Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
USERS' SCORE
Good
Based on 14 Reviews
8.5
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
83 mg (20 billion CFUs)
**
Inulin (Chicory root extract)
200 mg
**
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
2
We conducted a randomized, double-blind, placebo-controlled trial involving 94 children under 5, all suffering from functional constipation. Participants received either Lactobacillus rhamnosus or a placebo for four weeks. While we observed some increase in bowel movements in both groups throughout the study, Lcr35 did not show significant effectiveness compared to the placebo. Overall, our findings suggest that using this specific probiotic alone is not an effective treatment for constipation in young children. It reinforces existing guidelines against probiotics for this issue.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
Most Useful Reviews
9
Eliminated constipation
3 people found this helpful
An excellent probiotic; I bought it for the first time and am very satisfied. It effectively addressed my issues, and after taking one capsule at night, my stool improved immediately, constipation disappeared, and abdominal distension went away. This is essentially a SYNbiotic, as it contains I. rhamnosus and inulin. I recommend following a probiotic course of 1-2 months.
Read More
9
Effective solution
2 people found this helpful
This product works excellently; my adult granddaughter suffers from constipation, and it has worked like a charm for her.
Read More
9
Resolved constipation
1 people found this helpful
A remarkable probiotic I consume in courses, and it resolves all my digestive issues. I now have regular daily stools without any constipation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
- All Researches
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus VHProbi®M15 on constipation caused by sucralfate in mice. In a controlled study, groups of mice were either untreated, constipated, or given treatments with M15 or a standard laxative.
Our findings showed that M15 improved fecal water content and intestinal movement compared to untreated mice. Additionally, it helped restore gut health and boosted certain neurotransmitters related to digestion. Overall, M15 showed promise in alleviating constipation symptoms in this mouse model.
Our findings showed that M15 improved fecal water content and intestinal movement compared to untreated mice. Additionally, it helped restore gut health and boosted certain neurotransmitters related to digestion. Overall, M15 showed promise in alleviating constipation symptoms in this mouse model.
Read More
9
Lactobacillus rhamnosus restores gut motility
We investigated the impact of environmental pollutants on gut motility and whether Lactobacillus rhamnosus GG (LGG) could help restore normal function.
Exposed to pollutants, zebrafish showed reduced intestinal movement alongside decreased serotonin levels.
However, when treated with LGG, the zebrafish exhibited a significant improvement in gut motility through enhanced serotonin secretion.
This suggests that LGG may offer a probiotic solution to gut dysmotility caused by pollutants by rebuilding serotonin levels.
Exposed to pollutants, zebrafish showed reduced intestinal movement alongside decreased serotonin levels.
However, when treated with LGG, the zebrafish exhibited a significant improvement in gut motility through enhanced serotonin secretion.
This suggests that LGG may offer a probiotic solution to gut dysmotility caused by pollutants by rebuilding serotonin levels.
Read More
9
We examined whether synbiotics, which include Lactobacillus rhamnosus and other beneficial bacteria, help relieve functional constipation in children aged 4 to 18. In a controlled study, one group received synbiotics while the other received a placebo for four weeks.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eliminated constipation
3 people found this helpful
An excellent probiotic; I bought it for the first time and am very satisfied. It effectively addressed my issues, and after taking one capsule at night, my stool improved immediately, constipation disappeared, and abdominal distension went away. This is essentially a SYNbiotic, as it contains I. rhamnosus and inulin. I recommend following a probiotic course of 1-2 months.
Read More
9
Effective solution
2 people found this helpful
This product works excellently; my adult granddaughter suffers from constipation, and it has worked like a charm for her.
Read More
9
Resolved constipation
1 people found this helpful
A remarkable probiotic I consume in courses, and it resolves all my digestive issues. I now have regular daily stools without any constipation.
Read More
9
Enhanced digestion
I bought this for my boyfriend after his antibiotic course. The results surpassed our expectations; his digestion improved significantly, and he experienced no constipation or bloating. A high-quality product that supports gut health.
