Ginkgo
9.5
Reduced anxiety
Most Useful Review
Amazing! I have been taking ginkgo for a few months, feeling more energetic and less tired. It seems to help with PMS symptoms, headaches, and even contains powerful antioxidants. I take it in the morning with a meal, and at night with ashwagandha, which calms me and reduces anxiety. I highly recommend it.
9.5
Miraculous effect
Most Useful Review
Along with "Gotu Kola," my experience has been fabulous! I'm 35 with a weight problem and noticed memory issues. After a month of Ginkgo Biloba and Gotu Kola, my capillaries improved and my memory significantly sharpened. It also helped my brother with anxiety and depression. We feel it's a miracle! Start slowly and consult a doctor if necessary.
9
Supports stress resilience
Most Useful Review
To manage prolonged stress, adaptogens are essential. The adrenal glands produce hormones like cortisol and adrenaline to combat stress, but constant tension leaves us unwell. Adaptogens help the body endure stress without severe side effects, unlike synthetic drugs. After losing my husband, this combination of adaptogens truly assisted me in coping.
9.5
Reduces anxiety
Most Useful Review
The scent of peppermint oil soothes and alleviates stress, with a calming effect that helps to ease feelings of anxiety. I truly adore it and wholeheartedly recommend it!
Vitamin B Complex
9.5
Effective for anxiety
Most Useful Review
100% Effective! This is the first supplement I've tried that truly worked. My eye twitching, off-season stress, and internal anxiety have all improved. I'll be purchasing this regularly.
9.5
Effective for anxiety
Most Useful Review
Working complex of B vitamins! It’s gluten-free, non-GMO, and vegan. The complex is hypoallergenic and does not cause abdominal discomfort. It effectively suppresses anxiety and restlessness and works better than Combilipen. Moreover, B vitamins positively impact hair health and help normalise sleep. In summary, Solgar's B-Complex is effective and safe, deserving top marks and recommendations!
Multivitamins
8.8
Positive anxiety relief
Most Useful Review
For a long time, I researched various vitamin B complex brands before choosing this one, and I have no regrets. These vitamins positively affect the nervous system, improving sleep, reducing anxiety, and helping to combat stress. They work best in combination as they enhance each other's effects. The dosages are high for quick replenishment, and the bright yellow urine is a normal bodily reaction. My whole family takes them, and we are very satisfied with the results. I highly recommend them.
8.8
Helps reduce anxiety
Most Useful Review
This vitamin complex positively impacts all body systems, particularly the nervous system. It helps combat stress, alleviates tension, headaches, and anxiety, while improving attention and sleep. The dosages are well-balanced for enhanced effectiveness. I highly recommend it.
Polygonum Cuspidatum Complex
9.5
Reduces anxiety
Most Useful Review
Excellent! It increases sirtuin levels, which helps to lower neurotoxicity. My mood has improved and anxiety is reduced. I'm very satisfied!
9.5
Mitigates anxiety
Most Useful Review
I appreciate that this brand crosses the blood-brain barrier. Resveratrol aids in managing my brain injury, anxiety, and depression, while boosting my energy and overall well-being.
Vitamin Bs
8
Niacin helps reduce anxiety symptoms
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment.
Most Relevant Research
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
8.8
Normalised blood pressure
Most Useful Review
Magnesium B6 was prescribed by a neurologist for my mother to combat stress. After just two months, she became calm, positive, and the pressure stabilised. This supplement helped eliminate anxiety and insomnia, normalising her condition without needing additional medications. Cardiologists suggest a daily intake of 400-600 mg of magnesium, which I found beneficial for managing hypertension.
Hypericum Perforatum
8
Hypericum perforatum alleviates post-MI anxiety
Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats.
Most Relevant Research
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
9.5
No more anxiety
Most Useful Review
I have a family history of depression and noticed signs in myself at 35. Prescription medications didn't work and caused anxiety. I tried St. John's Wort, discarding my prescriptions. After 15 years, I’m depression-free and quite mellow without anxiety attacks from ineffective drugs. I take two in the morning and one at noon, satisfied with Now Foods' quality and price.
