NOW Supplements Silymarin Milk Thistle Extract

Silibinin shows promise for asthma

Based on 4 Researches

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.

Digestive aid

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1 people found this helpful

This product helps with various allergies and aids digestion. It's now a staple in my purchases, and I recommend it.

Updated: Mar 2026

Cancer details

Investigating silibinin's cancer treatment role

Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901

We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.

Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.

Effective for cancer treatment

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11 people found this helpful

Great. It is working for my cancer. Thanks for the product.

Updated: Mar 2026

Cold Sores details

I utilised the properties of this complex supplement to address my liver function and bile-related issues. After nearly a month of use, I've noticed positive results. Diagnosed with cholecystitis, I experienced significant side pain. Fortunately, after starting the supplement, the discomfort eased considerably within days, and I am incredibly grateful that silymarin has been beneficial for me.

Silymarin shows no significant benefit

Eczema details

Iraji F, Sharif Makhmalzadeh B, Abedini M, Aghaei A, Siahpoush A. Effect of herbal cream containing and silymarin for treatment of eczema: A randomized double-blind controlled clinical trial. Avicenna J Phytomed. 2022;12:155. doi:10.22038/AJP.2022.19492

We examined how an herbal cream containing silymarin affects patients with eczema compared to a standard treatment. In a study with 40 patients suffering from mild to moderate eczema, participants used either the herbal cream or mometasone for two weeks.

After this period, we found notable improvements in skin severity scores for both treatments. However, there wasn't a significant difference between the two groups. This suggests that while both treatments are effective, silymarin may not be superior to traditional therapies for eczema relief.

Eczema disappeared

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I had red eczema around my eyes, and I drank this because eye problems can also indicate liver issues. While the effects aren't immediate, the eczema has vanished. It's safe to consume as the liver plays a crucial role in detoxification.

Updated: Apr 2025

Knee Pain details

1 people found this helpful

My joint pain has significantly eased, and I am impressed with the quality of this company's products.

Pancreatitis details

Silymarin promotes pancreatic cell growth

Based on 2 Researches

Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008

This study investigated how Silymarin affects the growth of insulin-producing cells in a model of partial pancreas removal in rats.

We treated 72 Wistar rats, half of which were given Silymarin daily. The results were clear: the Silymarin-treated rats showed significant increases in both the Pdx1 gene, which is vital for pancreatic health, and insulin production.

Additionally, their β-cell proliferation improved, leading to better blood sugar control. However, the specific effects on pancreatitis were not explored in this study.

Feeling revitalised

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4 people found this helpful

Liver says thank you! Prescribed by a sports doctor, confirmed by three others. I am a professional sportsman and have chronic pancreatitis. I took numerous medications, but Silymarin truly saved me. Although I didn’t follow the dosage strictly—two tablets three times daily—I feel fantastic. It has greatly benefited my health.

Updated: Mar 2026

Attention Deficit Hyperactivity Disorder details

Improved digestion, skin

I had no idea what Silymarin was until recently when I bought it for my husband who has gallbladder issues. After starting this dietary supplement consistently, I realised that my digestion improved remarkably. Usually, I consume a lot of healthy fats, yet I experienced no discomfort after meals, even after large portions. Additionally, I noticed that my skin cleared up significantly. The connection between liver function and skin health is evident; when I stopped taking Silymarin temporarily, I faced acne flare-ups. However, reintroducing Silymarin led to clear skin again within five days. It's evident this supplement supports my digestion and skin health effectively.

Silibinin shows toxicity via EGFR

Brain Tumor details

Qi L, Singh RP, Lu Y, Agarwal R, Harrison GS, et al. Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biol Ther. 2003;2:526.

We explored how silibinin, a compound from milk thistle, impacts brain tumor cells by focusing on the epidermal growth factor receptor (EGFR). In our study, we created a specific rat glioma cell line expressing human EGFR. Our results showed that the presence of EGFR was crucial for silibinin to exert its toxic effects on cancer cells. By inhibiting the activation of EGFR, silibinin demonstrates potential as a therapeutic agent for targeting tumor growth. However, further research is needed to understand the detailed mechanisms at play.

