, like severe tics, linked with higher FRAA binding titers. Notably, we observed that kids with autism spectrum disorder (ASD) had lower binding titers of FRAAs.
A remarkable case highlighted how treatment with leucovorin, a form of folate, resulted in symptom improvements in a child with PANS/PANDAS who tested positive for FRAAs. These findings suggest that abnormalities in folate metabolism could play a role in the symptomatology of PANS/PANDAS, presenting the potential for folate-based therapies to be a viable treatment option.
Overall, this study sheds light on the connection between folate-related factors and pediatric neuropsychiatric disorders, calling for further research into leucovorin as a targeted treatment.
Our results showed that a significant number of these children—about 63.8%—had binding or blocking FRAAs. Additionally, certain symptoms, like severe tics, linked with higher FRAA binding titers. Notably, we observed that kids with autism spectrum disorder (ASD) had lower binding titers of FRAAs.
A remarkable case highlighted how treatment with leucovorin, a form of folate, resulted in symptom improvements in a child with PANS/PANDAS who tested positive for FRAAs. These findings suggest that abnormalities in folate metabolism could play a role in the symptomatology of PANS/PANDAS, presenting the potential for folate-based therapies to be a viable treatment option.
Overall, this study sheds light on the connection between folate-related factors and pediatric neuropsychiatric disorders, calling for further research into leucovorin as a targeted treatment.
9.5
Hormonal balance restored
Most Useful Review
My wife, who has an autoimmune disorder related to hormonal imbalance, was prescribed folic acid and vitamin E. After trying a "pharmacy course", we sought a better quality supplement from iHerb, which proved beneficial, resulting in her improved health.
Common Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Folate benefits in colds unclear
[Dietary efficacy of a micronutrient combination in patients with recurrent upper respiratory tract infections. Results of a placebo-controlled double-blind study].
Most Relevant Research
We explored the effectiveness of a special combination of micronutrients, including folate, in helping patients who suffer from recurrent upper respiratory tract infections, commonly known as colds. Our study involved 192 participants over 16 weeks in a randomized, placebo-controlled, double-blind trial that allowed us to compare results objectively.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
7.5
Effective cold relief
Most Useful Review
The doctor recommended this product to me for when I have a common cold. I usually take two tablets, which act like a dose of folic acid. It's very helpful for those who struggle to absorb B vitamins.
Liver Disease
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
6.8
Reduced homocysteine
Most Useful Review
Methylfolate is an effective, active form of folate, essential due to the body’s limited ability to convert synthetic folic acid. It helps lower homocysteine levels linked to cardiovascular diseases. It's best taken alongside vitamins B12 and B6. Highly recommend this supplement as one of the best available.
Autism
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Improved focus
Most Useful Review
Works great! I've been using these for my ADD symptoms, and they help me focus. My 12-year-old daughter, who has autism and ADHD, has been given them too. She is now able to focus and express herself more effectively. Great product!
Diarrhea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
IBS-D relief
Most Useful Review
Fixed my IBS-D. I suffered from horrible IBS-D for three years, which doctors or probiotics couldn't help. I had to take Ibgard and Metamucil at every meal but, after a week of taking this, I no longer needed those medications to keep my bowel regular. I can now enjoy coffee and dairy products, which I couldn’t before, making me much happier.
Hot Flashes
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.4
USERS' SCORE
Good
Based on 1 Review
8.5
9
Folic acid reduces hot flashes
The effect of folic Acid on menopausal hot flashes: a randomized clinical trial.
Most Relevant Research
We investigated how folic acid might help with menopausal hot flashes, a common and often uncomfortable experience for many women. In our study, we enrolled 70 menopausal women and divided them randomly into two groups. One group received folic acid tablets, while the other group received a placebo for four weeks. This method allowed us to closely monitor the effects of folic acid against a control.
Throughout the study, we collected information using questionnaires, interviews, and hot flash diaries to track the severity, duration, and frequency of hot flashes. Our analysis revealed significant differences in hot flash experiences before and after treatment in both groups. Most notably, the group taking folic acid showed a reduction in mean severity and frequency of hot flashes during the second, third, and fourth weeks of treatment.
Given these findings, we concluded that folic acid effectively alleviates the challenging symptoms of hot flashes. This treatment alternative may be a promising option for women seeking relief, offering an affordable and accessible change in their daily health regimen.
