Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 49 Researches
7.8
USERS' SCORE
Good
Based on 9 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 30
Amount Per Serving
%DV
Ultimate Care Probiotic Culture Blend 100 Billion CFU
301 mg
***
Bifido Probiotic BlendBifidobacterium lactis BI-04®, Bifidobacterium lactis HN019™, Bifidobacterium infantis Bi-26™, Bifidobacterium lactis Bi-07®
54 Billion CFU
Lacto Probiotic BlendLactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus acidophilus NCFM®, Lactobacillus brevis Lbr-35™
46 Billion CFU
Top Medical Research Studies
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
9
We assessed the effectiveness of Bifidobacterium animalis subsp. lactis XLTG11 in helping children with functional constipation through a well-structured study with a randomized, double-blinded, placebo-controlled design. The children were split into two groups: one received the probiotic treatment alongside conventional care, while the other did not.
Over the treatment period, we saw a consistent increase in bowel movements in the group taking the probiotic, showing higher fecal frequency compared to the control group. Additionally, the beneficial bacteria in their guts improved, which suggests that this treatment is a promising approach for managing constipation in children.
Over the treatment period, we saw a consistent increase in bowel movements in the group taking the probiotic, showing higher fecal frequency compared to the control group. Additionally, the beneficial bacteria in their guts improved, which suggests that this treatment is a promising approach for managing constipation in children.
Read More
Most Useful Reviews
9
Effective and reliable
25 people found this helpful
I've used this product for years! It helps with both the odour and constipation I've battled since my teenage years. Antibiotics worsened my BV, but this probiotic cured it quickly. I now take it once a day and manage any flare-ups effectively.
Read More
10
Effective for constipation
2 people found this helpful
I bought it for leaky gut treatment. Constipation cured!
Read More
10
Supports intestinal health
Excellent quality! The ingredients are beneficial, supporting intestinal health with improved absorption. It effectively removes constipation, restores microflora quickly, and enhances digestion. The packaging is user-friendly, and the supplement offers extensive benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 49 Researches
7.8
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
9
Bifidobacterium lactis effective for constipation
We assessed how Bifidobacterium animalis subsp. lactis BLa80 could help adults struggling with chronic constipation. In a multicentre, randomised, double-blind, placebo-controlled trial involving 46 participants, we compared the effects of the probiotic against a placebo over 12 weeks.
Our findings revealed that those taking the probiotic experienced a significant improvement in stool consistency and a reduction in constipation symptoms. By weeks 8 and 12, their stool types shifted towards more normal classifications on the Bristol scale, while constipation rates increased in the placebo group.
This highlights the potential of Bifidobacterium lactis as a helpful solution for managing constipation.
Our findings revealed that those taking the probiotic experienced a significant improvement in stool consistency and a reduction in constipation symptoms. By weeks 8 and 12, their stool types shifted towards more normal classifications on the Bristol scale, while constipation rates increased in the placebo group.
This highlights the potential of Bifidobacterium lactis as a helpful solution for managing constipation.
Read More
9
We assessed the effectiveness of Bifidobacterium animalis subsp. lactis XLTG11 in helping children with functional constipation through a well-structured study with a randomized, double-blinded, placebo-controlled design. The children were split into two groups: one received the probiotic treatment alongside conventional care, while the other did not.
Over the treatment period, we saw a consistent increase in bowel movements in the group taking the probiotic, showing higher fecal frequency compared to the control group. Additionally, the beneficial bacteria in their guts improved, which suggests that this treatment is a promising approach for managing constipation in children.
Over the treatment period, we saw a consistent increase in bowel movements in the group taking the probiotic, showing higher fecal frequency compared to the control group. Additionally, the beneficial bacteria in their guts improved, which suggests that this treatment is a promising approach for managing constipation in children.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective and reliable
25 people found this helpful
I've used this product for years! It helps with both the odour and constipation I've battled since my teenage years. Antibiotics worsened my BV, but this probiotic cured it quickly. I now take it once a day and manage any flare-ups effectively.
Read More
10
Effective for constipation
2 people found this helpful
I bought it for leaky gut treatment. Constipation cured!
Read More
10
Supports intestinal health
Excellent quality! The ingredients are beneficial, supporting intestinal health with improved absorption. It effectively removes constipation, restores microflora quickly, and enhances digestion. The packaging is user-friendly, and the supplement offers extensive benefits.
Read More
9
Very good effect
With high-quality ingredients and luxurious packaging, this product is effective and beneficial. It aids digestion and absorption, and is particularly good for constipation. The taste is neutral.
