NOW Supplements Silymarin Milk Thistle Extract

Silymarin promotes pancreatic cell growth

Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008

This study investigated how Silymarin affects the growth of insulin-producing cells in a model of partial pancreas removal in rats.

We treated 72 Wistar rats, half of which were given Silymarin daily. The results were clear: the Silymarin-treated rats showed significant increases in both the Pdx1 gene, which is vital for pancreatic health, and insulin production.

Additionally, their β-cell proliferation improved, leading to better blood sugar control. However, the specific effects on pancreatitis were not explored in this study.

Supports digestion

Most Useful Review

I find this supplement essential and take it daily after my pancreatitis attack and gallstones treatment. It's been incredibly helpful.

Updated: Mar 2026

We explored the effects of Silybum marianum fruit extract on acne treatment using a topical formulation over 48 weeks in a group of acne patients. The study identified microcomedones, which are early signs of future acne lesions, as a target for prevention.

Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.

Effective for acne

Most Useful Review

189 people found this helpful

I'm amazed! After years of battling acne linked to sugar and hormones, I discovered that liver health affects skin. I began taking milk thistle, which lowered my blood sugar and supported my liver. Within a week, my skin improved immensely and I could enjoy sweets without suffering breakouts.

Updated: Apr 2026

Bruise details

An excellent drug! I purchased it for my husband, and his skin has improved significantly; the bruise under his eyes has disappeared.

Cardiovascular Disease details

SM reduces cardiac triglyceride levels

Based on 11 Researches

Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014

We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.

Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.

Normalises bilirubin levels

Most Useful Review

1 people found this helpful

After years of elevated bilirubin and high cholesterol, I tried milk thistle for three months. Now, my bilirubin is normal. This product has improved my digestion and overall well-being without any side effects.

Updated: Mar 2026

Celiac details

Essential liver support

13 people found this helpful

Seriously, how could one manage without this product? It is incredibly effective. My entire family has used it for years, providing a wonderful feeling of lightness. I realised how crucial it is, especially considering the potential harm from medications and alcohol on the liver. This plant protects and cleanses the liver, making one feel revitalised. Many of us experience a burden from our stomachs and livers due to modern living. The milk thistle, in my opinion, is essential for every household. It alleviates abdominal pain, bloating, and discomfort after consuming gluten and white flour. It also aids in clearing trapped gases that lead to malaise. I highly recommend it to all!

Hashimoto details

I purchased this milk thistle supplement from iHerb to enhance my immunity and detoxify my liver. Alongside other supplements, it has greatly improved my Hashimoto's thyroiditis. Thank you very much.

2 people found this helpful

Hot Flashes details

This supplement contains a high level of silybin and silymarin. Initially, I experienced white mildews on my body, which gradually disappeared. It has proven effective for my hot flashes as menopause symptoms stem from liver health.

Updated: Apr 2026

Hypothyroidism details

Compensates thyroid function

This is an excellent drug for my hypothyroidism. It has successfully balanced my thyroid function. Additionally, it's a fantastic antioxidant.

Transformed skin appearance

Rosacea details

100 people found this helpful

I purchased Silymarin from NOW Foods to support my liver, but it has unexpectedly transformed my face! After suffering from rosacea and constant inflammation, I noticed major improvements in my skin. I no longer need to strictly control my diet; the redness is manageable and my acne has greatly reduced. I’m thrilled I can enjoy sweets and still see positive results. Silymarin has truly worked wonders for me!

Updated: Mar 2025

Abscess details

Abscesses disappeared

It works! After the first dose, the abscesses disappeared. I will definitely repeat the course since I feel better and it's clearly effective. I highly recommend it.

