Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.1
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%
Total Omega-3sâŠ
500 mg
â
EPA (Eicosapentaenoic Acid)
240 mg
â
DHA (Docosahexaenoic Acid)
160 mg
â
Evening Primrose Oil
800 mg
â
Gamma-Linolenic Acid (Omega-6)
76 mg
â
Top Medical Research Studies
8
We explored the impact of polyunsaturated fatty acids (PUFAs), particularly omega-3s, on anxiety and depression in over 102,000 participants from the UK Biobank.
The study revealed that higher levels of omega-3 PUFAs were linked to lower risks of developing anxiety and depressive disorders, alongside improvement in adverse psychological symptoms.
Additionally, the research highlighted significant associations between these fatty acids and brain white matter structure, providing valuable insights into how omega-3s might support mental wellness.
The study revealed that higher levels of omega-3 PUFAs were linked to lower risks of developing anxiety and depressive disorders, alongside improvement in adverse psychological symptoms.
Additionally, the research highlighted significant associations between these fatty acids and brain white matter structure, providing valuable insights into how omega-3s might support mental wellness.
Read More
8
DHA improves milk and reduces anxiety
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
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7
Omega-3 shows uncertain anxiety benefits
We explored the effects of omega-3 fatty acids on anxiety through a systematic review of 23 trials with nearly 2,200 participants. The results indicated that taking omega-3 at a dose of 2 grams per day may lead to a notable reduction in anxiety symptoms, although the certainty of this evidence is very low. Doses lower than 2 grams showed minimal impact on anxiety levels. While omega-3 supplementation did not result in more adverse effects, further high-quality trials are needed for clearer conclusions.
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Most Useful Reviews
9
Reduced PMS anxiety
68 people found this helpful
Works brilliantly for extreme PMS. I started using this alongside magnesium for PMS-related depression and anxiety. After a month, I hardly noticed my period approaching. Previously, I endured emotional breakdowns and severe cramps for two weeks beforehand, but now it feels like a complete turnaround. I did my research to check if this is right for me, and I can confidently say I made the right choice.
Read More
9
Eased depressive thoughts
10 people found this helpful
These really help with my PMS-related depression and anxiety. Last cycle, I didnât realise my period was imminent until the day before it was due, a stark contrast to the usual two weeks of battling severe depression and intrusive thoughts. Just one daily dose makes a significant difference. Thank you!
Read More
7.5
Positive effects
29 people found this helpful
I started taking this supplement as recommended by a naturopathic doctor, and I couldnât be happier! I've been taking two in the morning and two before bed. Itâs fantastic for PMS and has noticeably helped with my anxiety. I'm thrilled to have no breast pain and feel the fibrosis has lowered dramatically!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.1
- All Researches
9
EPA supplementation reduces anxiety
We explored how eicosapentaenoic acid (EPA), found in fish oil, impacts anxiety and mood disorders related to obesity. In our study, male mice were fed a high-fat diet for 20 weeks, which led to weight gain and anxiety-like behaviors.
To see if EPA could help, we administered fish oil enriched with equal amounts of EPA and DHA for the last five weeks of the study. The results were quite promising. Mice that received the fish oil not only showed reduced anxiety behaviors but also demonstrated improved metabolic health.
Specifically, these mice had better glucose tolerance and reduced food intake, indicating that fish oil could potentially correct some of the metabolic issues that come with obesity. Overall, the addition of EPA-rich fish oil appears to lessen both anxiety and metabolic disturbances caused by a saturated high-fat diet, suggesting its potential benefits for mood and health in similar conditions.
To see if EPA could help, we administered fish oil enriched with equal amounts of EPA and DHA for the last five weeks of the study. The results were quite promising. Mice that received the fish oil not only showed reduced anxiety behaviors but also demonstrated improved metabolic health.
Specifically, these mice had better glucose tolerance and reduced food intake, indicating that fish oil could potentially correct some of the metabolic issues that come with obesity. Overall, the addition of EPA-rich fish oil appears to lessen both anxiety and metabolic disturbances caused by a saturated high-fat diet, suggesting its potential benefits for mood and health in similar conditions.
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9
We explored how a diet rich in specific nutrients, including eicosapentaenoic acid (an omega-3 fatty acid), can impact cognitive function and anxiety levels in adolescents. Using a mild stress model, we focused on the effects of social instability stress on young rats, which led to noticeable cognitive and behavioral changes.
Our findings revealed that when these stressed rats were given a prolonged diet enriched with eicosapentaenoic acid, docosahexaenoic acid, and vitamin A, their performance in memory tests improved significantly. In fact, their anxiety levels and cognitive function returned to levels comparable to those of non-stressed rats.
We also observed that the enriched diet helped normalize brain chemistry and the balance of gut microbiota, both of which were disrupted by stress. Importantly, these positive changes persisted into adulthood, indicating that proper nutrition during stressful periods could have long-lasting benefits.
