5/1/2025
Last update
5/1/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 56 Researches
7.7
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Advanced 40+ Acidophilus 1.5 billion CFUproviding:Lactobacillus. acidophilus, (LA-5®)300 million CFULactobacillus rhamnosus GG (LGG®)300 million CFULactobacillus paracasei (L. CASEI 431®)300 million CFU Bifidobacterium lactis (BB-12®)300 million CFUStreptococcus thermophilus, (TH-4®)300 million CFU
2.4 mg
**
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
Most Useful Reviews
10
Significant improvement
14 people found this helpful
I used to struggle with constipation and irregularity, but this product has resolved that issue. My husband and I take one daily before breakfast, and it has greatly improved our digestive health.
Read More
9
Excellent digestion
4 people found this helpful
Excellent! Propyl whole package, enough for 2 months. I took it for prevention due to my very sensitive digestive tract. While on the Dukan Diet, I was concerned about how my bowel would react, but my digestion has been excellent and I've not experienced constipation, which is common with this protein diet! It's very convenient to take just 2 capsules per day.
Read More
9
Strong immunity boost
1 people found this helpful
A wonderful probiotic! It improves digestion, restores intestinal microflora, eliminates constipation, and strengthens immunity.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 56 Researches
7.7
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Significant improvement
14 people found this helpful
I used to struggle with constipation and irregularity, but this product has resolved that issue. My husband and I take one daily before breakfast, and it has greatly improved our digestive health.
Read More
9
Excellent digestion
4 people found this helpful
Excellent! Propyl whole package, enough for 2 months. I took it for prevention due to my very sensitive digestive tract. While on the Dukan Diet, I was concerned about how my bowel would react, but my digestion has been excellent and I've not experienced constipation, which is common with this protein diet! It's very convenient to take just 2 capsules per day.
Read More
9
Strong immunity boost
1 people found this helpful
A wonderful probiotic! It improves digestion, restores intestinal microflora, eliminates constipation, and strengthens immunity.
Read More
9
Effective for constipation
1 people found this helpful
This is excellent for constipation! I love the effect. I've tried many brand-name probiotics without any success. After a week of using this, it’s clear that it works! My constipation was severe, leading to a hard stomach and anal tears. I recommend taking two in the morning on an empty stomach. Initially, I experienced some abdominal pain, but now I have a routine that works perfectly.
Read More
8
No dependence
1 people found this helpful
Great product, reasonable size, and easy to swallow. It supports the digestive system, helps with constipation, and promotes bowel movements. It does not create dependence and has no aftertaste. Excellent quality – highly recommended!
Read More
Frequently Asked Questions
6
Gradual improvements
2 people found this helpful
I can recommend these. I liked them very much, as I noticed the effect by the second day. I take 2 capsules daily, one in the morning and one in the evening. I have experienced some bloating and a little excess weight. My child has regular constipation and has started taking these. There are improvements, but not very quickly. He's only been on them for a week, and I plan to order another jar for myself.
9
Effective for constipation
1 people found this helpful
This is excellent for constipation! I love the effect. I've tried many brand-name probiotics without any success. After a week of using this, it’s clear that it works! My constipation was severe, leading to a hard stomach and anal tears. I recommend taking two in the morning on an empty stomach. Initially, I experienced some abdominal pain, but now I have a routine that works perfectly.
2
No change noted
I have been trying various remedies to improve my bowel movements for my constipation. After a month of taking this, I haven't noticed any changes. Unfortunately, it didn’t seem compatible with my intestines.
8
No dependence
1 people found this helpful
Great product, reasonable size, and easy to swallow. It supports the digestive system, helps with constipation, and promotes bowel movements. It does not create dependence and has no aftertaste. Excellent quality – highly recommended!
9
Strong immunity boost
1 people found this helpful
A wonderful probiotic! It improves digestion, restores intestinal microflora, eliminates constipation, and strengthens immunity.
7.5
Short-term relief
4 people found this helpful
Good pills that manage bloating well, and I notice much less constipation! However, once I stop, the problems return the very next day. That's why I rate it 4 stars!
9
Excellent digestion
4 people found this helpful
Excellent! Propyl whole package, enough for 2 months. I took it for prevention due to my very sensitive digestive tract. While on the Dukan Diet, I was concerned about how my bowel would react, but my digestion has been excellent and I've not experienced constipation, which is common with this protein diet! It's very convenient to take just 2 capsules per day.
7
We evaluated the impact of two probiotic formulations on functional constipation in adults. This study involved 30 days of daily consumption of oral sachets containing various strains of Lactobacillus and Bifidobacterium.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
9
Bifidobacterium lactis effective for constipation
We assessed how Bifidobacterium animalis subsp. lactis BLa80 could help adults struggling with chronic constipation. In a multicentre, randomised, double-blind, placebo-controlled trial involving 46 participants, we compared the effects of the probiotic against a placebo over 12 weeks.
Our findings revealed that those taking the probiotic experienced a significant improvement in stool consistency and a reduction in constipation symptoms. By weeks 8 and 12, their stool types shifted towards more normal classifications on the Bristol scale, while constipation rates increased in the placebo group.
This highlights the potential of Bifidobacterium lactis as a helpful solution for managing constipation.