Effective skin improvement

Bacterial Infection details

This is my most favourite and effective Silymarin))) Without it, I truly feel like I'm without hands, as I suffer from eczema of the hands. The primary cause of this bacterial infection is my liver and gallbladder issues. Throughout my life, I've endured pain in my right side, nausea, and intestinal disturbances, which worsened after pregnancy, leading to eczema. This supplement is like salvation. The only downside is its occasional unavailability, forcing me to order smaller dosages or from other companies, confirming THIS IS THE BEST! It also enhances my facial skin, cleansing it of bumps, acne, and blackheads, resulting in an even, beautiful, and healthy complexion. Many people often ask which beauty salon I frequented))))

Blood Clot details

Flavonolignans reduce platelet activity

Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. doi:10.1186/s12906-017-1897-7

We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.

The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.

7.5

Fatty liver treatment

Most Useful Review

8 people found this helpful

My liver was in a poor state due to fatty liver. After taking this, my blood test results returned to normal values. I don't feel the effects, but the data shows improvement. I took one after breakfast and dinner.

Updated: Mar 2026

Heartburn details

Heartburn improvement

336 people found this helpful

I absolutely adore this silymarin! After being ill and taking various medications, my husband and I completed a liver support course. We noticed a marked improvement in our overall condition, especially with heartburn and discomfort in the upper abdomen. We would gladly repeat this course if necessary.

Lung Cancer details

Potential NSCLC treatment candidate

Based on 14 Researches

Rugamba A, Kang DY, Sp N, Jo ES, Lee JM, et al. Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells. Cells. 2021;10. doi:10.3390/cells10071632

We investigated the potential of silibinin, a natural compound from milk thistle, in treating non-small cell lung cancer (NSCLC). Our study employed various assays to analyze how silibinin impacts cancer cell growth and migration.

We found that silibinin effectively inhibited the growth of NSCLC cells and suppressed important pathways linked to tumor progression. It worked by preventing tumor cells' ability to form new tumors and inhibited the expression of proteins associated with cancer growth.

Overall, silibinin shows promise as a candidate for both tumor immunotherapy and targeting cancer stem cells.

Liver function improvement

Most Useful Review

1 people found this helpful

My sister is undergoing chemotherapy for lung cancer. Her liver enzyme levels increased after starting treatment, but after I suggested this product, her doctor prescribed it too. Now, her liver function is normal, and the chemotherapy is effective for her lung cancer.

Updated: Apr 2025

Osteoporosis details

Promising silibinin effects on osteoporosis

Based on 5 Researches

Kim JL, Kang SW, Kang MK, Gong JH, Lee ES, et al. Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts. J Cell Biochem. 2012;113:247. doi:10.1002/jcb.23351

In our exploration, we found that silibinin, a key component of silymarin derived from milk thistle, shows promising effects on osteoporosis treatment. Through in vitro studies involving murine osteoblast and macrophage cells, silibinin not only boosted bone formation by promoting the growth and mineralization of bone cells but also helped inhibit the harmful activity of osteoclasts, which are responsible for bone resorption.

Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings.

Improves liver function

Most Useful Review

My doctor recommended silymarin to protect and restore my liver. After using 100 capsules, my liver function improved significantly, and my acne cleared up. This is likely the best silymarin available; I will order more for my parents to support their osteoporosis prevention.

Updated: Mar 2026

Pneumonia details

Inhalable silymarin shows promise

Hanafy NAN, El-Kemary MA. Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment. Int J Biol Macromol. 2022;198:101. doi:10.1016/j.ijbiomac.2021.12.073

We explored the potential of a new inhalable delivery system packed with silymarin and curcumin for treating lung inflammation caused by COVID-19. Through our research, we observed a significant reduction in key inflammatory markers in those treated with our formulated nanoparticles compared to control groups.

Furthermore, our study showed improved tissue profiles, indicating enhanced lung health. Additionally, silymarin demonstrated antiviral properties in laboratory tests against COVID-19. Overall, this innovative treatment approach could help address inflammation and improve recovery in respiratory conditions.

Restored health post-covid

Most Useful Review

This helped me after pneumonia from COVID. Following treatment, my test results improved significantly and the rash disappeared.

