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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
The product is found useful for the following medical conditions
Brain Tumor details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.8
8
Folate micelles for tumor diagnosis
Radiolabelled folate micellar carriers as proposed diagnostic aid for CNS tumors by nasal route.
Most Relevant Research
We explored the potential of folate as a diagnostic aid for brain tumors, specifically targeting gliomas—some of the most challenging brain cancers. A key part of our approach involved developing a micellar delivery system that could be given through the nose. This method is less invasive and may provide a more effective way to reach brain tumors.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
9.5
Essential for development
Most Useful Review
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.8
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9.5
Less severe illness
Most Useful Review
After using this vitamin for over a year, I've noticed a significant improvement in my quality of life. Not only do I feel healthier and get sick less often, but it has noticeably improved my mood. Given my family history of depression, I am very grateful for this change.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 7 Reviews
8.7
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Most Relevant Research
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
10
Life changer
Most Useful Review
This vitamin has transformed my life. I have experienced no mood swings, anxiety or stress since switching to this product. It's a fantastic supplement and I recommend it to anyone looking for something natural that truly works!
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Back feels great
Most Useful Review
Vitamin B is fantastic! My husband and I regularly consume it, and my back pain feels great!
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Folic acid effects on hypertension
The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
Most Relevant Research
We explored how low levels of folic acid (FA) and Vitamin B12 (VB12) relate to high blood pressure (BP) in children and adolescents. Conducting both nested case-control and cohort studies, we focused on primary school participants. In our research, we found that children with elevated BP exhibited lower levels of FA and VB12 compared to those with normal BP.
Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.
In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.
Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.
In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.
9.5
Lowers blood pressure
Most Useful Review
Folic acid, a synthetic form of folate, is crucial for the formation of new cells. Insufficient folic acid may heighten the risk of cardiovascular diseases, including hypertension. Research indicates that folic acid might assist in reducing high blood pressure by relaxing arterial walls, hence lowering pressure. The jar is also economically sized. I highly recommend this product.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.7
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Most Relevant Research
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
9.5
Relieved insomnia
Most Useful Review
I had suffered from insomnia for years, initially thinking it was stress-related due to my job. However, feeling exhausted with no improvement led me to suspect I needed proper rest.
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8.7
7
Folate linked to reduced knee pain
Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis.
Most Relevant Research
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
9.5
Pain-free menstruation
Most Useful Review
I have been taking folic acid for two months. The most significant effect for me was pain-free menstruation, which started five days earlier than expected. Along with this, there’s no fatigue or moodiness. Folic acid also positively influences emotional well-being and reduces PMS symptoms, and it has no side effects, apart from rare individual intolerance. I highly recommend this supplement; it’s beneficial for every woman.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.7
9.5
Reduced rashes
Most Useful Review
After a prolonged period of self-isolation and vaccination, I returned to my usual working rhythm and noticed my menstrual cycle had worsened. It decreased by 5 days, with prolonged PMS and pain across several cycles. I decided to take a course of folic acid, particularly this product as it was discounted and suited my dosage. In a month, my cycle returned to 28-29 days, I hardly feel PMS, and the pain has reduced to simple discomfort. I took it post-breakfast, occasionally missing doses when flying. Additionally, my skin condition improved with fewer rashes, and my immune system feels stronger! Highly recommend consulting your doctor prior to purchase.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 13 Reviews
8.7
8
Folate may protect against OSA
The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study.
Most Relevant Research
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
9.5
Life-changing vitamin
Most Useful Review
After my doctor recommended this vitamin due to frequent illnesses, it has transformed my life. I rarely get sick now, require less sleep, and feel more energetic—waking up in the mornings is no longer a struggle!
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
No breast swelling
Most Useful Review
I take this medication with my teenage daughter, and we are thrilled with the results! My critical days pass without noticeable swelling of the mammary glands, unlike before. It is easy to take, just one small tablet with breakfast, and we take it in a month-on, month-off cycle. Highly recommended!
