' 
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
The product is found useful for the following medical conditions
Pelvic Pain
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 4 Reviews
8.8
7
Lactobacillus association with pelvic pain
Urinary Microbiome and Cytokine Levels in Women With Interstitial Cystitis.
Most Relevant Research
We examined the urinary microbiome of women with interstitial cystitis and found it less diverse and containing fewer Lactobacillus acidophilus compared to a control group.
This lack of Lactobacillus was linked to more severe symptoms and poor quality of life. While we noted some associations between higher inflammatory markers and the severity of symptoms, we didn’t see a clear causal relationship.
Essentially, we’re still unsure if the presence of Lactobacillus can effectively reduce pelvic pain in this context.
This lack of Lactobacillus was linked to more severe symptoms and poor quality of life. While we noted some associations between higher inflammatory markers and the severity of symptoms, we didn’t see a clear causal relationship.
Essentially, we’re still unsure if the presence of Lactobacillus can effectively reduce pelvic pain in this context.
9.5
Pain alleviation achieved
Most Useful Review
I know individuals who were painfully bedridden and unable to digest properly, and after a megadose of this probiotic, they are thriving. My own experience has been remarkable; after using multiple probiotics with little effect, this one has transformed my digestion. I am currently on 6 capsules a day, and the pelvic pain has diminished significantly, along with bloating, allowing me a regular bowel routine.
Yeast Infection
SCIENTIFIC SCORE
Moderately Effective
Based on 30 Researches
8.3
USERS' SCORE
Good
Based on 7 Reviews
8.8
9.5
Lactobacillus salivarius effectively reduces yeast
In Vitro Probiotic Properties of Lactobacillus salivarius MG242 Isolated from Human Vagina.
Most Relevant Research
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
9.5
Cured yeast infection
Most Useful Review
Amazing! This was my first experience with this product, and it was a life-changer. After one night, a pesky yeast infection I had was gone!
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
L. plantarum reduces heart disease risk
Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE mice through modulation of proinflammatory cytokines and oxidative stress.
Most Relevant Research
We set out to explore the effects of Lactobacillus plantarum ATCC 14917 on heart disease in ApoE-deficient mice. Over 12 weeks, these mice were given the probiotic, and we analyzed their heart health and inflammation levels.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
9.5
Heart burn relief
Most Useful Review
Amazing! I have been meaning to write this review for months! I've had fantastic results using this product (Primal Defense Ultra). I suffered from severe heart burn for years and even developed an ulcer a couple of years ago. I took one capsule last Halloween, anticipating the usual discomfort from candy. To my delight, I felt near-instant relief. This product has provided what my gut needed! I highly recommend it to everyone! I haven't experienced heart burn since taking the first capsule!
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 7 Reviews
8.6
8
Lactobacillus aids chronic fatigue treatment
Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences.
Most Relevant Research
We explored the effects of Lactobacillus acidophilus, both free and in floating beads, as a possible treatment for chronic fatigue syndrome in a rat model. The study involved inducing fatigue through a forced swim test and then administering the probiotics over the last week of the experiment.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.
9.5
Improved bowel health
Most Useful Review
5 billion of the best strains of bacteria I’ve tried. I recommend this product for those suffering from chronic fatigue syndrome. After starting, my health improved, no more constipation or bloating, and my digestion is better. I appreciate that the capsules don’t require refrigeration and are gluten-free and vegan. The inclusion of the strain Saccharomyces Boulardii is significant, as it’s highly regarded for colonic issues.
Urinary Tract Infection
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Probiotics effective for UTI prevention
Efficacy of Probiotic Prophylaxis After The First Febrile Urinary Tract Infection in Children With Normal Urinary Tracts.
Most Relevant Research
We investigated whether a probiotic mix containing Lactobacillus acidophilus could prevent recurrent urinary tract infections (UTIs) in children aged 4 months to 5 years.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
9.5
Life-changing effect
Most Useful Review
Amazing! This was my first experience with this product and it truly was an overnight game-changer. I had been suffering from a stubborn yeast infection, but after just one night of use, it was gone!