Updated: Mar 2026

Ulcer details

Silybin nanoparticles reduce ulcer markers

Based on 5 Researches

Varshosaz J, Minaiyan M, Khaleghi N. Eudragit nanoparticles loaded with silybin: a detailed study of preparation, freeze-drying condition and in vitro/in vivo evaluation. J Microencapsul. 2015;32:211. doi:10.3109/02652048.2014.995728

We investigated the use of silybin nanoparticles in treating ulcerative colitis (UC). These nanoparticles were carefully prepared and tested in a rat model, where UC was induced with acetic acid.

Over five days, we compared the effects of silybin nanoparticles with other treatments. The results showed significant improvements in both macroscopic and histopathological evaluations.

Notably, levels of harmful markers such as TNF-α and IL-6 were reduced, highlighting the potential benefit of silybin nanoparticles in ulcer treatment.

Ulcer healing support

Most Useful Review

I recommend it; it enhances the functioning of my intestines and pancreas, aids in detoxifying the body, speeds up metabolism, normalises appetite, and helps heal ulcers.

Updated: Mar 2026

Anemia details

Questionable

Silymarin shows potential in thalassemia

Gharagozloo M, Moayedi B, Zakerinia M, Hamidi M, Karimi M, et al. Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial. Fundam Clin Pharmacol. 2009;23:359. doi:10.1111/j.1472-8206.2009.00681.x

We conducted a randomized, double-blind clinical trial to investigate the effects of silymarin on patients with beta-thalassemia major.

Over three months, 59 patients received either silymarin along with desferrioxamine or a placebo.

While silymarin showed promising benefits, particularly in liver and red blood cell health, there was no significant difference in serum ferritin levels between groups after treatment.

However, we believe that this combination can be safely integrated into therapies for iron-overloaded patients.

Boosted energy levels

Most Useful Review

I've just started taking this supplement and was pleasantly surprised by the surge of energy it provides while I tackle my anaemia. My hair had been falling out in clumps for four years, and now I feel more confident while washing and combing it again.

Updated: Mar 2026

Anxiety details

Silibinin shows promise for anxiety

Based on 4 Researches

Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593

We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.

Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.

Reduced anxiety symptoms

Most Useful Review

1 people found this helpful

This is my third bottle. I take it to support my liver and I've found it helps significantly with anxiety during parties. A couple of capsules in the morning helps me manage anxiety, which I previously couldn't overcome without beer.

Updated: Mar 2026

Back Pain details

17 people found this helpful

Bulimia details

Mental and energy boost

I’ve been using this supplement for the past month with notable positive effects. It's not just physical; my mental clarity has increased, and my energy levels are consistent. The quality formula uses natural ingredients and is easy to integrate into my routine—there's no aftertaste or side effects. I highly recommend this for anyone seeking to improve their health and well-being, as it has made a significant difference for me.

Chemotherapy details

Liver function improved

The doctor prescribed the same treatment. My sister is on chemotherapy for lung cancer, and her liver enzyme levels increased after starting. I assured her that this would help protect her liver and lower the enzyme levels. After several blood tests, her oncology doctor also prescribed the same medication for daily use. Her liver function returned to normal, and chemotherapy is working effectively for her lung cancer.

Excellent! This drug is quite comfortable, and I recommend it to anyone who cares for their health. I have gastritis, but I have no adverse effects and my stomach tolerates it well. I bought a larger jar for a 3-month course. This should benefit anyone looking to improve liver health.

Gastritis details

Since starting this supplement, I have not had any gout attacks. The detox effect has been excellent.

Gout details

Kidney Stones details

Reduced kidney stones

6 people found this helpful

After a month of taking this supplement, I noticed improvements in my overall health. I took one pill in the morning and evening, and a kidney stone eventually passed. My metabolism improved, waist volume decreased, and I felt generally better overall. However, I noted white tongue coating indicating bad breath, which I monitored closely.

Obesity details

Silymarin reduces obesity effects

Based on 8 Researches

Kim S, You Y, Kim OK, Lee J, Chung JW, et al. Silymarin Prevents High-Fat Diet-Induced Muscle Atrophy by Regulating Protein Degradation and Synthesis in Mice. J Med Food. 2022;25:793. doi:10.1089/jmf.2021.K.0175

We explored how silymarin helps with obesity and muscle atrophy in mice. In our study, we divided the mice into three groups: a control group on a normal diet, another group on a high-fat diet, and a third group receiving silymarin alongside the high-fat diet.