By highlighting the protective effects of eicosapentaenoic acid within a nutritious diet, we suggest exciting possibilities for using diet to help manage stress and anxiety during key developmental years.
Our findings revealed that when these stressed rats were given a prolonged diet enriched with eicosapentaenoic acid, docosahexaenoic acid, and vitamin A, their performance in memory tests improved significantly. In fact, their anxiety levels and cognitive function returned to levels comparable to those of non-stressed rats.
We also observed that the enriched diet helped normalize brain chemistry and the balance of gut microbiota, both of which were disrupted by stress. Importantly, these positive changes persisted into adulthood, indicating that proper nutrition during stressful periods could have long-lasting benefits.
By highlighting the protective effects of eicosapentaenoic acid within a nutritious diet, we suggest exciting possibilities for using diet to help manage stress and anxiety during key developmental years.
Read More
8
We explored the impact of an omega-3-rich diet on male mice and found exciting results. Mice that consumed omega-3 showed enhancements in the endocannabinoid system, vital for synaptic function. These dietary changes led to better object recognition and reduced anxiety-like behaviors, as indicated by their time in open arms of an elevated maze.
Though the study demonstrated notable improvements in behavior and cognition, it primarily focused on mice, leaving further research needed to understand omega-3âs effects on human anxiety.
Though the study demonstrated notable improvements in behavior and cognition, it primarily focused on mice, leaving further research needed to understand omega-3âs effects on human anxiety.
Read More
8
We explored the impact of polyunsaturated fatty acids (PUFAs), particularly omega-3s, on anxiety and depression in over 102,000 participants from the UK Biobank.
The study revealed that higher levels of omega-3 PUFAs were linked to lower risks of developing anxiety and depressive disorders, alongside improvement in adverse psychological symptoms.
Additionally, the research highlighted significant associations between these fatty acids and brain white matter structure, providing valuable insights into how omega-3s might support mental wellness.
The study revealed that higher levels of omega-3 PUFAs were linked to lower risks of developing anxiety and depressive disorders, alongside improvement in adverse psychological symptoms.
Additionally, the research highlighted significant associations between these fatty acids and brain white matter structure, providing valuable insights into how omega-3s might support mental wellness.
Read More
8
We examined how eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, influences anxiety levels in a juvenile mouse model affected by stress. Using an ultrasound (US) stress method, we subjected one-month-old C57/BL6 mice to varying sound frequencies that can mimic depressive-like symptoms.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Alongside the stress exposure, these mice received either an omega-3 food supplement containing EPA and docosahexaenoic acid (DHA) or a placebo. The results were striking: mice treated with the omega-3 supplement showed no signs of anxiety or depression, while those given the placebo exhibited increased anxiety, lowered motivation for reward, and elevated stress hormones in their blood.
Additionally, our metabolomic analysis revealed beneficial changes, particularly in brain energy metabolism, thanks to the omega-3 treatment. These findings suggest that eicosapentaenoic acid may help alleviate anxiety in stressful situations, implying its potential role as a therapeutic option for tackling anxiety and depression, especially in young populations.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced PMS anxiety
68 people found this helpful
Works brilliantly for extreme PMS. I started using this alongside magnesium for PMS-related depression and anxiety. After a month, I hardly noticed my period approaching. Previously, I endured emotional breakdowns and severe cramps for two weeks beforehand, but now it feels like a complete turnaround. I did my research to check if this is right for me, and I can confidently say I made the right choice.
Read More
9
Eased depressive thoughts
10 people found this helpful
These really help with my PMS-related depression and anxiety. Last cycle, I didnât realise my period was imminent until the day before it was due, a stark contrast to the usual two weeks of battling severe depression and intrusive thoughts. Just one daily dose makes a significant difference. Thank you!
Read More
7.5
Positive effects
29 people found this helpful
I started taking this supplement as recommended by a naturopathic doctor, and I couldnât be happier! I've been taking two in the morning and two before bed. Itâs fantastic for PMS and has noticeably helped with my anxiety. I'm thrilled to have no breast pain and feel the fibrosis has lowered dramatically!
