Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 89 Researches
7.6
USERS' SCORE
Good
Based on 44 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Colon Care BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221), Bifidobacterium lactis (SD-5674), Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk) Concentrate, ^Eastern European Wild Kefir Culture containing Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum, Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris, Streptococcus thermophilus, Lactobacillus kefir, Lactobacillus parakefir, Lactobacillus plantarum, Lactococcus lactis biovar diacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromyces marxianus, Brettanomyces anomalus, Debaryomyces hansenii, Saccharomyces unisporus, Saccharomyces turicensis, Saccharomyces cerevisiae, Saccharomyces exiguus, Torulaspora delbrueckii
50 Billion CFU¹
+
Colon Transit Support Enzyme BlendAmylase, Protease, Lactase, Glucoamylase, alpha-Galactosidase, Lipase, Pectinase, Peptidase, Bromelain, Phytase, Hemicellulase, beta-Glucanase, Papain, Cellulase, Xylanase, Diastase, Invertase
50 mg
+
Eastern European Raw Fruit & Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+

Top Medical Research Studies

9
Probiotic improves IBS-C symptoms
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.

After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.

Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
BLa80 shows promise for constipation
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.

The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
Bifidobacterium lactis alleviates constipation
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.

After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.

Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More

Most Useful Reviews

9.5
Homeopathic relief
Diagnosed with gastroparesis, I've faced awful constipation. Prescription laxatives added nausea, so I sought homeopathic remedies. This product, combined with other herbs, has worked wonders. I'm off laxatives and can finally eat easier-digested solid foods.
Read More
9.5
Resolved constipation
Good probiotic. The product genuinely works. My constipation problem has been resolved.
Read More
9.5
Eliminated constipation
I found this probiotic ideal for restoring intestinal microflora. With 33 strains and 50bn CFU per capsule, it effectively improves colon health and bowel function. It contains a beneficial blend of prebiotics and enzymes. This high-potency formula has noticeably restored gut health and has successfully eliminated constipation for me. I recommend taking one daily.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 89 Researches
7.6
  • All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.

At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.

The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.

Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
Lactobacillus rhamnosus reduces constipation
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).

We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
Probiotic improves IBS-C symptoms
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.

After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.

Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More

User Reviews

USERS' SCORE
Good
Based on 44 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Homeopathic relief
Diagnosed with gastroparesis, I've faced awful constipation. Prescription laxatives added nausea, so I sought homeopathic remedies. This product, combined with other herbs, has worked wonders. I'm off laxatives and can finally eat easier-digested solid foods.
Read More
9.5
Resolved constipation
Good probiotic. The product genuinely works. My constipation problem has been resolved.
Read More
9.5
Eliminated constipation
I found this probiotic ideal for restoring intestinal microflora. With 33 strains and 50bn CFU per capsule, it effectively improves colon health and bowel function. It contains a beneficial blend of prebiotics and enzymes. This high-potency formula has noticeably restored gut health and has successfully eliminated constipation for me. I recommend taking one daily.
Read More
8.8
Improved bowel regularity
From the 7th month of pregnancy, I suffered from constipation, but once I began using these probiotics, the situation improved almost immediately. After two months of use, I find my bowel movements are regular now. A balanced diet with fruits and vegetables has also contributed to this improvement.
Read More
7
Improved digestion
Microbiome support while taking Upd. After completing the course, my constipation returned. I have dolichocolon, and constipation is frequent for me; I know a lot about it. The packaging is designed for a month's use. It's vital to open the capsule and consume the contents for the drug's effect to be seen—the stool has improved. I take one capsule on an empty stomach. The ingredients are natural, and my digestion has notably improved. The benefits are clear; my intestines have begun functioning well. This is the first time I purchased this brand, and I am pleased with the results.
Read More

Frequently Asked Questions

Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.

To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.

Probiotics are live microorganisms, primarily bacteria, that are intended to provide health benefits when consumed in adequate amounts. These beneficial bacteria are often referred to as "good" or "friendly" bacteria because they help maintain a balanced gut microbiome, which plays a vital role in digestion, immune function, and overall health. Probiotics can be found in various foods such as yogurt, kefir, sauerkraut, and kombucha, as well as in dietary supplements. The most common strains include Lactobacillus and Bifidobacterium, which have been studied for their positive effects on gastrointestinal health, including the alleviation of symptoms related to irritable bowel syndrome (IBS) and diarrhea.