7.5

Mental boost

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2 people found this helpful

I was unsure about which milk thistle to choose, but this one proved to be the right decision! Along with its effectiveness, the pleasant scent of turmeric in the ingredients is soothing. I feel revitalised after drinking it, and I notice my brain feels stimulated thanks to the turmeric. This is a supplement I intend to continue using!

Updated: Apr 2025

Pelvic Pain details

I noticed a decrease in pelvic pain after just one day of use, which wasn’t the case with other medications. This natural remedy is quite effective; I will continue taking it.

Reflux details

Under trial is an important food supplement for cleansing the liver and eliminating toxins. This reflects positively on skin health, enhances absorption of vitamins and minerals, aids in alleviating reflux esophagitis, balances stomach acidity, and reduces liver fat.

Rosacea details

MSM, along with silymarin, zinc, and copper, has worked wonders for my rosacea!

The heaviness on the right side and the swelling under my son's eyes, who is 40 and a big drinker, have gone. The craving for alcohol has also disappeared. Miracle milk thistle! I'm ordering again.

Swollen Lymph Nodes details

Arthritis details

Silymarin shows anti-arthritis potential

Based on 5 Researches

Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7:21.

We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.

While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.

Enhances joint mobility

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Curcumin may alleviate pain and enhance joint mobility in those with arthritis. Furthermore, turmeric may aid digestion by stimulating bile production and breaking down fats efficiently.

Updated: Apr 2025

Cold details

Boosts immunity effectively

Great cool vitamins. They are well-dosed, have an excellent composition, and boost my immunity during the cold season. 👍🏻

Effective cleansing remedy

Common Cold details

1 people found this helpful

Excellent! Let’s cleanse the liver as a family. The remedy works well. Occasionally, I've experienced a breakout, but that’s part of the body's detox process.

Heart Disease details

2,3-dehydrosilybin shows heart protection

Based on 8 Researches

Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028

We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.

The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.

7.5

Supports liver function

Most Useful Review

Milk Thistle has been very helpful for me as I have to take a potent heart medication that puts considerable strain on my liver.

Updated: Mar 2026

Rash details

18 people found this helpful

Random allergies disappeared. I wanted to detox and bought this product hoping to cleanse something. I used to suffer from everyday fatigue and random skin rashes on my hands and feet at night, causing itchiness. Since I started taking Silymarin daily with vitamins, waking up in the morning has been easier. Halfway through the bottle, I noticed my skin normalised, and there were no rashes. I didn't expect this; dermatologists previously attributed my symptoms to random allergic reactions due to my sensitive skin. After the first bottle, I will wait before starting the second to avoid my body becoming immune to silymarin. However, I am definitely pleased and will purchase a second one.

Depression details

Silibinin reduces depression in mice

Based on 8 Researches

Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593

We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.

Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.

7.5

Aiding depression treatment

Most Useful Review

This excellent product is vital for maintaining our liver’s health, acting as a filter against harmful substances. It aids in the repair of damaged cells, reduces fat oxidation, and normalises lipid metabolism. Additionally, it helps manage depression and the effects of stress, while improving biochemical parameters and regulating cellular fluid transport. It also neutralises and removes hepatotoxic substances. I trust my review is useful to you.

Updated: Apr 2025

Diabetes details

Silibinin shows potential for diabetes

Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x

We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.

It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.

Improves digestion quality

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1 people found this helpful

Excellent for individuals with diabetes type 2 and enhances digestion. It's of excellent quality and comes in a good quantity. I wholeheartedly recommend it.

Updated: Mar 2026

High Cholesterol details

Silymarin positively influences cholesterol

Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050

We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.

Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.

However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.

Liver function support

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4 people found this helpful

I have been using Silymarin Milk Thistle Extract for years, and it's brilliant! My liver is in excellent condition, as confirmed by recent blood tests. I've tried both 150 mg and 300 mg doses, both of which protect my liver effectively. Highly recommended!

