NOW Supplements Silymarin Milk Thistle Extract

Excellent! I don't know why, but drinking this makes me feel better and lessens my headaches. I don’t take it daily because it’s very effective, and that can be a bit daunting.

Hepatitis details

No more fatty hepatitis

I had fatty hepatitis in my liver, but after prolonged, regular use, ultrasound confirmed it was no longer present.

Ulcer details

Silybin nanoparticles reduce ulcer markers

Based on 5 Researches

Varshosaz J, Minaiyan M, Khaleghi N. Eudragit nanoparticles loaded with silybin: a detailed study of preparation, freeze-drying condition and in vitro/in vivo evaluation. J Microencapsul. 2015;32:211. doi:10.3109/02652048.2014.995728

We investigated the use of silybin nanoparticles in treating ulcerative colitis (UC). These nanoparticles were carefully prepared and tested in a rat model, where UC was induced with acetic acid.

Over five days, we compared the effects of silybin nanoparticles with other treatments. The results showed significant improvements in both macroscopic and histopathological evaluations.

Notably, levels of harmful markers such as TNF-α and IL-6 were reduced, highlighting the potential benefit of silybin nanoparticles in ulcer treatment.

Cured ulcer quickly

Most Useful Review

This product worked remarkably well as my mouth ulcer was cured almost instantly.

Cancer details

Investigating silibinin's cancer treatment role

Based on 16 Researches

Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901

We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.

Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.

9.5

Effective for cancer treatment

Most Useful Review

Great. It is working for my cancer. Thanks for the product.

Diabetes details

Silibinin shows potential for diabetes

Based on 16 Researches

Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x

We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.

It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.

8.8

Supports borderline diabetes

Most Useful Review

I have been using this product for many years and have noticed it is a great complement to the other products I take for my borderline diabetes. It has benefitted my liver and overall health, which is why I sometimes feel a slight twitch in the liver area after taking it.

Pots details

Excellent! A very effective and good supplement, made from natural ingredients. I took it for a friend who could not find the cause of her food allergies after many medications and examinations. It turned out to be related to her gall and liver. This supplement works incredibly well with lecithin, cleansing and supporting both the liver and gall. When taken in courses of three months during spring and autumn, I have noticed marked improvements in her wellbeing. Definitely worth the money!

Swollen Lymph Nodes details

The heaviness on the right side and the swelling under my son's eyes, who is 40 and a big drinker, have gone. The craving for alcohol has also disappeared. Miracle milk thistle! I'm ordering again.

Acne details

Silybum marianum reduces acne severity

Based on 3 Researches

Fontao F, von Engelbrechten M, Seilaz C, Sorg O, Saurat JH. Microcomedones in non-lesional acne prone skin New orientations on comedogenesis and its prevention. J Eur Acad Dermatol Venereol. 2020;34:357. doi:10.1111/jdv.15926

We explored the effects of Silybum marianum fruit extract on acne treatment using a topical formulation over 48 weeks in a group of acne patients. The study identified microcomedones, which are early signs of future acne lesions, as a target for prevention.

Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.

9.5

Transformed my skin

Most Useful Review

This product transformed my face after 10 years of struggling with acne. I took Silymarin to support my liver while not always maintaining a healthy diet. It significantly improved my facial skin condition, particularly regarding rosacea and inflammation.

Arthritis details

Silymarin shows anti-arthritis potential

Based on 5 Researches

Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7:21.

We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.

While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.

9.5

Enhances joint mobility

Most Useful Review

Curcumin may alleviate pain and enhance joint mobility in those with arthritis. Furthermore, turmeric may aid digestion by stimulating bile production and breaking down fats efficiently.

Brain Tumor details

Silibinin shows toxicity via EGFR

Qi L, Singh RP, Lu Y, Agarwal R, Harrison GS, et al. Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biol Ther. 2003;2:526.

We explored how silibinin, a compound from milk thistle, impacts brain tumor cells by focusing on the epidermal growth factor receptor (EGFR). In our study, we created a specific rat glioma cell line expressing human EGFR. Our results showed that the presence of EGFR was crucial for silibinin to exert its toxic effects on cancer cells. By inhibiting the activation of EGFR, silibinin demonstrates potential as a therapeutic agent for targeting tumor growth. However, further research is needed to understand the detailed mechanisms at play.

8.8

Mental boost

Most Useful Review

I was unsure about which milk thistle to choose, but this one proved to be the right decision! Along with its effectiveness, the pleasant scent of turmeric in the ingredients is soothing. I feel revitalised after drinking it, and I notice my brain feels stimulated thanks to the turmeric. This is a supplement I intend to continue using!

