NOW Supplements NOW Supplements Folic Acid

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

Based on 17 Researches

Vitamin B12 aids low back pain

We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.

By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.

Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.

Back feels great

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1 people found this helpful

Vitamin B is fantastic! My husband and I regularly consume it, and my back pain feels great!

Depression details

Vitamin B12 shows no benefit for depression

Based on 29 Researches

Alzahrani H. Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. Cureus. 2024;16:e73350. doi:10.7759/cureus.73350

We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.

After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.

This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.

Less severe illness

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88 people found this helpful

After using this vitamin for over a year, I've noticed a significant improvement in my quality of life. Not only do I feel healthier and get sick less often, but it has noticeably improved my mood. Given my family history of depression, I am very grateful for this change.

Liver Disease details

Folate treatment aids liver fat reduction

Based on 16 Researches

Huang C, Luo Y, Liu Y, Liu J, Chen Y, et al. DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner. J Nutr Biochem. 2025. doi:10.1016/j.jnutbio.2025.109870

We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.

By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.

When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.

Liver recovery noted

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1 people found this helpful

This works well for me. I suffered from liver problems, and it was determined that a folic acid deficiency had caused damage. After purchasing a liver cleanse along with this folic acid, my liver was completely healed and returned to normal after three months. My doctor was shocked and pleased. Good quality at a great price; I'm continuing to take them daily.

We explored the potential of folate as a diagnostic aid for brain tumors, specifically targeting gliomas—some of the most challenging brain cancers. A key part of our approach involved developing a micellar delivery system that could be given through the nose. This method is less invasive and may provide a more effective way to reach brain tumors.

In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.

Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.

The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.

Essential for development

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8 people found this helpful

The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.

Cold details

Folic acid improved anemia symptoms

Based on 3 Researches

Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. doi:10.7759/cureus.75257

We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.

Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.

This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.

Life-changing vitamin

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84 people found this helpful

I am so pleased to have found this vitamin. It has been a life-altering experience for my family and me. My mood has improved, my energy levels have increased, and my immunity against colds is far better. I highly recommend it!

Insomnia details

Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.

Based on 10 Researches

Vitamin B12 promotes sleep in rats

We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.

During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.

Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.

Relieved insomnia

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87 people found this helpful

I had suffered from insomnia for years, initially thinking it was stress-related due to my job. However, feeling exhausted with no improvement led me to suspect I needed proper rest.

Knee Pain details

Folate linked to reduced knee pain

Liu Z, Chen Z, Wu Z, Tang M, Lin Y, et al. Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:973. doi:10.1186/s12891-024-08095-5

We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.

Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.

Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.

Pain-free menstruation

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I have been taking folic acid for two months. The most significant effect for me was pain-free menstruation, which started five days earlier than expected. Along with this, there’s no fatigue or moodiness. Folic acid also positively influences emotional well-being and reduces PMS symptoms, and it has no side effects, apart from rare individual intolerance. I highly recommend this supplement; it’s beneficial for every woman.

Rash details

Methotrexate causes significant skin reactions

Zuber M, Chhabra M, Venkataraman R, Kumar S, Rashid M. Methotrexate related cutaneous adverse drug reactions: a systematic literature review. J Basic Clin Physiol Pharmacol. 2022;33:549. doi:10.1515/jbcpp-2021-0165

We reviewed numerous studies to understand the skin reactions stemming from Methotrexate (MTX). Our analysis included data from over 8,000 papers, ultimately focusing on 31 relevant studies involving 38 patients.

Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.

Reduced rashes

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27 people found this helpful

After a prolonged period of self-isolation and vaccination, I returned to my usual working rhythm and noticed my menstrual cycle had worsened. It decreased by 5 days, with prolonged PMS and pain across several cycles. I decided to take a course of folic acid, particularly this product as it was discounted and suited my dosage. In a month, my cycle returned to 28-29 days, I hardly feel PMS, and the pain has reduced to simple discomfort. I took it post-breakfast, occasionally missing doses when flying. Additionally, my skin condition improved with fewer rashes, and my immune system feels stronger! Highly recommend consulting your doctor prior to purchase.

Anxiety details

Folic acid alleviates postpartum anxiety

Based on 17 Researches

Zhang Q, Huang Q, Yao L, Liu W, Ruan J, et al. Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice. Front Pharmacol. 2021;12:701009. doi:10.3389/fphar.2021.701009

We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.

Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.