Updated: Mar 2026

Migraine details

Effective migraine relief

This is a great way to support liver regeneration, but more impressively, I've used it instead of a pain killer and found that when taken on time, it often prevents a headache from developing into a full-blown migraine attack.

Acne details

Silybum marianum reduces acne severity

Based on 3 Researches

Fontao F, von Engelbrechten M, Seilaz C, Sorg O, Saurat JH. Microcomedones in non-lesional acne prone skin New orientations on comedogenesis and its prevention. J Eur Acad Dermatol Venereol. 2020;34:357. doi:10.1111/jdv.15926

We explored the effects of Silybum marianum fruit extract on acne treatment using a topical formulation over 48 weeks in a group of acne patients. The study identified microcomedones, which are early signs of future acne lesions, as a target for prevention.

Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.

Transformed my skin

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8 people found this helpful

This product transformed my face after 10 years of struggling with acne. I took Silymarin to support my liver while not always maintaining a healthy diet. It significantly improved my facial skin condition, particularly regarding rosacea and inflammation.

Updated: Mar 2026

Chemotherapy details

Decreased liver enzymes

7 people found this helpful

I purchased this for my mother, who was undergoing chemotherapy. Due to high ASAT and ALAT levels, she needed liver support, and I found milk thistle to be the best natural remedy. After combining it with Chlorella from Now, her ASAT and ALAT levels significantly decreased and almost returned to normal.

Cholecystitis details

Liver health improved

43 people found this helpful

Silymarin (milk thistle extract) effectively cleanses the liver and positively impacts skin quality. After two weeks, the heaviness in my liver area and morning bitterness disappeared. An ultrasound prior to use is advisable to check for gallbladder stones. In addition to milk thistle, it contains turmeric, which aids bile removal and supports liver function. It's best to limit alcohol and adjust my diet whilst taking Silymarin. My liver feels much better now. I highly recommend this product to those who care for their health!

Hepatitis details

Milk thistle shows potential in treatment

Questionable

Based on 3 Researches

Payer BA, Reiberger T, Rutter K, Beinhardt S, Staettermayer AF, et al. Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient. J Clin Virol. 2010;49:131. doi:10.1016/j.jcv.2010.07.006

We explored the potential of intravenous silibinin, a milk thistle extract, in treating an HIV-HCV coinfected patient who didn't respond to standard therapy. After just two weeks of silibinin treatment, both HCV and HIV levels became undetectable.

While silibinin appeared promising, leading to a trend of increased CD4+ cells, the follow-up showed that HIV levels returned to their previous state after stopping additional therapy.

These findings suggest that while silibinin may help some, more research is needed to understand its benefits fully.

Protects liver cells

Most Useful Review

15 people found this helpful

Silymarin helps reduce damage in the liver caused by medications, protects against toxins, and addresses fatty liver. After using it for some time, I noticed impressive results in my liver health.

Updated: Mar 2026

Bloating details

17 people found this helpful

Great! Sensational quality product indeed! The price is very reasonable, and this supplement is excellent for detoxifying the liver and relieving the stomach. I take 1 capsule at night and sleep well—no bloating or gas. For those who consume a lot of junk foods and take many medicines, this product detoxifies your body effectively. In Brazil, Forfig is expensive and not as effective as this brand. It's also beneficial for those who drink alcohol, as it helps the liver regenerate. Thanks for a great product!

40 people found this helpful

Chest Pain details

Following a Covid-19 illness and necessary antibiotics, my doctor recommended milk thistle to support my liver. I opted for silymarin due to its higher dosage. After two months, the chest pain I previously had disappeared. I plan to continue using this supplement for ongoing liver support. Just remember to check for gallstones before starting.

Liver Disease details

Silymarin improves liver protection

Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520

We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.

Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.

Diminished spots

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100 people found this helpful

This is the best supplement I've taken for my liver and bile health. I've noticed a reduction in red spots on my body, and it’s currently my favourite remedy for liver disease, with a reasonable price.

Updated: Mar 2026

Nausea details

Stomach discomfort eased

1 people found this helpful

This supplement effectively relieved the "fat" feeling in my stomach and calmed my nausea after eating. It truly works as advertised.

