 NOW Foods, Real Food, Raw Pumpkin Seeds, Unsalted, 16 oz (454 g) | | |
IGF2BP3 promotes bone differentiationIGF2BP3 facilitates the osteogenic differentiation of bone marrow mesenchyml stem cells via upregulating KLK4. We explored how a specific protein, Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), influences the development of bone marrow mesenchymal stem cells (BMSCs) into bone-forming cells, especially in the context of osteoporosis (OP). Our aim was to uncover the molecular mechanisms that contribute to this transformation and possibly identify new treatment routes for OP.
We conducted a series of experiments that included analyzing mRNA expression levels and protein detection through various methods. Through techniques like alkaline phosphatase staining and Alizarin Red staining, we evaluated how well BMSCs differentiated into bone-forming cells. Our findings revealed that KLK4—a protein crucial for bone formation—was underexpressed in OP patients but significantly increased in successfully differentiated BMSCs.
Importantly, we observed that IGF2BP3 enhances the expression of KLK4, thereby promoting the osteogenic differentiation of the BMSCs. When KLK4 levels were increased, they could counteract the negative effects seen when IGF2BP3 was downregulated. These results highlight the significant role IGF2BP3 plays in supporting BMSC development into bone-forming cells, presenting a promising target for osteoporosis treatment. Bone density support Most Useful Review The benefits of pumpkin seeds for bones are significant; magnesium, calcium, and phosphorus increase bone density and reduce osteoporosis risk in women. The quality, taste, and ingredients surpass those in stores, and the self-sealing package contains 454 grams. However, it's not safe for infants, as it can cause discomfort due to its protein and iron content. |
 NOW Foods, Ultra A & D3, 100 Softgels | | |
Vitamin D derivatives enhance bone healthSynthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health. Strengthens bones Most Useful Review We used it daily to protect against osteoporosis and strengthen bones. |
 Mason Natural, Vitamin K2 Plus Vitamin D3, 100 Tablets | | |
Vitamin D derivatives enhance bone healthSynthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health. Effective for calcium absorption Most Useful Review 11 people found this helpful Two vitamins in one! This vitamin K2 combined with vitamin D3 is excellent for calcium absorption. I purchased it for my 9-year-old with dental issues. After a month, there was significant improvement in his teeth's condition. This product is highly recommended for anyone dealing with osteoporosis or dental problems. |
 Life Extension, Vitamins D and K with Sea-Iodine, 60 Capsules | | |
Vitamin D derivatives enhance bone healthSynthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health. Visible changes Most Useful Review 6 people found this helpful My son has osteoporosis and blood clotting issues. Within days of taking this supplement, bleeding decreased significantly, and joint pain improved, reducing the need for painkillers. The small capsules are easy to take, and the price is very reasonable for such quick results. |
 Carlson, Baby's Super Daily® D3, 10 mcg (400 IU), 0.35 fl oz (10.3 ml) | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Prevents osteoporosis Most Useful Review Very good. It is D3 at a reasonable price, most suitable for children. Remember to take it after a meal for better absorption. It has no fishy smell and is not rejected by children. D3 aids calcium absorption. If you have doubts about growth, consult a doctor. I hope there will be more discounts in the future, as I will consider buying more. It promotes calcium and phosphorus absorption, prevents osteoporosis, and can be beneficial for the elderly. |
 Nordic Naturals, Kids Vitamin D3 Gummies, Ages 3+, Wild Watermelon Splash, 400 IU, 120 Gummies | | |
Rickets prevention Most Useful Review Vitamin D helps prevent rickets, a condition linked to poor bone development. For adolescents and adults, it guards against caries, gum diseases, and osteoporosis, while also speeding up fracture healing. Bone strength improvement Most Useful Review Excellent! Vitamin D prevents rickets in babies and protects against caries and gum issues in older individuals. It is vital for preventing osteoporosis and promotes quicker recovery from fractures. |
 NOW Foods, C-1000, 250 Tablets | | |
Vitamin C may support bone healthThe Positive Association of Plasma Levels of Vitamin C and Inverse Association of VCAM-1 and Total Adiponectin with Bone Mineral Density in Subjects with Diabetes. We explored the connection between vitamin C levels and bone mineral density (BMD) in individuals with diabetes. By examining a group of 74 diabetic patients alongside 26 age-matched non-diabetic controls, we focused on how vitamin C intake could potentially influence bone health. Our goal was to see if higher vitamin C levels were associated with improved BMD and whether this effect might be related to decreases in certain inflammatory markers like VCAM-1 and adiponectin.
The results were quite promising. We observed a positive link between circulating levels of vitamin C and BMD, suggesting that higher vitamin C might indeed contribute to healthier bones. Notably, we found that this beneficial effect was closely tied to lower levels of inflammatory markers in the blood. This indicates that vitamin C might help not just in improving BMD but also in lowering inflammation, which can be particularly valuable for those living with diabetes.
Overall, our findings highlight the importance of maintaining adequate vitamin C levels as a potential strategy to reduce the risk of osteoporosis in individuals with diabetes. Incorporating vitamin C in the diet could be a simple yet effective way to support bone health while also combatting underlying inflammation. Strengthens bones Most Useful Review It is beneficial for those suffering from osteoporosis or joint pain. The formulation contains vitamins and minerals that support overall bone health. The recommended dosage is four capsules daily with meals, ideally split into doses. Personally, I prefer taking it during episodes of pain. |
 NOW Foods, Vitamin A, 10,000 IU, 100 Softgels | | |
Improved health noted Most Useful Review 8 people found this helpful Vitamins are well absorbed: no allergies, heartburn, or digestive issues. I firmly believe that without vitamin D3, youth and beauty are unattainable. So, I went to the pharmacy and found D3 only sold with calcium, which I didn’t need. I take the capsules as directed, ideally with fatty foods: butter, cheese, or soup works well. After two weeks, my overall health has improved, and the whole family enjoys them. I take three to five capsules daily. My skin feels supple, and my hair shines, showing these vitamins' effects even without tests. My children's academic performance has risen, and they seem more energetic. It’s vital for women to help prevent osteoporosis. I highly recommend these vitamins for anyone. Supports collagen production Most Useful Review I purchased this vitamin A for my sister to support her in battling osteoporosis, as it stimulates collagen production, essential for bones, nails, hair, and skin. When combined with other supplements, it can help reverse osteoporosis and also enhances eye health. We chose this quality brand. |
 NOW Foods, Vitamin D-3, High Potency, 5,000 IU, 120 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Improves fertility Most Useful Review 6013 people found this helpful A good dose of Vitamin D is crucial. I’m an endocrinologist and assert that it's a hormone rather than a vitamin. Testing for Vitamin D levels before supplementation is essential. The optimal level should be above 65 ng/ml, and dosages can be higher without adverse reactions. It's evident that Vitamin D enhances fertility in men and women, boosts mood, and helps prevent osteoporosis. |
 Solgar, Vitamin D3 (Cholecalciferol), 125 mcg (5,000 IU), 240 Vegetable Capsules | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Immune booster Most Useful Review Excellent vitamin D for immunity! It's vital for preventing osteoporosis in adults and aiding in combating chronic fatigue. I highly recommend it for overall health and immune function. |
 NOW Foods, Vegetarian Dry Vitamin D, 1,000 IU, 120 Veg Capsules | | |
Doxercalciferol improves bone healthDoxercalciferol Alleviates Bone Deteriorations and Cartilage Degeneration in Aging Mice. We sought to understand how doxercalciferol, a form of vitamin D2, affects bone health in aging mice, particularly in relation to osteoporosis. Through a series of experiments, we investigated its potential benefits in preventing bone loss, a common issue as animals age.
