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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Organic Echinacea purpurea (stem, leaf, flower)
1.2 g
**
Top Medical Research Studies
9
Echinacea modulates gut health in cancer
Echinacea purpurea polysaccharide intervene in hepatocellular carcinoma via modulation of gut microbiota to inhibit TLR4/NF-κB pathway.
Highly relevant cancer treatment study
We investigated how Echinacea purpurea polysaccharide (EPP) might help in fighting hepatocellular carcinoma, a common type of liver cancer. Our findings showed that EPP not only reduced liver damage caused by cancer but also helped in slowing down cancer cell growth and promoting their death, a process known as apoptosis.
An interesting aspect of our study was how EPP influenced gut microbiota. After treatment with EPP, we observed a significant increase in beneficial bacteria that produce propionic and butyric acids. These changes in gut microbes led to strengthening the intestinal barrier, which is crucial for keeping harmful substances like lipopolysaccharides (LPS) from leaking into the bloodstream. By controlling LPS leakage, EPP helped reduce inflammation and hindered the TLR4/NF-κB signaling pathway that cancer cells often exploit to survive.
On a molecular level, our metabolomics analysis revealed that EPP treatment downregulated certain metabolic pathways associated with tumor growth while enhancing butyrate metabolism, which is linked to healthier cellular functions. Overall, our research highlights EPP's potential to combat liver cancer through beneficial modifications to the gut microbiome and consequent impacts on inflammation and cancer cell survival.
An interesting aspect of our study was how EPP influenced gut microbiota. After treatment with EPP, we observed a significant increase in beneficial bacteria that produce propionic and butyric acids. These changes in gut microbes led to strengthening the intestinal barrier, which is crucial for keeping harmful substances like lipopolysaccharides (LPS) from leaking into the bloodstream. By controlling LPS leakage, EPP helped reduce inflammation and hindered the TLR4/NF-κB signaling pathway that cancer cells often exploit to survive.
On a molecular level, our metabolomics analysis revealed that EPP treatment downregulated certain metabolic pathways associated with tumor growth while enhancing butyrate metabolism, which is linked to healthier cellular functions. Overall, our research highlights EPP's potential to combat liver cancer through beneficial modifications to the gut microbiome and consequent impacts on inflammation and cancer cell survival.
Read More
9
Echinacea shows potential against HCC
Material basis research for Echinacea purpurea (L.) Moench against hepatocellular carcinoma in a mouse model through integration of metabonomics and molecular docking.
Highly relevant cancer treatment study
The effectiveness of Echinacea purpurea (EP) in combating hepatocellular carcinoma (HCC) was investigated through a structured approach that combined tumor growth analysis, biochemical tests, and pathology in mice. We found that treatment with EP led to a significant suppression of tumor growth, accompanied by a reduction in alpha-fetoprotein (AFP) levels—a common marker associated with liver cancer.
Our examination of tissues revealed substantial areas of cell death in tumors from EP-treated mice, which were notably absent in those that did not receive the treatment. We utilized advanced techniques, including LC-MS-based metabolomics and molecular docking, to better understand the components of EP that contribute to its effects on HCC.
The results highlighted 12 key metabolites affected by EP, particularly those linked to important biological processes like phenylalanine and tryptophan metabolism. Moreover, we identified five critical genetic targets influenced by EP and constructed a comprehensive network to visualize its metabolic pathways. Ultimately, 19 compounds were pinpointed as potential active ingredients, reinforcing the notion that EP has practical benefits in the fight against liver cancer.
Our examination of tissues revealed substantial areas of cell death in tumors from EP-treated mice, which were notably absent in those that did not receive the treatment. We utilized advanced techniques, including LC-MS-based metabolomics and molecular docking, to better understand the components of EP that contribute to its effects on HCC.
The results highlighted 12 key metabolites affected by EP, particularly those linked to important biological processes like phenylalanine and tryptophan metabolism. Moreover, we identified five critical genetic targets influenced by EP and constructed a comprehensive network to visualize its metabolic pathways. Ultimately, 19 compounds were pinpointed as potential active ingredients, reinforcing the notion that EP has practical benefits in the fight against liver cancer.
Read More
9
Echinacoside inhibits cancer cell growth
Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.