Chest Pain details

Following a Covid-19 illness and necessary antibiotics, my doctor recommended milk thistle to support my liver. I opted for silymarin due to its higher dosage. After two months, the chest pain I previously had disappeared. I plan to continue using this supplement for ongoing liver support. Just remember to check for gallstones before starting.

Cold Sores details

I utilised the properties of this complex supplement to address my liver function and bile-related issues. After nearly a month of use, I've noticed positive results. Diagnosed with cholecystitis, I experienced significant side pain. Fortunately, after starting the supplement, the discomfort eased considerably within days, and I am incredibly grateful that silymarin has been beneficial for me.

Cold details

Boosts immunity effectively

Great cool vitamins. They are well-dosed, have an excellent composition, and boost my immunity during the cold season. 👍🏻

Eczema details

Silymarin shows no significant benefit

Iraji F, Sharif Makhmalzadeh B, Abedini M, Aghaei A, Siahpoush A. Effect of herbal cream containing and silymarin for treatment of eczema: A randomized double-blind controlled clinical trial. Avicenna J Phytomed. 2022;12:155. doi:10.22038/AJP.2022.19492

We examined how an herbal cream containing silymarin affects patients with eczema compared to a standard treatment. In a study with 40 patients suffering from mild to moderate eczema, participants used either the herbal cream or mometasone for two weeks.

After this period, we found notable improvements in skin severity scores for both treatments. However, there wasn't a significant difference between the two groups. This suggests that while both treatments are effective, silymarin may not be superior to traditional therapies for eczema relief.

9.5

Eczema disappeared

Most Useful Review

I had red eczema around my eyes, and I drank this because eye problems can also indicate liver issues. While the effects aren't immediate, the eczema has vanished. It's safe to consume as the liver plays a crucial role in detoxification.

Knee Pain details

My joint pain has significantly eased, and I am impressed with the quality of this company's products.

Migraine details

Effective migraine relief

This is a great way to support liver regeneration, but more impressively, I've used it instead of a pain killer and found that when taken on time, it often prevents a headache from developing into a full-blown migraine attack.

Nausea details

This is a fantastic quality product! It has genuinely detoxified my liver and alleviated my nausea. I take one capsule at night, and I sleep well without any bloating or gas. For anyone consuming a lot of unhealthy food or alcohol, this supplement is incredibly beneficial.

Pancreatitis details

Silymarin promotes pancreatic cell growth

Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008

This study investigated how Silymarin affects the growth of insulin-producing cells in a model of partial pancreas removal in rats.

We treated 72 Wistar rats, half of which were given Silymarin daily. The results were clear: the Silymarin-treated rats showed significant increases in both the Pdx1 gene, which is vital for pancreatic health, and insulin production.

Additionally, their β-cell proliferation improved, leading to better blood sugar control. However, the specific effects on pancreatitis were not explored in this study.

9.5

Feeling revitalised

Most Useful Review

Liver says thank you! Prescribed by a sports doctor, confirmed by three others. I am a professional sportsman and have chronic pancreatitis. I took numerous medications, but Silymarin truly saved me. Although I didn’t follow the dosage strictly—two tablets three times daily—I feel fantastic. It has greatly benefited my health.

Rash details

Random allergies disappeared. I wanted to detox and bought this product hoping to cleanse something. I used to suffer from everyday fatigue and random skin rashes on my hands and feet at night, causing itchiness. Since I started taking Silymarin daily with vitamins, waking up in the morning has been easier. Halfway through the bottle, I noticed my skin normalised, and there were no rashes. I didn't expect this; dermatologists previously attributed my symptoms to random allergic reactions due to my sensitive skin. After the first bottle, I will wait before starting the second to avoid my body becoming immune to silymarin. However, I am definitely pleased and will purchase a second one.

Bloating details

Great! Sensational quality product indeed! The price is very reasonable, and this supplement is excellent for detoxifying the liver and relieving the stomach. I take 1 capsule at night and sleep well—no bloating or gas. For those who consume a lot of junk foods and take many medicines, this product detoxifies your body effectively. In Brazil, Forfig is expensive and not as effective as this brand. It's also beneficial for those who drink alcohol, as it helps the liver regenerate. Thanks for a great product!

Chemotherapy details

Decreased liver enzymes

I purchased this for my mother, who was undergoing chemotherapy. Due to high ASAT and ALAT levels, she needed liver support, and I found milk thistle to be the best natural remedy. After combining it with Chlorella from Now, her ASAT and ALAT levels significantly decreased and almost returned to normal.

