Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 77 Researches
7.7
USERS' SCORE
Good
Based on 17 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Replenish BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221),Lactobacillus paracasei (SD-5218), Bifidobacterium lactis (SD-5220),Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk)Concentrate, ^Eastern European Wild Kefir Culture containingBifidobacterium lactis, Bifidobacterium longum, Lactobacillusacidophilus, Lactobacillus brevis, Lactobacillus bulgaricus,Lactobacillus casei, Lactobacillus fermentum, Lactobacillushelveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum,Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris,Streptococcus thermophilus, Lactobacillus kefir, Lactobacillusparakefir, Lactobacillus plantarum, Lactococcus lactis biovardiacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides,Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromycesmarxianus, Brettanomyces anomalus, Debaryomyces hansenii,Saccharomyces unisporus, Saccharomyces turicensis,Saccharomyces cerevisiae, Saccharomyces exiguus,Torulaspora delbrueckii
100 Billion CFU¹
+
Protein-Digesting Enzyme BlendProtease, Acid Protease, Protease S
50 mg
+
Eastern European Raw Fruit and Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
Most Useful Reviews
10
Restores microflora
13 people found this helpful
PERFECT PROBIOTIC. The ideal probiotic for the restoration of intestinal microflora - 34 probiotic strains, with clinically studied species and culture of the Eastern European wild kefir culture; 100 billion CFU in 1 capsule. Each capsule contains an excellent composition of prebiotic - red bell peppers, green peas, carrots, plums, cherries, strawberries, raspberries and a mixture of enzymes for digesting proteins. No refrigeration is required. Perfectly restores intestinal microflora and eliminates constipation. I really liked it. I bought the same probiotic for the health of the colon, and I was pleased with the action.
Read More
9
Instant relief from constipation
6 people found this helpful
Worth it. After being on triple therapy and high doses of antibiotics, my gut flora suffered terribly. I tried various probiotics, but none worked until I discovered this one. This probiotic provided immediate relief from gas, bloat, and constipation within 30 minutes. After the second dose, I had a bowel movement. It's also convenient for travel, as I opted for the shelf-stable version.
Read More
10
Constipation relief
5 people found this helpful
This product is a godsend! I used to have trouble with constipation and yeast infection, but after trying my first bottle, it helped solve both issues. I'm now on my third bottle and feeling great. I try to maintain a healthy, low-sugar, no-yeast diet which helps tremendously with my yeast infection. I highly recommend it to everyone!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 77 Researches
7.7
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Restores microflora
13 people found this helpful
PERFECT PROBIOTIC. The ideal probiotic for the restoration of intestinal microflora - 34 probiotic strains, with clinically studied species and culture of the Eastern European wild kefir culture; 100 billion CFU in 1 capsule. Each capsule contains an excellent composition of prebiotic - red bell peppers, green peas, carrots, plums, cherries, strawberries, raspberries and a mixture of enzymes for digesting proteins. No refrigeration is required. Perfectly restores intestinal microflora and eliminates constipation. I really liked it. I bought the same probiotic for the health of the colon, and I was pleased with the action.
Read More
9
Instant relief from constipation
6 people found this helpful
Worth it. After being on triple therapy and high doses of antibiotics, my gut flora suffered terribly. I tried various probiotics, but none worked until I discovered this one. This probiotic provided immediate relief from gas, bloat, and constipation within 30 minutes. After the second dose, I had a bowel movement. It's also convenient for travel, as I opted for the shelf-stable version.
Read More
10
Constipation relief
5 people found this helpful
This product is a godsend! I used to have trouble with constipation and yeast infection, but after trying my first bottle, it helped solve both issues. I'm now on my third bottle and feeling great. I try to maintain a healthy, low-sugar, no-yeast diet which helps tremendously with my yeast infection. I highly recommend it to everyone!
Read More
9
Effective for husband's constipation
2 people found this helpful
GREAT PRODUCT! These are fantastic! My husband struggled with constipation until he started taking these pills each night before bed. They work remarkably well for gut health!
Read More
10
Effective bowel care
1 people found this helpful
Excellent probiotic. It works best for me compared to other brands regarding bowel movements. No longer have constipation. Other brands can cause me bloating. It helps replenish gut bacteria after antibiotics.
Read More
Frequently Asked Questions
10
Symptoms resolved
This is a great product for anyone needing to take frequent courses of antibiotics or suffering from symptoms like bloating or constipation. After several days of taking this product, my symptoms were gone and I felt better than I had in months.
10
Constipation relief
5 people found this helpful
This product is a godsend! I used to have trouble with constipation and yeast infection, but after trying my first bottle, it helped solve both issues. I'm now on my third bottle and feeling great. I try to maintain a healthy, low-sugar, no-yeast diet which helps tremendously with my yeast infection. I highly recommend it to everyone!
