Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 9 Reviews
8.9
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
10
No side effects noted
Most Useful Review
4 people found this helpful
The best form of folic acid, as suggested by my paediatrician for my child’s low hemoglobin during HV. I chose this form for myself as it digests better than the usual type. I did not notice any side effects or allergies, and the capsules are small and convenient to take.
Updated: Mar 2026
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.7
10
Drastic improvement
Most Useful Review
I did a blood test, revealing that methylfolate could be beneficial due to my lifelong heartburn issues. This pill has transformed my life—just one a day has dramatically reduced my heartburn symptoms. I highly recommend it for others with similar issues. It’s high quality, small, and effective.
Updated: Mar 2026
Back Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
9
Deficiency solved!
Most Useful Review
34 people found this helpful
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9
Reduced homocysteine levels
Most Useful Review
221 people found this helpful
My blood tests revealed elevated homocysteine, which can indicate poor lifestyle choices and heightens the risk of heart and vascular issues. I discovered I have folic acid malabsorption, so I was prescribed Methylfolate instead. After 2 weeks of taking 4000 mcg daily, my homocysteine dropped from 14 to 5.8. I now take 800 mcg per day.
Updated: Mar 2026
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 8 Reviews
8.6
9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
9
Improved sleep quality
Most Useful Review
145 people found this helpful
My doctor recommended 5-MTHF due to high homocysteine levels that link to inflammation and insomnia. After just three days of taking it, I was sleeping through the night.
Updated: Mar 2026
Neuropathy details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Effective methylfolate
Most Useful Review
133 people found this helpful
This works for me. I have MTHFR and peripheral neuropathy. Many medications worsen my condition. This methylfolate is effective without fillers that aggravate my neuropathy. I take 2-3 daily and am tolerating it well.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.3
USERS' SCORE
Good
Based on 8 Reviews
8.5
9
Folate alleviates dizziness symptoms
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
10
Dizziness gone
Most Useful Review
1 people found this helpful
I used to experience slight dizziness when standing, but after using this product, it completely disappeared. Thank goodness, I have requested it several times.
Updated: Apr 2025
Abscess details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.4
7
Liver abscess improvement inconclusive
We investigated how a rumen-protected folic acid (RPFA) supplement affects the health and performance of beef steers. This study used a randomized design with 180 Angus-crossbred steers divided into different treatment groups.
Although we observed that RPFA increased plasma folate levels and improved certain growth metrics, the findings on liver abscesses were less pronounced. The percentage of livers without abscesses showed a tendency to improve with lower RPFA doses, but no significant benefits overall were found.
It's essential to note that vitamin B12 levels were low across all treatments, which might have influenced the outcomes related to RPFA effectiveness.
Although we observed that RPFA increased plasma folate levels and improved certain growth metrics, the findings on liver abscesses were less pronounced. The percentage of livers without abscesses showed a tendency to improve with lower RPFA doses, but no significant benefits overall were found.
It's essential to note that vitamin B12 levels were low across all treatments, which might have influenced the outcomes related to RPFA effectiveness.
9
Discomfort alleviated
Most Useful Review
Excellent shape and effect. During ovulation, I experienced unpleasant sensations in my lower abdomen, feeling full. An ultrasound revealed an ovarian cyst. The gynaecologist suggested hormonal pills, but due to previous side effects, I chose not to follow this advice. I learned that folic acid could help, and after completing the course, the discomfort vanished, and my menstruation became more regular. I highly recommend it to women facing similar issues! There are no overdoses from methylfolate, and it seems to have no side effects, so I believe it can be taken without prior consultation.
Updated: Mar 2026
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Effective relief noted
Most Useful Review
At the first signs of the illness, such as perspiration and sore throat, I give the child 3-4 pieces a day after meals. It helps immensely and quickly alleviates discomfort. No side effects were noted.