Our findings revealed that those taking the probiotic experienced a significant improvement in stool consistency and a reduction in constipation symptoms. By weeks 8 and 12, their stool types shifted towards more normal classifications on the Bristol scale, while constipation rates increased in the placebo group.
This highlights the potential of Bifidobacterium lactis as a helpful solution for managing constipation.
References
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. 10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. 10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. 10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. 10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. 10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. 10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. 10.1111/1751-2980.12797
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. 10.3920/BM2018.0163
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. 10.5851/kosfa.2017.37.6.906
- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. 10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. 10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. 10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. 10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. 10.1089/jmf.2009.1307
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. 10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. 10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. 10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. 10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. 10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. 10.1039/d2fo01900k
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. 10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. 10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. 10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. 10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. 10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. 10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. 10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD004827.pub4
- Zhu S, Guo Z, Liu L, Gao Y, Bai L, et al. Complex Probiotics Relieve Constipation Through Regulation of the Intestinal Microbiota in Kittens. Microorganisms. 2025;13. 10.3390/microorganisms13030563
- Zhang Z, Li J, Wan Z, Fang S, Zhao Y, et al. subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025;16:2347. 10.1039/d4fo06350c
- Ma W, Zhao Y, Liu Y, Wang Y, Yu S, et al. subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota. Front Microbiol. 2025;16:1525887. 10.3389/fmicb.2025.1525887
- Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. 10.1039/d4fo04660a
- Salo E, Roche D, Gomez-Martinez VB, Cruz-Domenech JM, Garcia-Mora LG, et al. Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study. Benef Microbes. 2024;15:679. 10.1163/18762891-bja00038
- Lan W, Yang H, Zhong Z, Luo C, Huang Q, et al. subsp. LPL-RH improves postoperative gastrointestinal symptoms and nutrition indexes by regulating the gut microbiota in patients with valvular heart disease: a randomized controlled trial. Food Funct. 2024;15:7605. 10.1039/d4fo01471e
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. 10.1007/s00394-024-03398-8
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. 10.1007/s42770-024-01276-3
- Lu Y, Zhou X, Wu Y, Cui Q, Tian X, et al. Metabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway. Mol Nutr Food Res. 2024;68:e2200846. 10.1002/mnfr.202200846
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. 10.3390/jcm12144838
- Watanabe M, Maruo T, Suzuki T. Effects of intake of subsp. FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2023;74:695. 10.1080/09637486.2023.2236805
- Cui H, Wang Q, Feng C, Guo C, Zhang J, et al. Positive effect of subsp VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Front Microbiol. 2022;13:1040371. 10.3389/fmicb.2022.1040371
- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. 10.1016/j.clnu.2022.10.015
- Eor JY, Tan PL, Lim SM, Choi DH, Yoon SM, et al. Laxative effect of probiotic chocolate on loperamide-induced constipation in rats. Food Res Int. 2019;116:1173. 10.1016/j.foodres.2018.09.062
- Yoon JY, Cha JM, Oh JK, Tan PL, Kim SH, et al. Probiotics Ameliorate Stool Consistency in Patients with Chronic Constipation: A Randomized, Double-Blind, Placebo-Controlled Study. Dig Dis Sci. 2018;63:2754. 10.1007/s10620-018-5139-8
- Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2017;73:1199. 10.1007/s00228-017-2291-6
- Tanaka Y, Takami K, Nishijima T, Aoki R, Mawatari T, et al. Short- and long-term dynamics in the intestinal microbiota following ingestion of Bifidobacterium animalis subsp. lactis GCL2505. Biosci Microbiota Food Health. 2015;34:77. 10.12938/bmfh.2015-001
- Ivakhnenko ES, Nian'kovskiĭ SL. [Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants]. Georgian Med News. 2013.
- Higashikawa F, Noda M, Awaya T, Nomura K, Oku H, et al. Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial. Nutrition. 2010;26:367. 10.1016/j.nut.2009.05.008
- Drouault-Holowacz S, Bieuvelet S, Burckel A, Cazaubiel M, Dray X, et al. A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol. 2008;32:147. 10.1016/j.gcb.2007.06.001
- Astegiano M, Pellicano R, Terzi E, Simondi D, Rizzetto M. Treatment of irritable bowel syndrome. A case control experience. Minerva Gastroenterol Dietol. 2006;52:359.
- Noda M, Danshiitsoodol N, Kanno K, Sugiyama M. Silk-derived sericin/fibroin mixture drink fermented with plant-derived BM32-1 improves constipation and related microbiota: a randomized, double-blind, and placebo-controlled clinical trial. Biosci Microbiota Food Health. 2024;43:282. 10.12938/bmfh.2023-102
- Tan Q, Hu J, Zhou Y, Wan Y, Zhang C, et al. Inhibitory Effect of subsp. HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway. Drug Des Devel Ther. 2021;15:1971. 10.2147/DDDT.S309675
- Gotoh Y, Nanba F, Shioya N, Sugimura H, Suzuki T. A dose-finding study for a supplement containing subsp. FC in healthy adults with mild constipation. Biosci Microbiota Food Health. 2020;39:19. 10.12938/bmfh.19-009
- Ozaki K, Maruo T, Kosaka H, Mori M, Mori H, et al. The effects of fermented milk containing Lactococcus lactis subsp. cremoris FC on defaecation in healthy young Japanese women: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2018;69:762. 10.1080/09637486.2017.1417977
