Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 64 Researches
7.7
USERS' SCORE
Moderately Good
Based on 215 Reviews
7.3
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
Most Useful Reviews
9
Best for constipation
76 people found this helpful
I take these every morning on an empty stomach and am very pleased with the results. Bloating has decreased, and my digestion has improved, allowing for regular visits to the restroom. When I stop, constipation returns. After trying various probiotics, I find this one to be the best quality.
Read More
9
Beneficial probiotics
64 people found this helpful
These probiotics are trustworthy and help maintain intestinal flora. They enhance digestion, combat flatulence, and promote regularity, making them ideal for preventive care. I appreciate the well-sealed capsules that dissolve effectively in the intestines.
Read More
9
Child's improvement
33 people found this helpful
This is the most effective probiotic I have tried. After giving it to my child, who suffered from constipation, they now go to the toilet easily every day. I highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 64 Researches
7.7
- All Researches
9
We explored the potential of the probiotic CCFM1163 to alleviate slow-transit constipation caused by prolonged laxative use, known as cathartic colon. Using a mouse model, we observed how this probiotic affects the gut's nerve and barrier functions.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
Read More
9
Probiotics effectively relieve constipation
We explored how specific microbial agents can change the gut bacteria and help relieve constipation in mice. The study focused on two treatments, including Lactobacillus, and found they increased beneficial gut bacteria and improved peristalsis, which is the movement that helps waste pass through the intestines.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Read More
9
Lactobacillus reduces constipation symptoms
We explored the effects of a fermented milk product containing two specific probiotic strains, Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1, on relieving constipation in mice.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 215 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Best for constipation
76 people found this helpful
I take these every morning on an empty stomach and am very pleased with the results. Bloating has decreased, and my digestion has improved, allowing for regular visits to the restroom. When I stop, constipation returns. After trying various probiotics, I find this one to be the best quality.
Read More
9
Beneficial probiotics
64 people found this helpful
These probiotics are trustworthy and help maintain intestinal flora. They enhance digestion, combat flatulence, and promote regularity, making them ideal for preventive care. I appreciate the well-sealed capsules that dissolve effectively in the intestines.
Read More
9
Child's improvement
33 people found this helpful
This is the most effective probiotic I have tried. After giving it to my child, who suffered from constipation, they now go to the toilet easily every day. I highly recommend it.
Read More
10
Improved digestion observed
27 people found this helpful
For me, this is the best probiotic. I have tried numerous supplements over the years, and none compare to this. It has various strains of beneficial bacteria, stays stable at room temperature, and most importantly, it works. My digestion has improved, and I no longer suffer from constipation. I firmly believe everyone should take a quality probiotic, and I highly recommend this brand. If it doesn't help you, try another with different strains. This one is a great starting point, and Jarrow is a reputable manufacturer.
Read More
7.5
IBS and reflux relief
25 people found this helpful
I’ve been using this product for a month, and it has notably improved my irritable bowel syndrome and acid reflux. Although not completely gone, my symptoms are significantly better, alleviating my issues with constipation.
Read More
Frequently Asked Questions
9
Improved bowel movement
18 people found this helpful
After a week of using this product, I noticed significant changes! My stools improved remarkably after breakfast, and I feel much more comfortable every morning. My mother, who has irritable bowel syndrome, also began using it and is pleased with the results. This product has become an essential in our daily routine.
10
Restored bowel routine
6 people found this helpful
After switching to this supplement, I was able to go to the restroom comfortably and consistently after just four days. Now, I take one capsule each morning and no longer struggle with constipation.
7.5
IBS and reflux relief
25 people found this helpful
I’ve been using this product for a month, and it has notably improved my irritable bowel syndrome and acid reflux. Although not completely gone, my symptoms are significantly better, alleviating my issues with constipation.
9
Effective over time
5 people found this helpful
After suffering from constipation in military training, my sister sent me this product. I initially felt no effect, but after three days of taking it, I noticed improved bowel movements. I have continued taking it and have seen consistent results.
9
Best for constipation
76 people found this helpful
I take these every morning on an empty stomach and am very pleased with the results. Bloating has decreased, and my digestion has improved, allowing for regular visits to the restroom. When I stop, constipation returns. After trying various probiotics, I find this one to be the best quality.