Updated: Apr 2025
Adrenal Gland Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
7.5
Increased energy
Most Useful Review
17 people found this helpful
Great! Initially, I was taking one tiny capsule per day, but recently I learned about my MTHFR issue, which could be impacting me. I tried taking 10 of these (4 mg) over two consecutive days to see if it would help. Remarkably, I felt energetic for five days and found it easier to wake in the mornings. Even after a heavy drinking weekend, I didn't suffer from my usual severe hangovers. Normally, I require 12 hours of sleep due to adrenal fatigue, yet during this period, I managed to get by on just 9 hours. After five days, the effects diminished, so I plan to increase my intake.
Updated: Apr 2025
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.4
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
9
Effective for hot flashes
Most Useful Review
4 people found this helpful
This product is effective and reasonably priced. I use it for hot flashes, even though I am past menopause, as my medications might also be causing them. It's been very effective; when I ran out, the hot flashes returned! The price is fair, so I’m satisfied.
Updated: Mar 2026
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
8
Decreased acne spots
Most Useful Review
1 people found this helpful
Very good. Excellent for the skin; since I started using it, I have noticed a decrease in acne spots. Additionally, my hair feels shinier, falls out less, and my hair and nails have grown faster.
Updated: Mar 2026
Adhd details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7
Effective treatment
Most Useful Review
Good product for ADHD. I found it useful for mine.
Updated: Mar 2026
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
7.5
Maintains artery health
Most Useful Review
176 people found this helpful
Made the switch to Methyl Folate from ordinary Folic Acid; Methyl Folate is much superior. The capsule is compact, which is important for me after neck surgery. I have taken Folic Acid, Vitamin B6, and Vitamin B12 for over 25 years to keep my arteries plaque-free. Despite my diet, my cholesterol and triglycerides have improved. I thought I was having a heart attack during Thanksgiving, but it was gallstones. The cardiologist was astonished at how clean my arteries were for my age. I credit this to the vitamins I take, which I will continue for my vascular health.
Updated: Mar 2026
Hot Flashes details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
We conducted a study with 70 menopausal women, randomly assigning them to receive either folic acid or a placebo for four weeks. Through questionnaires and hot flash diaries, we monitored changes in the severity, duration, and frequency of hot flashes.
Our findings revealed that folic acid treatment significantly reduced all three measures of hot flashes compared to the placebo, particularly in the later weeks of the treatment. This suggests that folic acid could be a valuable, low-risk option for managing menopausal hot flashes.
Our findings revealed that folic acid treatment significantly reduced all three measures of hot flashes compared to the placebo, particularly in the later weeks of the treatment. This suggests that folic acid could be a valuable, low-risk option for managing menopausal hot flashes.
9
Reduced flushing
Most Useful Review
As I have considerable white hair, I tried active folic acid for the first time. After a week, I feel fine. I no longer experience the redness and hot flashes that came with niacin. The price is reasonable, though the packaging is somewhat basic. If it proves effective, I will purchase it again.
Updated: Apr 2025
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 9 Reviews
8.3
9
Folic Acid Improves Cognitive Function
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
9
Highly absorbable
Most Useful Review
Highly absorbable and well tolerated, I am taking this supplement following a vitamin B9 deficiency linked to my hypothyroidism. Methylfolate is the active form of folic acid, directly assimilated by the body and crossing the blood-brain barrier. This product is of good quality and easy to take.
Updated: Mar 2026
Polycystic Ovary Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.3
7.5
Effective treatment
Most Useful Review
6 people found this helpful
I recommend this drug; it was effective in combination with inositol for treating Polycystic ovary syndrome.
Updated: Apr 2025
Psoriasis details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 4 Reviews
8.3
8
Folate's role in psoriasis management
We explored the relationship between homocysteine levels and psoriasis, with particular attention on how folate treatment may influence this chronic skin condition. Recent findings have shown that individuals suffering from psoriasis typically have elevated serum homocysteine levels. This condition, known as hyperhomocysteinaemia, can be associated with deficiencies in essential nutrients like folic acid and vitamin B12.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
9
Notable skin improvement
Most Useful Review
It was prescribed by a naturopath to enhance skin condition in psoriasis. I noticed a significant improvement within one month.