Our findings revealed that aging mice exhibited increased urine calcium excretion, decreased bone calcium content, and a reduction in biomechanical strength. However, upon administering doxercalciferol, we observed significant effects; especially, it lowered serum parathyroid hormone (PTH) levels which are commonly elevated in aging.
Additionally, our analysis through specific staining techniques confirmed that doxercalciferol helped protect against bone loss and supported cartilage regeneration. We also noted that the treatment enhanced the activity of bone-building cells while inhibiting the activity of cells that break down bone.
Overall, these results suggest that doxercalciferol could be an effective treatment for aging-related osteoporosis by enhancing bone health and improving overall quality of life. Helps manage osteoporosis Most Useful Review Excellent! This product is crucial for me due to osteoporosis. Following my doctor's recommendation, it has been beneficial. |
 Life Extension, Vitamin D3, 125 mcg (5,000 IU), 60 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Improved vitamin levels Most Useful Review I have been using this brand of Vitamin D3 for about ten years, since my diagnosis of osteoporosis, which revealed exceedingly low levels of Vitamin D3. This product has optimised my Vitamin D3 results and improved my osteoporosis. My husband takes it too, and during winter, we take 5,000 units twice a week while ensuring we have regular Vitamin D3 tests every six months. They are easy to swallow with breakfast. |
 NOW Foods, Chewable Vitamin D-3, Natural Fruit Flavor, 1,000 IU, 180 Chewables | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Immune system support Most Useful Review This product is excellent! Vitamin D plays a key role in calcium-phosphorus metabolism, helping to absorb calcium from the intestines. Insufficient vitamin D can lower blood calcium levels, leading to osteoporosis and fractures. It’s also vital for immune health, reducing the risk of autoimmune diseases. |
 NOW Foods, Vitamin D-3, 400 IU, 180 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Improves bone density Most Useful Review 1 people found this helpful After being diagnosed with osteoporosis following a lumbar compression fracture, I noticed a 4% improvement in bone density after taking supplements for six months, alongside calcium. Although I initially questioned the supplement's effectiveness, the osteoporosis test results confirmed its benefits. I stopped taking the hospital-prescribed vitamin D3 after two weeks (laughs). |
 Solgar, Vitamin D 3 (Cholecalciferol), 25 mcg (1,000 IU), 100 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Stronger immunity Most Useful Review 1 people found this helpful Vitamin D3 is essential for immunity and bone health. After three months of use, my levels normalised, and my health improved significantly. I felt energised and positive, and I firmly believe that this vitamin helps prevent osteoporosis and boosts overall bodily functions, especially during the winter months when sunlight is scarce. |
 NOW Foods, Vitamin D-3, High Potency, 2,000 IU, 240 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Supports healthy bones Most Useful Review 6 people found this helpful We take vitamin D3 as a family. It is essential for preventing osteoporotic changes and supports growth, immunity, and other bodily functions. It's particularly important given the current health climate with Covid. |
 Nutricost, Vitamin D3, 10,000 IU, 240 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Improves Calcium Absorption Most Useful Review A large dose of vitamin D3, 10,000 IU, is very beneficial for calcium absorption and bone health. It effectively aids in preventing osteoporosis and enhancing immunity. It is recommended for those in need to take supplements. |
 Garden of Life, Vitamin Code®, RAW D3™, 125 mcg (5,000 IU), 60 Vegetarian Capsules | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Improves mood Most Useful Review Vitamin D helps combat depression, boosts mood, enhances immunity, promotes calcium absorption, and prevents Osteoporosis. I also believe vitamin D3 must be paired with vitamin K2 for best results. I will definitely buy it again and highly recommend it! |
 Life Extension, Vitamin D3 with Sea-Iodine, 125 mcg (5,000 IU), 60 Capsules | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Levels normalised Most Useful Review Great for my arthritis and Osteoporosis; it has helped normalise my levels. |
 Nature's Bounty, D3, 50 mcg (2,000 IU), 350 Rapid Release Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Recommended for osteoporosis Most Useful Review I have severe osteoporosis (-2.9) and recommend this to everyone. My orthopaedic specialist tested my vitamin D concentration and found it low, advising me to supplement with Vitamin D3. After taking Nature's Treasure Vitamin D3, 2000IU daily along with 1200 seaweed calcium, I've made lifestyle changes and will test my bone density again in a year. I'm now at (-2.3). Even though I'm not keen on swallowing pills, these are easy to take. The dosage varies based on personal needs, but I truly recommend it. |
 Jarrow Formulas, Vitamin D3, 125 mcg (5,000 IU), 100 Softgels | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Childhood development Most Useful Review Vitamin D3 strengthens teeth and bones, supporting normal skeletal growth in children. It also enhances muscle strength and heart health, helping prevent illnesses like osteoporosis and rickets. |
 Superior Source, D3, Extra Strength, 125 mcg (5,000 IU), 100 MicroLingual® Instant Dissolve Tablets | | |
Vitamin D's impact on osteoporosisThe Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment. Essential for osteoporosis Most Useful Review It is crucial for osteoporosis, and the dosage I take is appropriate. I take a sublingual tablet, which is easy to consume. |
 NOW Foods, L-Lysine, 500 mg, 250 Tablets | | |
NSD2 inhibition may reduce osteoporosisNSD2-mediated H3K36me2 exacerbates osteoporosis via activation of hoxa2 in bone marrow mesenchymal stem cells. We explored the connection between NSD2 and bone health, specifically how it affects bone marrow stem cells in osteoporosis. By using advanced techniques, we found that NSD2 inhibits the growth of these cells, which is crucial for healthy bones.