9
Child's improvement
33 people found this helpful
This is the most effective probiotic I have tried. After giving it to my child, who suffered from constipation, they now go to the toilet easily every day. I highly recommend it.
0
Worsened constipation
8 people found this helpful
It was ineffective. I wanted to improve my constipation, but taking lactobacilli made it worse. I've tried various products from iHerb, but none have worked. Lactobacillus only contributed to my constipation, despite my efforts with dietary fibre and exercise.
9
Impressive effect
12 people found this helpful
Although intended for pleasure rather than constipation, I found it remarkably effective; after consuming it with yoghurt, I felt a complete relief from constipation.
9
Comfortable usage
5 people found this helpful
These beneficial bacteria are excellent for those with constipation and bloating issues. I reduced my intake from three to two pills a day, which allows me to feel comfortable without pain or cramps.
7.5
Indigestion improvement
4 people found this helpful
Lactobacillus has truly helped my indigestion. I take one tablet on an empty stomach before breakfast, and my chronic constipation has improved dramatically.
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
7
We examined how lactobacillus, a type of beneficial bacteria, might help alleviate constipation and other digestive system issues. The review of existing research presented evidence that lactobacillus works through several mechanisms, like producing helpful metabolites and improving gut microbiome balance.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
8
We conducted a dose-escalation study to explore how Lactococcus lactis affects constipation in healthy adults. Twenty-seven participants took either a placebo or two different doses of the supplement over two weeks.
At a dose of 2 × 10 cfu, we saw a notable increase in how often participants had bowel movements each week. Additionally, a lower dose of 1 × 10 cfu resulted in larger stool volumes.
Overall, our findings indicate that Lactococcus lactis can effectively improve defecation, particularly with consistent intake.
At a dose of 2 × 10 cfu, we saw a notable increase in how often participants had bowel movements each week. Additionally, a lower dose of 1 × 10 cfu resulted in larger stool volumes.
Overall, our findings indicate that Lactococcus lactis can effectively improve defecation, particularly with consistent intake.
7
We examined the potential of probiotics, particularly bifidobacterium lactis, in alleviating chronic constipation symptoms. Through a systematic review and analysis of randomized controlled trials, we found that certain probiotics might enhance treatment responses and stool frequency. However, the evidence for the effectiveness of synbiotics remains insufficient.
It's important to note that results vary widely among studies, and there's a significant risk of bias, so we should interpret these findings carefully.
It's important to note that results vary widely among studies, and there's a significant risk of bias, so we should interpret these findings carefully.
References
- Tan F, Kong CS. Inhibitory Effect of HFY11 on Compound Diphenoxylate-Induced Constipation in Mice. Biomolecules. 2025;15. doi:10.3390/biom15030358
- Guo K, Tang Y, Yang T, Yan Y. Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. Front Cell Infect Microbiol. 2025;15:1556915. doi:10.3389/fcimb.2025.1556915
- Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. doi:10.1016/j.anireprosci.2025.107785
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
- Liu TH, Chen GL, Lin CH, Tsai TY, Cheng MC. TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. Food Funct. 2025;16:181. doi:10.1039/d4fo02270j
- Zhao B, Wang Y, Wang S, Mu G, Wu X. Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk. J Sci Food Agric. 2025;105:2594. doi:10.1002/jsfa.14032
- Zhang X, Jia Y, Li X, Wang X, Li L, et al. Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation. Benef Microbes. 2024;16:35. doi:10.1163/18762891-bja00039
- Tanihiro R, Yuki M, Sakano K, Sasai M, Sawada D, et al. Effects of Heat-Treated CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16142191
- Yang WC, Zeng BS, Liang CS, Hsu CW, Su KP, et al. Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Eur J Pediatr. 2024;183:3531. doi:10.1007/s00431-024-05568-6
- Han Y, Zhou Y, Xu X, Chen S, Zhang S, et al. Improvement of Post-Surgery Constipation in Patients with Fractures by JYLR-127: A Single-Blind Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16101505
- Zhang C, Wang L, Liu X, Wang G, Guo X, et al. Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation. Benef Microbes. 2024;15:311. doi:10.1163/18762891-bja00011