9
DHA reduces anxiety risk
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
Most Relevant Research
We explored the potential benefits of docosahexaenoic acid (DHA) in reducing anxiety among middle-aged and elderly adults. This was part of a larger study involving over 102,000 participants, where we assessed the impact of various polyunsaturated fatty acids (PUFAs) on mental health conditions, including anxiety and depression.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
9.5
Reduced anxiety levels
Most Useful Review
Our family adores this tea! The Tulsi Ashwagandha has a lovely aroma. After using it in courses, I noticed a significant reduction in anxiety, allowing me to handle stress much more calmly. My libido has also improved; Ashwagandha works wonders for it.
Vitamin D3
4
Vitamin D3 and adolescent anxiety response
Exploring the Influence of / Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines.
Most Relevant Research
We aimed to understand how vitamin D3 might influence anxiety and depressive symptoms among adolescents in central Italy. Our study examined the relationship between specific genetic variants of the vitamin D receptor (VDR) and anxious or depressive traits in young individuals. Despite our thorough approach, we found no significant difference in the genetic makeup of those experiencing symptoms and those who did not.
Our investigation involved HN9.10e cell lines representing different genetic variations, which showed varied responses to vitamin D3 treatment. Notably, certain cell lines with the AA genotype responded positively to vitamin D3, while others did not show any response at all. Interestingly, this suggests that the effectiveness of vitamin D3 in treating potential mental health issues may depend on the specific genetic variants present in individuals.
Ultimately, while the study explored important genetic influences, we did not find strong evidence that vitamin D3 treatment has a meaningful effect on anxiety symptoms in the adolescent population we studied. This highlights the complexity of mental health treatments and the need for further research to better understand these interactions.
Our investigation involved HN9.10e cell lines representing different genetic variations, which showed varied responses to vitamin D3 treatment. Notably, certain cell lines with the AA genotype responded positively to vitamin D3, while others did not show any response at all. Interestingly, this suggests that the effectiveness of vitamin D3 in treating potential mental health issues may depend on the specific genetic variants present in individuals.
Ultimately, while the study explored important genetic influences, we did not find strong evidence that vitamin D3 treatment has a meaningful effect on anxiety symptoms in the adolescent population we studied. This highlights the complexity of mental health treatments and the need for further research to better understand these interactions.
9.5
Reduced anxiety
Most Useful Review
I have been taking this vitamin for over a month now, and I have noticed significant improvements in my quality of life. I used to frequently suffer from anxiety and depression, but since using this supplement, those symptoms have vanished.
Potassium
8.8
Reduced anxiety
Most Useful Review
Excellent for water retention. It balances my electrolytes and helps with anxiety, improving my sleep.
9.5
Soothing sleep
Most Useful Review
I take it with magnesium before bed. For those with heightened anxiety, I recommend this combination for restful sleep.
Zinc
7
Zinc alleviates acrylamide-induced anxiety
Zinc Ameliorates Acrylamide-Induced Cognitive Impairment in Male Wistar Rats: Modulation of Oxidative Stress, Neuro-inflammation, and Neurotrophic Pathways.
Most Relevant Research
We explored the effects of zinc treatment on anxiety caused by exposure to acrylamide, a harmful chemical found in some foods that can lead to cognitive decline and emotional distress. In our study, twenty male Wistar rats were divided into four groups; one group received water, while the other groups were given a daily oral dose of acrylamide.
Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.
Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.
Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
9.5
Reduced anxiety
Most Useful Review
This vitamin has significantly helped me with my anxiety and depression over the past year. Taking it consistently has made a considerable difference. I highly recommend this vitamin to anyone struggling with mental health or not feeling their best.
L Lysine
8
L-lysine shows anxiety-reducing effects
Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study.
Most Relevant Research
We explored how L-lysine, an essential amino acid, impacts anxiety and body weight management in rats. During our study, we treated the animals with doses of L-lysine for 20 days and then assessed their behavior. Interestingly, we noted that L-lysine had a significant anxiolytic effect, meaning it helped reduce anxiety-like behaviors in the rats.
While the treatment did not impact their food intake, we observed a reduction in body weight. Measurements showed that after repeated L-lysine treatment, levels of serotonin in key brain areas increased, which is often associated with improved mood and reduced anxiety. We also found that a metabolite of serotonin decreased, suggesting that L-lysine might help in preventing the breakdown of serotonin, thus supporting its uplifting effects on mood.
