5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 72 Researches
7.7
USERS' SCORE
Moderately Good
Based on 24 Reviews
7.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Men's Daily Probiotic BlendLactobacillus acidophilusLactobacillus caseiLactobacillus gasseriLactobacillus plantarumLactobacillus paracaseiLactobacillus brevisLactobacillus bulgaricusLactobacillus rhamnosusLactobacillus salivariusLactobacillus fermentumTotal Lacto Cultures (35 Billion CFU)Bifidobacterium lactisBifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (15 Billion CFU)
218 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
365 mg
+
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
Most Useful Reviews
10
Cured constipation
4 people found this helpful
This probiotic has been a lifesaver! After trying various remedies for age-related constipation, I discovered this one. Although pricey, the quality is exceptional. I've reduced my other laxatives to just this probiotic alone, something I never thought possible! Those suffering from long-term constipation will understand my delight; it works brilliantly with 50 million beneficial bacteria.
Read More
10
Chronic issues resolved
4 people found this helpful
This product has resolved my chronic constipation issue. I highly recommend it if you face similar struggles. Thankfully, I no longer suffer from chronic constipation.
Read More
8.5
Improved constipation
3 people found this helpful
I recently finished a bottle of this well-known probiotic brand. The effect was notably good, greatly improving my father's constipation. He had struggled with other low-content probiotics without success, but I believe this one will be effective for him too. Taking one pill a day is quite sufficient.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 72 Researches
7.7
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 24 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Cured constipation
4 people found this helpful
This probiotic has been a lifesaver! After trying various remedies for age-related constipation, I discovered this one. Although pricey, the quality is exceptional. I've reduced my other laxatives to just this probiotic alone, something I never thought possible! Those suffering from long-term constipation will understand my delight; it works brilliantly with 50 million beneficial bacteria.
Read More
10
Chronic issues resolved
4 people found this helpful
This product has resolved my chronic constipation issue. I highly recommend it if you face similar struggles. Thankfully, I no longer suffer from chronic constipation.
Read More
8.5
Improved constipation
3 people found this helpful
I recently finished a bottle of this well-known probiotic brand. The effect was notably good, greatly improving my father's constipation. He had struggled with other low-content probiotics without success, but I believe this one will be effective for him too. Taking one pill a day is quite sufficient.
Read More
10
Golden stool
1 people found this helpful
Absolutely the best! I purchased this due to my constipation, and after a few days of taking it, it really works. I've experienced golden stools!
Read More
9.5
Incredible supplement
1 people found this helpful
Super probiotic! I gave it to my dad, and I'm very satisfied with the quality, size, and packaging. The digestion has greatly improved, and constipation has been resolved. The microbiome is restored, and absorption is excellent. In a word, this supplement is incredible, and it has a neutral taste.
Read More
Frequently Asked Questions
10
Golden stool
1 people found this helpful
Absolutely the best! I purchased this due to my constipation, and after a few days of taking it, it really works. I've experienced golden stools!
10
Effective probiotics
I find these probiotics to be the most effective I've tried. I take them consistently and notice immediate results, as they help me get rid of constipation.
0
No effect observed
I bought this for my father, who suffers from chronic constipation, but after a month of use, there has been no effect. It is rather expensive, yet I intend to purchase it again to give it another try.
4
Weak effects
5 people found this helpful
If I take just one capsule daily as suggested, it has no effect. Taking two yields only minimal results, meaning my constipation remains at a lesser severity.
10
Cured constipation
4 people found this helpful
This probiotic has been a lifesaver! After trying various remedies for age-related constipation, I discovered this one. Although pricey, the quality is exceptional. I've reduced my other laxatives to just this probiotic alone, something I never thought possible! Those suffering from long-term constipation will understand my delight; it works brilliantly with 50 million beneficial bacteria.
2
No effect
Very expensive, but one bottle had no effect. I purchased it for my dad, who suffers from frequent constipation due to renal issues, but unfortunately, it was ineffective. I will not repurchase.