Common Cold details

Effective cleansing remedy

Excellent! Let’s cleanse the liver as a family. The remedy works well. Occasionally, I've experienced a breakout, but that’s part of the body's detox process.

Depression details

Silibinin reduces depression in mice

Based on 8 Researches

Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593

We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.

Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.

8.8

Aiding depression treatment

Most Useful Review

This excellent product is vital for maintaining our liver’s health, acting as a filter against harmful substances. It aids in the repair of damaged cells, reduces fat oxidation, and normalises lipid metabolism. Additionally, it helps manage depression and the effects of stress, while improving biochemical parameters and regulating cellular fluid transport. It also neutralises and removes hepatotoxic substances. I trust my review is useful to you.

Food Poisoning details

Milk thistle aids liver recovery after poisoning. I take it annually and feel a marked improvement. My husband used it for three months post-severe food poisoning, and his liver enzyme levels normalised.

High Cholesterol details

Silymarin positively influences cholesterol

Based on 16 Researches

Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050

We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.

Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.

However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.

7.5

Decreased liver enzymes

Most Useful Review

I bought this for my mother undergoing chemotherapy due to high ASAT and ALAT levels. After using milk thistle alongside Chlorella, her liver support improved significantly, and her ASAT and ALAT levels dropped close to normal.

Obesity details

Kim S, You Y, Kim OK, Lee J, Chung JW, et al. Silymarin Prevents High-Fat Diet-Induced Muscle Atrophy by Regulating Protein Degradation and Synthesis in Mice. J Med Food. 2022;25:793. doi:10.1089/jmf.2021.K.0175

Based on 8 Researches

Silymarin reduces obesity effects

We explored how silymarin helps with obesity and muscle atrophy in mice. In our study, we divided the mice into three groups: a control group on a normal diet, another group on a high-fat diet, and a third group receiving silymarin alongside the high-fat diet.

The results showed that the silymarin group had less weight gain and maintained better muscle mass compared to the high-fat diet group. Moreover, the grip strength of the mice on silymarin improved. Overall, silymarin seems beneficial for not only tackling obesity but also preserving muscle health.

Positive liver results

Most Useful Review

I found this product very helpful for my family, as it has numerous benefits: it aids in the regeneration of liver cells and protects the liver from harmful substances like alcohol and cigarette smoke. It regulates bilirubin, enhances bile secretion, and improves skin conditions related to the liver. Unfortunately, I experienced an allergic reaction to turmeric in the formulation and opted for a different milk thistle product. However, my husband has had excellent results. He was diagnosed with liver obesity years ago and always felt overheated. After using this product for a month, he now feels comfortable and has become more even-tempered, which suggests a positive effect on his liver health.

Rosacea details

MSM, along with silymarin, zinc, and copper, has worked wonders for my rosacea!

Yeast Infection details

Yun DG, Lee DG. Silibinin triggers yeast apoptosis related to mitochondrial Ca influx in Candida albicans. Int J Biochem Cell Biol. 2016;80:1. doi:10.1016/j.biocel.2016.09.008

Silibinin induces yeast apoptosis

We explored how silibinin, derived from the milk thistle plant, affects Candida albicans, the yeast that can lead to infections. Our research demonstrated that silibinin treatment significantly increased reactive oxygen species, triggering a cascade of events that caused yeast cell death, or apoptosis. Notably, we observed that mitochondrial calcium overload plays a vital role in this process. While silibinin shows promise for combating yeast infections, our findings highlight the importance of further research to fully understand its potential and mechanisms.

8.8

Effective for liver

Most Useful Review

My favourite bad. Milk thistle enhances bile excretion and improves gastrointestinal function, increasing the liver's protective abilities against infections and toxins. I suffer from biliary dyskinesia, so I take it regularly. It works very well and does not trigger allergies.

Allergies details

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

Based on 4 Researches

Silibinin shows promise for asthma

We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.

9.5

Allergies disappeared

Most Useful Review

Random allergies vanished after taking Silymarin alongside multivitamins. I had suffered from fatigue and skin rashes for years, but felt more energised and noticed my skin had returned to normal. I was surprised as dermatologists had said my issues were due to allergies from my sensitive skin. I'm pleased with the results and plan to continue with a second bottle.

Autoimmune Disorder details

Silybin shows promise for autoimmune disorders

Based on 9 Researches

Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678

We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).

In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.

The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.

9.5

Liver function restored

Most Useful Review

My nephew experienced a spike in liver function tests, raising concerns of an autoimmune disorder. However, after using silymarin, his liver tests returned to normal, much to our relief. This product clearly supports liver health effectively.