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Folic acid lowers inflammatory pain
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Most Relevant Research
We investigated the effects of folic acid on chronic inflammatory pain, especially in the context of arthritis. Adult rats were used in our study, and we induced inflammatory pain by injecting a substance called complete Freund's adjuvant (CFA) into their hind paws. Through behavioral tests, we assessed pain responses by measuring how long it took for the rats to withdraw their paws from painful stimuli.
Our findings showed that the CFA injections not only caused significant pain but also increased the expression of Matrix metalloproteinase 2 (MMP2), a protein associated with inflammation. Notably, MMP2 was primarily found in nerve cells rather than glial cells, indicating its crucial role in the pain pathway.
In an exciting twist, we discovered that long-term treatment with folic acid managed to reduce the overexpression of MMP2. This led to lasting relief from chronic inflammatory pain for the rats and also alleviated pain-related anxiety. These results suggest that folic acid could be a promising therapeutic option for managing chronic inflammatory pain and anxiety in arthritis patients, allowing for better pain management in the long term.
Our findings showed that the CFA injections not only caused significant pain but also increased the expression of Matrix metalloproteinase 2 (MMP2), a protein associated with inflammation. Notably, MMP2 was primarily found in nerve cells rather than glial cells, indicating its crucial role in the pain pathway.
In an exciting twist, we discovered that long-term treatment with folic acid managed to reduce the overexpression of MMP2. This led to lasting relief from chronic inflammatory pain for the rats and also alleviated pain-related anxiety. These results suggest that folic acid could be a promising therapeutic option for managing chronic inflammatory pain and anxiety in arthritis patients, allowing for better pain management in the long term.
9.5
Excellent quality
Most Useful Review
Excellent! This supplement is ideal for anyone with immune diseases. My mother suffers from rheumatoid arthritis, and it’s of high quality. It should not be cut.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 20 Reviews
8.6
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Essential for pregnancies
Most Useful Review
I absolutely adore this folate! I only need to take one small yellow tablet daily with food, which is far more convenient than the three doses required by other brands. It's essential for women who are pregnant or planning to be. It significantly contributes to the developing baby's neural tubes. I also share this with my pregnant friend, and let's just say 250 tablets will last us quite a while during our planning! Please support my review with a thumbs up!
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Vision improvement noted
Most Useful Review
Excellent! I ordered this for my vision along with lutein. After taking it, I consulted my doctor, and it helped in combination. I wasn't aware before that folic acid is crucial for women's health. Thank you!
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.6
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Most Relevant Research
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
8.8
Supports healthy cell development
Most Useful Review
NOW Foods Folic Acid is a quality product ideal for health maintenance. It is beneficial for all ages, particularly women planning to conceive. The large package of 250 tablets allows for long-term use. The high bioavailability of folic acid is essential for maintaining healthy homocysteine levels and cell development. Regular use visibly improves the nervous system and cardiovascular health. The neutral taste makes it easy to take.
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.6
7
Folate's Role in Diabetes Management
The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES.
Most Relevant Research
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
9.5
Enhances alertness
Most Useful Review
The best around! Having PCOS, Type 2 diabetes, and cholesterol, I often experience brain fog. However, this folic acid has kept me alert for over a year. It's easy to swallow with breakfast and has no aftertaste, making it a daily essential.
Gout details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Folate's impact on gout therapy
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.
Most Relevant Research
We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
9.5
Pain relief
Most Useful Review
I ordered it for my mum. She seemed to have arthrosis, and another doctor suspected gout. This diagnosis followed a popular disease. They took it alongside calcium and magnesium from the same brand, as per the instructed scheme. The results were swift; the pain disappeared, redness and swelling subsided, and the bumps noticeably shrank. I'm ordering again and want to try it myself after reading such positive reviews. If you find my review helpful, please give it a rating. Thank you!
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
Folic acid reduces cholesterol risk
Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis.
Most Relevant Research
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9.5
Pregnancy success
Most Useful Review
Folic acid is crucial for women before, during, and after pregnancy and is often deficient. I chose this product due to its great price and ease of consumption. I became pregnant the month after starting it, continuing the supplement until after childbirth. Both my child and I are healthy. Folic acid is essential for those not pregnant as well, though it's important to manage dosage.
