Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.8
USERS' SCORE
Moderately Good
Based on 36 Reviews
7.4
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
40 mg (10 billion CFUs)
**
Inulin (Chicory Root Extract)
200 mg
**
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
8
Lactobacillus shows promise for constipation
We investigated the effects of a new microbial strain, LP-HFY11, on constipation caused by a common medication in mice. The results showed that LP-HFY11 helped maintain fecal weight and improved gut movement. Those given a high dose expelled stool faster than others treated with lactulose, although still slower than in normal mice.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
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2
We conducted a randomized, double-blind, placebo-controlled trial involving 94 children under 5, all suffering from functional constipation. Participants received either Lactobacillus rhamnosus or a placebo for four weeks. While we observed some increase in bowel movements in both groups throughout the study, Lcr35 did not show significant effectiveness compared to the placebo. Overall, our findings suggest that using this specific probiotic alone is not an effective treatment for constipation in young children. It reinforces existing guidelines against probiotics for this issue.
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Most Useful Reviews
10
Life-changing results
24 people found this helpful
For almost two years, I've battled painful constipation and tried numerous supplements. Three days in with this product, I've been able to go every single day. It’s completely life-changing. My mind is clearer, my stomach pain is gone, and there's been no negative side effects. I’m so pleased with the improvement.
Read More
9
Chronic issues solved
13 people found this helpful
Not all prebiotics are equal! I suffer from chronic constipation and had tried everything, but only after using this prebiotic did I find relief! I take one in the morning with a glass of water and another at night before bed. The next morning, I have a regular movement without straining, something I previously struggled with. As long as I take this, I feel wonderful, though the price is a bit steep!
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9
Effective relief
9 people found this helpful
Culturelle has completely turned things around for me in under a week. I previously struggled with painful bloating and constipation for months and found Unbloat ineffective. Now, I'm really impressed and happy with the results. I highly recommend giving this a try.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.8
- All Researches
9
We explored the potential of the probiotic CCFM1163 to alleviate slow-transit constipation caused by prolonged laxative use, known as cathartic colon. Using a mouse model, we observed how this probiotic affects the gut's nerve and barrier functions.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
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9
Probiotics effectively relieve constipation
We explored how specific microbial agents can change the gut bacteria and help relieve constipation in mice. The study focused on two treatments, including Lactobacillus, and found they increased beneficial gut bacteria and improved peristalsis, which is the movement that helps waste pass through the intestines.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
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9
Lactobacillus reduces constipation symptoms
We explored the effects of a fermented milk product containing two specific probiotic strains, Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1, on relieving constipation in mice.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
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9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
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9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 36 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing results
24 people found this helpful
For almost two years, I've battled painful constipation and tried numerous supplements. Three days in with this product, I've been able to go every single day. It’s completely life-changing. My mind is clearer, my stomach pain is gone, and there's been no negative side effects. I’m so pleased with the improvement.
Read More
9
Chronic issues solved
13 people found this helpful
Not all prebiotics are equal! I suffer from chronic constipation and had tried everything, but only after using this prebiotic did I find relief! I take one in the morning with a glass of water and another at night before bed. The next morning, I have a regular movement without straining, something I previously struggled with. As long as I take this, I feel wonderful, though the price is a bit steep!
Read More
9
Effective relief
9 people found this helpful
Culturelle has completely turned things around for me in under a week. I previously struggled with painful bloating and constipation for months and found Unbloat ineffective. Now, I'm really impressed and happy with the results. I highly recommend giving this a try.
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0
Worsened constipation
5 people found this helpful
I became constipated and my stomach felt unwell after starting it, so I stopped. It was a quality product, but unfortunately, it did not suit me.
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7.5
Improves digestion
4 people found this helpful
Contains inulin, which works as a prebiotic and aids in digestion. It promotes beneficial bacteria growth, reduces constipation, lowers cholesterol levels, and helps control appetite. I appreciate the healing properties it offers.
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Frequently Asked Questions
9
Effective remedy
3 people found this helpful
My elderly relative struggled with constipation for years, but after just two doses, they noticed an immediate improvement. They felt much better overall and have decided to continue using it.