Chronic Fatigue Syndrome details

I suffered from chronic fatigue syndrome for years and tried various treatments with little success. Upon starting Silymarin from Now Foods, I noticed a complete turnaround in my energy levels. I can now manage housework and work from home, and my overall mood has improved significantly.

Reflux details

Under trial is an important food supplement for cleansing the liver and eliminating toxins. This reflects positively on skin health, enhances absorption of vitamins and minerals, aids in alleviating reflux esophagitis, balances stomach acidity, and reduces liver fat.

Back Pain details

Good liver helper! After being ill with Covid-19 and needing antibiotics, my doctor recommended milk thistle for my liver. I opted for silymarin due to its higher milk thistle content and added turmeric. After two months, my back pain in the right hypochondrium vanished. I continue to take it for ongoing liver maintenance. Just check for gallstones first. Be healthy!

Kidney Stones details

I have gallbladder issues and cholesterol stones, and I've been taking milk thistle for six months. It has alleviated my symptoms and I no longer feel heaviness after meals. I take it once daily after breakfast, and it has greatly improved my condition.

Pelvic Pain details

Pain management success

Silymarin has been instrumental in alleviating my pelvic pain associated with a poor diet. I take it regularly before meals, and I noticed the pain and discomfort subsiding from the first days of use. It has really worked for me.

Psoriasis details

Milk thistle shows anti-psoriatic effects

Kamel NM, El-Sayed SS, El-Said YAM, El-Kersh DM, Hashem MM, et al. Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress. Int Immunopharmacol. 2024;139:112781. doi:10.1016/j.intimp.2024.112781

We investigated how milk thistle extract might help treat psoriasis in mice. Our study involved forty Swiss albino mice divided into four groups, including a test group treated with the milk thistle extract after inducing psoriasis with imiquimod.

The results were encouraging, showing that the extract significantly reduced skin symptoms like redness and scaling, similar to traditional cortisone treatments. It worked by inhibiting specific cellular pathways, reducing inflammation and boosting antioxidant defenses, suggesting that milk thistle could be an effective new option for psoriasis treatment.

9.5

Effective psoriasis treatment

Most Useful Review

This supplement works wonders for my psoriasis! I've been taking it since May 2013, and it has significantly improved my condition. If I follow the instructed dosage, my blood pressure elevates excessively, so I only take two pills each morning and use an oily cream at night. The progress is slow, but at this rate, I anticipate being completely psoriasis-free by next summer!

Weight Loss details

Silymarin with turmeric is from a well-known company. This is my second order, this time with curcumin. I felt it helped me lose weight. The ingredients include silymarin and turmeric, and the quantity is good for the price. It aids in eliminating liver toxins, which in turn helps with weight loss and burning fat. Honestly, I've noticed a difference in my weight. It effectively rids the body of toxins, and its absorption is high. Its taste is a turmeric flavour, and it's a nutritional supplement.

Constipation details

Regular bowel activity

I really liked Milk thistle; I took 1 tablet twice a day, and my bowel movements became regular. I previously endured frequent constipation, but this product improved my condition.

Heart Disease details

2,3-dehydrosilybin shows heart protection

Based on 8 Researches

Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028

We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.

The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.

6.3

Supports liver function

Most Useful Review

Milk Thistle has been very helpful for me as I have to take a potent heart medication that puts considerable strain on my liver.

Gastritis details

I suffer from reflux gastritis, and after taking one capsule of silymarin, I noticed an increased bile secretion. So, this seems to be conducive for bile flow, especially for those without reflux. The effects are definitely apparent.

Irritable Bowel Syndrome details

Effective supplement for IBS relief

Di Pierro F, Putignano P, Villanova N. Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia. Acta Biomed. 2018;88:462. doi:10.23750/abm.v88i4.5851

We explored the effects of a supplement called Berberol®K, which contains silybum marianum, on patients dealing with irritable bowel syndrome (IBS) alongside diabetes and dyslipidemia.

In a retrospective study with 59 subjects, those who were treated showed notable improvements after six months, including reduced diarrhea symptoms.

The results suggest that this food supplement could be beneficial, especially for those who cannot tolerate standard treatments like statins.

8.8

Enhanced endurance

Most Useful Review

I had been suffering from terrible fatigue and irritable bowel syndrome for over a decade, unable to carry out housework. After trying various supplements without success, I discovered Silymarin from Now Foods. Since I began taking it, my life has transformed. My energy has increased, my bowel movements have improved, and I'm now able to engage in daily activities. Although I'm not yet back to full health, I feel considerably brighter and more active than before. I wholeheartedly recommend it!

Diarrhea details

Questionable