Read More
9
Aids digestion
The finest quality supplement for digestion. It truly aids my gut and alleviates constipation.
Read More
Frequently Asked Questions
7.5
Discomfort relief
1 people found this helpful
A great quality product. I wanted lactobacilli without bifidobacteria, and this fits perfectly. The small pill size is convenient, and my constipation ended within the second week of use. It has a mildly neutral flavour and is easy to digest and absorb.
8
Improves regularity
Fast delivery. I previously had issues with constipation, but this product has significantly improved my regularity. Good value for money. I will purchase it again.
9
Eliminated constipation
3 people found this helpful
An excellent probiotic; I bought it for the first time and am very satisfied. It effectively addressed my issues, and after taking one capsule at night, my stool improved immediately, constipation disappeared, and abdominal distension went away. This is essentially a SYNbiotic, as it contains I. rhamnosus and inulin. I recommend following a probiotic course of 1-2 months.
9
Resolved constipation
1 people found this helpful
A remarkable probiotic I consume in courses, and it resolves all my digestive issues. I now have regular daily stools without any constipation.
9
Enhanced digestion
I bought this for my boyfriend after his antibiotic course. The results surpassed our expectations; his digestion improved significantly, and he experienced no constipation or bloating. A high-quality product that supports gut health.
9
Aids digestion
The finest quality supplement for digestion. It truly aids my gut and alleviates constipation.
6
Alleviates diarrhoea
1 people found this helpful
I purchased this for my frequent diarrhoea, not constipation. The Ultimate Strength version worked well for me. I also changed my diet and included digestive enzymes.
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
9
We examined the effects of Lacticaseibacillus rhamnosus VHProbi®M15 on constipation caused by sucralfate in mice. In a controlled study, groups of mice were either untreated, constipated, or given treatments with M15 or a standard laxative.
Our findings showed that M15 improved fecal water content and intestinal movement compared to untreated mice. Additionally, it helped restore gut health and boosted certain neurotransmitters related to digestion. Overall, M15 showed promise in alleviating constipation symptoms in this mouse model.
Our findings showed that M15 improved fecal water content and intestinal movement compared to untreated mice. Additionally, it helped restore gut health and boosted certain neurotransmitters related to digestion. Overall, M15 showed promise in alleviating constipation symptoms in this mouse model.
8
We evaluated the potential of inulin, a popular prebiotic, in alleviating constipation symptoms based on a thorough review of existing studies. The research examined both animal models and clinical trials, uncovering that inulin appears to be one of the most effective prebiotics for promoting regular bowel movements.
Specifically, the findings suggest that inulin supplementation can enhance defecation frequency and improve stool consistency, making it a viable option for those grappling with constipation. Participants taking inulin reported positive changes in their gastrointestinal functions, leading to more comfortable and regular bowel habits.
However, while the results are promising, some critical questions around inulin's long-term effectiveness and the ideal dosage remain unanswered. We need further high-quality research to determine the best practices for using inulin in managing constipation more effectively.
In summary, while inulin shows significant potential as a remedy, ongoing investigation is essential to fine-tune our understanding and application in clinical settings.
Specifically, the findings suggest that inulin supplementation can enhance defecation frequency and improve stool consistency, making it a viable option for those grappling with constipation. Participants taking inulin reported positive changes in their gastrointestinal functions, leading to more comfortable and regular bowel habits.
However, while the results are promising, some critical questions around inulin's long-term effectiveness and the ideal dosage remain unanswered. We need further high-quality research to determine the best practices for using inulin in managing constipation more effectively.
In summary, while inulin shows significant potential as a remedy, ongoing investigation is essential to fine-tune our understanding and application in clinical settings.
8
We looked at how inulin, a type of prebiotic fiber, might help with constipation, especially in people suffering from irritable bowel syndrome (IBS). Given that IBS is a widespread issue causing significant discomfort and expense, finding effective treatments is crucial.
The research highlights that inulin appears to improve bowel regularity by influencing muscle contractions in the intestines and adjusting stool consistency and frequency. This occurs through the positive changes it makes to the gut microbiota, which is the community of microorganisms living in our digestive tracts.