The in-silico analysis reinforced our findings, indicating that L-lysine has a strong connection with monoamine oxidases—enzymes involved in serotonin degradation. These insights suggest that L-lysine may inhibit the breakdown of serotonin, contributing to its calming effects. Overall, our study indicates that L-lysine holds promise as a natural anxiolytic agent and might aid in body weight reduction through its influence on serotonin levels.
While the treatment did not impact their food intake, we observed a reduction in body weight. Measurements showed that after repeated L-lysine treatment, levels of serotonin in key brain areas increased, which is often associated with improved mood and reduced anxiety. We also found that a metabolite of serotonin decreased, suggesting that L-lysine might help in preventing the breakdown of serotonin, thus supporting its uplifting effects on mood.
The in-silico analysis reinforced our findings, indicating that L-lysine has a strong connection with monoamine oxidases—enzymes involved in serotonin degradation. These insights suggest that L-lysine may inhibit the breakdown of serotonin, contributing to its calming effects. Overall, our study indicates that L-lysine holds promise as a natural anxiolytic agent and might aid in body weight reduction through its influence on serotonin levels.
8.8
Decreases anxiety
Most Useful Review
I take 1 tablet three times a day for three months; during herpes flare-ups, I take 2-3 capsules at once. L-lysine is essential for collagen production and effectively inhibits the herpes virus, while also reducing anxiety and cortisol levels.
Evening Primrose
9.5
Hormonal balance
Most Useful Review
I discovered Evening Primrose Oil through a TikTok video. I have a hormone imbalance and was advised to take birth control, but after experiencing side effects previously, I opted for EPO instead. After three months, my periods have become regular, with significantly reduced pain and anxiety.
9.5
PMS relief
Most Useful Review
I had the worst PMS symptoms but wanted to avoid chemical options. After taking two pills a day, my crippling colic reduced from two weeks to just a couple of days. Symptoms like irritability, depression, anxiety, and lower back pain improved significantly. I highly recommend it.
Fish Oil
9
DHA reduces anxiety risk
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
Most Relevant Research
We explored the potential benefits of docosahexaenoic acid (DHA) in reducing anxiety among middle-aged and elderly adults. This was part of a larger study involving over 102,000 participants, where we assessed the impact of various polyunsaturated fatty acids (PUFAs) on mental health conditions, including anxiety and depression.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
9.5
Relief from anxiety
Most Useful Review
Прекрасно! When I began taking this vitamin, I experienced a sensation of relief as my stress and anxiety seemed to fade. It helps me feel more grounded and calm. I cannot imagine living without this vitamin.
Probiotics
5
Probiotic effects on anxiety limited
Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial.
Most Relevant Research
We conducted a clinical trial aimed at understanding the effect of caloric restriction combined with probiotic supplementation on various health factors, including anxiety, in obese men.
After 12 weeks, while the probiotic had no additional benefit on body composition or overall quality of life, we noted improvements in anxiety and depressive symptoms among those who received the probiotics.
However, there were no significant differences between the groups overall, suggesting that more research is necessary to fully understand this relationship.
After 12 weeks, while the probiotic had no additional benefit on body composition or overall quality of life, we noted improvements in anxiety and depressive symptoms among those who received the probiotics.
However, there were no significant differences between the groups overall, suggesting that more research is necessary to fully understand this relationship.
9.5
Improved mood
Most Useful Review
Excellent! I suffered from mild depression and anxiety for a long time but struggled to find the right antidepressants until I started taking this. Initially, I wanted it for an energy and immunity boost, but now on my third bottle, my mood has significantly improved!
Tumeric
8
Curcumin shows potential for anxiety relief
Decreased Systemic Monocyte Colony Protein-1 (MCP-1) Levels and Reduced sCD14 Levels in Curcumin-Treated Patients with Moderate Anxiety: A Pilot Study.
Most Relevant Research
We evaluated whether curcumin, a compound found in turmeric, can help reduce anxiety and improve immune system responses. In this study, 81 individuals were divided into two groups: a control group without anxiety and a group experiencing moderate anxiety. The anxious participants took curcumin supplements for 15 days, receiving 1800 mg per day.