Autoimmune Disorder details

Silybin shows promise for autoimmune disorders

Based on 9 Researches

Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678

We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).

In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.

The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.

Liver function restored

Most Useful Review

5 people found this helpful

My nephew experienced a spike in liver function tests, raising concerns of an autoimmune disorder. However, after using silymarin, his liver tests returned to normal, much to our relief. This product clearly supports liver health effectively.

Updated: Mar 2026

Kidney Stones details

I have gallbladder issues and cholesterol stones, and I've been taking milk thistle for six months. It has alleviated my symptoms and I no longer feel heaviness after meals. I take it once daily after breakfast, and it has greatly improved my condition.

5 people found this helpful

Chronic Fatigue Syndrome details

Chronic fatigue syndrome plagued me, making me feel weak. After starting this product, I found my fatigue lifted, and I felt more energetic overall. My liver function seemed to improve as well, contributing to my recovery.

Psoriasis details

Milk thistle shows anti-psoriatic effects

Based on 2 Researches

Kamel NM, El-Sayed SS, El-Said YAM, El-Kersh DM, Hashem MM, et al. Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress. Int Immunopharmacol. 2024;139:112781. doi:10.1016/j.intimp.2024.112781

We investigated how milk thistle extract might help treat psoriasis in mice. Our study involved forty Swiss albino mice divided into four groups, including a test group treated with the milk thistle extract after inducing psoriasis with imiquimod.

The results were encouraging, showing that the extract significantly reduced skin symptoms like redness and scaling, similar to traditional cortisone treatments. It worked by inhibiting specific cellular pathways, reducing inflammation and boosting antioxidant defenses, suggesting that milk thistle could be an effective new option for psoriasis treatment.

Effective psoriasis treatment

Most Useful Review

1 people found this helpful

This supplement works wonders for my psoriasis! I've been taking it since May 2013, and it has significantly improved my condition. If I follow the instructed dosage, my blood pressure elevates excessively, so I only take two pills each morning and use an oily cream at night. The progress is slow, but at this rate, I anticipate being completely psoriasis-free by next summer!

Updated: Apr 2025

Constipation details

Regular bowel activity

4 people found this helpful

I really liked Milk thistle; I took 1 tablet twice a day, and my bowel movements became regular. I previously endured frequent constipation, but this product improved my condition.

Endometriosis details

Limited effectiveness

I drank the entire packaging but noticed little effect. I understand that milk thistle is not recommended for fibroids or Endometriosis. This leaves me wondering how women can safely detoxify their bodies without causing harm.

Updated: Apr 2026

Weight Loss details

Silymarin with turmeric is from a well-known company. This is my second order, this time with curcumin. I felt it helped me lose weight. The ingredients include silymarin and turmeric, and the quantity is good for the price. It aids in eliminating liver toxins, which in turn helps with weight loss and burning fat. Honestly, I've noticed a difference in my weight. It effectively rids the body of toxins, and its absorption is high. Its taste is a turmeric flavour, and it's a nutritional supplement.

Avoid during exacerbation

Gastritis details

Great supplement! However, with an exacerbation of gastritis, it's better to avoid taking it. The capsules are convenient and easy to swallow.

Effective supplement for IBS relief

Irritable Bowel Syndrome details

Di Pierro F, Putignano P, Villanova N. Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia. Acta Biomed. 2018;88:462. doi:10.23750/abm.v88i4.5851

We explored the effects of a supplement called Berberol®K, which contains silybum marianum, on patients dealing with irritable bowel syndrome (IBS) alongside diabetes and dyslipidemia.

In a retrospective study with 59 subjects, those who were treated showed notable improvements after six months, including reduced diarrhea symptoms.

The results suggest that this food supplement could be beneficial, especially for those who cannot tolerate standard treatments like statins.

No side effects

Most Useful Review

3 people found this helpful

Excellent product! I experienced no side effects, and it improved my bowel movements. I recommend taking it with a meal.

Updated: Mar 2026

Diarrhea details