Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.7
USERS' SCORE
Moderately Good
Based on 74 Reviews
7.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Blend of Probiotic Bacteria:Lactobacillus acidophilus (La-14),Bifidobacterium lactis (Bl-04),Bifidobacterium longum (Bl-05)
8 Billion CFU
*
Top Medical Research Studies
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
9
We explored the potential of Lactococcus lactis subsp. HFY14, a unique bacterium from yak yogurt, to treat constipation in mice. By inducing constipation using diphenoxylate, we observed significant improvements in weight, fecal output, and overall colon health after treatment with LLSL-HFY14.
The effects mirrored those of lactulose, a known constipation remedy. LLSL-HFY14 also positively influenced several important serum markers and colonic signals. These findings suggest that LLSL-HFY14 could serve as a promising biological agent for addressing constipation.
The effects mirrored those of lactulose, a known constipation remedy. LLSL-HFY14 also positively influenced several important serum markers and colonic signals. These findings suggest that LLSL-HFY14 could serve as a promising biological agent for addressing constipation.
Read More
Most Useful Reviews
9
Positive GI health
41 people found this helpful
Excellent product! As a pharmacist, I find this one of the best probiotics available. Within two days of taking it, my gastrointestinal health improved significantly. I experienced reduced indigestion, bloating, and both constipation and diarrhoea. There are other effective products, but they are often pricier with less quantity.
Read More
9
Constipation relief
22 people found this helpful
I will definitely repurchase! After years of struggling with constipation and trying various supplements, this product has made a noticeable difference in just two days. I experienced regular bowel movements without discomfort. I take it twice daily and plan to cut back on other supplements. This has truly improved my intestinal health and overall happiness.
Read More
9
Constipation normalised
10 people found this helpful
Very happy! I’ve been taking one capsule in the morning and one in the evening for two months. My previous issues with constipation have normalised.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.7
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We investigated the impact of Bifidobacterium animalis subsp. lactis XLTG11 on functional constipation in children using a randomized, double-blind, placebo-controlled design.
Our findings showed that children receiving this probiotic experienced a significant increase in their weekly fecal frequency compared to those on conventional treatment without probiotics.
Additionally, the introduction of XLTG11 altered gut microbiota positively and influenced the metabolism of short-chain fatty acids. These results suggest that Bifidobacterium can benefit children suffering from constipation.
Our findings showed that children receiving this probiotic experienced a significant increase in their weekly fecal frequency compared to those on conventional treatment without probiotics.
Additionally, the introduction of XLTG11 altered gut microbiota positively and influenced the metabolism of short-chain fatty acids. These results suggest that Bifidobacterium can benefit children suffering from constipation.
Read More
9
We explored the effectiveness of Bifidobacterium longum W11 in treating constipation, particularly in patients with irritable bowel syndrome (IBS). Our research included rigorous reviews and clinical trials, one of which was randomized and placebo-controlled.
The findings were promising—B. longum W11 significantly reduced constipation symptoms, especially in those experiencing reduced gut motility due to calorie-restricted diets.
Additionally, its non-transmissible antibiotic resistance may offer advantages when used alongside antibiotics like rifaximin, showing improved outcomes in certain conditions like diverticular disease.
The findings were promising—B. longum W11 significantly reduced constipation symptoms, especially in those experiencing reduced gut motility due to calorie-restricted diets.
Additionally, its non-transmissible antibiotic resistance may offer advantages when used alongside antibiotics like rifaximin, showing improved outcomes in certain conditions like diverticular disease.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 74 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Positive GI health
41 people found this helpful
Excellent product! As a pharmacist, I find this one of the best probiotics available. Within two days of taking it, my gastrointestinal health improved significantly. I experienced reduced indigestion, bloating, and both constipation and diarrhoea. There are other effective products, but they are often pricier with less quantity.
Read More
9
Constipation relief
22 people found this helpful
I will definitely repurchase! After years of struggling with constipation and trying various supplements, this product has made a noticeable difference in just two days. I experienced regular bowel movements without discomfort. I take it twice daily and plan to cut back on other supplements. This has truly improved my intestinal health and overall happiness.
Read More
9
Constipation normalised
10 people found this helpful
Very happy! I’ve been taking one capsule in the morning and one in the evening for two months. My previous issues with constipation have normalised.