Life changer

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65 people found this helpful

This vitamin has transformed my life. I have experienced no mood swings, anxiety or stress since switching to this product. It's a fantastic supplement and I recommend it to anyone looking for something natural that truly works!

Frozen Shoulder details

This product has significantly helped me with managing the pain associated with my frozen shoulder.

Gout details

Botson JK, Tesser JRP, Bennett R, Kenney HM, Peloso PM, et al. A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study. Arthritis Res Ther. 2022;24:208. doi:10.1186/s13075-022-02865-z

Based on 5 Researches

Folate's impact on gout therapy

We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.

Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.

While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.

Pain relief

Most Useful Review

I ordered it for my mum. She seemed to have arthrosis, and another doctor suspected gout. This diagnosis followed a popular disease. They took it alongside calcium and magnesium from the same brand, as per the instructed scheme. The results were swift; the pain disappeared, redness and swelling subsided, and the bumps noticeably shrank. I'm ordering again and want to try it myself after reading such positive reviews. If you find my review helpful, please give it a rating. Thank you!

High Cholesterol details

Folic acid reduces cholesterol risk

Based on 2 Researches

Qi J, Wu H, Chen H, Han W. Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis. Sci Rep. 2024;14:19052. doi:10.1038/s41598-024-69728-2

We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.

Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.

Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.

Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.

Pregnancy success

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8 people found this helpful

Folic acid is crucial for women before, during, and after pregnancy and is often deficient. I chose this product due to its great price and ease of consumption. I became pregnant the month after starting it, continuing the supplement until after childbirth. Both my child and I are healthy. Folic acid is essential for those not pregnant as well, though it's important to manage dosage.

Hot Flashes details

Folic acid reduces menopausal hot flashes

Based on 5 Researches

Bani S, Hasanpour S, Farzad Rik L, Hasankhani H, Sharami SH. The effect of folic Acid on menopausal hot flashes: a randomized clinical trial. J Caring Sci. 2013;2:131. doi:10.5681/jcs.2013.016

We conducted a study with 70 menopausal women, randomly assigning them to receive either folic acid or a placebo for four weeks. Through questionnaires and hot flash diaries, we monitored changes in the severity, duration, and frequency of hot flashes.

Our findings revealed that folic acid treatment significantly reduced all three measures of hot flashes compared to the placebo, particularly in the later weeks of the treatment. This suggests that folic acid could be a valuable, low-risk option for managing menopausal hot flashes.

Eases hot flashes

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2 people found this helpful

Really works. It is very helpful for easing hot flashes of menopause and assists thyroid function. I previously used it for period pain, taking two pills at the onset, and within ten minutes the pain would diminish. If I didn't achieve complete relief, I would repeat the dose and, like magic, no more cramps. It also boosts energy for those with ME/CFS or constant tiredness. I appreciate that it contains B12 as well. A definite thumbs up from me. :)

Hypertension details

Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w

Based on 10 Researches

Folic acid effects on hypertension

We explored how low levels of folic acid (FA) and Vitamin B12 (VB12) relate to high blood pressure (BP) in children and adolescents. Conducting both nested case-control and cohort studies, we focused on primary school participants. In our research, we found that children with elevated BP exhibited lower levels of FA and VB12 compared to those with normal BP.

Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.

In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.

Lowers blood pressure

Most Useful Review

Folic acid, a synthetic form of folate, is crucial for the formation of new cells. Insufficient folic acid may heighten the risk of cardiovascular diseases, including hypertension. Research indicates that folic acid might assist in reducing high blood pressure by relaxing arterial walls, hence lowering pressure. The jar is also economically sized. I highly recommend this product.

Low Libido details

Great! My insomnia has vanished, my skin appears better, and my libido has increased. It also aids in regulating my menstrual cycle.

Migraine details

Folate intake reduces migraine frequency

Based on 16 Researches

Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. doi:10.3389/fnut.2024.1456502

We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.

Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.

The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.

Migraine relief

Most Useful Review

Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When I start feeling effects, I take my pills as usual, add magnesium, and my migraine eases gently, usually within a few hours. It used to incapacitate me for half a day. The frequency has also reduced, and I have medicinal support. Regular magnesium intake makes PMS and menstruation much easier. Chronic nasopharyngeal pain has barely worsened, though attributing this solely to magnesium is difficult, given my other supplements. If consuming magnesium, lecithin, and protein, the effect of collagen is really noticeable. I was pleasantly surprised by this. We had no issues with allergies, rashes, or stomach problems. The quality is excellent, and the ingredients are natural.