In animal models of osteoporosis, blocking NSD2 not only promoted stem cell differentiation but also helped prevent bone loss. Our findings suggest that targeting NSD2 could be a new way to treat osteoporosis and improve bone health. Prevents osteoporosis Most Useful Review Now Foods L-Lysine 500 mg is crucial for health. It aids immunity and helps prevent and treat yeast, fungal infections, and herpes due to its role in collagen synthesis. It's essential for calcium absorption, which is vital in preventing osteoporosis. |
 Nature's Bounty, Magnesium, 500 mg, 100 Coated Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Prevents osteoporosis Most Useful Review Magnesium is a crucial mineral within the human body, with around 60% stored in bone tissue, making it vital for osteoporosis prevention and maintaining good bone density. Additionally, magnesium regulates nervous system functions, aids in DNA synthesis, facilitates muscle relaxation and contraction, and supports energy extraction from food. |
 Nature Made, Magnesium, 250 mg, 200 Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Relieves insomnia Most Useful Review 2 people found this helpful Excellent vitamins with no side effects. Magnesium normalises heart rate, lowers blood pressure, regulates blood sugar levels, and reduces muscle cramps. I suffered from insomnia and cramps. After taking magnesium, I now sleep normally, and the cramps are rare. Its benefits for osteoporosis prevention are enormous! |
 Source Naturals, Magnesium Malate, 3,750 mg, 360 Tablets (1,250 mg per Tablet) | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Provides relief Most Useful Review My mother suffers from osteoporosis, along with issues with her bones and muscles. Once she started taking this vitamin, it provided her with relief, and she refuses to stop using it. |
 NOW Foods, Magnesium Caps, 400 mg, 180 Veg Capsules | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Helps with osteoporosis Most Useful Review 1 people found this helpful Magnesium helps alleviate insomnia, muscle cramps, and anxiety, and it’s essential for calcium absorption, which aids in preventing osteoporosis. I take a pill before bed and found my body adjusted well to it after initial relaxation effects. |
 NATURELO, Magnesium Glycinate Chelate Complex, 120 Vegetarian Capsules | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Suitable for osteoporosis Most Useful Review I purchased this natural, safe product for my mother, who suffers from osteoporosis, and it suits her perfectly. It's excellent for her needs. |
 NOW Foods, Magnesium Citrate, 400 mg, 120 Veg Capsules (133 mg per Capsule) | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Alleviates constipation Most Useful Review 12 people found this helpful I purchased magnesium citrate for my mother’s constipation, which laxatives didn't help. After taking magnesium citrate, her long-term constipation resolved. It also aids her osteoporosis, and I hope it improves her bone density. |
 Life Extension, Neuro-Mag, Magnesium L-Threonate, 144 mg, 90 Vegetarian Capsules (48 mg per Capsule) | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Bone density improvement Most Useful Review 2 people found this helpful This magnesium supplement has noticeably improved my bones and joints since I began using it. The pill is large but of excellent quality. Magnesium aids bone formation by assisting in calcium absorption and activates vitamin D, crucial for bone health. Sufficient magnesium is linked to increased bone density and improved crystal formation, reducing osteoporosis risk, particularly in postmenopausal women. Additionally, it has positively affected my sleep. |
 Doctor's Best, High Absorption Magnesium, 200 mg, 120 Tablets, (100 mg per Tablet) | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Promotes strong bones Most Useful Review 57 people found this helpful After researching magnesium's role in osteoporosis, I started taking two 200mg tablets daily. They are cheap and effective, with no digestive issues. As someone training for a demanding mountain walking challenge at seventy, I recommend these for anyone wanting to maintain their health, especially in later life. |
 Life Extension, Magnesium Caps, 500 mg, 100 Vegetarian Capsules | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Muscle tension relief Most Useful Review I trust the quality of this magnesium product, which contains 500mg. It’s easy to consume, and the packaging is convenient. I find it effective in relieving muscle and nerve tension while also aiding in osteoporosis treatment. |
 NOW Foods, MSM, Methylsulfonylmethane, 1,000 mg, 120 Veg Capsules | | |
MSM enhances bone cell differentiationMethylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly. Pain relief noted Most Useful Review 2 people found this helpful Excellent! My mother is quite elderly and suffers from severe osteoporosis, as well as occasional low back pain following a lower back injury, which caused her to bend over. Due to concerns about side effects from Western medicine, alongside taking Life Extension’s Bone Strength Collagen Formula, I also added MSM for its anti-inflammatory benefits and to strengthen cartilage and connective tissue. After nearly a month, my mother can finally straighten her back and has experienced significant pain relief. This product has been beneficial for her back pain, and I plan to continue purchasing it. |
 Jarrow Formulas, Vegan MSM, 1,000 mg, 200 Veggie Capsules | | |
MSM enhances bone cell differentiationMethylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly. Menopause support Most Useful Review This is good for osteoporosis and essential during menopause. |
 Doctor's Best, MSM with OptiMSM®, 3,000 mg, 360 Capsules (1,000 mg per Capsule) | | |
MSM enhances bone cell differentiationMethylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly. Joint health support Most Useful Review Great product for joint health and osteoporosis support. |
 NOW Foods, Cal-Mag DK, 180 Capsules | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Significant improvement Most Useful Review Excellent! I purchased this for my 87-year-old mother-in-law suffering from osteoporosis. She took one capsule after dinner with dietary fat and consumed milk powder daily. Her condition has improved significantly. |
 Nature Made, Calcium Magnesium Zinc with Vitamin D3, 300 Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Improves grandmother's health Most Useful Review I continually give this to my grandmother, who has osteoporosis; she takes one capsule three times a day and feels better. It's been hard to find, but it's the best and most worthwhile, so I plan to buy several packages at once. |
 Garden of Life, Vitamin Code, RAW Calcium, 120 Vegetarian Capsules | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Reversed osteoporosis Most Useful Review 15 people found this helpful I will always take this product. I had osteoporosis, and after starting it, my condition began to improve within months. After two years, my bone density tests were normal. When I tried to stop and switched to regular calcium, I developed osteopenia, so I resumed this and returned to the normal range. No other calcium compares to this one. |
 Nature's Bounty, Calcium Magnesium Zinc with Vitamin D3, 100 Coated Caplets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Supports osteoporosis treatment Most Useful Review 19 people found this helpful Calcium is vital for human health. A deficiency can lead to osteoporosis. Magnesium calms the nervous system, while zinc strengthens immunity. This 3-in-1 combo, featuring D3 to enhance calcium absorption, is an excellent supplement for its price and quality. |
 NOW Foods, Bone Meal Powder, 1 lb (454 g) | | |
Calcium complex enhances bone healthA calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health. Joint pain relief Most Useful Review 6 people found this helpful I purchased this for my mother, aged 70, who has a history of arthrosis and osteoporosis along with calcium deficiency. After daily intake for two months, her joint pain, particularly in her fingers and hands, has decreased significantly. We've also noticed a marked improvement in her hair and nails. The packaging is substantial and quite economical; a teaspoon daily lasted nearly a year. It dissolves effectively in sugar-free juice, though it tastes unusual; my mother prefers it in milk. While the additive is flavourless, it is less palatable in water. The benefits are unmistakable. I will certainly buy more, now also for myself and my pet. Thank you for the quality product. Cheers! |
 Garden of Life, MyKind Organics, Organic Plant Calcium, 90 Vegan Tablets | | |
Calcium complex enhances bone healthA calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health. Stronger nails Most Useful Review 11 people found this helpful The result is impressive! My husband has osteoporosis in parts of his spine, and my nails were as thin as paper. After two months, my nails became much stronger, and my partner's back pain has improved. We intend to undergo examination for clinical confirmation of the results. |
 NOW Foods, Calcium Hydroxyapatite Caps, 120 Capsules | | |
Calcium complex enhances bone healthA calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health. Effective prevention Most Useful Review 1 people found this helpful The doctor prescribed this to prevent osteoporosis. It’s a good product that helps me. I recommend it. |
 21st Century, 600+D3 Plus Minerals, 120 Tablets | | |
Calcium complex enhances bone healthA calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health. Improves bone health Most Useful Review 1 people found this helpful Calcium is excellent for bones and aids in increasing height during adolescence. It alleviates dental pain and helps repair fractures quickly, making it beneficial for osteoporosis. Starting at 25, particularly after pregnancy and lactation, is advisable. Women need calcium, and this type includes vitamin D for better absorption. However, be cautious of iron supplements and avoid liver on the day of consumption. Stay safe! 💜💜💜 |
 21st Century, Calcium Supplement , 600 mg, 400 Tablets | | |