Our findings showed that those with anxiety had elevated levels of certain inflammatory markers and cortisol, a stress hormone. After curcumin treatment, the levels of these markers, particularly MCP-1 and sCD14, decreased significantly. This was promising, as it suggests that curcumin not only helps lower anxiety symptoms but also reduces inflammation and oxidative stress in the body.
Overall, we observed that curcumin may have protective effects against anxiety by balancing various bodily responses. However, it's important to note that while the results are encouraging, more extensive studies are needed to fully understand how curcumin impacts anxiety and inflammation.
Our findings showed that those with anxiety had elevated levels of certain inflammatory markers and cortisol, a stress hormone. After curcumin treatment, the levels of these markers, particularly MCP-1 and sCD14, decreased significantly. This was promising, as it suggests that curcumin not only helps lower anxiety symptoms but also reduces inflammation and oxidative stress in the body.
Overall, we observed that curcumin may have protective effects against anxiety by balancing various bodily responses. However, it's important to note that while the results are encouraging, more extensive studies are needed to fully understand how curcumin impacts anxiety and inflammation.
9.5
Reduces anxiety effectively
Most Useful Review
If you suffer from inflammation or pain, this supplement is essential. Curcumin, shown to be as effective as ibuprofen, is a key addition for my joint pain and headaches. It may also alleviate anxiety if linked to inflammation. I double my dose when feeling unwell, and it noticeably speeds up recovery from infections.
Taurine
8
Taurine reduces anxiety in mice
Long-term taurine supplementation regulates brain mitochondrial dynamics in mice.
Most Relevant Research
We looked into how taurine, a common amino acid found in the brain, affects anxiety levels. Young mice were given different concentrations of taurine (0.25%, 0.5%, and 1%) in their drinking water for six months to see its potential benefits on memory, cognition, and mood.
Throughout the study, we observed that taurine had a significant effect on improving memory performance and reducing signs of anxiety and depression-like behavior in the mice. In addition to these behavioral changes, taurine also appeared to enhance mitochondrial function, which plays a crucial role in energy and cell health within the brain.
Interestingly, we found no significant difference in anxiety reduction between the various doses of taurine. This suggests that even lower amounts of taurine may be effective. Overall, our findings point towards taurine's potential as a therapeutic option for addressing anxiety and related neurological issues, although further research in humans is necessary to confirm these results.
Throughout the study, we observed that taurine had a significant effect on improving memory performance and reducing signs of anxiety and depression-like behavior in the mice. In addition to these behavioral changes, taurine also appeared to enhance mitochondrial function, which plays a crucial role in energy and cell health within the brain.
Interestingly, we found no significant difference in anxiety reduction between the various doses of taurine. This suggests that even lower amounts of taurine may be effective. Overall, our findings point towards taurine's potential as a therapeutic option for addressing anxiety and related neurological issues, although further research in humans is necessary to confirm these results.
9.5
Anxiety relief
Most Useful Review
Taking this every night helps me manage my anxious feelings and nervous stomach. It works quickly, and I often combine it with magnesium malate, resulting in a calm state. The powder mixes easily with water and has no taste. I will definitely purchase it again as it is effective for me.
Coenzyme Q10
7
Q10 and ultrasound improve anxiety
Low-intensity pulsed ultrasound enhances delivery of 30 nm Q10 for improving mental and memory disorder in APP/PS1 mice.
Most Relevant Research
We explored the potential of coenzyme Q10 (Q10) in alleviating anxiety and depression in a mouse model of Alzheimer's disease. The study involved APPswe/PS1dE9 mice that received either Q10 or a combination of Q10 and low-intensity pulsed ultrasound (LIPUS). The latter approach aimed to enhance the delivery of Q10 through the blood-brain barrier, which is crucial since many treatments struggle to reach the brain effectively.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
10
Increased energy
Most Useful Review
Energy charge! I bought this dietary supplement to enhance my performance, especially after covid. On the third week, I felt more energetic, waking up easily with one alarm. My productivity improved, and I felt less fatigued. My anxiety diminished and my mood stabilised. My light tachycardia is gone, and my recovery from gym sessions has improved. Q10 is essential for everyone, as its production decreases with age—suggesting it should be supplemented. I hope this review helps!