The results showed that the silymarin group had less weight gain and maintained better muscle mass compared to the high-fat diet group. Moreover, the grip strength of the mice on silymarin improved. Overall, silymarin seems beneficial for not only tackling obesity but also preserving muscle health.

Enhanced energy levels

Most Useful Review

6 people found this helpful

Initially sceptical, I found Silymarin effective for my fatty liver caused by obesity. Within two weeks, my GGT levels decreased by 20, and I feel significantly better—more energetic and free from heartburn. I’m pleased with the results from taking two capsules daily.

Updated: Mar 2026

Acne Rosacea details

I have serious rosacea. After taking Silymarin for a week, my skin started to improve significantly. I have continued taking it for around two years now, and my skin is nearly restored. It has genuinely helped in managing my acne rosacea!

Arthritis details

Silymarin shows anti-arthritis potential

Based on 5 Researches

Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7:21.

We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.

While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.

Improved liver tests

Most Useful Review

Silymarin is outstanding for liver support. A friend with arthritis saw improvements in her liver tests after taking it while on strong medication. I highly recommend it.

Updated: Mar 2026

Chest Pain details

361 people found this helpful

Oops! I absolutely adore MILK THISTLE! It has 80% silymarin, which works wonders. After just one dose, the chest pain in my right side disappeared! Taking it with breakfast seems best as it aids bile production without irritating the gastrointestinal tract. Research supports silymarin's protective effects on liver cells and its ability to reduce liver inflammation. I have fatty hepatosis and decided to help my liver recover. This brand is effective and quick-acting. Highly recommended! Wishing everyone good health!

Updated: Mar 2025

Depression details

Silibinin reduces depression in mice

Based on 8 Researches

We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.

Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.

7.5

Improved well-being

Most Useful Review

1 people found this helpful

I really like this company, as the quality is good. My liver feels better with this product after a month. However, if I stop using it, I experience issues again. Milk Thistle has effects beyond liver health; it aids in tissue repair and even depression. I will continue taking this supplement.

Updated: Mar 2026

Eczema details

Silymarin shows no significant benefit

Iraji F, Sharif Makhmalzadeh B, Abedini M, Aghaei A, Siahpoush A. Effect of herbal cream containing and silymarin for treatment of eczema: A randomized double-blind controlled clinical trial. Avicenna J Phytomed. 2022;12:155. doi:10.22038/AJP.2022.19492

We examined how an herbal cream containing silymarin affects patients with eczema compared to a standard treatment. In a study with 40 patients suffering from mild to moderate eczema, participants used either the herbal cream or mometasone for two weeks.

After this period, we found notable improvements in skin severity scores for both treatments. However, there wasn't a significant difference between the two groups. This suggests that while both treatments are effective, silymarin may not be superior to traditional therapies for eczema relief.

7.5

Reduced symptoms

Most Useful Review

8 people found this helpful

My eczema has been painful for five years, making daily tasks difficult. After starting liver care with silymarin, my symptoms have notably improved. I feel better and will continue this treatment.

Updated: Mar 2026

Floaters details

I have been taking this supplement for quite some time, and it appears to lessen the intensity of my floaters.

Skin condition improvement

Frozen Shoulder details

A good supplement for liver and bile health, considerably cheaper and more effective than chophytol from a pharmacy. I purchased it for my child with keratosis on his shoulders and back, due to poor fat absorption and bile stagnation. The keratosis is nearly resolved, but progress takes time and multiple supplements.

High Cholesterol details

Silymarin positively influences cholesterol

Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050

We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.

Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.

However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.

Improved liver function

Most Useful Review

145 people found this helpful

Milk thistle is excellent for high liver enzymes. After being diagnosed with fatty liver, I took this supplement and immediately noticed a reduction in abdominal bloating and discomfort. Six months later, my liver function tests are nearly normal. I feel progressively better with no side effects.