Calcium complex enhances bone healthA calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health. Value for osteoporosis Most Useful Review 2 people found this helpful 21st Century Calcium Supplement 600 offers excellent value. As a sufferer of osteoporosis, taking calcium daily is essential, and buying a 400-tablet bottle at an affordable price is fantastic. It’s not in a gel cap, which suits me as a vegetarian. |
 NOW Foods, Magnesium & Calcium, 250 Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Highly effective Most Useful Review This supplement is very effective for treating osteoporosis. |
 Solgar, Calcium Magnesium with Vitamin D3, 300 Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. No swelling experienced Most Useful Review 1 people found this helpful This is the best calcium I’ve tried. It doesn’t cause swelling or negatively impact the kidneys, making it excellent for osteoporosis. I certainly recommend it to anyone in need. |
 Solgar, Calcium Magnesium Plus Zinc, 250 Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Cramps alleviated Most Useful Review 6 people found this helpful I ordered this for my husband and now our whole family enjoys it. He had concerns about leg cramps, but after more than a month on the supplement, the cramps have ceased. I also began taking calcium, magnesium, and zinc to prevent osteoporosis. The dosage is appropriate, and the large packaging lasts a long time. |
 NOW Foods, Calcium & Magnesium, 250 Tablets | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Reduced cravings Most Useful Review 55 people found this helpful I take this as prescribed by my orthopaedic surgeon for osteoporosis management before and after pelvic surgery. It's a great remedy for the cramps common during pregnancy. After consuming other types of calcium without relief, I finally found this one. My calcium levels have improved, and the urge to eat chalk has disappeared entirely. |
 Country Life, Target-Mins, Calcium Magnesium with Vitamin D Complex, 240 Vegan Capsules | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Preventing osteoporosis Most Useful Review I purchased this product to prevent osteoporosis. |
 Country Life, Target-Mins, Calcium-Magnesium Complex, 1,000 mg, 180 Tablets (500 mg per Tablet) | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Normal bone density Most Useful Review 2 people found this helpful After being diagnosed with osteoporosis years ago due to steroids, it was vital to manage this quickly. My doctor recommended calcium and magnesium along with daily walks. Since starting Country Life, my bone density has returned to normal, and I feel much more secure, especially after a recent fall. |
 NOW Foods, MK-7 Vitamin K-2 , 100 mcg, 120 Veg Capsules | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Reduces osteoporosis risk Most Useful Review 420 people found this helpful Vitamin K2 (MK-7) is essential for treating osteoporosis by removing calcium from arteries and directing it to bones. I take it regularly with vitamin D3 to strengthen my bones. In high doses, it lowers cholesterol and prevents vascular calcification. The 100 mcg dosage is optimal, and the packaging is intact. It could be cheaper, though! |
 Jarrow Formulas, MK-7, 90 mcg, 120 Softgels | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Essential for osteoporosis Most Useful Review 55 people found this helpful It’s crucial to take Vitamin K2 alongside high doses of D3, especially over 5000 IU. K2 improves calcium absorption and helps prevent conditions like osteoporosis. I recommend taking one capsule with breakfast. |
 Solgar, Naturally Sourced Vitamin K2, 100 mcg, 50 Vegetable Capsules | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Preventing osteoporosis Most Useful Review 70 people found this helpful MK-7 is a highly bioavailable form of vitamin K2 involved in blood clotting and cellular regulation. It slows down the effects of natural aging and is vital for activating calcium-binding proteins. Vitamin K2 prevents osteoporosis and improves bone health. It is often taken alongside vitamin D, which aids calcium absorption, ensuring both vitamins work effectively. If my review is helpful, please click "Yes". |
 NOW Foods, Vitamin K-2, 100 mcg, 100 Veg Capsules | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Positive calcium trend Most Useful Review 2 people found this helpful After my thyroid was removed and I began hormone therapy, I was told to take vitamin D. My tests showed calcium leaching from bones, indicating osteoporosis. The doctor recommended K2, which improved my calcium levels after a month. Now, K2 is essential for me. |
 Doctor's Best, Natural Vitamin K2 MK-7 , 45 mcg, 60 Veggie Caps | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Effective osteoporosis support Most Useful Review 31 people found this helpful Works for osteoporosis. My mother developed this condition, and after researching, I found that the combination of vitamin D and K2 is beneficial. This product helps raise vitamin D levels in the blood effectively. The capsules are small and easy to swallow. |
 Life Extension, Super K, 2,600 mcg, 90 Softgels | | |
Vitamin K2 supports BMD in osteoporosisEfficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis. Enhances endurance Most Useful Review 1 people found this helpful This product has a relatively high content of vitamin K, combined with multiple components of vitamin 2 in scientifically balanced doses. It significantly aids those with osteoporosis, particularly individuals who exercise regularly, as it helps enhance endurance alongside proper diet conditioning. |
 NOW Foods, Ultra Omega 3-D, 600 EPA / 300 DHA, 90 Fish Softgels | | |
EPA helps balance bone healthEicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice. We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans. Joint pain relief Most Useful Review Excellent! Omega-3 fatty acids prevent the development of Osteoporosis, maintain healthy joints, and alleviate pain during exacerbations. They combat bone loss, reduce inflammation, and help mitigate symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis. |
 Solgar, Omega 3, EPA & DHA, Triple Strength, 950 mg, 100 Softgels | | |
EPA helps balance bone healthEicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice. We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans. Lowers cholesterol Most Useful Review Omega-3 normalises blood pressure and clears blood vessels of 'bad' cholesterol, preventing plaque formation. These fatty acids effectively prevent the development of osteoporosis, maintain joint health, and relieve pain during exacerbations. |
 Jarrow Formulas, Fish Oil, EPA-DHA Balance®, 120 Softgels | | |
DHA linked to osteoporosis riskCausal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area. Prevents osteoporosis Most Useful Review High-quality product made from natural ingredients, particularly vital for the elderly. Omega-3 fatty acids help prevent osteoporosis by maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, lessen rheumatoid arthritis symptoms, slow cartilage destruction during arthrosis, lower bad cholesterol, hydrate skin and hair, and promote heart health. |
 NOW Foods, Omega-3 Fish Oil, 1,000 mg, 180 EPA - 120 DHA, 200 Softgels | | |
DHA linked to osteoporosis riskCausal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area. Similar to others Most Useful Review Omega-3 fatty acids prevent osteoporosis, maintain joint health, and lessen pain during flare-ups. They combat bone loss and relieve inflammation, helping with rheumatoid arthritis and cartilage issues. |
 Nordic Naturals, Omega-3, Great Lemon, 690 mg, 120 Soft Gels (345 mg per Soft Gel) | | |
DHA linked to osteoporosis riskCausal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area. Highly effective Most Useful Review Great! Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They fight bone loss, alleviate rheumatoid arthritis symptoms, and slow down the destruction of cartilage in arthrosis. The quality is exceptional, with natural ingredients and optimal effectiveness. |
 Natrol, Omega-3 Fish Oil, Lemon, 1,000 mg, 150 Softgels | | |
DHA linked to osteoporosis riskCausal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area. Supports joint health Most Useful Review 2 people found this helpful Omega-3s support joint health and help prevent osteoporosis. They reduce inflammation and fight bone loss, alleviating joint pain, and mitigate symptoms of rheumatoid arthritis while slowing cartilage degradation in arthrosis. The fish oil is of high quality with no side effects like heartburn. I take it regularly and find it excellent value for money. |
 Carlson, Wild Norwegian, Elite Omega-3 Gems®, Natural Lemon, 120 Soft Gels | | |
DHA linked to osteoporosis riskCausal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area. Prophylactic use Most Useful Review Omega-3 from my favourite brand, Carlson Products, is of excellent quality. Each bank lasts a long time as I take this twice a year for three months. One capsule, containing 800 mg, suffices for the prophylactic intake. Omega-3 fatty acids effectively prevent the development of osteoporosis, maintain joint health, and alleviate pain during flare-ups. They also help combat bone loss and inflammation, which is especially beneficial given my age. |
 New Chapter, Plant Calcium, Bone Strength Take Care, 180 Vegetarian Slim Tablets | | |
Hyperoside shows promise for osteoporosisEffect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway. We examined how hyperoside, a compound in Semen cuscutae, can combat osteoporosis in ovariectomized mice, particularly after menopause. The study revealed that hyperoside effectively increased bone density and improved bone structure by reducing the differentiation of osteoclasts—cells that break down bone.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways. Improved bone density Most Useful Review 8 people found this helpful This product has aided my bone density after a year of use. I'm continuing to take it to improve the fourth area in my scan. In the three areas that improved, I've transitioned from osteoporosis to osteopenia! |
 Jarrow Formulas, BoneUp 3 Per-Day, 1,000 mg, 90 Capsules | | |