While the initial findings pointing to inulin's benefits for IBS patients with constipation (often called IBS-C) are promising, we recognize that more extensive randomized controlled trials are essential. These studies should involve larger patient groups to further validate inulin's effectiveness and better understand how it can be used in treatment plans.
The research highlights that inulin appears to improve bowel regularity by influencing muscle contractions in the intestines and adjusting stool consistency and frequency. This occurs through the positive changes it makes to the gut microbiota, which is the community of microorganisms living in our digestive tracts.
While the initial findings pointing to inulin's benefits for IBS patients with constipation (often called IBS-C) are promising, we recognize that more extensive randomized controlled trials are essential. These studies should involve larger patient groups to further validate inulin's effectiveness and better understand how it can be used in treatment plans.
References
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
- Zhang Z, Liu B, Liu W, Liu X, Zhang C, et al. Different Efficacy of Five Soluble Dietary Fibers on Alleviating Loperamide-Induced Constipation in Mice: Influences of Different Structural Features. Int J Mol Sci. 2025;26. doi:10.3390/ijms26031236
- Andreozzi V, Cuoco S, Balestrieri M, Fierro F, Ferrara N, et al. Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study. Sci Rep. 2024;14:23095. doi:10.1038/s41598-024-74400-w
- García-Milla P, Peñalver R, Nieto G. Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13060683
- Zou H, Gao H, Liu Y, Zhang Z, Zhao J, et al. Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid. Int J Biol Macromol. 2024;259:129420. doi:10.1016/j.ijbiomac.2024.129420
- Isakov VA, Pilipenko VI, Vlasova AV, Kochetkova AA. Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study. Curr Dev Nutr. 2023;7:102037. doi:10.1016/j.cdnut.2023.102037
- Araújo MM, Botelho PB. Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Front Nutr. 2022;9:935830. doi:10.3389/fnut.2022.935830
- Pilipenko VI, Isakov VA, Morozov SV, Vlasova AV, Kochetkova AA. [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]. Vopr Pitan. 2022;91:95. doi:10.33029/0042-8833-2022-91-5-95-104
- Liao W, Su M, Zhang D. A study on the effect of symbiotic fermented milk products on human gastrointestinal health: Double-blind randomized controlled clinical trial. Food Sci Nutr. 2022;10:2947. doi:10.1002/fsn3.2890
- Bărboi OB, Chirilă I, Ciortescu I, Anton C, Drug VL. Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study. J Clin Med. 2022;11. doi:10.3390/jcm11082248
- Yu X, Fu C, Cui Z, Chen G, Xu Y, et al. Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows. J Anim Sci. 2021;99. doi:10.1093/jas/skab257
- Omori K, Miyakawa H, Watanabe A, Nakayama Y, Lyu Y, et al. The Combined Effects of Magnesium Oxide and Inulin on Intestinal Microbiota and Cecal Short-Chain Fatty Acids. Nutrients. 2021;13. doi:10.3390/nu13010152
- Bărboi OB, Ciortescu I, Chirilă I, Anton C, Drug V. Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Exp Ther Med. 2020;20:185. doi:10.3892/etm.2020.9315
- García Contreras AA, Vásquez Garibay EM, Sánchez Ramírez CA, Fafutis Morris M, Delgado Rizo V. DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12102971
- Glibowski P, Skrzypek M, Ćwiklińska M, Drozd M, Kowalska A. Chemical stability of fructans in apple beverages and their influence on chronic constipation. Food Funct. 2020;11:3860. doi:10.1039/c9fo02596k
- Le Bastard Q, Chapelet G, Javaudin F, Lepelletier D, Batard E, et al. The effects of inulin on gut microbial composition: a systematic review of evidence from human studies. Eur J Clin Microbiol Infect Dis. 2020;39:403. doi:10.1007/s10096-019-03721-w
- Chu JR, Kang SY, Kim SE, Lee SJ, Lee YC, et al. Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study. World J Gastroenterol. 2019;25:6129. doi:10.3748/wjg.v25.i40.6129