10
Regular bowel movements
1 people found this helpful
Wonderful. I was suffering from constipation, bloating, and indigestion. It helped me go to the bathroom regularly and absorb food better. I feel my mood has improved substantially.
2
No immediate effect
I used this for three months for severe constipation, but it had no effect. While I'm not seeing significant improvements yet, I hope that consistency with bathroom visits and meals may yield better results, even if I’m only going once a day.
10
Solves constipation
This probiotic is high quality, with many strains, and effectively resolves my constipation issue. I often find myself needing to go to the toilet in the mornings, and there are no adverse side effects!
10
Effective bowel care
1 people found this helpful
Excellent probiotic. It works best for me compared to other brands regarding bowel movements. No longer have constipation. Other brands can cause me bloating. It helps replenish gut bacteria after antibiotics.
7
We evaluated the impact of two probiotic formulations on functional constipation in adults. This study involved 30 days of daily consumption of oral sachets containing various strains of Lactobacillus and Bifidobacterium.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
7
We explored the impact of multistrain probiotics, including Lactobacillus acidophilus, on functional constipation in elderly individuals living in a nursing home. In a controlled study with 60 participants, those receiving the probiotic mixture for 12 weeks showed a slight increase in stool frequency compared to the placebo group.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
8
We investigated how a multi-strain probiotic blend affects constipation caused by loperamide in a rat model. After loperamide was used to induce constipation, we treated the rats with probiotics and observed notable improvements.
The treatment significantly increased fecal pellet output and enhanced gastrointestinal transit. Additionally, levels of serotonin and certain beneficial gut metabolites were also boosted in the probiotic-treated rats. This suggests that these probiotics can effectively alleviate constipation by positively adjusting gut microbiota and biochemistry.
The treatment significantly increased fecal pellet output and enhanced gastrointestinal transit. Additionally, levels of serotonin and certain beneficial gut metabolites were also boosted in the probiotic-treated rats. This suggests that these probiotics can effectively alleviate constipation by positively adjusting gut microbiota and biochemistry.
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
9
Bifidobacterium lactis improves bowel function
We studied how Bifidobacterium lactis affects constipation symptoms in healthy individuals with mild constipation. The research involved 83 participants divided into groups receiving different doses of the probiotic.
Through this double-blind, placebo-controlled study, we found that those taking the probiotic experienced significantly increased bowel movements compared to the placebo group. The participants receiving 50 mg and 75 mg of Bifidobacterium lactis also reported notable improvements in stool appearance and volume.
Our findings suggest that this probiotic not only boosts defecation but may also enhance some immune responses, particularly with increased naive T cell counts at the 75 mg dose.
Through this double-blind, placebo-controlled study, we found that those taking the probiotic experienced significantly increased bowel movements compared to the placebo group. The participants receiving 50 mg and 75 mg of Bifidobacterium lactis also reported notable improvements in stool appearance and volume.
Our findings suggest that this probiotic not only boosts defecation but may also enhance some immune responses, particularly with increased naive T cell counts at the 75 mg dose.
4
We looked at how Bifidobacterium longum subsp. infantis IM-1® impacts gut health in infants, specifically its effects on diarrhea and constipation. This probiotic was tested in various models, including clinical trials involving 190 babies under three months old.
Our findings revealed that B. infantis IM-1® helped decrease diarrhea episodes, but it was also noted that it may contribute to a lower prevalence of constipation. This suggests it supports overall gut health in infants, making it a promising option for gastrointestinal protection.
Our findings revealed that B. infantis IM-1® helped decrease diarrhea episodes, but it was also noted that it may contribute to a lower prevalence of constipation. This suggests it supports overall gut health in infants, making it a promising option for gastrointestinal protection.
8
We conducted a dose-escalation study to explore how Lactococcus lactis affects constipation in healthy adults. Twenty-seven participants took either a placebo or two different doses of the supplement over two weeks.
At a dose of 2 × 10 cfu, we saw a notable increase in how often participants had bowel movements each week. Additionally, a lower dose of 1 × 10 cfu resulted in larger stool volumes.
Overall, our findings indicate that Lactococcus lactis can effectively improve defecation, particularly with consistent intake.
At a dose of 2 × 10 cfu, we saw a notable increase in how often participants had bowel movements each week. Additionally, a lower dose of 1 × 10 cfu resulted in larger stool volumes.
Overall, our findings indicate that Lactococcus lactis can effectively improve defecation, particularly with consistent intake.
References
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. doi:10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. doi:10.1111/1751-2980.12797
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. doi:10.3920/BM2018.0163
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. doi:10.5851/kosfa.2017.37.6.906
- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. doi:10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. doi:10.1089/jmf.2009.1307
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. doi:10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. doi:10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. doi:10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. doi:10.1039/d1fo04151g
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
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