Updated: Mar 2026

Menopause details

Effective herbal treatment for menopause

Based on 4 Researches

Saberi Z, Gorji N, Memariani Z, Moeini R, Shirafkan H, et al. Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial. Phytother Res. 2020;34:3359. doi:10.1002/ptr.6789

We evaluated the effects of Silybum marianum, a herbal remedy, on menopausal symptoms, particularly hot flashes. In a well-structured study with eighty women, half were given S. marianum extract while the other half received a placebo over 12 weeks.

Remarkably, the group taking Silybum saw a significant drop in the frequency and severity of hot flashes. Their scores on relevant scales improved notably compared to those on placebo.

This suggests that Silybum marianum could be an effective option for managing menopausal symptoms, making it a promising choice for women seeking relief.

Post-menopause refreshment

Most Useful Review

2 people found this helpful

Excellent! During menopause, I noticed my liver function declined. Drinking this before bed has me feeling refreshed in the mornings. I would like to continue using it for a while longer.

Updated: Mar 2026

Migraine details

YES! This works! Whenever I have a migraine due to indulging in brownies and sugar, I take this and it alleviates my migraine for sure. It detoxifies the liver.

Prostate Cancer details

Supports liver function

5 people found this helpful

Milk thistle seeds contain silymarin, a polyphenol known for its excellent effects, including anti-cancer properties and liver function improvement. Additionally, it normalises blood sugar, acts as an antioxidant, and lowers LDL cholesterol. With 100mg of dandelion root and 50mg of artichoke leaves, it’s the perfect combination. Now, I need not take them separately, making it the best value for money. This product may be a saviour for those who enjoy alcohol. Each tablet contains 240mg of silymarin, vital for supporting liver health.

Psoriasis details

Milk thistle shows anti-psoriatic effects

Kamel NM, El-Sayed SS, El-Said YAM, El-Kersh DM, Hashem MM, et al. Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress. Int Immunopharmacol. 2024;139:112781. doi:10.1016/j.intimp.2024.112781

We investigated how milk thistle extract might help treat psoriasis in mice. Our study involved forty Swiss albino mice divided into four groups, including a test group treated with the milk thistle extract after inducing psoriasis with imiquimod.

The results were encouraging, showing that the extract significantly reduced skin symptoms like redness and scaling, similar to traditional cortisone treatments. It worked by inhibiting specific cellular pathways, reducing inflammation and boosting antioxidant defenses, suggesting that milk thistle could be an effective new option for psoriasis treatment.

Mild psoriasis improvement

Most Useful Review

33 people found this helpful

Silymarin Milk Thistle has been a game-changer for me. After three weeks, my mild psoriasis is almost gone. I noticed an immediate boost in my energy from the first tablet and have even started giving it to my son with similar positive results.

Updated: Mar 2026

Attention Deficit Hyperactivity Disorder details

Liver function enhancement

10 people found this helpful

I began using this to improve liver dysfunction caused by non-alcoholic fatty liver. I noticed normalisation in about three months with little exercise and careful diet management. It’s worth trying for anyone facing liver issues, as it enhances wellbeing and comfort.

Insomnia details

Better sleep achieved

Thistle has stabilised my insomnia, depression, and autonomic disorders. The quality ingredients help relieve stress, improve concentration and sleep quality, making my sleep deeper and more effective.

55 people found this helpful

Nausea details

We really liked this supplement. Both my son and I take two capsules a day for our bile duct issues. Since starting Silymarin, the nausea has diminished significantly. We're looking forward to continuing this treatment.

I have PCOS and was diagnosed with fatty liver from a CT scan. With no medication for metabolic fatty liver syndrome available, I chose to try this product. I've heard good reports about milk thistle's ability to reverse fatty liver conditions.

Polycystic Ovary Syndrome details

4 people found this helpful

Bloating details

I suspect I have IBS, and after certain meals, I often feel bloated. These pills provide quick relief from bloating, and I believe they help detoxify my liver as well.