Hyperoside shows promise for osteoporosisEffect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway. We examined how hyperoside, a compound in Semen cuscutae, can combat osteoporosis in ovariectomized mice, particularly after menopause. The study revealed that hyperoside effectively increased bone density and improved bone structure by reducing the differentiation of osteoclasts—cells that break down bone.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways. Reduced knee pain Most Useful Review 5 people found this helpful I requested it for myself and my mother due to knee roughness; it has helped immensely. I cannot stop taking it, as my knee fatigue returns without it. |
 Sports Research, Omega-3 Fish Oil, Triple Strength , 30 Softgels | | |
DHA linked to osteoporosis riskCausal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area. Prevents osteoporosis Most Useful Review 1 people found this helpful This Omega-3 fish oil, certified by IFOS, is extracted from wild Alaska pollock. Each capsule contains significant amounts of EPA and DHA. Its benefits include reducing cholesterol and triglycerides, managing blood pressure, preventing osteoporosis, and enhancing joint health. It’s recommended to take 1-2 capsules daily, and it’s a great value, currently on sale. |
 NOW Foods, Zinc Picolinate, 50 mg, 60 Veg Capsules (50 mg per Capsule) | | |
Zinc intake may protect bonesThe association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA. Supports osteoporosis treatment Most Useful Review 493 people found this helpful A tiny capsule of zinc helps combat various health issues. This small dietary supplement is easy to consume and plays a crucial role in preventing diseases such as osteoporosis. Zinc contributes to skin cell renewal and collagen formation, reducing dryness and helping combat wrinkles and acne. The importance of zinc in overall health cannot be overstated, particularly in maintaining beauty and preventing various health problems. |
 NOW Foods, Zinc Glycinate, 120 Softgels | | |
Zinc intake may protect bonesThe association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA. Helpful for osteoporosis Most Useful Review With advanced osteoporosis, this supplement effectively meets my needs, just as I expect from the "Now" brand. |
 Jarrow Formulas, Vegan Zinc Balance, 100 Veggie Capsules | | |
Zinc intake may protect bonesThe association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA. Essential for Bones Most Useful Review Very good product that maintains the immune system and aids in the growth and repair of damaged cells and tissues. Zinc plays a crucial role in bone formation and health, helping to prevent osteoporosis. It is also vital for male sexual health, with potential benefits stemming from zinc's antioxidant properties and its role in sustaining normal hormone levels. |
 Solgar, Zinc Picolinate, 22 mg, 100 Tablets | | |
Zinc intake may protect bonesThe association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA. Helpful for osteoporosis Most Useful Review I have been ordering this supplement for years on my endocrinologist's advice. Although I have no severe illnesses, there is a risk of osteoporosis due to my age and premenopausal state. Tests show it is absorbed well and very beneficial, with a natural composition. |
 Jarrow Formulas, Lactoferrin, Freeze Dried, 250 mg, 60 Capsules | | |
Lactoferrin enhances osteoblast activityLactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling. We explored how lactoferrin, a key component found in milk, plays a role in promoting osteoblast formation, which is crucial for preventing and treating osteoporosis. Our investigation looked at the effects of lactoferrin on the activity of primary osteoblasts—cells responsible for bone formation.
Our findings revealed that lactoferrin enhances the autophagy activity of these cells, a process that helps with cellular maintenance and function. We observed that lactoferrin impacts the BCL2 protein level in osteoblasts, which is connected to how autophagy is regulated. By increasing lactoferrin, we noted a decrease in BCL2 expression and its interaction with Beclin1, a protein needed for autophagy.
Ultimately, we learned that when BCL2 was overexpressed or Beclin1 was silenced, the beneficial effects of lactoferrin on autophagy and important osteogenic parameters were reversed. This suggests that lactoferrin may provide significant support for bone health by enhancing a specific pathway in osteoblast function, making it a promising candidate for osteoporosis treatment. Antibacterial properties Most Useful Review 6 people found this helpful Lactoferrin is a crucial protein found in breast milk that aids in iron absorption and possesses antibacterial properties. It combats pathogenic bacteria and is beneficial for fighting herpes viruses and preventing osteoporosis. I give my child one capsule daily, and I’ve found the Jarrow supplement to be the most effective in terms of price and quality. It’s proven to work, and I highly recommend it. |
 NOW Foods, Milk Thistle Extract, Double Strength, 300 mg, 200 Veg Capsules | | |
Promising silibinin effects on osteoporosisOsteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts. In our exploration, we found that silibinin, a key component of silymarin derived from milk thistle, shows promising effects on osteoporosis treatment. Through in vitro studies involving murine osteoblast and macrophage cells, silibinin not only boosted bone formation by promoting the growth and mineralization of bone cells but also helped inhibit the harmful activity of osteoclasts, which are responsible for bone resorption.
Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings. Improves liver function Most Useful Review My doctor recommended silymarin to protect and restore my liver. After using 100 capsules, my liver function improved significantly, and my acne cleared up. This is likely the best silymarin available; I will order more for my parents to support their osteoporosis prevention. |
 Doctor's Best, Glucosamine Chondroitin MSM with OptiMSM®, 240 Capsules | | |
MSM enhances bone cell differentiationMethylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly. Slows osteoporosis progression Most Useful Review 7 people found this helpful Doctor's Best Glucosamine, Chondroitin, and MSM is a remarkable tool for aiding cartilage health. It slows bone resorption and enhances calcium retention, promoting bone tissue repair and inhibiting cartilage degeneration. Its topical application can slow osteoporosis progression and stimulate regeneration in connective tissues. I highly recommend it for managing joint pain and enhancing the normal physiological processes! |
 NOW Foods, Glucosamine & Chondroitin with MSM, 180 Veg Capsules | | |
MSM enhances bone cell differentiationMethylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly. Improved flexibility Most Useful Review This amazing product is for elderly people suffering from Osteoporosis. I purchased it for my mother, and it enhances cartilage and bone strength while reducing discomfort related to Osteoporosis. |
 Nature Made, Calcium with Vitamin D3, 600 mg, 100 Softgels | | |
Calcium and vitamin D reduce fracturesCalcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities. Effective for osteoporosis Most Useful Review 2 people found this helpful Capsules are preferable. I have osteoporosis, and my doctor recommended avoiding hard tablets. This product also provides a good dose of vitamin D, and the combination has been beneficial for me. |
 Citracal, Calcium Supplement +D3, Petites, 200 Coated Caplets | | |
Calcium and vitamin D reduce fracturesCalcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities. Significant improvement noted Most Useful Review 1 people found this helpful Several years ago, my mother was diagnosed with osteoporosis. We tried numerous drugs, but none were effective until I found this one on iHerb. It truly works. Each year, she undergoes a bone density X-ray, which previously showed no improvement, only deterioration. After starting the calcium supplement, her indicators began to improve almost immediately. While results aren't instantaneous, she had a noticeable improvement after six months, which is fantastic! The supply lasts a long time. She also takes vitamin D. |
 21st Century, Calcium Citrate + D3 Maximum, 75 Tablets | | |
Calcium and vitamin D reduce fracturesCalcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities. Essential for women Most Useful Review 34 people found this helpful Calcium citrate with vitamin D3 is a true find. It absorbs completely and is vital for women to prevent osteoporosis while improving hair, nails, and teeth health. |
 Citracal, Calcium Supplement + D3, Slow Release 1200 , 80 Coated Tablets | | |
Calcium and vitamin D reduce fracturesCalcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities. Improved bone density Most Useful Review 6 people found this helpful Better with slow release—since I began this instead of regular Citracal, I believe it's better for me. It's absorbed more effectively as it releases throughout the day. I have osteoporosis, and after the removal of a parathyroid gland, I require a calcium supplement that works. My surgeon suggested Citracal post-operation, and I followed that advice, but switched to this one. As a registered nurse, I understand the importance of slow absorption. So far, my bone densities have improved with this and Reclast IV. Now, I am off Reclast and managing well without any broken bones. |
 NOW Foods, Coral Calcium Plus, 100 Veg Capsules | | |
Magnesium's role in osteoporosis therapyMg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease. Bioavailable source Most Useful Review 1 people found this helpful Coral calcium is a readily bioavailable source of calcium and is well absorbed by the body. My doctor prescribed it, and I would recommend it to anyone facing osteoporosis. |
 NOW Foods, Coral Calcium, 1,000 mg, 100 Veg Capsules | | |
Coral calcium aids bone healthDietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss. We explored the effect of coral calcium and zeolite on bone health in mice, particularly focusing on postmenopausal bone loss caused by ovariectomy. After six months of supplementation, we observed that these treatments helped restore bone mass in the distal femur and improved bone structure.