Updated: Apr 2025
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 10 Reviews
8.2
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
9
Monitored effectiveness
Most Useful Review
1 people found this helpful
The correct form of methyl folate raised my B9 levels and reduced homocysteine alongside B12. I plan to continue taking it while monitoring my blood tests.
Updated: Mar 2026
Low Libido details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
Increased libido
Most Useful Review
Great product! Methyl Folate, unlike folic acid, has an excellent formula for absorption. The quality is high, and I trust this company. The ingredients are natural, the capsules are small, and the taste is neutral, packaged in plastic. I noticed results after the first month of taking it. Personally, my libido increased. I recommend buying it.
Updated: Apr 2025
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
USERS' SCORE
Good
Based on 14 Reviews
8.2
7
Folic acid linked to OSA severity
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
9
Improved sleep quality
Most Useful Review
21 people found this helpful
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Updated: Mar 2026
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.8
USERS' SCORE
Good
Based on 25 Reviews
8.1
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
9
Combatting folate deficiency
Most Useful Review
113 people found this helpful
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
Updated: Mar 2026
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 18 Reviews
8.1
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
9
Controls anxiety effectively
Most Useful Review
112 people found this helpful
This supplement has been instrumental in maintaining my anxiety levels. Its effects were subtle at first, but when I skipped several days, the anxiety returned, reminding me of its efficacy. I ensure I take it daily as it helps manage my anxiety better than anything else I've tried, alongside a balanced diet.
Updated: Mar 2026
Autism details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.1
7.5
Improved focus
Most Useful Review
8 people found this helpful
Works great! I've been using these for my ADD symptoms, and they help me focus. My 12-year-old daughter, who has autism and ADHD, has been given them too. She is now able to focus and express herself more effectively. Great product!
Updated: Mar 2026
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.1
8
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9
Guaranteed regularity
Most Useful Review
1 people found this helpful
After starting folate on my doctor's advice, my menstrual cycle became regular and my pain disappeared, which is quite pleasing.
Updated: Apr 2025
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Good
Based on 11 Reviews
8.1
8
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
9
Increased energy levels
Most Useful Review
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Updated: Mar 2026
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 14 Reviews
8.1
7
We formulated a functional food product designed specifically for elderly individuals with Parkinson's disease, focusing on the common issue of constipation. Our approach involved creating a muffin recipe enriched with inulin, cacao, and Moringa, all of which play a role in supporting digestive health.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
9
Convenient to consume
Most Useful Review
1 people found this helpful
Very straightforward! It's really convenient to take. Other folic acids cause constipation, but this one does not. I'm preparing for pregnancy, so I'm taking it with my husband!
Updated: Apr 2025
Diabetes details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.1
7
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
9
Improves feline health
Most Useful Review
I purchased methylfolate for my diabetic cat, which developed diabetic neuropathy. After four months on a regimen of methylcobalamin and methylfolate, the improvement was noticeable within a month. I plan to continue this treatment for my cat's ongoing health.
Updated: Mar 2026
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.1
9
Ideal vegan supplement
Most Useful Review
Jarrow Formulas Vegan Methylfolate is a high-quality supplement, ideal for those seeking a natural source of active folic acid. With an extra concentration of 400 mcg per capsule, it supports metabolism and the nervous system. This vegan option is perfect for plant-based diets, with 60 capsules ensuring a long-term supply. It improves energy without causing niacin flush, making it convenient for daily use. I highly recommend it for overall well-being!
Updated: Mar 2026
Liver Disease details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 7 Reviews
8.1
9
Folate treatment aids liver fat reduction
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
9
Supports liver function
Most Useful Review
1 people found this helpful
Methylfolate is an easily absorbed, active form of folate that is essential, especially for women during pregnancy. It aids liver function and detoxification, while positively influencing my skin and hair. I take it due to folate cycle mutations and use it alongside B12 for better absorption. Dosage varies based on B9 levels and mutation type. I take it with food, but it's also fine on its own.