MTH1 inhibition's specific relevance
We explored the effects of Echinacoside, a compound from Echinacea, on cancer cells, focusing on its ability to inhibit a critical enzyme known as MTH1. This enzyme is responsible for sanitizing nucleotide pools in cells, and when it's inhibited, it leads to oxidative damage in DNA, triggering cell death in cancer cells.
Our study utilized a high-throughput screening method to identify natural compounds that could inhibit MTH1 effectively. Echinacoside emerged as a promising candidate, showing considerable activity in laboratory tests. We treated various human cancer cell lines with Echinacoside and observed a notable increase in oxidized guanine levels, suggesting that the compound effectively hampers MTH1's activity within these cells.
Following treatment, we noted significant DNA damage markers and an increase in p21, a protein that inhibits cell cycle progression. These changes prompted apoptosis, or programmed cell death, specifically in cancer cells while leaving non-cancerous cells unharmed. Overall, our findings highlight Echinacoside's potential as a natural anticancer agent by targeting the MTH1 enzyme.
Our study utilized a high-throughput screening method to identify natural compounds that could inhibit MTH1 effectively. Echinacoside emerged as a promising candidate, showing considerable activity in laboratory tests. We treated various human cancer cell lines with Echinacoside and observed a notable increase in oxidized guanine levels, suggesting that the compound effectively hampers MTH1's activity within these cells.
Following treatment, we noted significant DNA damage markers and an increase in p21, a protein that inhibits cell cycle progression. These changes prompted apoptosis, or programmed cell death, specifically in cancer cells while leaving non-cancerous cells unharmed. Overall, our findings highlight Echinacoside's potential as a natural anticancer agent by targeting the MTH1 enzyme.
Read More
Most Useful Reviews
8.8
Effective immunity boost
Excellent! The echinacea plant is well-known for enhancing immunity and combating cancer cells. It's particularly useful for those with immunodeficiency. I obtained it for my mother and noticed an improvement in her condition. I highly recommend this brand as its products are very effective and the results are remarkable.
Read More
7.5
Immunity support for cancer
I took this to strengthen my immunity as I have cancer and my immune system is weak. I heard Duaa Harfoush recommending it for boosting immunity, preventing diseases, and reducing infections. The quantity is substantial and suitable.
Read More
8.8
Immune system boost
Great product! I am a cancer survivor and will always advocate for boosting one's immune system for better health. I had cancer in the colon, liver, and lungs. Diagnosed in 2011, I'm still here after being told I would only survive 5 years!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
9
Echinacea modulates gut health in cancer
Echinacea purpurea polysaccharide intervene in hepatocellular carcinoma via modulation of gut microbiota to inhibit TLR4/NF-κB pathway.
Highly relevant cancer treatment study
We investigated how Echinacea purpurea polysaccharide (EPP) might help in fighting hepatocellular carcinoma, a common type of liver cancer. Our findings showed that EPP not only reduced liver damage caused by cancer but also helped in slowing down cancer cell growth and promoting their death, a process known as apoptosis.
An interesting aspect of our study was how EPP influenced gut microbiota. After treatment with EPP, we observed a significant increase in beneficial bacteria that produce propionic and butyric acids. These changes in gut microbes led to strengthening the intestinal barrier, which is crucial for keeping harmful substances like lipopolysaccharides (LPS) from leaking into the bloodstream. By controlling LPS leakage, EPP helped reduce inflammation and hindered the TLR4/NF-κB signaling pathway that cancer cells often exploit to survive.
On a molecular level, our metabolomics analysis revealed that EPP treatment downregulated certain metabolic pathways associated with tumor growth while enhancing butyrate metabolism, which is linked to healthier cellular functions. Overall, our research highlights EPP's potential to combat liver cancer through beneficial modifications to the gut microbiome and consequent impacts on inflammation and cancer cell survival.
An interesting aspect of our study was how EPP influenced gut microbiota. After treatment with EPP, we observed a significant increase in beneficial bacteria that produce propionic and butyric acids. These changes in gut microbes led to strengthening the intestinal barrier, which is crucial for keeping harmful substances like lipopolysaccharides (LPS) from leaking into the bloodstream. By controlling LPS leakage, EPP helped reduce inflammation and hindered the TLR4/NF-κB signaling pathway that cancer cells often exploit to survive.