However, coral calcium's protection was less pronounced in other parts of the skeleton. Overall, while these supplements show promise for supporting bone health, the benefits may vary across different bone types. Helped recovery Most Useful Review 2 people found this helpful Recommended due to my mother-in-law's hip fracture. Since using this coral calcium, her osteoporosis improved significantly alongside her recovery. I also benefit from it for allergies and eczema. |
 NOW Foods, Certified Organic Inulin, Prebiotic Pure Powder, 8 oz (227 g) | | |
Inulin shows promise against osteoporosisBioassay-guided isolation and evaluation of anti-osteoporotic polysaccharides from Morinda officinalis. We investigated how inulin from Morinda officinalis can help with osteoporosis, particularly looking at its different polysaccharide fractions. Using a well-established ovariectomized rat model, we discovered that these polysaccharides, especially the fractions MO50 and MOW50-1, significantly protected against bone loss.
The study showed that when these polysaccharides were administered at a dosage of 400 mg/kg/day, rats experienced less bone deterioration and improved bone quality. Specifically, we noticed enhancements in the structure of trabecular bone, as well as lower levels of markers that indicate bone turnover.
Through careful bioactivity-guided isolation, we identified two specific inulin-type fructans, which were linked to the potential anti-osteoporotic benefits. Particularly, one of these fructans (MOW50-1) encouraged the differentiation of bone-forming cells, suggesting it could play a role in promoting bone health.
Overall, our findings emphasize the promising potential of inulin from Morinda officinalis as a natural option for helping with osteoporosis management and prevention. Improves calcium absorption Most Useful Review In addition to its prebiotic effects, inulin significantly increases calcium absorption, reducing osteoporosis risk. It influences lipid metabolism, decreasing atherosclerosis risk and possibly preventing type II diabetes, with preliminary data suggesting anticarcinogenic effects. Inulin also combats functional constipation and nourishes beneficial gut bacteria to maintain microbiota balance. |
 NOW Foods, B-12, 1,000 mcg, 100 Lozenges | | |
Folate protects osteoblasts from homocysteineFolate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells. We investigated how folate (FA) impacts osteoblasts, particularly under the influence of homocysteine (Hcy), which is linked to osteoporosis. In our study, we treated MC3T3-E1 cells—the classic model for studying bone formation—with different concentrations of FA and observed several key factors.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis. Memory and skincare Most Useful Review Vitamin B12 is not only delicious but also beneficial. It strengthens memory, prevents osteoporosis, and promotes healthy hair and skin. The large quantity and excellent quality make it a standout supplement. Ingredients like folic acid and niacin are energising and effective, providing support for metabolism, the nervous system, and overall health. |
 Doctor's Best, Fully Active B12, 1,500 mcg, 180 Veggie Caps | | |
Vitamin B12 linked to fracturesVitamin B12 as a novel risk biomarker of spinal fractures. We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis. Supports general health Most Useful Review This product is extremely useful. It greatly benefits the body, nerves, and overall health. I use it alongside my family as it’s one of the most important vitamins for daily health. It promotes bone growth and helps prevent osteoporosis. Nutritionists emphasise the significance of vitamin B12 and its role in supporting mood and mental health. |
 NOW Foods, Calcium Citrate, 250 Tablets | | |
Calcium citrate improves bone densityRandomized controlled trial of calcium in healthy older women. We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain. Effective calcium citrate Most Useful Review 2 people found this helpful I prefer this calcium citrate for its excellent formulation, making it easier than taking calcium with other components separately, which aid in better calcium absorption. Citrate absorbs better with fewer side effects than cheaper options. I have grade 2 osteoporosis and need calcium regularly. Since starting this, my bones and joints no longer ache as they did before. |
 Solgar, Calcium Citrate with Vitamin D3, 240 Tablets | | |
Calcium citrate improves bone densityRandomized controlled trial of calcium in healthy older women. We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain. Effective for healing bones Most Useful Review 19 people found this helpful At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones. |
 Citrucel, Methylcellulose Fiber Therapy for Irregularity, 180 Fiber Caplets | | |
Improves fertility Most Useful Review 6013 people found this helpful A good dose of Vitamin D is crucial. I’m an endocrinologist and assert that it's a hormone rather than a vitamin. Testing for Vitamin D levels before supplementation is essential. The optimal level should be above 65 ng/ml, and dosages can be higher without adverse reactions. It's evident that Vitamin D enhances fertility in men and women, boosts mood, and helps prevent osteoporosis. Effective for calcium absorption Most Useful Review 11 people found this helpful Two vitamins in one! This vitamin K2 combined with vitamin D3 is excellent for calcium absorption. I purchased it for my 9-year-old with dental issues. After a month, there was significant improvement in his teeth's condition. This product is highly recommended for anyone dealing with osteoporosis or dental problems. |
 Animal, Flex, Comprehensive Joint Care, 44 Pill Packs | | |
Pain relief Most Useful Review 12 people found this helpful Working!!! I purchased this for a family member suffering from third degree osteoporosis in the hip joints. Remarkably, after just three days, they felt lighter and experienced pain relief. I found the same product being used by a friend, whose knee was in poor condition. After using this for several years, they are now active again. My trust in this product comes from a relative, sceptical of supplements, who found it effective for treating vertebral hernias. In conclusion, it's effective for injuries and musculoskeletal disorders. Night cramp relief Most Useful Review Vitamins are great! This complex definitely works. It helps with osteoporosis, night cramps and strengthens teeth. My grandmother is very satisfied. |
 NOW Foods, Super Omega 3-6-9, 1,200 mg, 90 Softgels | | |
Pain relief noted Most Useful Review 3 people found this helpful Fast delivery and excellent quality. This drug is a panacea for me! It helps regulate my cycle, makes my skin glow, and reduces hair loss. Omega-3s prevent osteoporosis, maintain joint health, and alleviate pain during flare-ups. They combat bone mass loss, reduce inflammation, and slow cartilage destruction in arthrosis. Joint health improved Most Useful Review Omega-3s normalise blood pressure, cleanse blood vessels of bad cholesterol, and prevent cholesterol plaques. They help prevent osteoporosis, maintain joint health, and reduce pain during flare-ups. |
 NOW Foods, EVE, Superior Women's Multi, 180 Softgels | | |