Updated: Apr 2025
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.1
9
Increased energy boost
Most Useful Review
This is vitamin E (folic acid), vitamin B9 in an easily digestible methyl form. An essential vitamin for the nervous system and vital for blood formation, its deficiency can lead to dementia in the elderly. It's especially beneficial for pregnant women and athletes. I take it alongside B vitamins to support my nervous system and combat anaemia. I feel a rush of energy almost immediately!
Updated: Mar 2026
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 48 Reviews
8
8
Folic acid treatment shows promise
We explored the effects of folic acid on hair loss in a three-week-old Charolais calf showing signs typical of folic acid deficiency. After starting daily folic acid therapy at a dose of 1 mg/kg, we observed that the crusts and patches diminished within two weeks. Remarkably, hair growth resumed, and within two months, the calf returned to a normal state. This indicates that folic acid could be an effective treatment for certain types of alopecia related to deficiencies in this essential nutrient.
9
Mood and hair loss
Most Useful Review
10 people found this helpful
Methylfolate or vitamin B9 is of excellent quality with small capsules for easy swallowing. After using it for women's health, I've experienced improved mood, increased energy, and my hair loss has stopped.
Updated: Mar 2026
Pelvic Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 9 Reviews
8
9
We explored an innovative treatment for chronic bacterial prostatitis (CBP) by creating antibiotic-loaded nanoparticles modified with folic acid. These nanoparticles can effectively target and penetrate the prostate tissues where inflammation and pain occur.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
9
Cycle regularity
Most Useful Review
1 people found this helpful
Following my doctor's recommendation, I take this folate regularly and have experienced pleasing results: my cycle is now regular, and my pelvic pain has disappeared.
Updated: Mar 2026
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 33 Reviews
8
9
Reduced PMS pain
Most Useful Review
1 people found this helpful
Initially concerned about skin issues and PMS pain, I consulted my gynecologist who diagnosed multifollicular ovaries and prescribed inositol with folic acid. I chose the active form, methylfolate, for its effectiveness. Remarkably, I felt relief from PMS pain within the first month, and my skin cleared significantly.
Updated: Mar 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
9
Hormonal balance restored
Most Useful Review
115 people found this helpful
My wife, who has an autoimmune disorder related to hormonal imbalance, was prescribed folic acid and vitamin E. After trying a "pharmacy course", we sought a better quality supplement from iHerb, which proved beneficial, resulting in her improved health.
Updated: Mar 2026
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.9
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
9
Boosts immune function
Most Useful Review
3 people found this helpful
Vitamin B9 greatly aids cell division and supports the immune and cardiovascular systems. I take one methyl folate capsule daily, benefitting from its highly absorbable and effective form.
Updated: Mar 2026
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.9
8
We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
9
Prevented winter colds
Most Useful Review
These excellent vitamins come in a powerful dosage. Since I began taking them in January, I’ve noticed significant improvements. My energy levels have increased, leading to better sleep quality. Furthermore, I’ve not caught a cold during winter, a time when I typically get ill. Thanks to the dosage, I don’t have to take them daily, and it will last a long time.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
9
Lowers heart rate
Most Useful Review
7 people found this helpful
I am very pleased with this supplement. I’ve been using it for six months and noticed my pulse has dropped to around 65, which is a significant improvement. After struggling with my heart rate for years, I highly recommend this for anyone with similar issues.
Updated: Mar 2026
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
8
We explored the impact of folic acid supplementation on stroke risk by analyzing data from 21 randomized clinical trials involving over 115,000 participants.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
9
Promotes stroke recovery
Most Useful Review
1 people found this helpful
On my endocrinologist's advice, I started taking methyl folate while planning my pregnancy due to thyroid issues. It aided my quick conception and my uncle's swift recovery after his stroke, normalising his pressure and blood circulation.
Updated: Mar 2026
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
7.5
Supports cognitive function
Most Useful Review
1 people found this helpful
B9 is effective and safe for the body! I trust Jarrow's product as it contains biologically active methyltetrahydrofolate, unlike toxic folic acid. As I age, it helps stimulate digestion, supports protein, fat and carbohydrate breakdown, and is beneficial for brain function, enhances cognitive abilities, and reduces the risk of Alzheimer’s. It also aids blood formation, crucial for my B12 deficiency anaemia, and boosts my immune system to combat disease. The capsules are easy to swallow, and I’m pleased with the results from methylfolate. Highly recommend!
