Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 72 Researches
7.7
USERS' SCORE
Good
Based on 28 Reviews
8
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Mood Probiotic BlendLactobacillus acidophilusLactobacillus plantarumLactobacillus helveticus R0052Lactobacillus paracaseiLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus bulgaricusLactobacillus gasseriLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium longum R0175Bifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
200 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Stress Support BlendOrganic Ashwagandha (root), Blueberry (fruit)
350 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
675 mg
+
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
Most Useful Reviews
10
Best probiotic ever
6 people found this helpful
This is the best probiotic for my chronic constipation; I've tried everything over the counter including laxatives and enemas. Alongside flaxseed and "baby plum organics" pouches daily, this probiotic is more effective than any I've taken. It also helps improve my mood while I transition to supplements.
Read More
9
Improved bowel movements
3 people found this helpful
Sweet, it relieved my flatulence, and I felt a sense of relief. Before taking it, I felt suffocated and unfed. It also relieved my constipation since I can now go to the toilet naturally. The taste doesn't matter as I swallowed it with water. I take it daily, and it comes in good quality and quantity, with a sealed package.
Read More
7.5
Cleans intestines effectively
3 people found this helpful
The quality is excellent, with safe ingredients and appropriate quantity. I experienced great benefits in digestion and saw improvements in constipation. The taste is neutral, with no noticeable smell.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 72 Researches
7.7
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Best probiotic ever
6 people found this helpful
This is the best probiotic for my chronic constipation; I've tried everything over the counter including laxatives and enemas. Alongside flaxseed and "baby plum organics" pouches daily, this probiotic is more effective than any I've taken. It also helps improve my mood while I transition to supplements.
Read More
9
Improved bowel movements
3 people found this helpful
Sweet, it relieved my flatulence, and I felt a sense of relief. Before taking it, I felt suffocated and unfed. It also relieved my constipation since I can now go to the toilet naturally. The taste doesn't matter as I swallowed it with water. I take it daily, and it comes in good quality and quantity, with a sealed package.
Read More
7.5
Cleans intestines effectively
3 people found this helpful
The quality is excellent, with safe ingredients and appropriate quantity. I experienced great benefits in digestion and saw improvements in constipation. The taste is neutral, with no noticeable smell.
Read More
9
Impressive results for constipation
2 people found this helpful
An excellent supplement to support the digestive and immune system as well as mood health. The quality is outstanding, and the ingredients are clean. I took it to combat constipation, and the result was impressive; I will repeat my purchase.
Read More
9
Relieves constipation effectively
2 people found this helpful
Very cool! It suited me from the second use. I relieved my constipation effectively with my method of taking two pills daily—one in the morning and one in the evening.
Read More
Frequently Asked Questions
9
Relieves constipation effectively
2 people found this helpful
Very cool! It suited me from the second use. I relieved my constipation effectively with my method of taking two pills daily—one in the morning and one in the evening.
10
Resolved stubborn constipation
1 people found this helpful
The probiotics ordered during the pandemic arrived quickly. They are of high quality. Taking two capsules daily resolved my stubborn constipation. It offers good value for money.
9
Recommends for constipation
1 people found this helpful
Amazing! I have been using it for a very long time. It is excellent as it increases beneficial bacteria and relaxes the stomach. It has a strong smell, but I recommend it to those who suffer from constipation.
9
Fights constipation
This is the best probiotic I've tried—high quality and effective against constipation. It greatly benefits the digestive system and has a pleasant, sweet taste.
9
Increases beneficial bacteria
1 people found this helpful
Excellent for constipation, it enhances beneficial bacteria in the intestines.
8
We investigated how a multi-strain probiotic blend affects constipation caused by loperamide in a rat model. After loperamide was used to induce constipation, we treated the rats with probiotics and observed notable improvements.
The treatment significantly increased fecal pellet output and enhanced gastrointestinal transit. Additionally, levels of serotonin and certain beneficial gut metabolites were also boosted in the probiotic-treated rats. This suggests that these probiotics can effectively alleviate constipation by positively adjusting gut microbiota and biochemistry.
The treatment significantly increased fecal pellet output and enhanced gastrointestinal transit. Additionally, levels of serotonin and certain beneficial gut metabolites were also boosted in the probiotic-treated rats. This suggests that these probiotics can effectively alleviate constipation by positively adjusting gut microbiota and biochemistry.
7
We evaluated the impact of two probiotic formulations on functional constipation in adults. This study involved 30 days of daily consumption of oral sachets containing various strains of Lactobacillus and Bifidobacterium.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
9
We examined whether synbiotics, which include Lactobacillus rhamnosus and other beneficial bacteria, help relieve functional constipation in children aged 4 to 18. In a controlled study, one group received synbiotics while the other received a placebo for four weeks.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
References
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- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
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- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
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- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. doi:10.5009/gnl.2011.5.1.22
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- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
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- Wang L, Wang L, Tian P, Wang B, Cui S, et al. A randomised, double-blind, placebo-controlled trial of CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct. 2022;13:1628. doi:10.1039/d1fo03896f
- Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. doi:10.1111/jdi.13698
- Chai M, Wang L, Li X, Zhao J, Zhang H, et al. Different strains change the intestinal flora composition of mice different mechanisms to alleviate loperamide-induced constipation. Food Funct. 2021;12:6058. doi:10.1039/d1fo00559f
- Fuyuki A, Higurashi T, Kessoku T, Ashikari K, Yoshihara T, et al. Efficacy of G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study. Biosci Microbiota Food Health. 2021;40:105. doi:10.12938/bmfh.2020-073
- Makizaki Y, Uemoto T, Yokota H, Yamamoto M, Tanaka Y, et al. Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. PLoS One. 2021;16:e0248584. doi:10.1371/journal.pone.0248584
- Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Alleviation of low-fiber diet-induced constipation by probiotic G9-1 is based on correction of gut microbiota dysbiosis. Biosci Microbiota Food Health. 2019;38:49. doi:10.12938/bmfh.18-020
- Wang L, Hu L, Xu Q, Jiang T, Fang S, et al. Bifidobacteria exert species-specific effects on constipation in BALB/c mice. Food Funct. 2017;8:3587. doi:10.1039/c6fo01641c
- Tanaka Y, Takami K, Nishijima T, Aoki R, Mawatari T, et al. Short- and long-term dynamics in the intestinal microbiota following ingestion of Bifidobacterium animalis subsp. lactis GCL2505. Biosci Microbiota Food Health. 2015;34:77. doi:10.12938/bmfh.2015-001
- Urita Y, Goto M, Watanabe T, Matsuzaki M, Gomi A, et al. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders. Biosci Microbiota Food Health. 2015;34:37. doi:10.12938/bmfh.2014-017
- de Milliano I, Tabbers MM, van der Post JA, Benninga MA. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Nutr J. 2012;11:80. doi:10.1186/1475-2891-11-80
- Ishizuka A, Tomizuka K, Aoki R, Nishijima T, Saito Y, et al. Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans. J Biosci Bioeng. 2012;113:587. doi:10.1016/j.jbiosc.2011.12.016
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. doi:10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. doi:10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. doi:10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. doi:10.1039/d1fo04151g
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