Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
BLa80 shows promise for constipation
subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota.
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
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9
Bifidobacterium lactis alleviates constipation
subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota.
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
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Most Useful Reviews
9
Improved digestion
196 people found this helpful
After two months, my 49-year-old mother, who has chronic constipation and has used laxatives for years, saw fantastic improvements with this probiotic. The blend of 12 strains, including Lactobacillus and Saccharomyces Boulardii, restored her intestinal flora. Within a week, she forgot about her constipation and is now hesitant to stop using the probiotic. Along with flax seeds, her nutrient absorption has significantly increased. I'm truly delighted I chose this product despite the cost.
Read More
9
Enhanced gastrointestinal function
22 people found this helpful
I rate Garden of Life - Primal Defense Ultra, 180 veggie caps, five stars due to immediate improvements in my digestion. Bowel movements became regular, bloating disappeared, and I could even enjoy cheese without experiencing constipation. For years, I overindulged in cheese and fatty foods, impacting my digestive health. My digestion was particularly constipated when I consumed whey-based protein shakes. However, after starting Garden of Life - Primal Defense Ultra, my system cleared out after about four days, returning to regular function. This product has offered the best results of any probiotics I’ve tried before.
Read More
9
Reduced bloating
21 people found this helpful
This probiotic has been a game-changer for my irritable bowel syndrome. I've experienced improvements in digestion, with significant reductions in constipation and gas. My bathroom habits have regularised, and I feel a general enhancement in my health. Plus, it's gluten-free and vegan, making it suitable for my dietary needs. I appreciate the inclusion of the Saccharomyces Boulardii strain, which is highly regarded for gut health.
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial.
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
Probiotics improve constipation symptoms
Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation.
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
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9
Lactobacillus rhamnosus reduces constipation
LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production.
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
Probiotic improves IBS-C symptoms
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After two months, my 49-year-old mother, who has chronic constipation and has used laxatives for years, saw fantastic improvements with this probiotic. The blend of 12 strains, including Lactobacillus and Saccharomyces Boulardii, restored her intestinal flora. Within a week, she forgot about her constipation and is now hesitant to stop using the probiotic. Along with flax seeds, her nutrient absorption has significantly increased. I'm truly delighted I chose this product despite the cost.
Read More
9
Enhanced gastrointestinal function
22 people found this helpful
I rate Garden of Life - Primal Defense Ultra, 180 veggie caps, five stars due to immediate improvements in my digestion. Bowel movements became regular, bloating disappeared, and I could even enjoy cheese without experiencing constipation. For years, I overindulged in cheese and fatty foods, impacting my digestive health. My digestion was particularly constipated when I consumed whey-based protein shakes. However, after starting Garden of Life - Primal Defense Ultra, my system cleared out after about four days, returning to regular function. This product has offered the best results of any probiotics I’ve tried before.
Read More
9
Reduced bloating
21 people found this helpful
This probiotic has been a game-changer for my irritable bowel syndrome. I've experienced improvements in digestion, with significant reductions in constipation and gas. My bathroom habits have regularised, and I feel a general enhancement in my health. Plus, it's gluten-free and vegan, making it suitable for my dietary needs. I appreciate the inclusion of the Saccharomyces Boulardii strain, which is highly regarded for gut health.
Read More
0
No effect
18 people found this helpful
I write this review with disappointment as I had hoped for positive results from these capsules. I did not experience any effect on my constipation, and the high price was not justified. I've suffered worsened symptoms like flatulence and spasms. I do not recommend this complex.
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0
Absolutely useless
11 people found this helpful
I was surprised by the positive reviews, but this product turned out to be absolutely useless for me. I experienced gases and constipation instead.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Probiotics are live microorganisms, primarily bacteria, that are intended to provide health benefits when consumed in adequate amounts. These beneficial bacteria are often referred to as "good" or "friendly" bacteria because they help maintain a balanced gut microbiome, which plays a vital role in digestion, immune function, and overall health. Probiotics can be found in various foods such as yogurt, kefir, sauerkraut, and kombucha, as well as in dietary supplements. The most common strains include Lactobacillus and Bifidobacterium, which have been studied for their positive effects on gastrointestinal health, including the alleviation of symptoms related to irritable bowel syndrome (IBS) and diarrhea.
Incorporating probiotics into your diet may help support a healthy gut by competing with harmful bacteria and promoting a more diverse microbiome. However, it's important to note that the specific effects of probiotics can vary widely depending on the strain, dosage, and individual health conditions. While many people may benefit from including probiotics in their diet, it's advisable to consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health issues or concerns. For those looking to explore the world of probiotics, it’s worth experimenting with various sources to find what works best for your body.