7.5
Aids digestion
1 people found this helpful
This product helps alleviate constipation and bloating effectively.
5
Still constipated
I am in my second week and still feel bloated and constipated. I hope to see results by the end of this trial month.
7.5
Relieves constipation
2 people found this helpful
I've often faced constipation since childhood despite being careful with my diet. After trying various supplements, I settled on Culturel. Since taking it, I haven't experienced constipation, and the capsules are small and easy to swallow.
9
Improved regularity
1 people found this helpful
One notable benefit I’ve experienced is improved regularity. This probiotic gently alleviates my occasional constipation, allowing me to feel more balanced and in control of my digestive system.
0
Did not work
1 people found this helpful
There was no response after taking one pill on the first two days and two pills from the third to the fifth day. I remained constipated for five days—this probiotic didn’t work for me.
1
Ineffective for constipation
It worked after the first dose, but then no effect. I believe the result was due to inulin, not the bacteria strain. It did not relieve my constipation, so I would not recommend this strain.
7.5
Improves digestion
4 people found this helpful
Contains inulin, which works as a prebiotic and aids in digestion. It promotes beneficial bacteria growth, reduces constipation, lowers cholesterol levels, and helps control appetite. I appreciate the healing properties it offers.
3
No effect on constipation
Honestly, I haven't seen any difference. The pill was easy to swallow, but my constipation hasn't improved after two months. Perhaps the quality is good, but it simply did not work for me.
9
Synbiotic treatment benefits constipation
We explored how synbiotic treatment, which included inulin and probiotics, could improve constipation and non-motor symptoms in patients with stable Parkinson's Disease (PD). In a study involving patients diagnosed with functional constipation, we administered a synbiotic product that contained the prebiotic fiber inulin for 12 weeks.
Throughout the study, we observed significant enhancements in various symptoms. On the neurological side, patients displayed better results in scales that measure non-motor symptoms, like mood and cognitive function. The gastroenterological evaluations, which specifically looked at constipation, showed notable improvements too. For instance, there was a measurable increase in the number of complete bowel movements and enhancements in patients’ overall comfort.
While our focus was on the synbiotic mixture, the role of inulin as a fiber source cannot be underestimated. It appears to contribute substantially to the observed gastrointestinal benefits. The evidence suggests that while synbiotics may help alleviate constipation and improve general well-being, we cannot make any definitive claims solely based on inulin's effects, as it was part of a combined formulation. Overall, our findings indicate that synbiotic supplementation can be beneficial for PD patients, especially those suffering from constipation.
Throughout the study, we observed significant enhancements in various symptoms. On the neurological side, patients displayed better results in scales that measure non-motor symptoms, like mood and cognitive function. The gastroenterological evaluations, which specifically looked at constipation, showed notable improvements too. For instance, there was a measurable increase in the number of complete bowel movements and enhancements in patients’ overall comfort.
While our focus was on the synbiotic mixture, the role of inulin as a fiber source cannot be underestimated. It appears to contribute substantially to the observed gastrointestinal benefits. The evidence suggests that while synbiotics may help alleviate constipation and improve general well-being, we cannot make any definitive claims solely based on inulin's effects, as it was part of a combined formulation. Overall, our findings indicate that synbiotic supplementation can be beneficial for PD patients, especially those suffering from constipation.
8
Lactobacillus improves infant constipation
We aimed to understand how Lactobacillus reuteri NCIMB 30351 drops could help infants experiencing constipation and other gastrointestinal issues.
In a controlled study with 90 infants, we found that those receiving the drops had an increase in the number of bowel movements compared to those taking a placebo.
Additionally, other symptoms like regurgitation and crying were significantly reduced. This suggests that L. reuteri is a safe and effective option for relieving constipation and associated discomfort in newborns.
In a controlled study with 90 infants, we found that those receiving the drops had an increase in the number of bowel movements compared to those taking a placebo.
Additionally, other symptoms like regurgitation and crying were significantly reduced. This suggests that L. reuteri is a safe and effective option for relieving constipation and associated discomfort in newborns.