Kidney Stones details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
No side effects
Most Useful Review
I certainly prefer iHerb over the pharmacy. Several times I experienced kidney pain from the pharmacy products, but after nearly a month on iHerb, I haven't encountered any side effects. Everything suits me well.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
10
Liver recovery noted
Most Useful Review
This works well for me. I suffered from liver problems, and it was determined that a folic acid deficiency had caused damage. After purchasing a liver cleanse along with this folic acid, my liver was completely healed and returned to normal after three months. My doctor was shocked and pleased. Good quality at a great price; I'm continuing to take them daily.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
9.5
Migraine relief
Most Useful Review
Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When I start feeling effects, I take my pills as usual, add magnesium, and my migraine eases gently, usually within a few hours. It used to incapacitate me for half a day. The frequency has also reduced, and I have medicinal support. Regular magnesium intake makes PMS and menstruation much easier. Chronic nasopharyngeal pain has barely worsened, though attributing this solely to magnesium is difficult, given my other supplements. If consuming magnesium, lecithin, and protein, the effect of collagen is really noticeable. I was pleasantly surprised by this. We had no issues with allergies, rashes, or stomach problems. The quality is excellent, and the ingredients are natural.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.5
7
Vitamin B12 hypersensitivity studied
Vitamin B Hypersensitivity: A Retrospective Multicenter Study.
Most Relevant Research
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
10
No issues noted
Most Useful Review
Excellent! I have no allergies!
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 22 Researches
6.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Folate may protect against Alzheimer’s
Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis.
Most Relevant Research
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
8
Mixed results
Most Useful Review
Good for Alzheimer; I've been giving it to my mum for years. It doesn't halt the progression, but after being ill for 8 years, she still recognises us. She also takes melatonin, alpha-lipoic acid, coconut oil, and B12.
Breast Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Folic acid's potential in treatment
Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity.
Most Relevant Research
We explored the potential of a unique nanocomposite made from cerium oxide nanoparticles, folic acid, and carboxymethyl cellulose to combat breast cancer and drug-resistant bacterial infections. Using a green synthesis approach with Moringa oleifera, this study highlights how bimolecular combinations, especially those involving folate, might improve therapeutic effectiveness.
Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.
It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.
Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.
It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.
8.8
Cancer protection
Most Useful Review
It's important to consume folic acid not just before and during pregnancy, as it may protect against various cancers, including breast cancer.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 10 Reviews
8.5
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
8.8
Increased energy levels
Most Useful Review
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Pain reduction
Most Useful Review
This product has significantly helped me with managing the pain associated with my frozen shoulder.
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 8 Reviews
8.5
8
Long-term PPI effects analyzed
Gastric atrophy and intestinal metaplasia in a patient on long-term proton pump inhibitor therapy.
Most Relevant Research
We explored the case of a 74-year-old man who had been taking proton pump inhibitors for 20 years to manage symptoms of gastroesophageal reflux disease. Despite stopping his acid-reducing medications for a month, he showed an unusually high gastric pH level, indicating a significant decrease in stomach acidity. This condition may have led to gastric atrophy and intestinal metaplasia, as revealed through multiple biopsies of his stomach lining. Interestingly, after halting all anti-secretory drugs and starting only prokinetic treatment, the patient reported a significant improvement in heartburn symptoms.
During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.
During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.
9.5
No heartburn noted
Most Useful Review
Folic acid was prescribed by my gynaecologist, and I took 1 piece with my spouse three months prior to our planned pregnancy. During the first trimester, I continued taking it as it comes in a convenient size, has no flavour, and does not cause heartburn. From the second trimester onwards, I switched to a vitamin complex for pregnant women. I was pleased with the results.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 7 Reviews
8.5
4
Nutrient supplements and nausea study
Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials.
Most Relevant Research
We observed the effects of various nutrient supplements, including folate, on nausea in pregnant and postpartum women in Ghana and Malawi. Participants in our study were given different types of supplements, with some receiving iron and folic acid, while others received multiple micronutrients or small-quantity lipid-based nutrient supplements.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
9.5
No nausea noted
Most Useful Review
Excellent! I used to take cheap pharmacy foil, but now I exclusively take this one. It’s essential both for nerves and at a climax, as well as for the assimilation of vitamins B12 and iron. I drink one a day, and sometimes two. There is no nausea.