Probiotics may offer relief for some individuals suffering from constipation by promoting a healthier gut microbiome and improving overall digestive function. Certain strains of probiotic bacteria, like Bifidobacterium and Lactobacillus, have been shown in studies to enhance stool frequency and consistency in some people. By balancing gut bacteria, probiotics can potentially assist in regulating bowel movements and improving gut motility, which is particularly beneficial for those experiencing chronic constipation.
However, the effectiveness of probiotics can vary greatly from person to person, and not all probiotic supplements are created equal. It's important to choose a product that contains strains specifically studied for constipation relief and to consult with a healthcare provider to identify the most suitable option for individual needs. Additionally, incorporating a diet rich in fiber and staying hydrated are essential complementary strategies for managing constipation.
Based on user reviews, the timeline for experiencing results from probiotics for constipation varies significantly among individuals. Some users report seeing improvements within a week, like the case of one reviewer whose mother, suffering from chronic constipation, experienced fantastic results in just a week after starting the probiotics Read Review. Other users suggest that it may take a longer duration, such as three weeks, for results to manifest, as noted by another reviewer who experienced significant improvements after three weeks on the supplement Read Review.
Among the user experiences, some reported initial discomfort, such as constipation or bloating, before ultimately finding relief with continued use Read ReviewRead Review. Thus, while a minority of users may find quick benefits, others could take a few weeks to see positive changes. Overall, it appears that patience is often key when using probiotics for constipation relief.
Emerging evidence supports the use of certain probiotics as a potential solution for managing constipation. For instance, a randomized controlled trial demonstrated significant improvements in stool frequency and consistency among participants taking Lactobacillus rhamnosus. Meanwhile, studies involving children with constipation showed promising results with Lactobacillus-containing probiotics, reporting increased bowel movement frequencies and a decrease in hard defecation episodes [3], [30]. The exploration of Bifidobacterium strains has also unveiled their benefits in relieving constipation, especially in combination with dietary fibers [1].
However, it's essential to note that while many studies suggest probiotics may help alleviate constipation symptoms, the effects can vary, and not all findings are statistically significant. For example, in adults, although both probiotics and dietary fibers showed improvements, differences across groups were not always marked enough to draw definitive conclusions [2], [27]. More comprehensive and controlled studies are encouraged to further investigate the efficacy of these supplements in treating constipation.
Based on user reviews, many individuals have reported significant improvements in digestive symptoms after using probiotics for constipation. A review highlights that one user’s mother, who had chronic constipation and used laxatives for years, noticed fantastic results, feeling free from constipation within just a week of starting the probiotics Read Review. Others have echoed similar sentiments, with users mentioning regularized bathroom habits and enhanced gut health, especially noted by those with irritable bowel syndrome Read Review. Some users, after a few weeks, reported a reduction in pain and bloating and an improvement in their overall well-being Read ReviewRead Review.
However, it’s important to note that individual results can vary, with some users experiencing no improvement or even worsening symptoms like gas or constipation Read ReviewRead Review. As with any supplement, patience and a personalized approach to dosage may be key, as certain users have found success by adjusting their intake Read ReviewRead Review. Overall, many users have reported positive transformations in their digestive health, reinforcing the potential benefits of these probiotics.
Users have reported mixed results when combining this probiotic supplement with additional supplements for managing constipation. For example, one user successfully combined the probiotics with flax seeds, which they noted significantly improved nutrient absorption and resolved chronic constipation that their mother had battled for years Read Review. However, other users experienced adverse effects when combining the probiotics with iron-containing supplements, leading to new constipation issues Read Review.
Furthermore, many users found that adjusting the dosage of the probiotic could enhance its efficacy when taken alone or in conjunction with other supplements. For instance, one reviewer mentioned that they gradually increased their intake from one to three capsules, which effectively alleviated their constipation and improved overall well-being Read Review. Another user who experienced persistent constipation reported positive changes after continuing the probiotic for several weeks Read Review. Overall, while some combinations worked well, others did not, showcasing the importance of individual trial and error.
Based on user reviews, the right dosage for probiotics when treating constipation appears to vary, with many users finding success through gradual adjustments. For instance, one user began with one capsule a day, then increased to three, which effectively eliminated their constipation (review ID: c8c71eb9-f0f8-497b-93e4-08d3f5c3d075). Another user reported taking two capsules daily, which significantly improved their condition related to hypothyroidism (review ID: d20d4f9d-5f72-4670-87c8-8206ec578a02). Users suggest that experimenting with the dosage may be necessary to discover what works best for individual circumstances, especially given the varying responses to different probiotic strains.
Conversely, not all experiences were positive. Some users reported increased constipation or adverse effects such as gas (review ID: 839083fe-2220-4e69-9e79-c474c90332bb, d122459e-da6c-43a4-8fd8-97441399349f). This indicates that while many have benefited from probiotics in managing constipation, the right dose may not be the same for everyone. Thus, starting at a lower dose and tapering up based on individual tolerance and response seems to be a recurring theme in achieving effective results.