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Yang C, Hu T, Xue X, Su X, Zhang X, et al. Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety. BMC Microbiol. 2023;23:389. doi:10.1186/s12866-023-03123-1
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
- Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, et al. in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023;13:1254198. doi:10.3389/fcimb.2023.1254198
- Huh KY, Chung WK, Park J, Lee S, Kim MG, et al. Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms. Clin Transl Sci. 2023;16:2177. doi:10.1111/cts.13617
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. doi:10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. doi:10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. doi:10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. doi:10.1039/d1fo04151g
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
- Ito D, Yamamoto Y, Maekita T, Yamagishi N, Kawashima S, et al. Do synbiotics really enhance beneficial synbiotics effect on defecation symptoms in healthy adults?: Randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2022;101:e28858. doi:10.1097/MD.0000000000028858
- Astó E, Huedo P, Altadill T, Aguiló García M, Sticco M, et al. Probiotic Properties of KABP042 and KABP041 Show Potential to Counteract Functional Gastrointestinal Disorders in an Observational Pilot Trial in Infants. Front Microbiol. 2021;12:741391. doi:10.3389/fmicb.2021.741391
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. doi:10.1016/j.clnesp.2020.12.025
- Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. doi:10.1016/j.clnu.2020.01.005
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. doi:10.1111/1751-2980.12797
- Zhu S, Guo Z, Liu L, Gao Y, Bai L, et al. Complex Probiotics Relieve Constipation Through Regulation of the Intestinal Microbiota in Kittens. Microorganisms. 2025;13. doi:10.3390/microorganisms13030563
- Zhang Z, Li J, Wan Z, Fang S, Zhao Y, et al. subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025;16:2347. doi:10.1039/d4fo06350c
- Ma W, Zhao Y, Liu Y, Wang Y, Yu S, et al. subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota. Front Microbiol. 2025;16:1525887. doi:10.3389/fmicb.2025.1525887
- Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. doi:10.1039/d4fo04660a
- Salo E, Roche D, Gomez-Martinez VB, Cruz-Domenech JM, Garcia-Mora LG, et al. Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study. Benef Microbes. 2024;15:679. doi:10.1163/18762891-bja00038
- Lan W, Yang H, Zhong Z, Luo C, Huang Q, et al. subsp. LPL-RH improves postoperative gastrointestinal symptoms and nutrition indexes by regulating the gut microbiota in patients with valvular heart disease: a randomized controlled trial. Food Funct. 2024;15:7605. doi:10.1039/d4fo01471e
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. doi:10.1007/s00394-024-03398-8
- Lu Y, Zhou X, Wu Y, Cui Q, Tian X, et al. Metabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway. Mol Nutr Food Res. 2024;68:e2200846. doi:10.1002/mnfr.202200846
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. doi:10.3390/jcm12144838
- Watanabe M, Maruo T, Suzuki T. Effects of intake of subsp. FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2023;74:695. doi:10.1080/09637486.2023.2236805
- Cui H, Wang Q, Feng C, Guo C, Zhang J, et al. Positive effect of subsp VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Front Microbiol. 2022;13:1040371. doi:10.3389/fmicb.2022.1040371
- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. doi:10.1016/j.clnu.2022.10.015
- Noda M, Danshiitsoodol N, Kanno K, Sugiyama M. Silk-derived sericin/fibroin mixture drink fermented with plant-derived BM32-1 improves constipation and related microbiota: a randomized, double-blind, and placebo-controlled clinical trial. Biosci Microbiota Food Health. 2024;43:282. doi:10.12938/bmfh.2023-102
- Tan Q, Hu J, Zhou Y, Wan Y, Zhang C, et al. Inhibitory Effect of subsp. HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway. Drug Des Devel Ther. 2021;15:1971. doi:10.2147/DDDT.S309675
- Gotoh Y, Nanba F, Shioya N, Sugimura H, Suzuki T. A dose-finding study for a supplement containing subsp. FC in healthy adults with mild constipation. Biosci Microbiota Food Health. 2020;39:19. doi:10.12938/bmfh.19-009
- Ozaki K, Maruo T, Kosaka H, Mori M, Mori H, et al. The effects of fermented milk containing Lactococcus lactis subsp. cremoris FC on defaecation in healthy young Japanese women: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2018;69:762. doi:10.1080/09637486.2017.1417977
- Higashikawa F, Noda M, Awaya T, Nomura K, Oku H, et al. Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial. Nutrition. 2010;26:367. doi:10.1016/j.nut.2009.05.008