8.5
Improved constipation
3 people found this helpful
I recently finished a bottle of this well-known probiotic brand. The effect was notably good, greatly improving my father's constipation. He had struggled with other low-content probiotics without success, but I believe this one will be effective for him too. Taking one pill a day is quite sufficient.
0
Severe constipation
I bought this for my husband who had diarrhoea, but it caused me severe constipation. My husband refused to take it after experiencing this. Despite my normal digestion, my stool became odorous after using this product, which is something to consider.
7.5
Treats constipation
1 people found this helpful
Wonderful, excellent and comfortable for the digestive system and intestinal health. I use it once a day before breakfast for optimal absorption. I take it for a month, stop for a month, and then use it again if desired. It does not cause constipation; rather, it treats it due to its rich microbiome. This product serves as a nutritional supplement.
1
No difference noted
I did not notice a significant difference, and it does cause constipation, to be honest. Perhaps it did not work for me due to my colon ulcers.
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
7
We evaluated the impact of two probiotic formulations on functional constipation in adults. This study involved 30 days of daily consumption of oral sachets containing various strains of Lactobacillus and Bifidobacterium.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
7
We conducted a thorough trial to see if probiotics, specifically Lactobacillus rhamnosus, and various dietary fibers could help relieve constipation symptoms. Over four weeks, 250 participants received either dietary fibers, probiotics, or a placebo.
While there were no significant changes in bowel movement frequency, we did observe some positive impacts on stool quality across several treatment groups. Participants reported better stool consistency, indicating that while specific bowel movements didn’t change, the comfort of passing stools might improve.
In essence, these dietary interventions may aid those struggling with hard stools, and the response could depend on individual gut microbiota.
While there were no significant changes in bowel movement frequency, we did observe some positive impacts on stool quality across several treatment groups. Participants reported better stool consistency, indicating that while specific bowel movements didn’t change, the comfort of passing stools might improve.
In essence, these dietary interventions may aid those struggling with hard stools, and the response could depend on individual gut microbiota.
References
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. 10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. 10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. 10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. 10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. 10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. 10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. 10.1111/1751-2980.12797
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. 10.3920/BM2018.0163
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. 10.5851/kosfa.2017.37.6.906
- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. 10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. 10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. 10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. 10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. 10.1089/jmf.2009.1307
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. 10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. 10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. 10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. 10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. 10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. 10.1039/d2fo01900k
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. 10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. 10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. 10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. 10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. 10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. 10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. 10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD004827.pub4
- Roos S, Dahlgren AL, Mao YK, Pallin A, Stanisz AM, et al. Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation. Neurogastroenterol Motil. 2025. 10.1111/nmo.70012
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. 10.3168/jds.2023-24154
- Qiu B, Zhu L, Zhang S, Han S, Fei Y, et al. Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Li01. Nutrients. 2022;14. 10.3390/nu14194083
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. 10.1039/d4fo05835f
- Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. 10.1039/d4fo04660a
- Hashimoto Y, Kobayashi G, Kitagawa N, Okada H, Hamaguchi M, et al. Protocol of efficacy of bifidobacteria intake on gastrointestinal symptoms in symptomatic type 2 diabetes mellitus patients in abdominis: An open-label, randomized controlled trial (Binary STAR study). PLoS One. 2024;19:e0295998. 10.1371/journal.pone.0295998
- Wang L, Wang L, Tian P, Wang B, Cui S, et al. A randomised, double-blind, placebo-controlled trial of CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct. 2022;13:1628. 10.1039/d1fo03896f
- Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. 10.1111/jdi.13698
- Chai M, Wang L, Li X, Zhao J, Zhang H, et al. Different strains change the intestinal flora composition of mice different mechanisms to alleviate loperamide-induced constipation. Food Funct. 2021;12:6058. 10.1039/d1fo00559f
- Fuyuki A, Higurashi T, Kessoku T, Ashikari K, Yoshihara T, et al. Efficacy of G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study. Biosci Microbiota Food Health. 2021;40:105. 10.12938/bmfh.2020-073
- Makizaki Y, Uemoto T, Yokota H, Yamamoto M, Tanaka Y, et al. Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. PLoS One. 2021;16:e0248584. 10.1371/journal.pone.0248584
- Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Alleviation of low-fiber diet-induced constipation by probiotic G9-1 is based on correction of gut microbiota dysbiosis. Biosci Microbiota Food Health. 2019;38:49. 10.12938/bmfh.18-020
- Wang L, Hu L, Xu Q, Jiang T, Fang S, et al. Bifidobacteria exert species-specific effects on constipation in BALB/c mice. Food Funct. 2017;8:3587. 10.1039/c6fo01641c
- Tanaka Y, Takami K, Nishijima T, Aoki R, Mawatari T, et al. Short- and long-term dynamics in the intestinal microbiota following ingestion of Bifidobacterium animalis subsp. lactis GCL2505. Biosci Microbiota Food Health. 2015;34:77. 10.12938/bmfh.2015-001
- Urita Y, Goto M, Watanabe T, Matsuzaki M, Gomi A, et al. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders. Biosci Microbiota Food Health. 2015;34:37. 10.12938/bmfh.2014-017
- de Milliano I, Tabbers MM, van der Post JA, Benninga MA. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Nutr J. 2012;11:80. 10.1186/1475-2891-11-80
- Ishizuka A, Tomizuka K, Aoki R, Nishijima T, Saito Y, et al. Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans. J Biosci Bioeng. 2012;113:587. 10.1016/j.jbiosc.2011.12.016
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. 10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. 10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. 10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. 10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. 10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. 10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. 10.20960/nh.04315
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. 10.1039/d1fo04151g
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
- Ito D, Yamamoto Y, Maekita T, Yamagishi N, Kawashima S, et al. Do synbiotics really enhance beneficial synbiotics effect on defecation symptoms in healthy adults?: Randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2022;101:e28858. 10.1097/MD.0000000000028858
- Astó E, Huedo P, Altadill T, Aguiló García M, Sticco M, et al. Probiotic Properties of KABP042 and KABP041 Show Potential to Counteract Functional Gastrointestinal Disorders in an Observational Pilot Trial in Infants. Front Microbiol. 2021;12:741391. 10.3389/fmicb.2021.741391
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. 10.1016/j.clnesp.2020.12.025
- Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. 10.1016/j.clnu.2020.01.005
- Zhu S, Guo Z, Liu L, Gao Y, Bai L, et al. Complex Probiotics Relieve Constipation Through Regulation of the Intestinal Microbiota in Kittens. Microorganisms. 2025;13. 10.3390/microorganisms13030563
- Zhang Z, Li J, Wan Z, Fang S, Zhao Y, et al. subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025;16:2347. 10.1039/d4fo06350c
- Ma W, Zhao Y, Liu Y, Wang Y, Yu S, et al. subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota. Front Microbiol. 2025;16:1525887. 10.3389/fmicb.2025.1525887
- Salo E, Roche D, Gomez-Martinez VB, Cruz-Domenech JM, Garcia-Mora LG, et al. Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study. Benef Microbes. 2024;15:679. 10.1163/18762891-bja00038
- Lan W, Yang H, Zhong Z, Luo C, Huang Q, et al. subsp. LPL-RH improves postoperative gastrointestinal symptoms and nutrition indexes by regulating the gut microbiota in patients with valvular heart disease: a randomized controlled trial. Food Funct. 2024;15:7605. 10.1039/d4fo01471e
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. 10.1007/s00394-024-03398-8
- Lu Y, Zhou X, Wu Y, Cui Q, Tian X, et al. Metabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway. Mol Nutr Food Res. 2024;68:e2200846. 10.1002/mnfr.202200846
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. 10.3390/jcm12144838
- Watanabe M, Maruo T, Suzuki T. Effects of intake of subsp. FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2023;74:695. 10.1080/09637486.2023.2236805
- Cui H, Wang Q, Feng C, Guo C, Zhang J, et al. Positive effect of subsp VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Front Microbiol. 2022;13:1040371. 10.3389/fmicb.2022.1040371
- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. 10.1016/j.clnu.2022.10.015