9
Improved digestion
196 people found this helpful
After two months, my 49-year-old mother, who has chronic constipation and has used laxatives for years, saw fantastic improvements with this probiotic. The blend of 12 strains, including Lactobacillus and Saccharomyces Boulardii, restored her intestinal flora. Within a week, she forgot about her constipation and is now hesitant to stop using the probiotic. Along with flax seeds, her nutrient absorption has significantly increased. I'm truly delighted I chose this product despite the cost.
7.5
Bowel improvement
2 people found this helpful
Excellent! I became addicted to the keto diet, but it caused constipation. To improve my bowel function, I purchased these probiotics. I’ve been taking them for three weeks, and while the results weren't immediate, my bowel movements have improved significantly. I will continue to monitor my progress.
0
Wasted money
2 people found this helpful
I am extremely disappointed. After taking this product for a week, I became constipated. It was a waste of money for me.
7.5
Effective for constipation
These probiotics improve my microbiome composition and effectively alleviate my constipation. My intestines feel satisfied.
9
Reduced bloating
21 people found this helpful
This probiotic has been a game-changer for my irritable bowel syndrome. I've experienced improvements in digestion, with significant reductions in constipation and gas. My bathroom habits have regularised, and I feel a general enhancement in my health. Plus, it's gluten-free and vegan, making it suitable for my dietary needs. I appreciate the inclusion of the Saccharomyces Boulardii strain, which is highly regarded for gut health.
9
Reduced obstruction pain
4 people found this helpful
I was diagnosed with intestinal obstruction, leading to persistent constipation. After trying this supplement on my own, I began to notice a decrease in pain and bloating within the first month, and I’m pleased to say my constipation has significantly improved.
9
No more constipation
5 people found this helpful
This probiotic truly works! I began with one capsule a day, then gradually increased to two, and finally three. My constipation vanished, greatly enhancing my overall well-being. Highly recommend trying to adjust the dosage to find your best level.
0
No effect
18 people found this helpful
I write this review with disappointment as I had hoped for positive results from these capsules. I did not experience any effect on my constipation, and the high price was not justified. I've suffered worsened symptoms like flatulence and spasms. I do not recommend this complex.
0
Absolutely useless
11 people found this helpful
I was surprised by the positive reviews, but this product turned out to be absolutely useless for me. I experienced gases and constipation instead.
9
Improved digestion
1 people found this helpful
The benefits of this quality probiotic on my health have been outstanding. It has reduced constipation and gut bloating by improving my digestion. I found it works best taken either at night before bed or in the morning. I highly recommend it!
0
Constipation problems
3 people found this helpful
Alongside these probiotics, I also ordered a women's variant. After starting these, I encountered constipation issues, likely due to the iron content. After a few days, I switched to the women's ones and saw immediate relief. It's disappointing considering the price.
9
Probiotics improve constipation symptoms
Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial.
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
2
Probiotics ineffective for constipation
Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial.
We conducted a randomized, double-blind, placebo-controlled trial involving 94 children under 5, all suffering from functional constipation. Participants received either Lactobacillus rhamnosus or a placebo for four weeks. While we observed some increase in bowel movements in both groups throughout the study, Lcr35 did not show significant effectiveness compared to the placebo. Overall, our findings suggest that using this specific probiotic alone is not an effective treatment for constipation in young children. It reinforces existing guidelines against probiotics for this issue.
7
Probiotic efficacy on constipation analyzed
The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial.
We evaluated the impact of two probiotic formulations on functional constipation in adults. This study involved 30 days of daily consumption of oral sachets containing various strains of Lactobacillus and Bifidobacterium.
While participants experienced improvements in stool frequency and quality, the differences between the treatment groups were not statistically significant. An isolated case of abdominal pain was the only adverse event noted. Overall, these probiotics showed potential but did not produce noteworthy differences across groups.
7
Probiotics alleviate chemotherapy nausea
Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia.
Our pilot study focused on how Lactobacillus rhamnosus, a probiotic, affects gastrointestinal side effects in children undergoing chemotherapy for acute leukemia. We randomly assigned young patients to either receive probiotics twice daily or not, and tracked common gastrointestinal issues like nausea and constipation.
The findings were promising; we observed a notable reduction in several side effects, including significant decreases in nausea, vomiting, and abdominal distension in those taking the probiotics. Overall, daily probiotic supplementation appeared to support children by lessening discomfort during chemotherapy.
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Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
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Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
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Qiu B, Zhu L, Zhang S, Han S, Fei Y, et al. Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Li01. Nutrients. 2022;14. doi:10.3390/nu14194083
Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. doi:10.1039/d4fo04660a
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