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Most Relevant Research
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
8.8
Beautiful skin
Most Useful Review
Folic Acid is crucial. I take 6 pills twice a day, and it enhances my skin's appearance almost immediately. It also serves to prevent strokes. NOW usually offers excellent products.
Ulcer details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Causal link: Folic acid and ulcers
Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study.
Most Relevant Research
Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
8.3
Rapid healing effect
Most Useful Review
I took this to heal ulcers in my stomach, and the effect has been excellent. I've noticed that my hair and nails have also started to grow significantly faster.
Anemia details
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.8
USERS' SCORE
Good
Based on 22 Reviews
8.4
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Reduced anemia symptoms
Most Useful Review
Folic acid is touted as beneficial for pregnant women, and I found it cheaper to buy here. Having suffered from iron deficiency for decades, taking this alongside iron finally eliminated my anemia. I wish I had discovered it sooner; its effects are remarkable for both physical and mental health!
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 18 Reviews
8.4
8
Folic acid alleviates bone pain
Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.
Most Relevant Research
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
9.5
Menstrual relief
Most Useful Review
This folic acid helped me regulate a cycle plagued by 2-3 month delays. Just two weeks into taking it, my cycle resumed normally, which astonished me! I had tried various remedies before with minimal success. Although hormones could regulate it, I preferred not to take them. Consuming one tablet daily as instructed worked wonders. I recommend this to all women! It alleviates pain and normalises the female system perfectly.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
8.8
Pregnancy support
Most Useful Review
Folic acid is excellent for restoring immunity and enhancing the heart's function and blood vessels. I use it as per my doctor's advice for pregnancy planning. A pack of 150 is reasonably priced, and NOW is a preferred brand. It’s a beneficial supplement for any woman.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
10
No more convulsions
Most Useful Review
I regularly experienced cramps in my calf muscles, especially at night or during physical exertion. After starting this folic acid, I forgot about the convulsions within a week. It is perfectly absorbed with no side effects. Highly recommend! The product is excellent!
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
USERS' SCORE
Good
Based on 7 Reviews
8.4
7
Folic acid positively affects sexual health
Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial.
Most Relevant Research
We aimed to understand how folic acid might influence sexual function in postmenopausal women, a group that often experiences sexual dysfunction. For this investigation, we conducted a solid triple-blind randomized controlled trial in Tehran, Iran, involving 100 participants recruited from health centers. Each woman in the study received either 5 mg of folic acid or a placebo daily for eight weeks, always on an empty stomach.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
9.5
Reliable menopause aid
Most Useful Review
I've repeatedly ordered this brand due to its excellent quality and tested ingredients over the years. It serves as a vital aid for women during menopause—an indispensable supplement. I plan to keep buying this product as I've consistently observed improvements in my health at any age. The large packaging lasts long, which is a bonus.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.1
USERS' SCORE
Good
Based on 3 Reviews
8.4
9.5
Vitamin B shows promise for psoriasis
Superiority of a vitamin B-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis.
Most Relevant Research
We conducted a study to examine the effectiveness of a vitamin B-containing ointment in treating mild-to-moderate plaque psoriasis compared to a standard glycerol-petrolatum-based emollient cream. The trial was designed thoughtfully, with 24 patients participating in a randomized, controlled, single-blind format. Each patient received the vitamin B ointment on one side of their body and the standard cream on the other side.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
8.8
Boosts energy levels
Most Useful Review
I used this folic acid as part of a psoriasis treatment programme. It’s well-formulated, as folic acid is the inactive form of vitamin B9. "Inactive" means it’s not instantly absorbed but converted within the body to its active form. If your digestion is good, this supplement should work for you, and it’s very affordable. The dosage and size of the capsules are excellent. Taking B vitamins in the morning gives me a surge of energy.