Cervical Cancer details

Cervical Cancer prevention

38 people found this helpful

Folks preparing for pregnancy, pregnant women, and breastfeeding mothers should focus on folic acid intake. Continuity after birth is vital, as folic acid is present in breast milk, thus benefiting the nursing child. Both partners should take folic acid when trying to conceive. The pill is small, easy to chew, and I consistently choose solan * folate for its excellent price. Despite a headache now, I plan to continue for 1-2 years, as folic acid is noted to lower the risk of female cervical cancer. Always check that the content is 800 mcg before purchasing. If this review is helpful, please indicate so!

Diabetes details

Folate's Role in Diabetes Management

Based on 9 Researches

Liang Y, Ding L, Tao M, Zhu Y. The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES. Ren Fail. 2024;46:2420830. doi:10.1080/0886022X.2024.2420830

We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.

Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.

Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.

Enhances alertness

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5 people found this helpful

The best around! Having PCOS, Type 2 diabetes, and cholesterol, I often experience brain fog. However, this folic acid has kept me alert for over a year. It's easy to swallow with breakfast and has no aftertaste, making it a daily essential.

Heart Disease details

Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761

Based on 19 Researches

Vitamin B12 helps heart recovery

We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.

7.5

Pregnancy support

Most Useful Review

Folic acid is excellent for restoring immunity and enhancing the heart's function and blood vessels. I use it as per my doctor's advice for pregnancy planning. A pack of 150 is reasonably priced, and NOW is a preferred brand. It’s a beneficial supplement for any woman.

Mild Cognitive Impairment details

Supports mental well-being

Adequate amounts of folic acid can significantly reduce the risk of developing Alzheimer's disease, dementia, and other cognitive disorders while also helping regulate blood sugar levels and minimising side effects from various medications.

Nausea details

Folic acid reduces nausea effectively

Based on 4 Researches

Bumrungpert A, Pavadhgul P, Piromsawasdi T, Mozafari MR. Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial. Nutrients. 2022;14. doi:10.3390/nu14030452

We explored the impact of folic acid combined with ferrous bisglycinate on nausea in pregnant women facing iron deficiency. In a controlled trial involving 120 participants, we discovered that the group taking ferrous bisglycinate with folinic acid reported significantly fewer instances of nausea and other discomforts compared to those receiving a standard iron supplement.

Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.

No nausea noted

Most Useful Review

2 people found this helpful

Excellent! I used to take cheap pharmacy foil, but now I exclusively take this one. It’s essential both for nerves and at a climax, as well as for the assimilation of vitamins B12 and iron. I drink one a day, and sometimes two. There is no nausea.

Rheumatoid Arthritis details

Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. doi:10.1016/j.bbrc.2024.149668

Vitamin B12 may treat arthritis

We explored the impact of vitamin B12 on rheumatoid arthritis, focusing on its ability to inhibit a specific enzyme known as PADI-4, which plays a key role in the disease's progression. Our findings suggest that vitamin B12 preferentially targets PADI-4 compared to another similar enzyme, PADI-2. This inhibition corresponds with a significant reduction in overall citrullination levels in cells, including histone H3 citrullination, which is relevant to the condition.

In our experiment, we utilized a specific model of arthritis in mice, known as collagen type II antibody-induced arthritis (CAIA). We administered hydroxocobalamin, a form of vitamin B12, and observed a marked improvement in the severity of arthritis symptoms in these mice. Moreover, the treatment led to a decrease in the expression of various inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL17A, TNFα, and IL-6, as well as PADI-4 itself.

These findings indicate that vitamin B12 might represent a promising avenue for treating rheumatoid arthritis and warrant further investigation.

High-quality supplement

Most Useful Review

Excellent! This is perfect for anyone with immune conditions. My mother has rheumatoid arthritis, and this supplement should not be split; its quality is outstanding.

Sleep Apnea details

Chrysostomou S, Frangopoulos F, Koutras Y, Andreou K, Socratous L, et al. The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study. PLoS One. 2022;17:e0265148. doi:10.1371/journal.pone.0265148

Based on 2 Researches

Folic acid linked to OSA severity

We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.

The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.

Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.

Life-changing vitamin

Most Useful Review

84 people found this helpful

After my doctor recommended this vitamin due to frequent illnesses, it has transformed my life. I rarely get sick now, require less sleep, and feel more energetic—waking up in the mornings is no longer a struggle!