Strong bones Most Useful Review 1 people found this helpful ✔️Restores hormonal balance ✔️Normalises the menstrual cycle, alleviating PMS discomfort ✔️Benefits cardiovascular function and prevents varicose veins ✔️Normalises gastrointestinal activity, regenerates liver cells, and promotes healthy microflora ✔️Promotes calcium accumulation and optimal absorption for osteoporosis prevention and treatment ✔️Strengthens nails and promotes hair growth ✔️Enhances melanin production to prevent grey hair ✔️Activates collagen production for joint and skin health ✔️Boosts immunity ✔️Stimulates hair growth. Enhanced wellbeing Most Useful Review 1 people found this helpful This complex of vitamins and minerals is designed specifically for women, restoring hormonal balance while relieving climacteric symptoms and preventing osteoporosis. The B vitamins positively affect the cardiovascular and digestive systems, while a selected mineral blend supports skeletal and muscular formation. Vitamin C and silicon are vital for collagen production, which maintains skin elasticity and slows ageing. I appreciate this formulation. The 180-piece can is more economical. |
 Solgar, No. 7, Advanced Joint Support Complex, 90 Vegetable Capsules | | |
Great for mobility Most Useful Review My mum suffers from Osteoporosis and osteochondrosis and experiences constant pain. This drug has helped her immensely; she noticed increased mobility and reduced pain. The only downside is that it caused heartburn and some discomfort at the gastrointestinal level. Significant relief Most Useful Review I purchased this for my sister who has Osteoporosis of the 2nd degree. She struggled to sleep at night due to pain in her hip joint. After just 10 days of use, she experienced significant relief. She thanked me and asked me to order more, so I will certainly be doing that. |
 21st Century, Sentry Senior, Multivitamin & Multimineral Supplement, Women 50+, 100 Tablets | | |
Improves mood Most Useful Review I bought this for my mother, and she feels better. Despite the price, it effectively supports her mood and activity levels. It contains calcium and vitamin D, crucial for bone health and osteoporosis prevention, along with other beneficial vitamins for heart and brain health. Bone health support Most Useful Review The 21st Century Sentry Senior Women’s 50+ Multivitamin is excellent for women of this age group. It supports bone health with necessary nutrients like calcium and vitamin D, essential for osteoporosis prevention, while also offering a wide range of vitamins for overall health. |
 NOW Foods, Cal-Mag Caps with Trace Minerals and Vitamin D, 240 Capsules | | |
Convenient supplement Most Useful Review 1 people found this helpful The ingredients include trace elements alongside a combination of calcium, magnesium, and vitamin D. You can meet your nutritional needs conveniently without having to swallow pills frequently! It is tasteless and appears to enhance the management of Osteoporosis. Bone health support Most Useful Review After reviewing the ingredients, I realised this is precisely what I require. Magnesium has alleviated my seizures. The vitamin D-3 dosage here is low for me, so I purchased a good quality D-3 and K-2 complex separately. For those over 60, this is crucial for bone health and the prevention of Osteoporosis. |
 NOW Foods, Alfalfa, 650 mg, 500 Tablets | | |
Boosted vitality Most Useful Review 1 people found this helpful A wonderful addition to my diet! It is rich in proteins, carbohydrates, fibre, vitamins, and minerals (especially calcium, phosphorus, and iron). Alfalfa has assisted with menopause symptoms and has beneficial effects on Osteoporosis. It helps relieve nervous tension due to fatigue and enhances overall vitality. This unique medicinal plant is useful for various ailments, including chronic respiratory diseases. Moreover, it aids in the healing of bone fractures, improves the condition of bone tissue in Osteoporosis, and enhances metabolism. In essence, Alfalfa promotes health and wellness and is particularly beneficial for pregnant women to support calcium balance and the baby's bone formation. Stronger bones Most Useful Review 1 people found this helpful I truly appreciate alfalfa; it strengthens my bones as I have Osteoporosis. I feel much stronger since I started using it. Additionally, it aids my stomach problems and helps with constipation, proving to be an excellent detoxifier. |
 Natrol, Biotin, 10,000 mcg, 200 Tablets | | |
Vitamin D3 benefits Most Useful Review With a deficiency of vitamin D3 in women, the risk of various genitourinary diseases increases. During pregnancy, vitamin D3 aids calcium-phosphorus metabolism for a healthy gestation. Following menopause, the risk of osteoporosis significantly rises due to low estrogen. I took biotin for my hair, nails, and skin, and after one jar, I noticed a marked improvement. Prevents osteoporosis Most Useful Review It effectively prevents osteoporosis and balances immunity. I found it very beneficial and will certainly purchase it again! |
 NOW Foods, Selenium, 100 mcg, 100 Tablets | | |
Supports fertility Most Useful Review This wonderful product provides essential elements for the body, improving fertility and aiding in weight loss. It also promotes hair growth and is beneficial for osteoporosis. Overall, it is a fantastic product and represents great value for the price. Reduced fracture risk Most Useful Review Symptoms of selenium deficiency can include muscle weakness and pain, inflammation, increased fragility of red blood cells, and degeneration of the pancreas. This micronutrient is crucial for women, as it decreases osteoporosis risk during postmenopause. Additionally, it aids in hormone production, preventing dry mucous membranes, and is vital for pregnancy, supporting embryo implantation and placental development. |
 Life Extension, Super Selenium Complex & Vitamin E, 200 mcg, 100 Vegetarian Capsules | | |
Promotes better bones Most Useful Review Selenium is a crucial trace element in the body, obtainable through diet or supplements. It enhances metabolic health and protects against cardiovascular disease. Selenium promotes better bone formation and slows down bone loss, thus helping to prevent Osteoporosis, while also maintaining thyroid function and boosting the immune system. Enhances bone health Most Useful Review Selenium is essential for maintaining bone health, preventing Osteoporosis and fractures, while also promoting metabolic efficiency, aiding in fat loss and weight control, and supporting cardiovascular health by preventing related chronic diseases. |
 NOW Foods, Potassium Citrate, 99 mg, 180 Veg Capsules | | |
Supports bone health Most Useful Review I believe potassium citrate is an excellent supplement that promotes urinary tract health and lowers the risk of kidney stones. It enhances electrolyte balance and reduces dehydration risk, while also improving bone health and potentially diminishing the risk of osteoporosis. Overall, I find potassium citrate a worthwhile choice for enhancing health. Reduced osteoporosis risk Most Useful Review Potassium is an essential trace element that greatly diminishes the risk of swelling and stimulates enzyme production. Many people consume excessive salt while not getting enough potassium, leading to a deficiency. High potassium levels in the blood are associated with a significantly reduced risk of stroke and high blood pressure. Adequate potassium intake is also linked to better bone density and reduced osteoporosis risk. |
 Doctor's Best, Hyaluronic Acid + Chondroitin Sulfate with BioCell Collagen, 180 Veggie Capsules | | |
Highly beneficial treatment Most Useful Review 3 people found this helpful Excellent for my mother, who suffers from osteoporosis. She takes it every six months with a month’s break and finds it very helpful. Hyaluronic acid works wonders! At 75, her skin seems to have improved noticeably. I highly recommend it not just for older adults. It's essential to ensure our loved ones are doing well! Effective for osteoporosis Most Useful Review 1 people found this helpful Excellent! I've been buying this for my mother, who is 75. She's taken it for over five years, following a three-month regimen with a three-month break. It helps her significantly with osteoporosis. The packaging is convenient and hyaluronic acid is indeed effective. |