8
We evaluated the potential of inulin, a popular prebiotic, in alleviating constipation symptoms based on a thorough review of existing studies. The research examined both animal models and clinical trials, uncovering that inulin appears to be one of the most effective prebiotics for promoting regular bowel movements.
Specifically, the findings suggest that inulin supplementation can enhance defecation frequency and improve stool consistency, making it a viable option for those grappling with constipation. Participants taking inulin reported positive changes in their gastrointestinal functions, leading to more comfortable and regular bowel habits.
However, while the results are promising, some critical questions around inulin's long-term effectiveness and the ideal dosage remain unanswered. We need further high-quality research to determine the best practices for using inulin in managing constipation more effectively.
In summary, while inulin shows significant potential as a remedy, ongoing investigation is essential to fine-tune our understanding and application in clinical settings.
Specifically, the findings suggest that inulin supplementation can enhance defecation frequency and improve stool consistency, making it a viable option for those grappling with constipation. Participants taking inulin reported positive changes in their gastrointestinal functions, leading to more comfortable and regular bowel habits.
However, while the results are promising, some critical questions around inulin's long-term effectiveness and the ideal dosage remain unanswered. We need further high-quality research to determine the best practices for using inulin in managing constipation more effectively.
In summary, while inulin shows significant potential as a remedy, ongoing investigation is essential to fine-tune our understanding and application in clinical settings.
References
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- Guo K, Tang Y, Yang T, Yan Y. Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. Front Cell Infect Microbiol. 2025;15:1556915. doi:10.3389/fcimb.2025.1556915
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- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
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- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
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- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
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- Isakov VA, Pilipenko VI, Vlasova AV, Kochetkova AA. Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study. Curr Dev Nutr. 2023;7:102037. doi:10.1016/j.cdnut.2023.102037
- Araújo MM, Botelho PB. Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Front Nutr. 2022;9:935830. doi:10.3389/fnut.2022.935830
- Pilipenko VI, Isakov VA, Morozov SV, Vlasova AV, Kochetkova AA. [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]. Vopr Pitan. 2022;91:95. doi:10.33029/0042-8833-2022-91-5-95-104
- Liao W, Su M, Zhang D. A study on the effect of symbiotic fermented milk products on human gastrointestinal health: Double-blind randomized controlled clinical trial. Food Sci Nutr. 2022;10:2947. doi:10.1002/fsn3.2890
- Bărboi OB, Chirilă I, Ciortescu I, Anton C, Drug VL. Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study. J Clin Med. 2022;11. doi:10.3390/jcm11082248
- Yu X, Fu C, Cui Z, Chen G, Xu Y, et al. Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows. J Anim Sci. 2021;99. doi:10.1093/jas/skab257
- Omori K, Miyakawa H, Watanabe A, Nakayama Y, Lyu Y, et al. The Combined Effects of Magnesium Oxide and Inulin on Intestinal Microbiota and Cecal Short-Chain Fatty Acids. Nutrients. 2021;13. doi:10.3390/nu13010152
- Bărboi OB, Ciortescu I, Chirilă I, Anton C, Drug V. Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Exp Ther Med. 2020;20:185. doi:10.3892/etm.2020.9315
- García Contreras AA, Vásquez Garibay EM, Sánchez Ramírez CA, Fafutis Morris M, Delgado Rizo V. DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12102971
- Glibowski P, Skrzypek M, Ćwiklińska M, Drozd M, Kowalska A. Chemical stability of fructans in apple beverages and their influence on chronic constipation. Food Funct. 2020;11:3860. doi:10.1039/c9fo02596k
- Le Bastard Q, Chapelet G, Javaudin F, Lepelletier D, Batard E, et al. The effects of inulin on gut microbial composition: a systematic review of evidence from human studies. Eur J Clin Microbiol Infect Dis. 2020;39:403. doi:10.1007/s10096-019-03721-w
- Chu JR, Kang SY, Kim SE, Lee SJ, Lee YC, et al. Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study. World J Gastroenterol. 2019;25:6129. doi:10.3748/wjg.v25.i40.6129