On a molecular level, our metabolomics analysis revealed that EPP treatment downregulated certain metabolic pathways associated with tumor growth while enhancing butyrate metabolism, which is linked to healthier cellular functions. Overall, our research highlights EPP's potential to combat liver cancer through beneficial modifications to the gut microbiome and consequent impacts on inflammation and cancer cell survival.
Read More
9
Echinacea shows potential against HCC
Material basis research for Echinacea purpurea (L.) Moench against hepatocellular carcinoma in a mouse model through integration of metabonomics and molecular docking.
Highly relevant cancer treatment study
The effectiveness of Echinacea purpurea (EP) in combating hepatocellular carcinoma (HCC) was investigated through a structured approach that combined tumor growth analysis, biochemical tests, and pathology in mice. We found that treatment with EP led to a significant suppression of tumor growth, accompanied by a reduction in alpha-fetoprotein (AFP) levels—a common marker associated with liver cancer.
Our examination of tissues revealed substantial areas of cell death in tumors from EP-treated mice, which were notably absent in those that did not receive the treatment. We utilized advanced techniques, including LC-MS-based metabolomics and molecular docking, to better understand the components of EP that contribute to its effects on HCC.
The results highlighted 12 key metabolites affected by EP, particularly those linked to important biological processes like phenylalanine and tryptophan metabolism. Moreover, we identified five critical genetic targets influenced by EP and constructed a comprehensive network to visualize its metabolic pathways. Ultimately, 19 compounds were pinpointed as potential active ingredients, reinforcing the notion that EP has practical benefits in the fight against liver cancer.
Our examination of tissues revealed substantial areas of cell death in tumors from EP-treated mice, which were notably absent in those that did not receive the treatment. We utilized advanced techniques, including LC-MS-based metabolomics and molecular docking, to better understand the components of EP that contribute to its effects on HCC.
The results highlighted 12 key metabolites affected by EP, particularly those linked to important biological processes like phenylalanine and tryptophan metabolism. Moreover, we identified five critical genetic targets influenced by EP and constructed a comprehensive network to visualize its metabolic pathways. Ultimately, 19 compounds were pinpointed as potential active ingredients, reinforcing the notion that EP has practical benefits in the fight against liver cancer.
Read More
9
Echinacea shows promise against cancer
Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines.
Study evaluates Echinacea's efficacy
We explored the effects of Echinacea angustifolia DC extract in human breast cancer cell lines, specifically looking at how it influences cancer cell behavior. The study focused on extracts obtained using ethyl acetate and aimed to evaluate their potential as a cancer treatment.
We observed that the Echinacea extract demonstrated significant cytotoxic activity against two breast cancer cell lines, MDA-MB-231 and MCF-7, showing effective inhibition of cell growth. Importantly, no harmful effects were noted on normal breast cells, indicating a degree of selectivity for cancerous cells.
Additionally, the extract was found to cause cell cycle arrest and promote apoptosis, meaning it helped to trigger the programmed death of cancer cells. When combined with the chemotherapy drug paclitaxel, the Echinacea extract showed a synergistic effect, enhancing the overall treatment impact.
Overall, our findings suggest that Echinacea angustifolia DC extract presents itself as a promising candidate for breast cancer treatment, particularly when used alongside existing therapies like paclitaxel.
We observed that the Echinacea extract demonstrated significant cytotoxic activity against two breast cancer cell lines, MDA-MB-231 and MCF-7, showing effective inhibition of cell growth. Importantly, no harmful effects were noted on normal breast cells, indicating a degree of selectivity for cancerous cells.
Additionally, the extract was found to cause cell cycle arrest and promote apoptosis, meaning it helped to trigger the programmed death of cancer cells. When combined with the chemotherapy drug paclitaxel, the Echinacea extract showed a synergistic effect, enhancing the overall treatment impact.
Overall, our findings suggest that Echinacea angustifolia DC extract presents itself as a promising candidate for breast cancer treatment, particularly when used alongside existing therapies like paclitaxel.
Read More
9
Echinacoside shows anticancer potential
Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway.