Updated: Mar 2026
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.1
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
9
Effective against anxiety
Most Useful Review
1 people found this helpful
I quickly noticed that this methylfolate helped with my anxiety and depression. I felt its positive effects within a couple of weeks.
Updated: Mar 2026
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Moderately Good
Based on 43 Reviews
7.8
8
We explored the impact of folic acid combined with ferrous bisglycinate on nausea in pregnant women facing iron deficiency. In a controlled trial involving 120 participants, we discovered that the group taking ferrous bisglycinate with folinic acid reported significantly fewer instances of nausea and other discomforts compared to those receiving a standard iron supplement.
Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.
Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.
10
Light on stomach
Most Useful Review
Excellent! It is very easy on the stomach, does not cause nausea, and the pill is small and simple to swallow. I liked the product 🤍
Updated: Mar 2026
Uterine Fibroids details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
7.5
Support for pregnancy
Most Useful Review
We are planning a pregnancy soon, but I have Uterine Fibroids and endometriosis. The doctor suggested this easily absorbed medication. The capsules are small and easy to swallow, which makes it convenient for us.
Updated: Apr 2025
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.7
7.5
Increased energy levels
Most Useful Review
Excellent product! It's gluten-free and increases energy levels due to its high bioactive form of folate. Methylfolate is effective as the body struggles to convert synthetic folic acid, making (6S)-5-MTHF essential. I recommend it!
Updated: Apr 2025
Attention Deficit Hyperactivity Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.5
7.5
Mood enhancement
Most Useful Review
1 people found this helpful
I have three mutations in my folate cycle that have affected my health for 30 years. For years, I've been taking methyl forms of B9 and B12 regularly, which has notably improved my nervous system disorders, mood, and even eliminated evening chills. Regular use of magnesium supplements also contributed to my well-being. Importantly, my iron stores have improved, marking a significant recovery from long-standing anaemia.
Updated: Mar 2026
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.5
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9
Has anticancer properties
Most Useful Review
Methylfolate, the active form of folic acid, crosses the blood-brain barrier to promote a healthy nervous system. It supports cardiovascular health by managing homocysteine levels, which are linked to heart disease. Methylfolate aids in the production of essential neurotransmitters and improves mood. It positively affects cognitive functions and has been shown to have anticancer effects against various tumours, including cervical and colorectal cancers.
Updated: Mar 2026
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.4
8
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
9
Enhanced digestive function
Most Useful Review
The quality of this folic acid supplement is excellent, and I feel revitalised since taking it. It supports my energy, nervous system, and bowel movements. I've had significant improvement with digestive issues and constipation. I recommend this for anyone dealing with irritable bowel syndrome.
Updated: Mar 2026
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.1
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
10
Headache relief
Most Useful Review
Good quality. After a month, I started feeling better as my headaches stopped. I definitely recommend this manufacturer.
Updated: Apr 2025
Rash details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 12 Reviews
7
7
We reviewed numerous studies to understand the skin reactions stemming from Methotrexate (MTX). Our analysis included data from over 8,000 papers, ultimately focusing on 31 relevant studies involving 38 patients.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
7
Cell growth support
Most Useful Review
14 people found this helpful
High-quality, strong methylfolate. It promotes cell growth and renewal, enhances the functioning of the brain, heart, and blood vessels, while also preventing fatty infiltration of the liver. This supplement helps women maintain their youth and beauty by renewing hair follicles, slowing down wrinkle formation, and cleansing the skin of rashes, especially beneficial for those pregnant or planning a pregnancy.
Updated: Mar 2026
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.9
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
10
Migraine relief
Most Useful Review
I take inositol, 4000mg daily, with my husband, and the migraines that tormented me for six years have vanished. I'm amazed by this response to the medication; it has given me a surge of energy. I'm delighted I eventually tried it for my migraines, although it was originally recommended by my gynecologist for pregnancy planning.
Updated: Mar 2026
Data last updated:
