21st Century Acidophilus Probiotic Blend

Positive effects on gastrointestinal symptoms

Viramontes-Hörner D, Márquez-Sandoval F, Martín-del-Campo F, Vizmanos-Lamotte B, Sandoval-Rodríguez A, et al. Effect of a symbiotic gel (Lactobacillus acidophilus + Bifidobacterium lactis + inulin) on presence and severity of gastrointestinal symptoms in hemodialysis patients. J Ren Nutr. 2015;25:284. doi:10.1053/j.jrn.2014.09.008

Our research aimed to understand how a specific symbiotic gel, containing Lactobacillus acidophilus, affects gastrointestinal symptoms, including heartburn, in hemodialysis patients.

We conducted a double-blinded, placebo-controlled trial with 42 participants over two months. The group receiving the symbiotic gel reported significant improvements in the frequency and severity of symptoms like heartburn and stomachache compared to the control group.

Overall, the gel appeared safe with no adverse effects noted. More extensive studies are needed, but these findings suggest promising benefits for managing heartburn in dialysis patients.

Heartburn relief achieved

Most Useful Review

Excellent dietary supplement! I have been drinking probiotics for about five months and the result is evident. The heartburn and stomach pains that troubled me for a long time have vanished. Additionally, I have noticed fewer rashes on my face. I am very pleased with the product, and I hope to reorder soon when the political situation improves. My grandfather will also begin taking his pills and retire to his Gelendzhik castle.

Urinary Tract Infection details

Sadeghi-Bojd S, Naghshizadian R, Mazaheri M, Ghane Sharbaf F, Assadi F. Efficacy of Probiotic Prophylaxis After The First Febrile Urinary Tract Infection in Children With Normal Urinary Tracts. J Pediatric Infect Dis Soc. 2020;9:305. doi:10.1093/jpids/piz025

Based on 26 Researches

Probiotics improve UTI prevention

We explored the effectiveness of a probiotic mix, including Lactobacillus acidophilus, in preventing recurrent urinary tract infections (UTIs) in children. In a study involving 181 children aged 4 months to 5 years, half received the probiotics while the other half received a placebo over 18 months.

The results were significant. The probiotic group had a higher percentage of UTI-free patients and a longer median time before recurrence compared to the placebo group. This indicates that probiotics could be a helpful non-antibiotic option for preventing UTI recurrences in young children.

9.5

Effective probiotic

Most Useful Review

Excellent. A truly effective probiotic that delivers on its promise. My gastrointestinal tract quickly returned to normal after taking it. A bottle of 100 capsules lasts quite a while, and I recommend taking it for about 2-3 months continuously. The results have been impressive for a probiotic at this price.

Yeast Infection details

L. acidophilus shows promise against Candida

Based on 35 Researches

Vilela SF, Barbosa JO, Rossoni RD, Santos JD, Prata MC, et al. Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella. Virulence. 2015;6:29. doi:10.4161/21505594.2014.981486

We examined how Lactobacillus acidophilus ATCC 4356 can impact Candida albicans, the fungus responsible for yeast infections.

In our research, we studied both in vitro and in vivo. We found that L. acidophilus not only curbed biofilm formation and filamentation of C. albicans but also improved survival rates in Galleria mellonella larvae infected with this yeast.

The larvae given L. acidophilus showed fewer C. albicans, suggesting this probiotic strain might be beneficial in combating yeast infections.

9.5

Effective probiotic treatment

Most Useful Review

This probiotic significantly aided me after food poisoning and subsequent dysbiosis. Within days of taking one capsule daily, my symptoms such as bloating and nausea vanished. I recommended it to a friend post-surgery, and she enjoyed similar swift results. It's also utilised to create yogurt. The capsules are stabilised, meaning they require no special storage and are practically allergy-free. They contain beneficial bacteria and prebiotics to support intestinal health.

Autoimmune Disorder details

Probiotics help rheumatoid arthritis symptoms

Based on 23 Researches

Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. doi:10.1111/1756-185X.12888

This study explored how probiotic supplementation affects patients with rheumatoid arthritis (RA) over eight weeks.

We analyzed the results from sixty patients, split into groups receiving either probiotics or placebo.

The findings showed that those taking probiotics experienced a notable improvement in joint health, as well as reductions in insulin levels and inflammation markers.

We observed that the probiotics had a positive impact on overall metabolic health, significantly benefitting those with RA.

9.5

Normalised digestion

Most Useful Review

I noticed undigested food in my stools, so my doctor advised these probiotics. After several weeks of use, my tests normalised, and the doctor suggested I should periodically take this product.

We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.

In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.

However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.

This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.

9.5

Strength restores quickly

Most Useful Review

These probiotics provided significant support after my appendix was removed, especially following a course of antibiotics that had minimal effects. I noticed great efficacy and restoration of stomach function within days, even halting nausea. They are stable and safe for transportation, enhancing wellness dramatically.

Gastroesophageal Reflux Disease details

Cancelled doctor visit

I was having really bad stomachaches and issues 2-3 times per week. After making a doctor’s appointment, I started taking this product. A month later, I realised my appointment was the following week, but I hadn’t had a stomachache in weeks, so I cancelled it. I had been taking omeprazole, Dexilant, and all the GERD meds but became immune. Once I started this product, I stopped my GERD meds, and now haven’t taken them in years! When I run out, my acid reflux returns immediately. They seem more affordable than my past medications, so I’ll continue using them.

Headache details

Good composition, fast delivery, high-quality and convenient packaging with no damage. The capsules are slightly large but easy to swallow and taste citrusy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. I've noticed benefits already; prior to taking it, I frequently had headaches, nausea, and fatigue. Now, after 10 days, I feel more energetic, headaches have ceased, and my mood is excellent throughout the day. I recommend it for anyone interested in sports, fitness, or specific diets, as omega 3 revives and replenishes what the body lacks.

Heart Disease details

Probiotic lower cholesterol in mice

Damodharan K, Palaniyandi SA, Yang SH, Balaji S. Cholesterol-Lowering Activity of KS6I1 in High-Cholesterol Diet-Induced Hypercholesterolemic Mice. J Microbiol Biotechnol. 2024;35:e2404029. doi:10.4014/jmb.2409.04029

We investigated whether the probiotic KS6I1 could lower cholesterol levels in mice fed a high-cholesterol diet. Over six weeks, mice were divided into groups: one received the probiotic, another a positive control, and a third a normal diet.

The results were promising; the KS6I1 group showed significant reductions in both LDL and total cholesterol levels. They also had increased cholesterol and bile acid excretion in their feces.

This suggests that KS6I1 has potential as an alternative approach to managing high cholesterol and its associated heart disease risks.

9.5

Improves digestion significantly

Most Useful Review

This probiotic has transformed my intestinal function. Constipation has vanished, and my microbiome is healthier. I strongly recommend this supplement for anyone looking to enhance their intestinal absorption and overall health.

Hemorrhoids details

Effective remedy found

Excellent quality at an affordable price. I never thought I'd find a remedy for haemorrhoids that had troubled my mother for so long. Due to her blood pressure medication affecting her intestines, she developed constipation and consequently haemorrhoids. We tried many products, but only temporary relief was achieved. After starting a probiotic, her bowel movements returned to normal within weeks, the abdominal pain ceased, and the irritation in the rectal mucosa vanished. She got rid of haemorrhoids. Alongside the probiotics, she also used heparin ointment for inflammation. The capsules are easy to take, and I hope this product helps others with similar issues.

Indigestion details

Synbiotic improves digestive health

Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328

This study looked into how a specific synbiotic product, which includes Lactobacillus acidophilus along with other probiotics and fructooligosaccharides, affects digestive health among healthy adults. In a randomized, double-blind, placebo-controlled design, we monitored 36 participants—20 women and 16 men aged between 25 and 45 years—over six weeks.

Participants received either the synbiotic supplement or a placebo, taking three tablets daily. We gathered information on gastrointestinal symptoms and bowel habits through a self-administered questionnaire, focusing especially on those who experienced digestive disturbances like mild dyspepsia or bloating.

The results were promising; those who took the synbiotic product reported significant improvements in their overall gastrointestinal well-being and bowel movements. Interestingly, we also noted a reduction in a specific immune marker, L-selectin, in the synbiotic group, which could indicate a favorable shift in their immune profile. However, while the improvements in gut health were noteworthy, none of the other immunological parameters were significantly altered.

In summary, this study suggests that including Lactobacillus acidophilus as part of a synbiotic supplement can lead to better digestive comfort and may influence immune-related markers positively. However, pinpointing the exact effect of this specific strain on indigestion alone is challenging, given the multi-strain nature of the synbiotic treatment.

9.5

Relieves indigestion

Most Useful Review

I suffered from severe indigestion and high acidity, but after using this wonderful mixture, I felt a renewed appetite and relaxed intestines. I am grateful for this product's effectiveness.

Acne details

Renye JA, Mendez-Encinas MA, White AK, Miller AL, McAnulty MJ, et al. Antimicrobial activity of thermophilin 110 against the opportunistic pathogen Cutibacterium acnes. Biotechnol Lett. 2023;45:1365. doi:10.1007/s10529-023-03419-2

Potential acne treatment evaluated

We investigated the antimicrobial properties of thermophilin 110, a substance made by Streptococcus thermophilus, on the acne-related bacteria, Cutibacterium acnes. The study revealed that thermophilin 110 could significantly inhibit the growth and biofilm formation of C. acnes, especially at higher concentrations.

While it shows promise as a treatment option, current gel formulations struggle to release the bacteriocin effectively. Future improvements could turn these gels into effective delivery systems for targeting acne bacteria.

Effective for acne

Most Useful Review

I began taking this for health reasons, but it's significantly improved my acne. I used to have problematic skin, trying various supplements, but this probiotic has been the most effective. After about two weeks, I noticed no acne on my face. If you struggle with rough skin, I highly recommend giving this a try. I hope it helps!

Allergies details

Acidophilus reduces allergy symptoms

Based on 69 Researches

Li AL, Meng XC, Duan CC, Huo GC, Zheng QL, et al. Suppressive effects of oral administration of heat-killed Lactobacillus acidophilus on T helper-17 immune responses in a bovine β-lactoglobulin-sensitized mice model. Biol Pharm Bull. 2013;36:202.

We investigated how Lactobacillus acidophilus might affect allergy responses using a mouse model allergic to bovine β-lactoglobulin. The mice received varying doses of heat-killed L. acidophilus over several weeks prior to allergen exposure.

Our findings revealed that this treatment significantly reduced allergic reactions, including less inflammation and lower levels of IgE. We observed shifts in immune markers indicating improved balance in immune responses.

However, while there were beneficial effects observed, the overall significance of these findings needs further research.

9.5

Minimises allergies

Most Useful Review

Very good probiotics! This product contains four essential bacteria types at a good concentration. I noticed improved skin and reduced allergies in my child after giving him one capsule. It has helped immensely with his digestion issues from birth. I highly recommend it for anyone looking to boost immunity and minimise allergies!

Bloating details

Lactobacillus acidophilus reduces bloating

Based on 38 Researches

Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011;45:518. doi:10.1097/MCG.0b013e31820ca4d6

In a double-blind, placebo-controlled study, we investigated the effects of Lactobacillus acidophilus (L-NCFM) and Bifidobacterium lactis (B-LBi07) on bloating in patients with functional bowel disorders. Over 8 weeks, those taking the probiotics reported a significant improvement in abdominal bloating compared to the placebo group at both 4 weeks and 8 weeks.

The results were especially notable in patients with irritable bowel syndrome. This study highlights the potential of specific probiotics in managing bloating symptoms and emphasizes the importance of intestinal bacteria in gut health.

9.5

Reduced bloating

Most Useful Review

Taking these probiotics significantly improved my digestion. The bloating and heaviness in my stomach decreased, bringing my stool back to normal. I feel much lighter with them. They are also the most affordable probiotics available while maintaining excellent quality.

Candidiasis details

Lactobacillus impact on candidiasis

Likely Very Effective

ElFeky DS, Awad AR, Shamseldeen AM, Mowafy HL, Hosny SA. Comparing the therapeutic potentials of vs. against vulvovaginal candidiasis in female rats: an study. Front Microbiol. 2023;14:1222503. doi:10.3389/fmicb.2023.1222503

We set out to explore how lactobacillus acidophilus, specifically strain B-2178, impacts vulvovaginal candidiasis (VVC) in female rats. By dividing our study subjects into five groups, we included controls and examined the effects of different treatments.

In particular, we analyzed the immune response of the vaginal tissue after intravaginal inoculation to establish VVC. The rats treated with strain B-2178 showed a promising ability to maintain an immune-tolerant state in the vaginal epithelium. Through this action, it seemed capable of reducing uncontrolled inflammation, which is often a challenge during candidiasis.

Although our findings suggest that B-2178 may be beneficial in treating VVC, it's important to note that the overall focus was broader and did not isolate lactobacillus acidophilus alone. This makes it difficult to pinpoint the specific advantages of this particular strain compared to others.

Ultimately, it appears that while B-2178 exhibits potential, more targeted research is required to evaluate its effectiveness in isolating and addressing candidiasis comprehensively.

Effective for partner

Most Useful Review

As someone with Crohn's disease, this probiotic greatly helps maintain my intestinal microbiota. My girlfriend had recurrent candidiasis, but since using this probiotic, she has had no further episodes. The formula is diverse, reasonably priced, and the number of capsules is generous.

Chest Pain details

Only with their help did I cope with pain and discomfort in my stomach and gastrointestinal tract. I will always order as it really works. I'm quite pleased!

Ear Infection details

Potential in ear infection treatment

Algburi AR, Jassim SM, Popov IV, Weeks R, Chikindas ML. Lactobacillus acidophilus VB1 co-aggregates and inhibits biofilm formation of chronic otitis media-associated pathogens. Braz J Microbiol. 2024;55:2581. doi:10.1007/s42770-024-01363-5

We evaluated how Lactobacillus acidophilus might help with ear infections by analyzing its antibacterial properties, both alone and alongside ciprofloxacin. The study revealed that L. acidophilus effectively co-aggregated with harmful bacteria and showed significant activity against some pathogens associated with chronic otitis media.

Although we found it beneficial in certain combinations, there were also cases where its effects were counterproductive. Overall, while L. acidophilus shows promise as a complementary treatment for bacterial ear infections, its effectiveness may vary depending on the specific bacteria involved.

9.5

Saved from infection

Most Useful Review

I'm delighted with this product! I take it regularly, and it's truly effective. My child's intestinal health has improved, with no constipation issues. It has saved us from infections, improved absorption, fixed the microbiome, and enhanced digestion. Overall, it's been nothing but beneficial – a fantastic supplement. I've even used it to ferment milk alongside antibiotics, and everything has improved significantly.

Eczema details

Lactobacillus acidophilus helps eczema

Based on 7 Researches

Kim WK, Jang YJ, Park S, Min SG, Kwon H, et al. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. J Microbiol. 2024;62:91. doi:10.1007/s12275-024-00104-5

We explored the potential of Lactobacillus acidophilus KBL409 in addressing atopic dermatitis, a common form of eczema. By using a mouse model induced by house dust mites, we found that administering this probiotic led to significantly lower dermatitis scores and less immune cell infiltration in the skin.

Additionally, L. acidophilus KBL409 reduced serum immunoglobulin E and influenced various cytokines linked to inflammation. It also positively affected gut microbiota and concentrations of beneficial compounds, hinting at a broader impact on our immune responses. Overall, our findings suggest that L. acidophilus KBL409 may be a promising probiotic for eczema management.

9.5

Eczema improved significantly

Most Useful Review

Super !!! Hello, my name is Olga. These capsules are the best I have ever purchased. I have suffered from constipation since childhood and have tried everything available, but the eczema persisted. After taking these capsules for five days, I was able to go to the toilet comfortably. Subsequently, my eczema started to fade, and the nasal congestion I had for two months also began to clear up. The value is excellent; 150 capsules for a great price compared to the pharmacy. I've even started giving them to my child, and his stool has improved too. I recommend these for boosting immunity. A fantastic product.

Erectile Dysfunction details

After my Covid illness, I consumed these bacteria due to intestinal dysfunction. I took one capsule before bed for three months. My intestinal function improved after a month, and I experienced no discomfort. I plan to continue after a break. I highly recommend these bacteria! This isn't my first jar; they work better for me than others I’ve tried, especially during the autumn-winter period.

Hypothyroidism details

Effective stomach relief

It works well for me. Although I've always faced digestive issues due to hypothyroidism, now my toilet trips are hassle-free. I easily open the capsule and pour the powder beneath my tongue. The taste is pleasant, with a hint of sourness, and I appreciate the effect. After taking hard antibiotics following a major operation, this acidophilin has helped restore normal stomach function. It will always be a staple in my medicine cabinet. Thank you for a fantastic product!

Pancreatitis details

Eliminated supplements

I definitely recommend this product. I have chronic pancreatitis and irritable bowel syndrome, and after trying numerous domestic products, found this one to be cheap and very effective. I no longer need any prebiotics or enzymes from the pharmacy. My persistent digestive issues have resolved with just 1-2 capsules a day. I’m grateful to the producers and will reorder!

Rash details

Probiotics reduced rash incidence

Dotterud CK, Storrø O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. Br J Dermatol. 2010;163:616. doi:10.1111/j.1365-2133.2010.09889.x

We examined the impact of probiotics on preventing rash and allergic diseases in children. In a well-structured, randomized trial, pregnant women received either probiotic milk or a placebo from late pregnancy through breastfeeding.

Our findings indicated that probiotics reduced the incidence of atopic dermatitis (AD) in children by nearly half compared to those who received a placebo. However, these probiotics did not appear to prevent atopic sensitization or other allergic conditions.

Overall, while acidophilus and related probiotics show promise in reducing allergic rashes, they may not guard against broader allergic issues.

9.5

Rash cleared up

Most Useful Review

Our family takes probiotics in courses as we dislike sour milk products. I take them at night before bed. My daughter’s face cleared of rashes after two months. She also takes selenium and zinc, and I believe the combination has been beneficial. I will certainly buy more, as the price is reasonable and the quality is far better than that of our local pharmacy’s probiotics.

Salmonella details

Effective against salmonella

Inexpensive and effective, this stabilised probiotic contains four types of microorganisms and prebiotic fructooligosaccharides. The large package features transparent capsules of medium size with a slight condensed milk aroma. The recommended dosage is one capsule daily with meals. It contains Lactobacillus Acidophilus, which produces lactic acid, creating an acidic environment unfavourable for acid-sensitive pathogens such as staphylococcus and salmonella; Lactobacillus Salivarius, beneficial for inflammatory bowel disease and irritable bowel syndrome; and Bifidobacterium Bifidum, offering an antidiarrhoeal effect by antagonising pathogens, including salmonella, and enhancing intestinal health. I use this product in courses of 10-14 days as needed, storing it in the fridge after opening.

Tonsillitis details

Highly effective probiotics

Better than Linex! I purchased Atsidofolin to replenish our first aid kits. While on antibiotics for treating tonsillitis in my child, we usually used Linex but still faced issues with diarrhoea. This product proved far more effective! I experienced no intestinal reactions; I only needed to take one capsule a day, totalling five capsules. I'm absolutely delighted! It's long-lasting too!

Ulcer details

Effective ulcer treatment

Highly recommend! The 21st Century Acidophilus Probiotic Blend is top-rated. My mum and sister also praised these probiotics. I'll share my story that led me to this product. In January 2020, my duodenal ulcer flared up again. I followed a gastroenterologist’s recipe for eradicating Helicobacter pylori, which involved two strong antibiotics and a proton pump inhibitor for 10 days. This unfortunately eliminated beneficial microflora too. After the treatment, I began taking the probiotics twice a day for three weeks, and by March, my intestinal issues, including flatulence and irregular stools, had disappeared. I now take one capsule weekly as a precaution. These probiotics can be stored at room temperature, but I keep mine in the fridge. I highly recommend them!

Abscess details

The best probiotics I've ever tried! The results are evident; my stomach has been less bloated since the first few days of use. I will order more for my relatives as the price is exceptional for the quality and quantity offered.

Asthma details

Lactobacillus acidophilus reduces inflammation

Based on 3 Researches

Mastrandrea F, Coradduzza G, Serio G, Minardi A, Manelli M, et al. Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects. Eur Ann Allergy Clin Immunol. 2004;36:118.

We explored how the probiotic mixture ENDOLAC, containing Lactobacillus acidophilus, influences asthma-related allergic inflammation. In a study with 14 participants suffering from asthma and other allergic conditions, we measured the levels of circulating CD34+ Hemopoietic Precursors (HPC) before and after 30 days of treatment.

After taking the probiotic daily, participants showed a significant decrease in CD34+ cell counts, indicating that Lactobacillus acidophilus may help improve allergic responses. These findings suggest that integrating this probiotic into standard treatments could enhance their effectiveness for allergy management.

8.8

Rapid recovery

Most Useful Review

My mother-in-law suffers from asthma and often requires hospitalisation during autumn and late winter for antibiotics to alleviate her attacks. The recovery post-hospitalisation is challenging, as she struggles to eat anything. However, after taking a course of two tablets at night, her condition improved significantly, and she started to recover steadily.

Celiac details

I bought this for my wife, who has celiac and requires constant supplementation. The packaging size is a good value. She feels her digestion improves with probiotics. The quality seems good, and it has a neutral flavour with no bloating, unlike other brands.

Cold Sores details

I find this probiotic life-saving, especially after even slight colds, which often lead to digestion issues. Previously, I relied on expensive probiotics that provided only temporary relief. However, this one starts working in just 1-3 days. I will definitely continue using it.

Colitis details

I’m not new to this, as these capsules genuinely work. During episodes of diarrhoea and colic, I take two capsules thrice a day, adjusting the amount based on my condition. My children also benefit, and these probiotics significantly help with my Colitis, normalising my stools. Highly recommend!

Common Cold details

Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54:682. doi:10.1111/j.1442-200X.2012.03647.x

Based on 2 Researches

Probiotics reduced cold symptoms

We assessed the impact of a two-strain probiotic, Lactobacillus acidophilus and Bifidobacterium bifidum, on common cold symptoms in schoolchildren through a double-blind randomized controlled trial.

Over three months, children aged 8-13 in Thailand received either the probiotics or a placebo.

We found a significant reduction in cold symptoms and school absenteeism among those taking the probiotic, along with lower rates of fever and cough. Overall, this suggests probiotics could be beneficial in managing cold symptoms for school-aged kids.

9.5

Alleviated digestive issues

Most Useful Review

I've found it excellent for improving digestion and increasing beneficial bacteria, which has alleviated my constipation and bloating. Note: consult a doctor if you have Candida as it may not be advisable.

Depression details

Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. [Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. Vopr Pitan. 2021;90:63. doi:10.33029/0042-8833-2021-90-2-63-72

Based on 15 Researches

Probiotics reduce anxiety in rats

We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.

In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.

Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.

8.8

Overall health benefits

Most Useful Review

Truly incredible! A beautiful probiotic product with high quality and useful ingredients. The 150-capsule package is perfect. It offers numerous advantages for overall health, containing beneficial bacteria to protect the digestive system. It supports digestion and is effective for constipation and diarrhoea. Additionally, it promotes heart health by lowering blood pressure and reducing harmful cholesterol. It's particularly beneficial for those taking medication, relieving anxiety and depression, while also enhancing skin health and aiding in weight loss. Taken once daily on an empty stomach in the morning—thank you!

Floaters details

I cannot live without this in my routine. I was so accustomed to feeling floaters and blocked up, but this product has truly changed my life. I no longer experience those issues.

Gastritis details

Lactobacillus mitigates gastric inflammation

Based on 14 Researches

Shen S, Ren F, Qin H, Bukhari I, Yang J, et al. NCFM and Lp-115 inhibit colonization and gastric inflammation in a murine model. Front Cell Infect Microbiol. 2023;13:1196084. doi:10.3389/fcimb.2023.1196084

We explored how Lactobacillus strains, specifically NCFM and Lp-115, can help with gastritis caused by H. pylori. By testing them on human gastric cells and in mice, we assessed their ability to prevent H. pylori adhesion and manage inflammation.

The results showed that both strains significantly reduced the colonization and inflammatory responses in the stomach, evidenced by lower markers for inflammation and improved immune cell infiltration.

Overall, NCFM and Lp-115 appear to be promising options for helping to manage gastritis-related symptoms.

9.5

Bloating has disappeared

Most Useful Review

It saved me from gastritis. I take it alongside a complex of mushrooms and lecithin. The capsules are slightly larger than usual, but there are no side effects. I take one capsule during or after a meal. The package, holding 150 capsules, provides a six-month course of treatment, which I highly recommend. Even bloating and flatulence have disappeared.

Hashimoto details

This product has truly benefited my stomach. It enables me to eat foods that I would normally struggle to digest and keeps my stomach healthy. I suffer from Hashimoto, which is associated with leaky gut syndrome. I take 2-3 capsules before eating certain foods and 2 before bedtime.

High Cholesterol details

Based on 16 Researches

KS6I1 probiotic lowers cholesterol

We examined how the KS6I1 probiotic impacts cholesterol levels in mice fed a high-cholesterol diet. Over six weeks, mice receiving KS6I1 showed significant reductions in LDL cholesterol and total cholesterol compared to those only on a high-cholesterol diet.

Notably, the KS6I1 group also increased the amount of cholesterol and bile acids in their feces, suggesting better cholesterol excretion. While the results are promising, indicating potential for KS6I1 as a cholesterol-lowering probiotic, further research is necessary to confirm these effects in humans.

9.5

Health strengthens observed

Most Useful Review

The quality is superb, and the ingredients are excellent. I found the size to be average and suitable for adults. After a month of taking these probiotics, I noticed significant improvements: constipation disappeared, digestion improved, and my health strengthened overall. The packaging is also of high quality. I highly recommend these probiotics for their effectiveness.

Pneumonia details

Probiotics reduce respiratory infections

Based on 9 Researches

Khan Laghari I, Nawaz T, Mustafa S, Jamali AA, Fatima S. Role of multi-strain probiotics in preventing severity and frequency of recurrent respiratory tract infections in children. BMC Pediatr. 2023;23:505. doi:10.1186/s12887-023-04338-x

We explored the potential of probiotics, specifically Lactobacillus acidophilus, in reducing the severity and frequency of respiratory tract infections in children. Conducted at Abbassi Shaheed Hospital, our study analyzed 70 children over six months who received probiotics for two weeks.

Our results showed a significant decline in respiratory symptoms and infections among the participants. Overall, this suggests that probiotics can indeed play a beneficial role in supporting children's respiratory health.

9.5

No microflora issues

Most Useful Review

This is my second order for this prebiotic. My husband and I caught covid-19, which led to pneumonia. We took antibiotics alongside this prebiotic. Despite the usual struggles with microflora after antibiotics, we experienced none this time. It works much better than previous products from the pharmacy. I recommend it.

Swollen Lymph Nodes details

Improved digestive health

After giving birth, my gastrointestinal tract suffered immensely; I experienced stomach aches and upset stools. On my gynaecologist's advice, I began a course of probiotics, and the results were undeniably positive. My stomach no longer swells, flatulence has disappeared, and my stools have improved. I'm incredibly pleased with the outcome. Health to all!

Whooping Cough details

This is the best remedy for cough related to GERD. It’s my second purchase because it has been life saving; I endured GERD for the past two years, and anything I ate that didn't agree with me caused a miserable cough. After taking acidophilus, my cough subsides within minutes, and I am feeling better overall. It effectively addresses GERD-related symptoms.

Cold details

Love this product! I've used it for 15 years, and I'm grateful Amazon stocks it! It's less expensive than at my local pharmacy. While people may debate supplements, I can assure you my digestive issues are nearly non-existent. During cold and flu season, I take 2-3 per day as a teacher, and it keeps the stomach bugs at bay!

Anemia details

I have anemia and take iron supplements, but did not see the desired results despite reading other reviews. I decided to purchase this product, and it feels wonderful. I will continue using this alongside my iron supplements.

Appendicitis details

I regularly consume probiotics, as they help with my gastrointestinal health post-appendicitis. I take one capsule each morning on an empty stomach, 30 minutes to an hour before breakfast. They are effective, and my gut expresses its gratitude!

Back Pain details

Constipation resolved

These probiotics are exceptional! They have effectively eliminated my bloating and constipation, making my stomach feel smaller and more comfortable. Despite trying other expensive brands, I always return to these as my go-to supplement. I highly recommend them for their quality and effectiveness!

Bone Pain details

Life quality improved

This probiotic has changed my quality of life. I always had weak intestinal flora, and after using it, I experienced gas and abdominal pain initially. However, after a month, these issues vanished, my immunity improved, and my bowel movements became regular and easier.

Brain Tumor details

Enhanced digestive health

My delight! My skin has cleared and age spots have vanished. The intestine truly acts as our second brain, influencing metabolism and nutrient absorption. I’ve adopted a diet comprising fresh vegetables, greens, fruits, and reduced sugar. After cleansing my body of toxins, integrating probiotics was beneficial. Following just one dose, my stomach feels lighter, and my complexion is improving. I’m excited about my ongoing journey with prebiotics!

Cancer details

Probiotics show promise against colorectal cancer

Based on 16 Researches

Saffar KN, Larypoor M, Torbati MB. Analyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines. Mol Biol Rep. 2024;51:122. doi:10.1007/s11033-023-09008-w

This study focused on how Lactobacillus acidophilus and Saccharomyces cerevisiae might affect colorectal cancer cells. We discovered that these probiotics could effectively reduce the growth of cancer cells in two specific lines, HT29 and SW480.

Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.

8.8

Reduced tumor growth

Most Useful Review

Excellent product. If used correctly, Lactobacillus acidophilus makes a great contribution to the human body, particularly on three fronts: increasing antimicrobial activity, strengthening the intestinal barrier, and stimulating the immune system. The immunological benefits are significant; L. acidophilus can modulate the immune response by enhancing lymphocyte proliferation. This leads to reduced tumour growth, the inhibition of bacterial cancer enzymes, and lower production of the cytokine that shields tumours from immune surveillance.

Diarrhea details

Lactobacillus effectively reduces diarrhea

Based on 79 Researches

Fan W, Zhu Y, Hou H, Yao J, Zhu L, et al. Treatment and prevention of pigeon diarrhea through the application of Lactobacillus SNK-6. Poult Sci. 2024;103:103476. doi:10.1016/j.psj.2024.103476

We explored the impact of Lactobacillus salivarius SNK-6 on treating and preventing diarrhea in pigeons. In our research, we compared healthy pigeons with those infected with specific strains of E. coli known to cause diarrhea. After administering L. salivarius SNK-6, we observed a notable reduction in diarrhea among treated pigeons, while control pigeons still experienced a 10% incidence of diarrhea. This suggests that boosting levels of Lactobacillus can help maintain a healthy balance in the gut, potentially preventing diarrhea in the future.

9.5

Effective treatment

Most Useful Review

I recently had a severe flu and took antibiotics, raising the need for probiotics. I chose the 21st Century Acidophilus Probiotic Blend after reading reviews. The capsules are large but easy to swallow, with no taste. I took one daily while on antibiotics, and it worked well; I had no issues with diarrhoea afterwards. It seemed effective in maintaining digestive balance. I would recommend it for its action, effect, cost, and the number of capsules.

Menopause details

MENOLACTO alleviates menopausal symptoms

Lim EY, Lee SY, Shin HS, Lee J, Nam YD, et al. The Effect of YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. J Clin Med. 2020;9. doi:10.3390/jcm9072173

This study explored how MENOLACTO, a form of lactobacillus acidophilus, can help women manage menopausal symptoms. We conducted a rigorous, randomized, double-blinded, placebo-controlled trial with women aged 40 to 60, measuring the effectiveness through various symptom scores and quality of life assessments.

After 12 weeks, we observed a significant decrease in total menopausal symptom scores compared to placebo. Participants also reported improvements across all quality of life metrics. However, we found no notable differences in hormone levels or endometrial thickness between the groups. Overall, MENOLACTO showed promise as a supportive option for alleviating menopause symptoms.

9.5

Relieved constipation

Most Useful Review

As a woman in my 50s, I had difficulty going due to weakened intestinal movement linked to menopause. This probiotic is the right size and doesn't feel like it's blocking my throat. Previously, I tried Biothree which caused bloating and gas. This one solved my problems immediately, and I'm very pleased with the price.

Multiple Sclerosis details

Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. doi:10.1007/s12017-025-08837-1

Questionable

Based on 2 Researches

Lactic acid bacteria show promise

We explored how Lactobacillus and Bifidobacterium from traditional dairy might help with multiple sclerosis. In a study with 48 male rats, we induced demyelination and then supplemented with various lactic acid bacteria.