Read More
7.5
Effective for anxiety
11 people found this helpful
This product is excellent; it has significantly helped me with my anxiety and depression stemming from perimenopause.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Serrano M, Saumell-Esnaola M, Ocerin G, GarcĂa Del Caño G, Puente N, et al. Impact of Omega-3 on Endocannabinoid System Expression and Function, Enhancing Cognition and Behavior in Male Mice. Nutrients. 2024;16. 10.3390/nu16244344
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. 10.3390/nu16234065
- Bafkar N, Zeraattalab-Motlagh S, Jayedi A, Shab-Bidar S. Efficacy and safety of omega-3 fatty acids supplementation for anxiety symptoms: a systematic review and dose-response meta-analysis of randomized controlled trials. BMC Psychiatry. 2024;24:455. 10.1186/s12888-024-05881-2
- Bogachuk AP, Jacobs DS, Moghaddam B. Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology. Behav Neurosci. 2024;138:353. 10.1037/bne0000584
- Hanie MH, Mohammad Reza A, Mansoureh S, Fatemeh SB, Ali S. Exploring the impact of melatonin and omega-3, individually and in combination, on cognitive function, histological changes, and oxidant-antioxidant balance in male rats with dorsal CA1 hippocampal lesions. Brain Res. 2024;1840:149046. 10.1016/j.brainres.2024.149046
- Wang L, Liu T, Guo J, Zhao T, Tang H, et al. N-3 PUFA supplementation alleviates anxiety symptoms by manipulating erythrocyte fatty acid levels in depression. Eur J Nutr. 2024;63:2271. 10.1007/s00394-024-03421-y
- Gu Q, Jiang Z, Li K, Li Y, Yan X, et al. Effectiveness of probiotic- and fish oil-loaded water-in-oil-in-water (W/O/W) emulsions at alleviating ulcerative colitis. Food Funct. 2024;15:5797. 10.1039/d4fo00258j
- Nakajima S, Demers G, Machuca-Parra AI, Pour ZD, Bairamian D, et al. Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors. J Neuroinflammation. 2023;20:302. 10.1186/s12974-023-02978-5
- Kelaiditis CF, Gibson EL, Dyall SC. Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2023;192:102572. 10.1016/j.plefa.2023.102572
- Demin KA, Kolesnikova TO, Galstyan DS, Krotova NA, Ilyin NP, et al. The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety-Like Behavior and Hippocampal Transcriptomic Responses in Male Rats. J Neurosci Res. 2025;103:e70025. 10.1002/jnr.70025
- Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. 10.1016/j.ynstr.2024.100646
- Nguyen N, Woodside DB, Lam E, Quehenberger O, German JB, et al. Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes. Int J Mol Sci. 2024;25. 10.3390/ijms25105516
- Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. 10.1016/j.bbi.2024.03.019
- Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naĂŻve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. 10.1016/j.jad.2024.01.149
- Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, et al. Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome. Food Funct. 2023;14:5977. 10.1039/d3fo01452e
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. 10.1038/s41398-022-02026-5
- Mengelberg A, Leathem J, Podd J, Hill S, Conlon C. The effects of docosahexaenoic acid supplementation on cognition and well-being in mild cognitive impairment: A 12-month randomised controlled trial. Int J Geriatr Psychiatry. 2022;37. 10.1002/gps.5707
- Neto J, Jantsch J, de Oliveira S, Braga MF, Castro LFDS, et al. DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats. Br J Nutr. 2022;128:964. 10.1017/S0007114521003998
- Wang CC, Du L, Shi HH, Ding L, Yanagita T, et al. Dietary EPA-Enriched Phospholipids Alleviate Chronic Stress and LPS-Induced Depression- and Anxiety-Like Behavior by Regulating Immunity and Neuroinflammation. Mol Nutr Food Res. 2021;65:e2100009. 10.1002/mnfr.202100009
- Demers G, Roy J, Machuca-Parra AI, Dashtehei Pour Z, Bairamian D, et al. Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice. Int J Obes (Lond). 2020;44:1936. 10.1038/s41366-020-0623-6
- Nakajima S, Fukasawa K, Gotoh M, Murakami-Murofushi K, Kunugi H. Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level. Int J Obes (Lond). 2020;44:727. 10.1038/s41366-019-0468-z
- Provensi G, Schmidt SD, Boehme M, Bastiaanssen TFS, Rani B, et al. Preventing adolescent stress-induced cognitive and microbiome changes by diet. Proc Natl Acad Sci U S A. 2019;116:9644. 10.1073/pnas.1820832116
- GajdoĆĄovĂĄ L, KatrenÄĂkovĂĄ B, BorbĂ©lyovĂĄ V, MuchovĂĄ J. The Effect of Omega-3 Fatty Acid Supplementation and Exercise on Locomotor Activity, Exploratory Activity, and Anxiety-Like Behavior in Adult and Aged Rats. Physiol Res. 2024;73:461.
- Zambrano E, RodrĂguez-GonzĂĄlez GL, Reyes-Castro LA, Bautista CJ, Castro-RodrĂguez DC, et al. DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring. Nutrients. 2021;13. 10.3390/nu13124243
- Tang Q, Li S, Fang C, Yu H. Evaluating the reparative effects and the mechanism of action of docosahexaenoic acid on azithromycin-induced lipid metabolism dysfunction. Food Chem Toxicol. 2022;159:112699. 10.1016/j.fct.2021.112699
- Ponomarenko AI, Tyrtyshnaia AA, Pislyagin EA, Dyuizen IV, Sultanov RM, et al. N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Sci Rep. 2021;11:756. 10.1038/s41598-020-80818-9