Omega 3
7
Eicosapentaenoic Acid Reduces Anxiety
The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety-Like Behavior and Hippocampal Transcriptomic Responses in Male Rats.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA) on anxiety-like behavior in rats exposed to prolonged chronic unpredictable stress (PCUS). Through a 12-week experiment, we assessed how this treatment, along with fluoxetine and lipopolysaccharide, influenced both behavior and gene expression in their brains. The study found that PCUS led to signs of anxiety in the rats, but chronic treatment with EPA significantly corrected these behaviors.
However, while we noted changes in the rats' anxiety responses with EPA, the overall impact on brain gene expression wasn't markedly affected by the treatments. Some specific genes did show changes in expression when treated with fluoxetine, EPA, or their combination, hinting these could be targets for further investigation in stress-related conditions.
In summary, while EPA appears beneficial in reducing anxiety-like behavior, the complexities of its interactions with other treatments require more exploration to fully understand its role in managing anxiety. This study emphasizes the potential for EPA as a therapeutic option, while also inviting further research on its individual and combined effects with other treatments.
However, while we noted changes in the rats' anxiety responses with EPA, the overall impact on brain gene expression wasn't markedly affected by the treatments. Some specific genes did show changes in expression when treated with fluoxetine, EPA, or their combination, hinting these could be targets for further investigation in stress-related conditions.
In summary, while EPA appears beneficial in reducing anxiety-like behavior, the complexities of its interactions with other treatments require more exploration to fully understand its role in managing anxiety. This study emphasizes the potential for EPA as a therapeutic option, while also inviting further research on its individual and combined effects with other treatments.
8.8
Reduces anxiety effectively
Most Useful Review
Excellent Omega. This is one of my favourites. Omega-3 supplementation has helped me with my anxiety and overall well-being. I find it easier to obtain essential fatty acids through supplements rather than consuming fatty fish regularly. I take 1-2 capsules daily with breakfast, and I believe Omega-3 is essential for my health. It supports blood vessel health and overall cardiovascular system functionality, making it good value for money.
Vitamin D
8
High-dose vitamin D reduces anxiety
Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
Most Relevant Research
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
8.3
Anxiety disappears
Most Useful Review
This complex restores tooth enamel, strengthens nails, and significantly alleviates anxiety while improving sleep and mood. The dosage is convenient!
Magnesium
7
Magnesium's transient anxiety relief
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.
Most Relevant Research
In our quest to understand how magnesium influences anxiety, we conducted a randomized double-blind controlled trial involving 120 adults diagnosed with major depressive disorder (MDD). Participants took either a combination of probiotics, magnesium orotate, and coenzyme Q10 or a placebo for eight weeks.
At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.
Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.
At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.
Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.
9.5
Calm and balanced
Most Useful Review
I used to experience signs of magnesium deficiency, such as muscle cramps, poor sleep, and anxiety. After consistently taking magnesium for two years, I transformed from a constantly tired and anxious individual into a calm, balanced person. Magnesium has significantly improved my quality of life. I recommend aiming for a daily intake of 300-350 mg, as dietary sources alone are often insufficient.
Calcium
8
Calcium blockers reduce cocaine withdrawal anxiety
L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats.
Most Relevant Research
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
9.5
Reduced anxiety
Most Useful Review
This magnesium has helped alleviate my irritability and anxiety significantly. I've noticed improved productivity and quicker sleep onset, without daytime drowsiness. I combined it with vitamin D and omega 3, and I've seen positive effects on my nails and hair. I take three times a day, starting with lunch. Dosage can vary per person.
Iron
7
Iron boosts mental health in pregnancy
Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study.
Most Relevant Research
We examined how changes in iron levels during pregnancy relate to anxiety and overall wellbeing. The study followed pregnant women in Cape Coast, Ghana, tracking their iron status and psychological health throughout the first, second, and third trimesters.
Our findings indicate that improvements in iron levels from the first to the second trimester significantly reduced anxiety, especially concerning fearful feelings. The numbers showed that women who enjoyed better iron status experienced less anxiety, which suggests iron supplementation might play a helpful role in enhancing mental health during early pregnancy.