The results were promising! The bacteria helped reduce behavioral deficits, oxidative stress, and demyelination. Additionally, we noticed an increase in important vitamins D and B levels.

While more research is needed, these findings suggest a possible new avenue for treating demyelinating disorders like multiple sclerosis.

7.5

Improved wellness

Most Useful Review

I started using these probiotic capsules daily to enhance my digestive and immune health. After a month, I noticed significant improvement in my digestive regularity, and my occasional stomach discomfort had lessened. My energy levels felt more stable throughout the day. The capsules are easy to take with meals, and I appreciate the multiple probiotic strains included. At a reasonable price, they offer a straightforward, effective way to boost the good bacteria in my gut. I will continue taking them for overall wellness.

Polycystic Ovary Syndrome details

Lactobacillus acidophilus, taken alone or with other beneficial bacteria and prebiotics in milk or yoghurt, can aid in cholesterol reduction and alleviate symptoms of irritable bowel syndrome (IBS), which include abdominal pain, bloating, and flatulence. While the cause of Polycystic ovary syndrome (PCOS) is not entirely understood, some studies suggest it may be linked to specific gut bacteria. Research has shown that a strain of Lactobacillus acidophilus can reduce abdominal pain in individuals with PCOS. In conclusion, Lactobacillus acidophilus can alleviate symptoms associated with PCOS, like bloating and discomfort, but only with long-term use; a single dose does not produce significant effects.

Anxiety details

Lactobacillus anxiolytic effects proven

We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.

9.5

Supports anxiety relief

Most Useful Review

Really amazing! This probiotic product is of high quality with beneficial ingredients. The 150 capsules provide great value. It safeguards the digestive system and supports overall health. It's very effective for constipation and diarrhoea, promotes heart health by lowering blood pressure and harmful cholesterol, and is particularly helpful for stress relief. For those on medication, it can alleviate anxiety and depression. It also benefits skin health and aids in weight loss, best taken first thing in the morning on an empty stomach. Thank you for this excellent product!

Gastroenteritis details

Probiotics may reduce diarrhea duration

Based on 7 Researches

Higuchi T, Furuichi M, Maeda N, Tsugawa T, Ito K. Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan. J Infect Chemother. 2024;30:337. doi:10.1016/j.jiac.2023.11.005

We explored the impact of Lactobacillus acidophilus and other probiotics on children suffering from acute gastroenteritis. Our systematic review included randomized controlled trials comparing probiotics to placebos, focusing on strains available in Japan.

Although we found that probiotics like Lactobacillus acidophilus might shorten diarrhea duration by roughly one day, the evidence is not very strong.

Overall, while there were some positive signs in our findings, we recommend more research to confirm these effects and improve treatment strategies.

8.8

Effective for gastroenteritis

Most Useful Review

Works for gastroenteritis and ulcers. I was initially sceptical, but this definitely works. I suffer from severe gastroenteritis, possibly an ulcer and IBS, and I noticed a difference after starting these. Just one capsule a day sufficed for me. However, when my stomach was healthy, I didn’t see much change, suggesting that if you don’t have serious digestive issues, the effects may not be as pronounced. I paused taking them for two years but returned, and they still worked! However, be cautious with frequent constipation; high doses of acidophilus can worsen it. It's more effective for diarrhoea. People often overlook this, leading to complaints. For constipation, one requires bifidum. This blend includes bifidum too but check the dosage of acidophilus to avoid complications. My only issue is that they contain gelatin and whey, which I overlooked when purchasing.

Irritable Bowel Syndrome details

Probiotics enhance IBS treatment outcomes

Based on 55 Researches

Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;72:233.

In our clinical trial, we examined the effects of a probiotic combination of Lactobacillus acidophilus and L. plantarum on patients with diarrhea-predominant irritable bowel syndrome (IBS-D). We randomly assigned 100 participants to standard IBS treatment or the same treatment plus probiotics over 12 weeks.

Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.

9.5

Regular bowel movements

Most Useful Review

This probiotic has greatly helped my irritable bowel syndrome since childhood. I used to have stool problems and bloating, but after taking one tablet at night, I now have regular bowel movements twice a day. The gassiness has decreased significantly too. I will continue to order it and plan to share it with my mother as well.

Leg Cramps details

For leg cramps caused by sciatica, I have paralysis in my legs, and if they are cold or my blood flow is poor, I experience cramps. I often find myself getting cramps during the summer nights, so I take this supplement. When I do, it seems to prevent the cramps effectively.

Pelvic Pain details

Lactobacillus association with pelvic pain

Questionable

Based on 2 Researches

Abernethy MG, Rosenfeld A, White JR, Mueller MG, Lewicky-Gaupp C, et al. Urinary Microbiome and Cytokine Levels in Women With Interstitial Cystitis. Obstet Gynecol. 2017;129:500. doi:10.1097/AOG.0000000000001892

We examined the urinary microbiome of women with interstitial cystitis and found it less diverse and containing fewer Lactobacillus acidophilus compared to a control group.

This lack of Lactobacillus was linked to more severe symptoms and poor quality of life. While we noted some associations between higher inflammatory markers and the severity of symptoms, we didn’t see a clear causal relationship.

Essentially, we’re still unsure if the presence of Lactobacillus can effectively reduce pelvic pain in this context.

9.5

Appetite improved

Most Useful Review

After Covid, I lost my appetite and weight, faced issues with irritable bowel and malabsorption. The doctor recommended probiotics, which I've taken for two months. My appetite, particularly at lunchtime, has returned, and the stomach pain has vanished, as did the discomfort during self-massage. A balanced intestinal microflora is crucial for immunity; with it, I no longer have vitamin K deficiency, which intestinal bacteria synthesise. I have also ordered an omega supplement from this series.