Swollen Lymph Nodes details

I take this medication with my teenage daughter, and we are thrilled with the results! My critical days pass without noticeable swelling of the mammary glands, unlike before. It is easy to take, just one small tablet with breakfast, and we take it in a month-on, month-off cycle. Highly recommended!

Ulcer details

Li F, Huang F, Tang Y, Zhang F, Jiang H, et al. Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study. Br J Nutr. 2024;132:1348. doi:10.1017/S0007114524002368

Based on 8 Researches

Causal link: Folic acid and ulcers

Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.

The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.

Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.

Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.

Rapid healing effect

Most Useful Review

I took this to heal ulcers in my stomach, and the effect has been excellent. I've noticed that my hair and nails have also started to grow significantly faster.

Arthritis details

Folic acid lowers inflammatory pain

Based on 15 Researches

Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. doi:10.1016/j.neuropharm.2025.110352

We investigated the effects of folic acid on chronic inflammatory pain, especially in the context of arthritis. Adult rats were used in our study, and we induced inflammatory pain by injecting a substance called complete Freund's adjuvant (CFA) into their hind paws. Through behavioral tests, we assessed pain responses by measuring how long it took for the rats to withdraw their paws from painful stimuli.

Our findings showed that the CFA injections not only caused significant pain but also increased the expression of Matrix metalloproteinase 2 (MMP2), a protein associated with inflammation. Notably, MMP2 was primarily found in nerve cells rather than glial cells, indicating its crucial role in the pain pathway.

In an exciting twist, we discovered that long-term treatment with folic acid managed to reduce the overexpression of MMP2. This led to lasting relief from chronic inflammatory pain for the rats and also alleviated pain-related anxiety. These results suggest that folic acid could be a promising therapeutic option for managing chronic inflammatory pain and anxiety in arthritis patients, allowing for better pain management in the long term.

Excellent quality

Most Useful Review

Excellent! This supplement is ideal for anyone with immune diseases. My mother suffers from rheumatoid arthritis, and it’s of high quality. It should not be cut.

Breast Cancer details

Folic acid's potential in treatment

Based on 19 Researches

Boopathi TS, Rajiv A, Patel TSGM, Bareja L, Salmen SH, et al. Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity. Bioprocess Biosyst Eng. 2025;48:121. doi:10.1007/s00449-024-03097-y

We explored the potential of a unique nanocomposite made from cerium oxide nanoparticles, folic acid, and carboxymethyl cellulose to combat breast cancer and drug-resistant bacterial infections. Using a green synthesis approach with Moringa oleifera, this study highlights how bimolecular combinations, especially those involving folate, might improve therapeutic effectiveness.

Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.

It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.

7.5

Cancer protection

Most Useful Review

It's important to consume folic acid not just before and during pregnancy, as it may protect against various cancers, including breast cancer.

Kidney Stones details

I certainly prefer iHerb over the pharmacy. Several times I experienced kidney pain from the pharmacy products, but after nearly a month on iHerb, I haven't encountered any side effects. Everything suits me well.

Menopause details

Folic acid reduces menopausal hot flashes

Bani S, Hasanpour S, Farzad Rik L, Hasankhani H, Sharami SH. The effect of folic Acid on menopausal hot flashes: a randomized clinical trial. J Caring Sci. 2013;2:131. doi:10.5681/jcs.2013.016

We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.

Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.

Reliable menopause aid

Most Useful Review

I've repeatedly ordered this brand due to its excellent quality and tested ingredients over the years. It serves as a vital aid for women during menopause—an indispensable supplement. I plan to keep buying this product as I've consistently observed improvements in my health at any age. The large packaging lasts long, which is a bonus.

Premenstrual Syndrome details

Significant cycle improvement

27 people found this helpful

Honest review from a flight attendant! After a long self-isolation and a forced vaccination, I noticed that my female cycle had worsened: it decreased by 5 days, and I experienced premenstrual syndrome for a week, along with added pain (observations over 5-6 cycles). I decided to take folic acid, as it was on discount and the dosage suited me. After a month, my cycle returned to 28-29 days, I hardly feel PMS, and the pain has diminished to a level of simple discomfort. I took it after breakfast, sometimes missing a day or two when travelling. I also consumed vitamin C and zinc. My skin improved with fewer rashes, and my immune system is functioning well! Highly recommend! Consult your doctor beforehand.