Throughout the study, we collected information using questionnaires, interviews, and hot flash diaries to track the severity, duration, and frequency of hot flashes. Our analysis revealed significant differences in hot flash experiences before and after treatment in both groups. Most notably, the group taking folic acid showed a reduction in mean severity and frequency of hot flashes during the second, third, and fourth weeks of treatment.
Given these findings, we concluded that folic acid effectively alleviates the challenging symptoms of hot flashes. This treatment alternative may be a promising option for women seeking relief, offering an affordable and accessible change in their daily health regimen.
8.8
Effective for hot flashes
Most Useful Review
Effective and reasonably priced Folate. I use this product for hot flashes even though I've passed menopause. I believe my medications might be causing the hot flashes. It has proven very effective; when I ran out, they reappeared! The cost is reasonable, so I'm pleased. Additionally, I had read that one should take Folate, not folic acid.
Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.4
9
Folate-enhanced nanoparticle effectiveness
Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery.
Most Relevant Research
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
7.5
Supports mental health
Most Useful Review
I purchased this supplement for my 96-year-old mother with dementia, believing it might slow its progression. Research indicates folate could help with brain function and reduce the risk of developing certain cancers. This methyl form is highly absorbable, and I hope it proves beneficial for her health.
Allergies
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.3
9.5
Improved tolerance
Most Useful Review
Do you know your homocysteine levels? For women planning a pregnancy, this indicator is crucial. My levels were about 9, too high. I ordered this supplement due to my severe allergies to folic acid. After a month, my levels dropped to 7, indicating effectiveness. I tolerate it well, with no allergies. I took one capsule daily after meals, and notably, I felt clearer-headed and more cheerful, which likely improved my performance as well. I highly recommend it!
Chest Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.3
8
Folic acid improves angina symptoms
Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina.
Most Relevant Research
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9.5
Guaranteed regularity
Most Useful Review
After starting folate on my doctor's advice, my menstrual cycle became regular and my pain disappeared, which is quite pleasing.
Stroke
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 12 Reviews
8.2
9
Folate supplementation and stroke prevention
Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue.
Most Relevant Research
We explored the cost-effectiveness of different folic acid supplementation strategies aimed at preventing strokes in hypertensive individuals in China. By examining four policy options, we aimed to find the best approach to support stroke prevention while considering potential complications from undetected vitamin B12 deficiencies.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
9.5
Effective for stroke
Most Useful Review
This methyl folate is from a reputable firm, with adequate dosage. Though capsules are larger than tablets, they’re manageable to swallow. This form is better absorbed, benefiting those with absorption issues. Methyl folate can help lower the risk of strokes.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8
9.5
Cycle regularity
Most Useful Review
Following my doctor's recommendation, I take this folate regularly and have experienced pleasing results: my cycle is now regular, and my pelvic pain has disappeared.
Nausea
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Good
Based on 1 Review
8
4
Nutrient supplements and nausea study
Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials.
Most Relevant Research
We observed the effects of various nutrient supplements, including folate, on nausea in pregnant and postpartum women in Ghana and Malawi. Participants in our study were given different types of supplements, with some receiving iron and folic acid, while others received multiple micronutrients or small-quantity lipid-based nutrient supplements.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
3
Severe nausea
Most Useful Review
Made me extremely nauseous. I tried it multiple times with food and plenty of water but wish I could handle these.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Most Relevant Research
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
9.5
Supports health benefits
Most Useful Review
I take folate even when not planning a pregnancy. It’s helped my health immensely and might have reduced the risk of hereditary diseases. I've noticed an improvement in my restless legs syndrome, which is likely linked to my nerves and blood vessels. The attacks have lessened since I started taking methylfolate, and I hope they won't return after I stop. This is a helpful vitamin, especially for treating irritable bowel syndrome.
Knee Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.7
7
Folate linked to reduced knee pain
Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis.
Most Relevant Research
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
8.3
Easy to swallow
Most Useful Review
I'm using it for my knee pain. The capsules are small, tasteless, and easy to swallow. I opted for this brand due to its minimal ingredients and vegan formulation. It seems to be of good quality.
Migraine
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
0
Not suitable personally
Most Useful Review
These capsules are quite small, making them easy to swallow, which I appreciate. However, I began experiencing daily migraines from the very first dose. They might be beneficial for others, but they were a poor choice for me!
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.3
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Most Relevant Research
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
8.8
Effective energy boost
Most Useful Review
Good for energy levels and headaches. These are great as they really helped increase my energy levels. It took about a month and a half to notice a difference, but I now have fewer headaches than before. I will buy them again.