Read More
7.5
Natural ingredients
Excellent! High quality with natural ingredients. The medium-sized supplement promotes good health, improves digestion, and normalises microbes without causing constipation. The convenient packaging offers significant benefits.
Read More
Frequently Asked Questions
10
Supports intestinal health
Excellent quality! The ingredients are beneficial, supporting intestinal health with improved absorption. It effectively removes constipation, restores microflora quickly, and enhances digestion. The packaging is user-friendly, and the supplement offers extensive benefits.
9
Very good effect
With high-quality ingredients and luxurious packaging, this product is effective and beneficial. It aids digestion and absorption, and is particularly good for constipation. The taste is neutral.
0
Not effective for constipation
It doesn't work for constipation. If I consume just this product, I get a headache and feel sleepy. The capsule has a scent similar to an air freshener, which I personally dislike.
10
Effective for constipation
2 people found this helpful
I bought it for leaky gut treatment. Constipation cured!
6
Reduces gastrointestinal issues
Very good! It helps with gastrointestinal dryness and effectively reduces constipation problems.
9
Bifidobacterium lactis effective for constipation
We assessed how Bifidobacterium animalis subsp. lactis BLa80 could help adults struggling with chronic constipation. In a multicentre, randomised, double-blind, placebo-controlled trial involving 46 participants, we compared the effects of the probiotic against a placebo over 12 weeks.
Our findings revealed that those taking the probiotic experienced a significant improvement in stool consistency and a reduction in constipation symptoms. By weeks 8 and 12, their stool types shifted towards more normal classifications on the Bristol scale, while constipation rates increased in the placebo group.
This highlights the potential of Bifidobacterium lactis as a helpful solution for managing constipation.
Our findings revealed that those taking the probiotic experienced a significant improvement in stool consistency and a reduction in constipation symptoms. By weeks 8 and 12, their stool types shifted towards more normal classifications on the Bristol scale, while constipation rates increased in the placebo group.
This highlights the potential of Bifidobacterium lactis as a helpful solution for managing constipation.
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
2
We conducted a randomized, double-blind, placebo-controlled trial involving 94 children under 5, all suffering from functional constipation. Participants received either Lactobacillus rhamnosus or a placebo for four weeks. While we observed some increase in bowel movements in both groups throughout the study, Lcr35 did not show significant effectiveness compared to the placebo. Overall, our findings suggest that using this specific probiotic alone is not an effective treatment for constipation in young children. It reinforces existing guidelines against probiotics for this issue.
9
We examined whether synbiotics, which include Lactobacillus rhamnosus and other beneficial bacteria, help relieve functional constipation in children aged 4 to 18. In a controlled study, one group received synbiotics while the other received a placebo for four weeks.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
7
We explored the impact of multistrain probiotics, including Lactobacillus acidophilus, on functional constipation in elderly individuals living in a nursing home. In a controlled study with 60 participants, those receiving the probiotic mixture for 12 weeks showed a slight increase in stool frequency compared to the placebo group.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
References
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- Zhang Z, Li J, Wan Z, Fang S, Zhao Y, et al. subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025;16:2347. doi:10.1039/d4fo06350c
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- Watanabe M, Maruo T, Suzuki T. Effects of intake of subsp. FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2023;74:695. doi:10.1080/09637486.2023.2236805
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
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- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. doi:10.1016/j.clnu.2022.10.015
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- Tan Q, Hu J, Zhou Y, Wan Y, Zhang C, et al. Inhibitory Effect of subsp. HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway. Drug Des Devel Ther. 2021;15:1971. doi:10.2147/DDDT.S309675
- Gotoh Y, Nanba F, Shioya N, Sugimura H, Suzuki T. A dose-finding study for a supplement containing subsp. FC in healthy adults with mild constipation. Biosci Microbiota Food Health. 2020;39:19. doi:10.12938/bmfh.19-009
- Ozaki K, Maruo T, Kosaka H, Mori M, Mori H, et al. The effects of fermented milk containing Lactococcus lactis subsp. cremoris FC on defaecation in healthy young Japanese women: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2018;69:762. doi:10.1080/09637486.2017.1417977
- Higashikawa F, Noda M, Awaya T, Nomura K, Oku H, et al. Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial. Nutrition. 2010;26:367. doi:10.1016/j.nut.2009.05.008
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. doi:10.1038/s41598-024-71945-8
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
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- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