Hemorrhoids details

Effective for dysbiosis

I highly recommend milk thistle for healing liver cells and the body. It cleanses blood vessels and removes toxins. The fibre activates the intestines and helps with dysbiosis, hemorrhoids, hepatitis, and varicose veins. I have purchased it several times for my husband and myself, taking it as directed without side effects.

Reflux details

Reduced reflux symptoms

2 people found this helpful

I really liked this dietary supplement with milk thistle. My bile reflux has stopped, resulting in no more discomfort in my stomach after eating. It has helped cleanse my liver and normalise bile flow. I plan to continue taking it.

2 people found this helpful

Candidiasis details

Taking this has worked wonderfully for me as it cleanses the liver, especially when doing a detox diet to eliminate Candida overgrowth. It has also helped alleviate my constipation and eliminated toxins from my body—highly recommended and easy to swallow.

141 people found this helpful

Cholecystitis details

SILIMARINE is crucial for liver support! During my ultrasound, the doctor indicated mild obesity of the liver. This compelled me to consider liver health seriously. Despite being of normal weight, I acted quickly to support the liver, reading reviews and eventually purchasing silymarin. It’s my second order and maintaining liver health is a necessity. Milk thistle seeds contain valuable components like silymarin, which enhances metabolism and combats toxins. I'm currently taking two capsules daily and feel much lighter. The results have been positive, and I plan to continue using silymarin regularly.

10 people found this helpful

Chronic Cough details

Super Silymarin (Milk Thistle), recognised for centuries, may aid liver function. I take it due to chronic liver disease and gall bladder issues, combined with dandelion and artichoke, which enhance its effects. I also grind milk thistle seeds, adding them to my regimen.

Updated: Mar 2025

Heart Attack details

2,3-Dehydrosilybin aids heart protection

Based on 3 Researches

Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028

We investigated the effects of 2,3-dehydrosilybin, a component of silybum marianum, on heart protection during ischemia and reperfusion injuries in rats. Hearts treated with low doses of this compound experienced significantly reduced damage compared to untreated ones—only about 7.5% of the heart was affected versus over 75% in controls.

This suggests that silybum marianum could effectively support heart health by minimizing injury during heart attacks. Importantly, when specific kinases were inhibited, this protective effect vanished, highlighting the complexity of the mechanisms involved.

Heart health boost

Most Useful Review

The quality is high with excellent ingredients, beneficial for heart health. The wild squill is sealed and the quantity is ideal. I am very satisfied with this product.

Updated: Mar 2026

Hypertension details

Silybine lowers blood pressure in rats

Based on 3 Researches

Lecomte J. [General pharmacologic properties of silybine and silymarine in the rat]. Arch Int Pharmacodyn Ther. 1975;214:165.

We examined how silybine, the active ingredient in Silybum marianum, impacts blood pressure based on research conducted on normal albino rats. We found that even at low doses, silybine effectively lowers systemic blood pressure without causing increased vascular permeability.

Interestingly, it also helps counteract anaphylactic shocks and stabilize cell membranes, preventing histamine release. However, further studies are needed to fully understand its potential effects on hypertension in humans.

7.5

Blood pressure stabilised

Most Useful Review

I purchased this because of reviews suggesting it can improve hypertension and diabetes. I've only just started taking it, but my blood pressure has stabilised. I'm eager for my next appointment.

Updated: Mar 2026

Leg Cramps details

I’ve taken it a second time and really like its composition and effects. Leg cramps in my calves disappear quickly once I start taking it, and my emotional state becomes much more stable. I wish it were more readily available.

186 people found this helpful

Pelvic Pain details

An excellent product from a trusted brand! I've been using the silymarin complex for a month for liver issues. The pelvic pain is gone, and I'm pleased with the results. Highly recommended for those with liver problems!

Allergies details

Silibinin shows promise for asthma

Based on 4 Researches

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.

Effective support

Most Useful Review

64 people found this helpful

My husband suffered from seasonal allergies each spring, with watery and itchy eyes, and a runny nose. Over-the-counter antihistamines did nothing. Following a recommendation, I took a liver support regimen before the flowering season began, including silymarin and quercetin, alongside an antihistamine diet. It worked! Supporting the liver is crucial in managing allergies.