Read More
9
Immediate results
8 people found this helpful
Super Probiotic! This product has been a lifesaver for my long-standing issues. No other probiotic helped, but this one provided instant results. The ingredients are impressive, and the price is reasonable. It's important to use it cautiously if you're prone to constipation.
Read More
9
Improved intestinal environment
7 people found this helpful
I've struggled with stubborn constipation, but this has really helped. A healthy intestinal environment is crucial, and I plan to continue using it.
Read More
Frequently Asked Questions
9
Positive GI health
41 people found this helpful
Excellent product! As a pharmacist, I find this one of the best probiotics available. Within two days of taking it, my gastrointestinal health improved significantly. I experienced reduced indigestion, bloating, and both constipation and diarrhoea. There are other effective products, but they are often pricier with less quantity.
9
Constipation relief
22 people found this helpful
I will definitely repurchase! After years of struggling with constipation and trying various supplements, this product has made a noticeable difference in just two days. I experienced regular bowel movements without discomfort. I take it twice daily and plan to cut back on other supplements. This has truly improved my intestinal health and overall happiness.
9
Constipation normalised
10 people found this helpful
Very happy! I’ve been taking one capsule in the morning and one in the evening for two months. My previous issues with constipation have normalised.
9
Eliminated gas issues
5 people found this helpful
After years of struggling with smelly gas and constipation, this product worked wonders. I no longer have gas troubles, and I feel much better overall. It’s made such a difference that I've recommended it to my mother, and I wish I had discovered it sooner.
10
No constipation
1 people found this helpful
I consistently take this supplement with bifidus and inulin — no constipation for me!
9
No more constipation
2 people found this helpful
I mix this with sourdough when making homemade yoghurt. I open the capsule to add beneficial bacteria, which enhances the taste. My daily yoghurt intake has resolved my constipation issues completely.
7.5
Diarrhoea improved
2 people found this helpful
After dealing with both constipation and diarrhoea, introducing this supplement alongside digestive enzymes significantly improved my condition.
7.5
Natural bowel movement
2 people found this helpful
By taking one capsule in the morning and one at night, my bowel movements became easier and more regular. I previously struggled with constipation even with laxatives, so I’m glad I tried this.
9
Most effective supplement
2 people found this helpful
Out of all the constipation supplements I tried, this one proved to be the most effective. Just a drop before dinner has me feeling better by the next morning; I’m grateful for this discovery.
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
8
Probiotics ease constipation in patients
We investigated whether probiotics could ease complications like constipation in thyroid cancer patients undergoing thyroid hormone withdrawal. Fifty patients were randomly assigned to either probiotics or placebo during their treatment. The results showed that probiotics significantly reduced constipation alongside other symptoms, suggesting a positive impact on the gut and oral microbiota.
This improvement might be linked to the restoration of microbial diversity in these patients, highlighting the potential benefits of probiotics in managing constipation and other complications after thyroid surgery.
This improvement might be linked to the restoration of microbial diversity in these patients, highlighting the potential benefits of probiotics in managing constipation and other complications after thyroid surgery.
7
We explored the impact of multistrain probiotics, including Lactobacillus acidophilus, on functional constipation in elderly individuals living in a nursing home. In a controlled study with 60 participants, those receiving the probiotic mixture for 12 weeks showed a slight increase in stool frequency compared to the placebo group.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
7
We evaluated the impact of two probiotic formulations on functional constipation in adults. This study involved 30 days of daily consumption of oral sachets containing various strains of Lactobacillus and Bifidobacterium.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
4
We examined a well-structured study involving 94 healthy adults with functional constipation. Participants were randomly given either a multi-strain probiotic containing Lactobacillus acidophilus or a placebo over four weeks.
While both groups reported over 20% improvements in symptoms, the probiotic group experienced faster normalization of stool frequency and consistency. We observed a beneficial shift in gut bacteria towards a more fibrolytic microbiota in those receiving probiotics, although symptom differences between the groups were not significant.
While both groups reported over 20% improvements in symptoms, the probiotic group experienced faster normalization of stool frequency and consistency. We observed a beneficial shift in gut bacteria towards a more fibrolytic microbiota in those receiving probiotics, although symptom differences between the groups were not significant.