Echinacea's effect on cancer explored
We conducted an investigation into the effects of echinacoside, a compound found in the herbs Cistanche and Echinacea, on breast cancer. Our findings demonstrate that echinacoside has a remarkable ability to inhibit breast cancer cells in laboratory settings, specifically in the MDA-MB-231 and MDA-MB-468 cell lines.
Through a range of tests, including colony formation and transwell assays, we confirmed that echinacoside effectively reduces the growth and spread of these cancer cells. We also observed that it impacts critical proteins involved in the Wnt/β-catenin signaling pathway, which plays a significant role in cancer progression.
Moreover, in experiments using a xenograft model, we noted that treatment with echinacoside led to a significant decrease in tumor size, further highlighting its anticancer potential. Overall, our study suggests that echinacoside could serve as a valuable therapeutic option for combatting breast cancer through its ability to inhibit the Wnt/β-catenin signaling pathway.
Through a range of tests, including colony formation and transwell assays, we confirmed that echinacoside effectively reduces the growth and spread of these cancer cells. We also observed that it impacts critical proteins involved in the Wnt/β-catenin signaling pathway, which plays a significant role in cancer progression.
Moreover, in experiments using a xenograft model, we noted that treatment with echinacoside led to a significant decrease in tumor size, further highlighting its anticancer potential. Overall, our study suggests that echinacoside could serve as a valuable therapeutic option for combatting breast cancer through its ability to inhibit the Wnt/β-catenin signaling pathway.
Read More
9
Echinacoside inhibits cancer cell growth
Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.
MTH1 inhibition's specific relevance
We explored the effects of Echinacoside, a compound from Echinacea, on cancer cells, focusing on its ability to inhibit a critical enzyme known as MTH1. This enzyme is responsible for sanitizing nucleotide pools in cells, and when it's inhibited, it leads to oxidative damage in DNA, triggering cell death in cancer cells.
Our study utilized a high-throughput screening method to identify natural compounds that could inhibit MTH1 effectively. Echinacoside emerged as a promising candidate, showing considerable activity in laboratory tests. We treated various human cancer cell lines with Echinacoside and observed a notable increase in oxidized guanine levels, suggesting that the compound effectively hampers MTH1's activity within these cells.
Following treatment, we noted significant DNA damage markers and an increase in p21, a protein that inhibits cell cycle progression. These changes prompted apoptosis, or programmed cell death, specifically in cancer cells while leaving non-cancerous cells unharmed. Overall, our findings highlight Echinacoside's potential as a natural anticancer agent by targeting the MTH1 enzyme.
Our study utilized a high-throughput screening method to identify natural compounds that could inhibit MTH1 effectively. Echinacoside emerged as a promising candidate, showing considerable activity in laboratory tests. We treated various human cancer cell lines with Echinacoside and observed a notable increase in oxidized guanine levels, suggesting that the compound effectively hampers MTH1's activity within these cells.
Following treatment, we noted significant DNA damage markers and an increase in p21, a protein that inhibits cell cycle progression. These changes prompted apoptosis, or programmed cell death, specifically in cancer cells while leaving non-cancerous cells unharmed. Overall, our findings highlight Echinacoside's potential as a natural anticancer agent by targeting the MTH1 enzyme.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
8.8
Effective immunity boost
Excellent! The echinacea plant is well-known for enhancing immunity and combating cancer cells. It's particularly useful for those with immunodeficiency. I obtained it for my mother and noticed an improvement in her condition. I highly recommend this brand as its products are very effective and the results are remarkable.
Read More
8.8
Immune system boost
Great product! I am a cancer survivor and will always advocate for boosting one's immune system for better health. I had cancer in the colon, liver, and lungs. Diagnosed in 2011, I'm still here after being told I would only survive 5 years!
8
Supports cancer treatment
I will repurchase this. It’s flu season. I was frequently ill, so my colleague suggested Echinacea Purpurea Herb. She mentioned her brother-in-law, after dealing with cancer treatment, was advised by his doctor in Australia to take Echinacea for his immune system. So far, I feel better and am getting sick less often.
Read More
7.5
Immunity support for cancer
I took this to strengthen my immunity as I have cancer and my immune system is weak. I heard Duaa Harfoush recommending it for boosting immunity, preventing diseases, and reducing infections. The quantity is substantial and suitable.