Stroke details

Vitamin B12 alleviates stroke effects

Based on 28 Researches

Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480

We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.

Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.

Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.

7.5

Beautiful skin

Most Useful Review

1 people found this helpful

Folic Acid is crucial. I take 6 pills twice a day, and it enhances my skin's appearance almost immediately. It also serves to prevent strokes. NOW usually offers excellent products.

Alzheimer details

Folate may protect against Alzheimer’s

Based on 19 Researches

Ye M, Yang X, Yan J, Yao Y, Lv H, et al. Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2025;170:106068. doi:10.1016/j.neubiorev.2025.106068

We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.

Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.

However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.

Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.

7.5

Menopause relief

Most Useful Review

After forty, women require folic acid to alleviate menopause symptoms. A sufficient intake will help preserve memory long-term and reduce the risk of Alzheimer's disease.

Autism details

Erden S, Akbaş İleri B, Sadıç Çelikkol Ç, Nalbant K, Kılınç İ, et al. Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism. Int J Psychiatry Clin Pract. 2022;26:8. doi:10.1080/13651501.2021.1906906

Based on 7 Researches

Examining Vitamin B12 in Autism

We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.

Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.

Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.

Supports autism survival

Most Useful Review

1 people found this helpful

Stunning! Highly recommended! Folic acid is crucial from the B vitamin family for DNA synthesis and genetic repair, essential for rapidly dividing cells like red blood cells. It's also needed for synthesising methionine from homocysteine and contributes to the healthy functioning of the cardiovascular and nervous systems. The package arrived quickly, and the tiny balls are easy to swallow! I recall a study indicating that there is an 80% chance of surviving autism in children if folic acid is consumed during pregnancy! Just a wonderful supplement.

Cardiovascular Disease details

Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159

Folate levels affect stroke risk

We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.

Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.

7.5

Supports healthy cell development

Most Useful Review

1 people found this helpful

NOW Foods Folic Acid is a quality product ideal for health maintenance. It is beneficial for all ages, particularly women planning to conceive. The large package of 250 tablets allows for long-term use. The high bioavailability of folic acid is essential for maintaining healthy homocysteine levels and cell development. Regular use visibly improves the nervous system and cardiovascular health. The neutral taste makes it easy to take.

Flu details

Enhances overall health

Excellent folic acid for maintaining health! Now Foods' folic acid supports the nervous system, improves metabolism, and enhances overall well-being. The product quality is exceptional, featuring an effective formula that's well absorbed by the body. The pure ingredients are devoid of unwanted impurities, and the small tablet size makes them easy to consume. You feel a pleasant energy surge and improved well-being. The niacin influx aids blood circulation, making this supplement quite potent. With 250 tablets in convenient packaging, this product is highly recommendable!

Heartburn details

Long-term PPI effects analyzed

Chourasia D, Misra A, Pandey R, Ghoshal UC. Gastric atrophy and intestinal metaplasia in a patient on long-term proton pump inhibitor therapy. Trop Gastroenterol. 2008;29:172.

We explored the case of a 74-year-old man who had been taking proton pump inhibitors for 20 years to manage symptoms of gastroesophageal reflux disease. Despite stopping his acid-reducing medications for a month, he showed an unusually high gastric pH level, indicating a significant decrease in stomach acidity. This condition may have led to gastric atrophy and intestinal metaplasia, as revealed through multiple biopsies of his stomach lining. Interestingly, after halting all anti-secretory drugs and starting only prokinetic treatment, the patient reported a significant improvement in heartburn symptoms.

During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.

No heartburn noted

Most Useful Review

Folic acid was prescribed by my gynaecologist, and I took 1 piece with my spouse three months prior to our planned pregnancy. During the first trimester, I continued taking it as it comes in a convenient size, has no flavour, and does not cause heartburn. From the second trimester onwards, I switched to a vitamin complex for pregnant women. I was pleased with the results.

Anemia details

Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620

Based on 30 Researches

Vitamin B12's role in anemia

We explored the intriguing link between vitamin B12 deficiency and anemia, particularly through a rare condition known as pseudo-thrombotic microangiopathy. This condition mimics other thrombotic microangiopathies and could lead to unnecessary treatments such as plasmapheresis.

Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.

While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.