However, we also noted that as iron levels changed from the second to the third trimester, there was a surprising rise in anxiety. Despite initial improvements, some aspects of quality of life declined, indicating the complex relationship between iron status and mental wellbeing.
Overall, this study sheds light on the importance of monitoring and managing iron levels in expecting mothers, as it may impact not only physical health but also emotional wellbeing.
Our findings indicate that improvements in iron levels from the first to the second trimester significantly reduced anxiety, especially concerning fearful feelings. The numbers showed that women who enjoyed better iron status experienced less anxiety, which suggests iron supplementation might play a helpful role in enhancing mental health during early pregnancy.
However, we also noted that as iron levels changed from the second to the third trimester, there was a surprising rise in anxiety. Despite initial improvements, some aspects of quality of life declined, indicating the complex relationship between iron status and mental wellbeing.
Overall, this study sheds light on the importance of monitoring and managing iron levels in expecting mothers, as it may impact not only physical health but also emotional wellbeing.
7.5
Anxiety reduction
Most Useful Review
Upon starting this iron supplement, I noticed a warm feeling in my body and relief from anxiety and fatigue. Although I was initially alarmed by the black stools, I learned they are a normal effect of taking iron, which reassured me to continue.
Melatonin
7
Melatonin alleviates prenatal anxiety effects
Prenatal Constant Light Exposure Induces Behavioral Deficits in Male and Female Rat Offspring: Effects of Prenatal Melatonin Treatment.
Most Relevant Research
We explored the impact of prenatal constant light exposure (CLE) and melatonin treatment on anxiety-related behaviors in male and female rat offspring. In our study, six groups of rats were examined, with some experiencing a standard light/dark cycle while others were subjected to CLE. We treated these groups with either a saline solution or melatonin.
Through various anxiety assessments like the open field test and elevated plus maze, we observed that exposure to CLE led to significant behavioral deficits. Specifically, the rats showed heightened anxiety levels, alongside increased plasma cortisol levels. Surprisingly, melatonin treatment repaired these behavioral issues in a way that was different between sexes.
Even though melatonin did not change overall levels of melatonin in the bloodstream or normalize cortisol levels, it did boost the expression of specific brain receptors associated with mood regulation. This suggests that melatonin may hold therapeutic potential for addressing anxiety issues triggered by environmental factors experienced during prenatal development.
Through various anxiety assessments like the open field test and elevated plus maze, we observed that exposure to CLE led to significant behavioral deficits. Specifically, the rats showed heightened anxiety levels, alongside increased plasma cortisol levels. Surprisingly, melatonin treatment repaired these behavioral issues in a way that was different between sexes.
Even though melatonin did not change overall levels of melatonin in the bloodstream or normalize cortisol levels, it did boost the expression of specific brain receptors associated with mood regulation. This suggests that melatonin may hold therapeutic potential for addressing anxiety issues triggered by environmental factors experienced during prenatal development.
9.5
Peaceful sleep
Most Useful Review
I enjoyed taking it an hour before bed. It helped me sleep peacefully and comfortably. Occasionally, I took two pills without experiencing anxiety or addiction.
Choline
7
Myo-Inositol improves anxiety behavior
Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia.
Most Relevant Research
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
9.5
Stress reduction
Most Useful Review
These supplements effectively support the nervous system and reduce anxiety. My doctor recommended them, and I've noticed a significant decrease in stress, along with improved liver function. The quality is excellent, and I plan to continue taking them.
Inositol
7
Myo-Inositol improves anxiety behavior
Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia.
Most Relevant Research
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
9.5
Eliminates anxiety
Most Useful Review
This is my second time taking Inositol, and it effectively alleviates anxiety and nervousness within days. I find I can handle stressful situations more calmly without feeling drowsy or cloudy-headed. The supplement comes in easy-to-take capsules.
L Theanine
7
Myo-Inositol improves anxiety behavior
Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia.
Most Relevant Research
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
9.5
Calmness achieved
Most Useful Review
I’ve noticed very positive effects; I cope with anxiety better, feel more confident, and remain calm. It positively influences my mood and helps concentration without causing drowsiness. I take it regularly; its effect is similar to that of good tea. I highly recommend it to everyone.