References
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. 10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. 10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. 10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. 10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. 10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. 10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. 10.1111/1751-2980.12797
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. 10.3920/BM2018.0163
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. 10.5851/kosfa.2017.37.6.906
- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. 10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. 10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. 10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. 10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. 10.1089/jmf.2009.1307
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. 10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. 10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. 10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. 10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. 10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. 10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. 10.20960/nh.04315
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. 10.1039/d1fo04151g
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
- Ito D, Yamamoto Y, Maekita T, Yamagishi N, Kawashima S, et al. Do synbiotics really enhance beneficial synbiotics effect on defecation symptoms in healthy adults?: Randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2022;101:e28858. 10.1097/MD.0000000000028858
- Astó E, Huedo P, Altadill T, Aguiló García M, Sticco M, et al. Probiotic Properties of KABP042 and KABP041 Show Potential to Counteract Functional Gastrointestinal Disorders in an Observational Pilot Trial in Infants. Front Microbiol. 2021;12:741391. 10.3389/fmicb.2021.741391
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. 10.1016/j.clnesp.2020.12.025
- Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. 10.1016/j.clnu.2020.01.005
- Zhu S, Guo Z, Liu L, Gao Y, Bai L, et al. Complex Probiotics Relieve Constipation Through Regulation of the Intestinal Microbiota in Kittens. Microorganisms. 2025;13. 10.3390/microorganisms13030563
- Zhang Z, Li J, Wan Z, Fang S, Zhao Y, et al. subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025;16:2347. 10.1039/d4fo06350c
- Ma W, Zhao Y, Liu Y, Wang Y, Yu S, et al. subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota. Front Microbiol. 2025;16:1525887. 10.3389/fmicb.2025.1525887
- Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. 10.1039/d4fo04660a
- Salo E, Roche D, Gomez-Martinez VB, Cruz-Domenech JM, Garcia-Mora LG, et al. Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study. Benef Microbes. 2024;15:679. 10.1163/18762891-bja00038
- Lan W, Yang H, Zhong Z, Luo C, Huang Q, et al. subsp. LPL-RH improves postoperative gastrointestinal symptoms and nutrition indexes by regulating the gut microbiota in patients with valvular heart disease: a randomized controlled trial. Food Funct. 2024;15:7605. 10.1039/d4fo01471e
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. 10.1007/s00394-024-03398-8
- Lu Y, Zhou X, Wu Y, Cui Q, Tian X, et al. Metabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway. Mol Nutr Food Res. 2024;68:e2200846. 10.1002/mnfr.202200846
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. 10.3390/jcm12144838
- Watanabe M, Maruo T, Suzuki T. Effects of intake of subsp. FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2023;74:695. 10.1080/09637486.2023.2236805
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. 10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. 10.1080/19490976.2023.2197837
- Cui H, Wang Q, Feng C, Guo C, Zhang J, et al. Positive effect of subsp VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Front Microbiol. 2022;13:1040371. 10.3389/fmicb.2022.1040371
- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. 10.1016/j.clnu.2022.10.015
- Noda M, Danshiitsoodol N, Kanno K, Sugiyama M. Silk-derived sericin/fibroin mixture drink fermented with plant-derived BM32-1 improves constipation and related microbiota: a randomized, double-blind, and placebo-controlled clinical trial. Biosci Microbiota Food Health. 2024;43:282. 10.12938/bmfh.2023-102
- Tan Q, Hu J, Zhou Y, Wan Y, Zhang C, et al. Inhibitory Effect of subsp. HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway. Drug Des Devel Ther. 2021;15:1971. 10.2147/DDDT.S309675
- Gotoh Y, Nanba F, Shioya N, Sugimura H, Suzuki T. A dose-finding study for a supplement containing subsp. FC in healthy adults with mild constipation. Biosci Microbiota Food Health. 2020;39:19. 10.12938/bmfh.19-009
- Ozaki K, Maruo T, Kosaka H, Mori M, Mori H, et al. The effects of fermented milk containing Lactococcus lactis subsp. cremoris FC on defaecation in healthy young Japanese women: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2018;69:762. 10.1080/09637486.2017.1417977
- Higashikawa F, Noda M, Awaya T, Nomura K, Oku H, et al. Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial. Nutrition. 2010;26:367. 10.1016/j.nut.2009.05.008