Reduced anemia symptoms

Most Useful Review

10 people found this helpful

Folic acid is touted as beneficial for pregnant women, and I found it cheaper to buy here. Having suffered from iron deficiency for decades, taking this alongside iron finally eliminated my anemia. I wish I had discovered it sooner; its effects are remarkable for both physical and mental health!

Chronic Fatigue Syndrome details

Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.

Folinic acid may aid CFS

We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.

7.5

Increased energy levels

Most Useful Review

2 people found this helpful

Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!

Hair Loss details

Bouvet A, Baird JD, Basrur PK. Folic acid therapy for alopecia in a Charolais calf. Vet Rec. 1988;123:533.

Based on 4 Researches

Folic acid treatment shows promise

We explored the effects of folic acid on hair loss in a three-week-old Charolais calf showing signs typical of folic acid deficiency. After starting daily folic acid therapy at a dose of 1 mg/kg, we observed that the crusts and patches diminished within two weeks. Remarkably, hair growth resumed, and within two months, the calf returned to a normal state. This indicates that folic acid could be an effective treatment for certain types of alopecia related to deficiencies in this essential nutrient.

Mood improved

Most Useful Review

20 people found this helpful

After two months on these supplements, my hair loss stopped within the first month. My overall health improved, especially my mood and sleep quality. I also noticed an enhancement in my skin condition, although that may relate more to my skincare routine.

Leg Cramps details

I regularly experienced cramps in my calf muscles, especially at night or during physical exertion. After starting this folic acid, I forgot about the convulsions within a week. It is perfectly absorbed with no side effects. Highly recommend! The product is excellent!

Weight Loss details

My experience with folic acid has been remarkable. It restored my cycle, enhanced my skin colour, and even improved my libido. I noticed a clear improvement in skin tone and texture after taking it. Most importantly, my persistent fatigue and drowsiness have diminished significantly, aiding in my weight loss journey.

Autoimmune Disorder details

Folic acid improves rheumatoid arthritis treatment

Based on 22 Researches

Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. doi:10.1186/s12951-025-03096-5

We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.

Essential for pregnancies

Most Useful Review

257 people found this helpful

I absolutely adore this folate! I only need to take one small yellow tablet daily with food, which is far more convenient than the three doses required by other brands. It's essential for women who are pregnant or planning to be. It significantly contributes to the developing baby's neural tubes. I also share this with my pregnant friend, and let's just say 250 tablets will last us quite a while during our planning! Please support my review with a thumbs up!

Constipation details

Folate's role in constipation explored

García-Milla P, Peñalver R, Nieto G. Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13060683

We formulated a functional food product designed specifically for elderly individuals with Parkinson's disease, focusing on the common issue of constipation. Our approach involved creating a muffin recipe enriched with inulin, cacao, and Moringa, all of which play a role in supporting digestive health.

In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.

While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.

Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.

Improved microflora

Most Useful Review

The best probiotic I've ordered multiple times; the whole family takes it. It restores intestinal microflora effectively and helps with constipation. The capsules are small and easy to swallow. I keep them in the refrigerator.

Psoriasis details

Vitamin B shows promise for psoriasis

Based on 12 Researches

Del Duca E, Farnetani F, De Carvalho N, Bottoni U, Pellacani G, et al. Superiority of a vitamin B-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis. Int J Immunopathol Pharmacol. 2017;30:439. doi:10.1177/0394632017736674

We conducted a study to examine the effectiveness of a vitamin B-containing ointment in treating mild-to-moderate plaque psoriasis compared to a standard glycerol-petrolatum-based emollient cream. The trial was designed thoughtfully, with 24 patients participating in a randomized, controlled, single-blind format. Each patient received the vitamin B ointment on one side of their body and the standard cream on the other side.

Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.

This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.

7.5

Boosts energy levels

Most Useful Review

I used this folic acid as part of a psoriasis treatment programme. It’s well-formulated, as folic acid is the inactive form of vitamin B9. "Inactive" means it’s not instantly absorbed but converted within the body to its active form. If your digestion is good, this supplement should work for you, and it’s very affordable. The dosage and size of the capsules are excellent. Taking B vitamins in the morning gives me a surge of energy.

Bloating details

Folate shows limited impact

Hanevik K, Mørch K, Eide GE, Langeland N, Hausken T. Effects of albendazole/metronidazole or tetracycline/folate treatments on persisting symptoms after Giardia infection: a randomized open clinical trial. Scand J Infect Dis. 2008;40:517. doi:10.1080/00365540701827481

We aimed to understand how treatments with folate in combination with tetracycline affect bloating in patients recovering from giardiasis. In a well-structured clinical trial, two groups received different treatments: one group was given a combination of albendazole and metronidazole for a week, while the other received tetracycline alongside folic acid for four weeks. The key focus was on symptom improvement, particularly bloating.