 NOW Foods, Mega D-3 & MK-7, 5,000 IU / 180 mcg, 60 Capsules | | |
Osteoporosis prevention Most Useful Review 5 people found this helpful MK-7 does not cause blood hypercoagulability, as it activates liver proteins involved in the coagulation system. It should be taken regularly with vitamin D3. Together, MK-7 and D3 direct calcium from blood vessels to bones, effectively preventing and reducing osteoporosis. I’m really pleased with this vitamin; the small capsule is easy to take. Regular intake of high doses of K2 helps lower cholesterol, aiding in the prevention of artery stiffening. Osteoporosis risk reduction Most Useful Review 3 people found this helpful This is the best balanced complex of vitamin D3 and MK-7. A deficiency in vitamin D3 not only leads to osteoporosis but also increases cancer risk. Chronic deficiency affects obesity, cardiovascular health, immunity, and reproduction. The presence of K2 (MK-7) enhances D3 absorption and directs calcium to bones. This complex raised my vitamin D3 levels from 10 to 67 in two months. I highly recommend it. |
 Doctor's Best, Alpha-Lipoic Acid 600, 600 mg, 180 Veggie Caps | | |
Pain minimised quickly Most Useful Review I am a 66-year-old woman with Osteoporosis and chronic pain in my right arm. After taking it alongside B12, I found the quality to be excellent and the packaging nice. My pain was minimised, and I noticed a difference within just 20 days. The size is convenient, and I will definitely order again ❤️. Optimises bone health Most Useful Review The product is well packaged and cost-effective. It aids in optimising bone health and balancing electrolytes, while also reducing Osteoporosis. |
 NOW Foods, Quercetin with Bromelain, 120 Veg Capsules | | |
Obvious effects noted Most Useful Review It has a noticeable effect on my mother's osteoporosis. Improves multiple health aspects Most Useful Review Quercetin enhances kidney function, promotes heart health, prevents cancer, combats ageing, treats osteoporosis of the bones, extends life, and delays the onset of old age. I take it with resveratrol and coenzyme as antioxidants. |
 NOW Foods, Resveratrol, 200 mg, 120 Veg Capsules | | |
Benefits osteoporosis treatment Most Useful Review 1 people found this helpful Resveratrol is a dietary supplement that helps block tumour cell proliferation and reduces the risk of osteoporosis, particularly during menopause. It also stimulates collagen synthesis and may significantly lower cardiovascular disease risks. It is a powerful antioxidant, more effective than vitamin E. The packaging was excellent and undamaged. Supports osteoporosis prevention Most Useful Review This product is effective for maintaining youth, especially for menopausal women. It reduces the risk of osteoporosis and promotes collagen synthesis. |
 NOW Foods, Boron, 3 mg, 250 Veg Capsules | | |
Improves bone strength Most Useful Review Boron, derived from organo-boron glycine by NOW Foods, supports bone strength and influences the metabolism of calcium, magnesium, and phosphorus. While boron deficiency is rare, it can contribute to osteoporosis and other health issues. I am pleased with this supplement and recommend it. Positive bone support Most Useful Review I found boron capsules of 3 mg beneficial for bone health. Boron aids in maintaining bone structure and is especially helpful for those with osteoporosis or at risk. It also enhances calcium metabolism and hormonal balance. My experience has been positive with no side effects, but individual reactions can vary. Consulting a physician is advised. |
 NOW Foods, UC-II® Joint Health with Undenatured Type II Collagen, 120 Capsules | | |
Beneficial for elderly Most Useful Review This product does wonders for my mum’s osteoporosis. She has experienced positive effects since taking it. His back pain reduced Most Useful Review 1 people found this helpful My husband has osteoporosis and after starting this treatment, he feels significantly better. He reports that his back pain has decreased substantially. |
 Jarrow Formulas, Vegan BroccoMax, 35 mg, 120 Veggie Capsules | | |
Preserves bone integrity Most Useful Review 71 people found this helpful Removes carcinogens and is excellent for the liver. The main active ingredient is sulforaphane glucosinolate, derived from broccoli seed extract. A metabolist-geneticist recommended it due to a detox breakdown in phase 2. Sulforaphane promotes the production of glutathione in healthy cells, while antioxidants also affect cancer cells. This product cleanses the cardiovascular system, combats Helicobacter pylori, improves digestion, and protects against cell destruction from sugar consumption. It also positively influences testosterone levels, aids brain recovery after injury, alleviates asthma and viral infections, reduces chronic inflammation, protects vision, preserves bones, and inhibits the development of osteoporosis. I firmly trust this brand and have purchased numerous products. Supports bone health Most Useful Review 57 people found this helpful Replacing broccoli with tablets is ideal for those reluctant to consume 100 grams of raw broccoli daily. However, studies show that tablet forms have only 5-8 times lower bioavailability than fresh broccoli. Activation by myrosinase is crucial. Broccoli in any form helps suppress protein glycation, promoting longevity and strengthening bones whilst contributing to the prevention of various cancers. It's especially valued for its anti-aging properties on skin. Additionally, broccoli boosts immunity and skin health, significantly reduces mortality, and is vital for blood clotting and bone health by preventing osteoporosis. It's prudent for users of anticoagulants to consult a physician before increasing broccoli intake. |
 Doctor's Best, Nattokinase, 2,000 FUs, 270 Veggie Caps | | |
High-quality supplement Most Useful Review 1 people found this helpful Nattokinase, discovered in Japan, is a potent enzyme from natto known for improving blood fluidity and preventing osteoporosis, strokes, and heart diseases. The Japanese greatly value traditional soy products, leading to their longevity. This quality supplement is an excellent alternative to aspirin for maintaining healthy blood density. Improves osteoporosis treatment Most Useful Review 118 people found this helpful Nattokinase is an incredibly beneficial enzyme that helps to normalise blood circulation and blood density. It is particularly effective for addressing osteoporosis and preventing strokes and heart attacks. I have noticed that my blood flow has improved significantly since I started taking it, and it has other positive effects like enhancing immunity and lowering cholesterol. This high-quality enzyme is an excellent alternative to aspirin. |
 NOW Foods, Dong Quai, 520 mg, 100 Veg Capsules | | |
Alleviates menopausal symptoms Most Useful Review 31 people found this helpful Perfect for my mother, who was advised by her gynaecologist-endocrinologist to take Angelica officinalis during menopause. The doctor mentioned that its phytoestrogens and vitamin E increase receptor sensitivity to oestrogens and support prostaglandin balance, reducing unpleasant symptoms. Moreover, it aids in preventing osteoporosis, is anti-inflammatory, antispasmodic, has mild sedative effects, and improves gastrointestinal health while also reducing blood viscosity due to ferulic acid. My mother now takes 2 drops daily alongside a multivitamin, and she reports an improvement in her symptoms. Helps with constipation Most Useful Review Angelica is highly effective for menopausal women, alleviating unpleasant symptoms and preventing the onset of osteoporosis. It possesses anti-inflammatory, antispasmodic, and mild sedative qualities while benefitting the stomach and intestines. It's especially helpful for relieving constipation linked to menopause. I urge women to give it a try. |