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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
The product is found useful for the following medical conditions
Gout
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Folate's impact on gout therapy
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.
Most Relevant Research
We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
9.5
Pain relief
Most Useful Review
I ordered it for my mum. She seemed to have arthrosis, and another doctor suspected gout. This diagnosis followed a popular disease. They took it alongside calcium and magnesium from the same brand, as per the instructed scheme. The results were swift; the pain disappeared, redness and swelling subsided, and the bumps noticeably shrank. I'm ordering again and want to try it myself after reading such positive reviews. If you find my review helpful, please give it a rating. Thank you!
Anemia
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Cured anaemia
Most Useful Review
Cheap and functional. This is one of the best deals on folic acid, and switching to a folic with B12 cured my anaemia. As I must take folic (I’m on MTX), the fact that these are small, inexpensive and contain the B12 I need is great.
Neuropathy
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 1 Review
8.5
9
Nitrous oxide affects B12 levels
Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.
Most Relevant Research
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
8.3
Pain alleviation
Most Useful Review
I'm no expert in vitamins and supplements, but I know that I suffered from chemotherapy-related neuropathy. Online research indicated that folic acid might help, and for me, this product did indeed alleviate the neuropathy pain successfully.
Rheumatoid Arthritis
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin B12 may treat arthritis
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice.
Most Relevant Research
We explored the impact of vitamin B12 on rheumatoid arthritis, focusing on its ability to inhibit a specific enzyme known as PADI-4, which plays a key role in the disease's progression. Our findings suggest that vitamin B12 preferentially targets PADI-4 compared to another similar enzyme, PADI-2. This inhibition corresponds with a significant reduction in overall citrullination levels in cells, including histone H3 citrullination, which is relevant to the condition.
In our experiment, we utilized a specific model of arthritis in mice, known as collagen type II antibody-induced arthritis (CAIA). We administered hydroxocobalamin, a form of vitamin B12, and observed a marked improvement in the severity of arthritis symptoms in these mice. Moreover, the treatment led to a decrease in the expression of various inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL17A, TNFα, and IL-6, as well as PADI-4 itself.
These findings indicate that vitamin B12 might represent a promising avenue for treating rheumatoid arthritis and warrant further investigation.
In our experiment, we utilized a specific model of arthritis in mice, known as collagen type II antibody-induced arthritis (CAIA). We administered hydroxocobalamin, a form of vitamin B12, and observed a marked improvement in the severity of arthritis symptoms in these mice. Moreover, the treatment led to a decrease in the expression of various inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL17A, TNFα, and IL-6, as well as PADI-4 itself.
These findings indicate that vitamin B12 might represent a promising avenue for treating rheumatoid arthritis and warrant further investigation.
8.8
Needed product
Most Useful Review
I require this product for my rheumatoid arthritis and have always been satisfied with selections from NOW company.
Stroke
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Most Relevant Research
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
8.8
Beautiful skin
Most Useful Review
Folic Acid is crucial. I take 6 pills twice a day, and it enhances my skin's appearance almost immediately. It also serves to prevent strokes. NOW usually offers excellent products.
Diarrhea
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 1 Review
8
9.5
Vitamin B12 aids chronic diarrhea
CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY.
Most Relevant Research
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
2.5
Severe discomfort faced
Most Useful Review
I experienced intense stomach cramps after taking this. It wasn't just needing to use the bathroom, but severe cramps that forced me to leave work. I've never tried it since. It may have been too much folic acid for me, but the reaction was quite painful.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
9
Folate-enhanced nanoparticle effectiveness
Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery.
Most Relevant Research
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
0
Unsafe supplement
Most Useful Review
Folic acid is not a safe supplement; it is better to take folate. After researching, I've concluded that this form of the supplement is not safe, and I’m discarding it. Folate, a crucial B vitamin, is essential for lowering homocysteine levels and deficiency is linked to serious health issues. Unlike processed folic acid, natural folate from foods is generally safe. However, high levels of unmetabolised folic acid in the bloodstream are linked to cancer growth. It is crucial to choose folate supplements carefully.