Incorporating probiotics into your diet may help support a healthy gut by competing with harmful bacteria and promoting a more diverse microbiome. However, it's important to note that the specific effects of probiotics can vary widely depending on the strain, dosage, and individual health conditions. While many people may benefit from including probiotics in their diet, it's advisable to consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health issues or concerns. For those looking to explore the world of probiotics, it’s worth experimenting with various sources to find what works best for your body.

Probiotics may offer relief for some individuals suffering from constipation by promoting a healthier gut microbiome and improving overall digestive function. Certain strains of probiotic bacteria, like Bifidobacterium and Lactobacillus, have been shown in studies to enhance stool frequency and consistency in some people. By balancing gut bacteria, probiotics can potentially assist in regulating bowel movements and improving gut motility, which is particularly beneficial for those experiencing chronic constipation.

However, the effectiveness of probiotics can vary greatly from person to person, and not all probiotic supplements are created equal. It's important to choose a product that contains strains specifically studied for constipation relief and to consult with a healthcare provider to identify the most suitable option for individual needs. Additionally, incorporating a diet rich in fiber and staying hydrated are essential complementary strategies for managing constipation.

Based on user reviews, the time it typically takes to see results from this probiotic supplement for constipation varies. Many users report experiencing relief almost immediately or within days of starting the supplement. For example, one user mentioned that their constipation improved almost immediately after beginning to use the probiotics, while another indicated that positive changes were noted after just over a week of use (Read Review) (Read Review).

However, other users noted that it might take a bit longer for more noticeable results, with some reporting regular bowel movements after two weeks or more (Read Review) (Read Review). In summary, while some users notice quick improvements, others may need to consistently take the supplement for several days to weeks to experience the full benefits.

Scientific research supports some probiotic supplements for managing constipation, showing potential benefits across various populations. A number of studies have found that specific strains, particularly Lactobacillus and Bifidobacterium, can improve stool frequency and consistency in diverse groups including children, seniors, and individuals with specific health conditions. For instance, a trial involving children reported a significant increase in defecation frequency when treated with probiotics (research-id='36071965'), while elderly participants showed some improvement with multistrain probiotics (research-id='35927504'). Moreover, a study focusing on patients with functional constipation indicated the probiotics led to enhanced gastrointestinal comfort, highlighting their potential role in alleviating symptoms (research-id='35350100').

However, while the data indicates promise, the results are not uniformly significant across all trials. For instance, one study found improvements, but no statistically significant differences were observed between treatment and placebo groups (research-id='36316826'). Additionally, while many studies illustrated an increase in stool frequency or quality, others did not yield compelling evidence for the effectiveness of specific probiotic strains like Bifidobacterium longum in enhancing bowel movement frequency significantly (research-id='32005532'). Therefore, while certain probiotics show potential for constipation relief, ongoing research is critical to fully understand their efficacy and to tailor recommendations effectively.

Based on user reviews, many individuals have reported notable improvements in their constipation symptoms after starting this probiotic supplement. Users such as the one who stated, "The product genuinely works. My constipation problem has been resolved" illustrate the quick relief some have experienced (Read Review). Another user mentioned their bowel movements became regular within two months of use, evidencing the long-term benefits of consistent supplementation (Read Review). Additionally, several users have noted complete alleviation of their constipation, with one remarking, "constipation disappeared" after just one month of usage (Read Review).

It's important to note that while these improvements are encouraging, individual results can vary significantly. Not all reviews reflect a positive experience; for instance, one user expressed dissatisfaction, stating they experienced severe constipation after taking the product (Read Review). Others have mentioned that the supplement worked well for them, noting enhanced microbiome health and regular bowel function (Read Review). Overall, while many users have reported effective relief from constipation, responses to probiotics can differ from person to person.