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
5.6
USERS' SCORE
Good
Based on 10 Reviews
8.3
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Most Relevant Research
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
9.5
Reduces palpitations
Most Useful Review
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
Bloating details
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 4 Reviews
8.2
5
Folate shows limited impact
Effects of albendazole/metronidazole or tetracycline/folate treatments on persisting symptoms after Giardia infection: a randomized open clinical trial.
Most Relevant Research
We aimed to understand how treatments with folate in combination with tetracycline affect bloating in patients recovering from giardiasis. In a well-structured clinical trial, two groups received different treatments: one group was given a combination of albendazole and metronidazole for a week, while the other received tetracycline alongside folic acid for four weeks. The key focus was on symptom improvement, particularly bloating.
Both treatment groups noticed some reduction in overall symptoms by the end of the treatment period, with the tetracycline and folate group showing a more significant improvement. Notably, patients in both groups experienced a decrease in bloating, which is a common and uncomfortable symptom in gastrointestinal issues.
However, a month after the treatments, the number of patients reporting ongoing improvements was quite low. Additionally, symptoms, including bloating, returned over time, and by the end of the year, there was no lasting change in overall symptom scores for either group. This suggests that while folate and other treatments may provide short-term relief, they do not lead to long-standing benefits in managing persistent bloating following a Giardia infection. Ultimately, the reasons for ongoing bloating and discomfort remain unclear and deserve further investigation.
Both treatment groups noticed some reduction in overall symptoms by the end of the treatment period, with the tetracycline and folate group showing a more significant improvement. Notably, patients in both groups experienced a decrease in bloating, which is a common and uncomfortable symptom in gastrointestinal issues.
However, a month after the treatments, the number of patients reporting ongoing improvements was quite low. Additionally, symptoms, including bloating, returned over time, and by the end of the year, there was no lasting change in overall symptom scores for either group. This suggests that while folate and other treatments may provide short-term relief, they do not lead to long-standing benefits in managing persistent bloating following a Giardia infection. Ultimately, the reasons for ongoing bloating and discomfort remain unclear and deserve further investigation.
9.5
Less bloating observed
Most Useful Review
Great product, highly recommend. I've started taking this to improve my overall health and I think it's excellent. I've noticed my stomach is much less bloated. My menstrual cycle has improved and actually become longer, with fewer cramps during my period. It's great value for money.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.1
7
Folate's role in constipation explored
Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease.
Most Relevant Research
We formulated a functional food product designed specifically for elderly individuals with Parkinson's disease, focusing on the common issue of constipation. Our approach involved creating a muffin recipe enriched with inulin, cacao, and Moringa, all of which play a role in supporting digestive health.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
9.5
Improved microflora
Most Useful Review
The best probiotic I've ordered multiple times; the whole family takes it. It restores intestinal microflora effectively and helps with constipation. The capsules are small and easy to swallow. I keep them in the refrigerator.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.9
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Most Relevant Research
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
9.5
Noticed improvements
Most Useful Review
The capsule quality is commendable and while I felt persistent headaches and fatigue beforehand, now that I've been taking this for 10 days, I have more energy and no headaches. It’s an excellent supplement for everyone, especially athletes.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
9
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
9.5
Forget dizziness
Most Useful Review
I've been taking this regularly on my doctor's recommendation. Before, I experienced frequent dizziness due to a lack of B12, but now I've forgotten what that feels like. Folic acid is essential for women's health.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.7
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Maintained red blood cells
Most Useful Review
I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.
Diarrhea details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.1
9.5
Vitamin B12 aids chronic diarrhea
CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY.
Most Relevant Research
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
4.8
Caused diarrhea
Most Useful Review
Unfortunately, these tiny balls caused me stomach aches and diarrhoea, possibly due to the dosage. I suggest trying a dose of 400 mcg. Ultimately, I stopped using them.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Medium or Average
Based on 10 Reviews
6.7
9.5
Vitamin B12 causes acne-like eruptions
Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
Most Relevant Research
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
9.5
Chin acne disappeared
Most Useful Review
I bought it for fertility, but it remarkably improved my acne. I previously took Chocola BB for my skin, but this time started with different intentions, only to be pleased with the outcome. My chin acne, which typically flared before my period, has vanished. The small grain is easy to take, and I continue to use one daily.