Both treatment groups noticed some reduction in overall symptoms by the end of the treatment period, with the tetracycline and folate group showing a more significant improvement. Notably, patients in both groups experienced a decrease in bloating, which is a common and uncomfortable symptom in gastrointestinal issues.

However, a month after the treatments, the number of patients reporting ongoing improvements was quite low. Additionally, symptoms, including bloating, returned over time, and by the end of the year, there was no lasting change in overall symptom scores for either group. This suggests that while folate and other treatments may provide short-term relief, they do not lead to long-standing benefits in managing persistent bloating following a Giardia infection. Ultimately, the reasons for ongoing bloating and discomfort remain unclear and deserve further investigation.

Less bloating observed

Most Useful Review

1 people found this helpful

Great product, highly recommend. I've started taking this to improve my overall health and I think it's excellent. I've noticed my stomach is much less bloated. My menstrual cycle has improved and actually become longer, with fewer cramps during my period. It's great value for money.

Polycystic Ovary Syndrome details

5 people found this helpful

This is the best! I have PCOS, Type 2 Diabetes, and Cholesterol, which makes me prone to brain fog. This folic acid has enabled me to remain alert and focused throughout the day for over a year. I take it daily with breakfast; the pills are small and easy to swallow, with no aftertaste.

Bone Pain details

Gu YJ, Qian HY, Zhou F, Zhang L, Chen L, et al. Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats. Brain Res. 2023;1811:148405. doi:10.1016/j.brainres.2023.148405

Based on 3 Researches

Folic acid alleviates bone pain

We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.

Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.

This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.

Menstrual relief

Most Useful Review

16 people found this helpful

This folic acid helped me regulate a cycle plagued by 2-3 month delays. Just two weeks into taking it, my cycle resumed normally, which astonished me! I had tried various remedies before with minimal success. Although hormones could regulate it, I preferred not to take them. Consuming one tablet daily as instructed worked wonders. I recommend this to all women! It alleviates pain and normalises the female system perfectly.

Dizziness details

Folate alleviates dizziness symptoms

Based on 14 Researches

Trachtman JN, Pagano V. Antifolates and MTHFR. Ther Drug Monit. 2015;37:697. doi:10.1097/FTD.0000000000000215

We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.

After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.

Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.

Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.

Forget dizziness

Most Useful Review

I've been taking this regularly on my doctor's recommendation. Before, I experienced frequent dizziness due to a lack of B12, but now I've forgotten what that feels like. Folic acid is essential for women's health.

Headache details

Higher folate intake reduces headaches

Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. doi:10.1017/S000711452300137X

This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.

Noticed improvements

Most Useful Review

The capsule quality is commendable and while I felt persistent headaches and fatigue beforehand, now that I've been taking this for 10 days, I have more energy and no headaches. It’s an excellent supplement for everyone, especially athletes.

Heart Attack details

Qipshidze N, Tyagi N, Sen U, Givvimani S, Metreveli N, et al. Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;299:H1484. doi:10.1152/ajpheart.00577.2010

Based on 21 Researches

Folic acid improves heart function

We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.

However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.

Reduces palpitations

Most Useful Review

1 people found this helpful

It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.

Blood Clot details

Cerebral venous sinus thrombosis case

Based on 18 Researches

Zhang Y, Ye H, Chen D, Yan G, Li Z, et al. Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report. AJOG Glob Rep. 2025;5:100446. doi:10.1016/j.xagr.2025.100446

We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.

Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.

Maintained red blood cells

Most Useful Review

6 people found this helpful

I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.

Diarrhea details

Adil N, Mehraj A, Khan J, Bhutta S, Jamil M, et al. CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY. J Ayub Med Coll Abbottabad. 2024;36:155. doi:10.55519/JAMC-01-13026

Based on 4 Researches

Vitamin B12 aids chronic diarrhea

We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.

Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.

These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.

Caused diarrhea

Most Useful Review

Unfortunately, these tiny balls caused me stomach aches and diarrhoea, possibly due to the dosage. I suggest trying a dose of 400 mcg. Ultimately, I stopped using them.

Acne details