Based on user reviews, many individuals have successfully combined this probiotic supplement with other dietary supplements or lifestyle changes to better manage constipation. For instance, one user noted that alongside a balanced diet rich in fruits and vegetables, the probiotics led to improved regularity in bowel movements after two months (Read Review). Another user shared their experience of improved gut health and elimination of constipation by incorporating a higher intake of vegetables to support their microbiome while using the probiotics (Read Review).

Conversely, some users reported negative experiences when taking the probiotics without such complementary dietary adjustments. One review highlighted a lack of positive effects and an escalation in constipation when the user did not modify their dietary habits while taking the supplement (Read Review). Overall, it appears that combining this probiotic with a healthy diet or other supplements can enhance its effectiveness, though individual responses may vary.

According to user reviews, many individuals find that a daily dose of probiotics effectively alleviates their constipation issues. A commonly suggested dosage appears to be one capsule per day, which is noted for its role in restoring intestinal health and improving bowel functions. For instance, one user highlights that taking one capsule daily led to significant improvements in their gut health and eliminated their constipation, stating, "I recommend taking one daily" (Read Review). Another user reported achieving regular bowel movements after consistently using the probiotics for two months, suggesting that a sustained daily intake contributes to ongoing benefits (Read Review).

However, not all experiences were positive; a few users reported adverse effects, such as worsening constipation or requiring medical intervention, which could indicate the importance of finding the right product and dosage (Read Review). Overall, while a daily dose of one capsule is commonly recommended and has yielded positive results for many, individual responses can vary, emphasizing the need for users to pay attention to their digestive health and consult healthcare professionals when necessary.

8.8
Improved bowel regularity
From the 7th month of pregnancy, I suffered from constipation, but once I began using these probiotics, the situation improved almost immediately. After two months of use, I find my bowel movements are regular now. A balanced diet with fruits and vegetables has also contributed to this improvement.
8.8
Constipation relief
This is a super high-quality probiotic essential for healthy microflora. It enhances intestinal function, restores the microbiome, and improves digestion. After a little over a week, I've already noticed positive changes, and the benefits of the product are undeniable. I recommend it.
9.5
Smooth daily stools
The effect on constipation is excellent; I have smooth movements daily, and I will continue to repurchase...
9.5
Restored bowel function
Excellent probiotics! In the first month, my bowel function was restored, and constipation disappeared. This is my third order, and I am very pleased with the results. I highly recommend them.
9.5
Resolved constipation
Good probiotic. The product genuinely works. My constipation problem has been resolved.
0
Worsened constipation
The product’s quality is good with clean ingredients, but it is somewhat pricey. However, since starting it, I experienced severe constipation and cramps. The situation worsened, requiring a visit to the doctor, so I am returning it as it did not suit me at all.
9.5
Regular bowel function
A reliable remedy that I trust due to its high quality. With convenient packaging, my intestines now work like clockwork, increasing microbiome health and reducing constipation. The capsules are flavourless and easily swallowed with water.
4.8
No more gases
All products from this firm are unique and beneficial. This supplement helped me eliminate gases and enhance my immune system. Thanks to a healthy lifestyle and attention to my intestines, illnesses have become rare over the year. It's wise to increase vegetable intake while using this supplement to nourish the microbiome and prevent constipation.
9.5
Eliminated constipation
I found this probiotic ideal for restoring intestinal microflora. With 33 strains and 50bn CFU per capsule, it effectively improves colon health and bowel function. It contains a beneficial blend of prebiotics and enzymes. This high-potency formula has noticeably restored gut health and has successfully eliminated constipation for me. I recommend taking one daily.

References

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  2. Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
  3. Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
  4. Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
  5. Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
  6. Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
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  11. Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. doi:10.5851/kosfa.2017.37.6.906
  12. Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
  13. Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
  14. Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. doi:10.5009/gnl.2011.5.1.22
  15. Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328
  16. Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. doi:10.1089/jmf.2009.1307
  17. Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
  18. Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
  19. Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
  20. Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
  21. Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
  22. Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
  23. Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
  24. Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
  25. Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
  26. Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
  27. Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
  28. Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
  29. Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
  30. Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
  31. Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
  32. Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
  33. Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. doi:10.1007/s42770-024-01276-3
  34. Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
  35. Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. doi:10.1016/j.chom.2023.10.011
  36. Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
  37. Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
  38. Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
  39. Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. doi:10.14309/ajg.0000000000002028
  40. Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
  41. Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
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