Updated: Mar 2026

Diabetes details

Silibinin shows potential for diabetes

Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x

We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.

It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.

7.5

Supports insulin resistance

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Now Foods’ milk thistle extract supports liver health and aids detoxification. Research shows it not only protects the liver but also helps regenerate cells, contributing to better diabetes management. Additionally, it may help lower cholesterol levels and has been found effective as an antidote for mushroom poisoning.

Updated: Mar 2026

Endometriosis details

Suffering from endometriosis, I often deal with bloating. After researching liver detoxification, I decided to try this product. I've been using a powerful dosage for a couple of months and absolutely love it. I no longer experience terrible bloating in the evenings, likely due to this product.

Updated: Apr 2026

Breast Cancer details

Silibinin enhances apoptosis in cancer

Pirouzpanah MB, Sabzichi M, Pirouzpanah S, Chavoshi H, Samadi N. Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pac J Cancer Prev. 2015;16:2087.

We explored the effects of silibinin, a natural flavonoid, on MCF7 breast cancer cells to assess its potential as a treatment option. Using flow cytometry, we discovered that silibinin significantly inhibits cell growth and induces apoptosis in a dose-dependent manner after 24 hours of treatment.

Notably, the study found increased expression of important genes related to apoptosis and cancer suppression, suggesting that silibinin could enhance the effectiveness of traditional chemotherapy. Its low side effects make it an appealing candidate for further research in cancer therapy.

Liver function normalised

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1 people found this helpful

The doctor prescribed the same treatment. My sister, undergoing chemotherapy for breast cancer, had elevated liver enzyme levels after starting her treatment. I informed her this would protect her liver and lower those levels. Eventually, her oncology doctor also prescribed it for her daily use. Her liver function returned to normal and the chemotherapy has been effective for her breast cancer.

Updated: Apr 2025

Cancer details

Investigating silibinin's cancer treatment role

Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901

We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.

Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.

Natural hepatoprotector

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18 people found this helpful

Silymarin, derived from milk thistle, is a non-toxic natural substance known for its hepatoprotective and antioxidant properties. It exhibits anti-cancer effects, improves liver function, and has been extensively studied in over 3,000 scientific papers. Its zero toxicity has been noted in various clinical studies.

Updated: Apr 2025

Chronic Fatigue Syndrome details

70 people found this helpful

This product has become a staple for managing my chronic fatigue syndrome. Taking 300mg twice daily energises me and reduces tiredness significantly. I'm delighted with the results and enjoy taking this alongside my favourite drinks.

Headache details

Hangover headaches gone

3 people found this helpful

I plan to reorder this product. My lifestyle led to heavy hangovers, but after three days of using this supplement, I've avoided headaches completely. I’ll definitely recommend it to friends.

Liver Disease details

Silymarin improves liver protection

Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520

We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.

Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.

7.5

Liver recovery observed

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1382 people found this helpful

Recently, I discovered that I have liver disease after tests revealed high enzyme levels. In a panic, I researched and learned that the liver has remarkable self-restorative abilities. I started a diet and looked into dietary supplements, purchasing one containing milk thistle and artichoke extract. Although I can't be certain of its specific effects, my tests returned to normal after a month. I recommend looking into these supplements for liver support.

Updated: Mar 2026

Swollen Lymph Nodes details

Relieved oral swelling

4 people found this helpful

I've suffered from tongue pain and mouth swelling without any known cause. After visiting a Chinese doctor without success, I tried this liver protection tablet, and I am pleased to say that the symptoms have vanished. It has worked wonders, and I plan to continue using it regularly—thank you, IHerb!

Constipation details

Metabolism improvement

9 people found this helpful

This is a good product! I will order more for my family. The small capsules are easy to swallow. The instructions advise one capsule three times daily, but I noticed benefits after my husband and I took one capsule at breakfast. Our metabolism has improved, and constipation is no longer a problem. We will continue as recommended.

Hepatitis details