Reflux details

Probiotic supplement reduces GERD symptoms

Tursi F, Benedetto E, Spina A, De Ponti I, Amone F, et al. Efficacy of a Food Supplement Containing LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease. Nutrients. 2024;16. doi:10.3390/nu16111759

We aimed to find out how a food supplement containing probiotics, peptides, and vitamins impacts individuals with mild-to-moderate gastroesophageal reflux disease (GERD). In a thorough study, 56 participants were divided into two groups; one received the active supplement while the other got a placebo for 28 days.

The results were promising, showing a notable decrease in heartburn frequency and severity for those on the supplement. Additionally, they reported taking fewer over-the-counter medications, and their quality of life improved compared to the placebo group. This suggests that dietary supplements might offer a beneficial alternative for managing GERD symptoms.

9.5

Prevents stomachaches

Most Useful Review

I used to have severe stomachaches two to three times weekly. After starting these, I cancelled my doctor’s appointment as I hadn’t experienced pain in weeks. I had become resistant to all GERD medications. Since using this product, I’ve managed to stop taking those meds for years, but my acid reflux returns quickly if I run out. They are more affordable than my previous prescriptions, so I will continue using them.

Stroke details

I absolutely recommend this! This isn't the first time I've used it. It's an excellent probiotic that I took when unwell and needing antibiotics. Thankfully, there were no side effects—no diarrhoea or candida. My mother-in-law experiences frequent constipation after her stroke, but this helps her significantly; she takes it daily. I also make kefir from it, and it turns out brilliant. It's certainly more economical than pharmacy prices with better quality. Highly recommend!

Constipation details

Probiotics improve constipation symptoms

Based on 59 Researches

Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308

We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.

The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.

Effective treatment

Most Useful Review

Excellent! I’ve suffered from constipation for over 15 years, leading to haemorrhoids. This product modifies bacteria in my digestive system and has resolved my constipation! It also removes toxins and is best taken before bed. It has been a remarkable addition to my routine and significantly improved my digestive health.

Liver Disease details

Following a nutritionist's advice, I consumed this product while cutting out sweets, milk, and pastries due to liver and digestive issues. After several days, I noticed a positive outcome; my metabolism normalised, and my stomach felt light after meals. I decided to purchase a large package for future courses and would recommend this to others.

Adenoiditis details

I've used this not for the first time and have bought multiple packs, as my friends highly recommend it. The product truly enhances immunity and normalises the microflora in all mucous membranes, effectively inhibiting harmful bacteria. I take one capsule daily for prevention and maintenance of immunity, and two when I sense a sore throat or stuffy nose. It's the best alternative to antibiotics in the Russian pharmacy, without exaggeration.

Cardiovascular Disease details

Fermented soymilk supports heart health

Based on 16 Researches

Chen J, Wu Y, Yang C, Xu X, Meng Y. Antioxidant and hypolipidemic effects of soymilk fermented via Lactococcus acidophilus MF204. Food Funct. 2017;8:4414. doi:10.1039/c7fo00701a

This study explored how soymilk fermented with Lactococcus acidophilus influenced cardiovascular health in rats on a high-fat diet. We found that the fermented soymilk effectively reduced harmful lipid levels and improved antioxidant enzyme activity.

Notably, it significantly lowered indicators of arterial and coronary health risks compared to traditional hypolipidemic drugs. The results suggest that incorporating fermented soymilk may offer a natural way to support heart health and alleviate hyperlipidemia.

9.5

Effective for inflammation

Most Useful Review

To enhance my oral health, I purchased this to accompany biotin. After noticing my gums were swollen due to previous tooth decay, I learned Lactobacillus acidophilus could be helpful. I directly applied it to my gums, and the swelling reduced significantly within an hour. It seems quite beneficial for improving and preventing periodontal disease.

Chronic Cough details

Constipation resolved

I purchased this for my son, who suffered from chronic constipation for ten years. Today, he no longer experiences these issues and is extremely happy. Highly recommend!

Blood Clot details

Stimulates circulation

Amazing! This supplement really helps to improve and stimulate blood circulation, serving as a nutritional boost for beneficial bacteria.

Sleep Apnea details

I've tried various probiotics but none have worked as effectively as this one. Taking it before bed allows me to sleep deeply, with fewer interruptions—waking just once instead of two or three times. My bowel movements are also regular, reflecting my great condition.

Nausea details

Probiotic alleviates nausea effectively

Based on 7 Researches

Diop L, Guillou S, Durand H. Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Nutr Res. 2008;28:1. doi:10.1016/j.nutres.2007.10.001

In a well-structured, double-blind trial, we investigated how the probiotic preparation, Probio-Stick, influences gastrointestinal symptoms linked to stress. Volunteers experiencing stress-related issues received either the probiotic or a placebo over three weeks.

We observed that those taking Probio-Stick reported a significant reduction in nausea and abdominal pain. However, the probiotics didn't seem to help with other stress-related physical or psychological symptoms. This indicates that while acidophilus may help with nausea, it doesn't address all aspects of stress-related complications.

9.5

Immediate relief

Most Useful Review

Great product! These probiotics provided immediate relief from my symptoms. The capsules are swallowable and dissolve quickly, offering great dosage for breakfast. Nausea, vomiting, and abdominal discomfort disappeared. I highly recommend this for its favourable price and large volume.

Chronic Fatigue Syndrome details

Questionable