Back Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.5
10
Life-saving probiotic
Most Useful Review
This probiotic has truly transformed my life. For ten years, I struggled with IBS-D, often unable to venture far from home. I felt like a prisoner bound to the bathroom, and nothing seemed to provide complete relief. During a visit to a health food shop, a staff member recommended Primal Defense, which required no refrigeration. I bought it four years ago, and I've never felt better since. After running out during the pandemic and trying another product, my IBS-D flared up again. It became evident that I need Primal Defense for my wellbeing, and I was thrilled to find it on iHerb at a lower price. I can’t express enough how much this probiotic has saved my life.
Chronic Cough
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.8
Reduced symptoms
Most Useful Review
AMAZING help with my chronic cough. I increased from one to two per day and noticed significantly less IBS symptoms, including reduced gas and improved digestive regularity.
Hypothyroidism
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.8
Digestive improvement
Most Useful Review
I am doing well! This probiotic is an excellent supplement of very good quality. My nutritionist recommended it for my digestive issues related to hypothyroidism. I take two a day; it helps immensely. Taking it at night ensures that I feel light in the morning, without the constipation experienced with others. It has no flavour. The package arrived in good condition and quicker than expected. I recommend it; this is my third bottle.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.8
Helps leg cramps
Most Useful Review
Awesome product; it seems to alleviate some minor leg cramps I get in my legs. Cheers!
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 87 Researches
7.5
USERS' SCORE
Good
Based on 32 Reviews
8.3
9.5
Bifidobacterium bifidum improves IBS symptoms
Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study.
Most Relevant Research
We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
9.5
Satisfying improvement
Most Useful Review
I’ve tried numerous probiotic strains, and this product has greatly improved my health, notably reducing my irritable bowel syndrome symptoms. My discomfort from bloating and constipation has vanished, and I feel more absorbed with my food. The capsules don’t require refrigeration, and the ingredients are pure and vegan-friendly, making them suitable for vegetarians. I particularly appreciate the inclusion of Saccharomyces Boulardii, which research suggests is effective for irritable bowel syndrome.
Constipation
SCIENTIFIC SCORE
Possibly Effective
Based on 102 Researches
7.5
USERS' SCORE
Moderately Good
Based on 43 Reviews
7.9
9
Probiotic improves IBS-C symptoms
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
Most Relevant Research
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
9.5
Improved digestion
Most Useful Review
After two months, my 49-year-old mother, who has chronic constipation and has used laxatives for years, saw fantastic improvements with this probiotic. The blend of 12 strains, including Lactobacillus and Saccharomyces Boulardii, restored her intestinal flora. Within a week, she forgot about her constipation and is now hesitant to stop using the probiotic. Along with flax seeds, her nutrient absorption has significantly increased. I'm truly delighted I chose this product despite the cost.
Bloating
SCIENTIFIC SCORE
Possibly Effective
Based on 62 Researches
7.7
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.6
9
Bifidobacterium lactis alleviates bloating
Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation.
Most Relevant Research
We conducted a study to see if a fermented dairy product with Bifidobacterium lactis DN-173 010 could help reduce bloating in patients with irritable bowel syndrome (IBS) and constipation. In a controlled trial with 34 participants over four weeks, we found that this probiotic significantly decreased abdominal girth and improved gastrointestinal transit times.
Patients reported feeling less bloated, and symptom severity also decreased. These findings suggest that fostering faster transit times may be an effective method to combat abdominal distension.
Patients reported feeling less bloated, and symptom severity also decreased. These findings suggest that fostering faster transit times may be an effective method to combat abdominal distension.
9.5
Bloating relief
Most Useful Review
I’ve found 5 billion of the best strains of bacteria in this product. It significantly improved my health and eliminated my bloating and colon contractions. I absorb food better now, and my constipation has vanished. The capsules don't require refrigeration, and the ingredients are pure, gluten-free, and vegan. I appreciate the inclusion of the Saccharomyces Boulardii strain, which is highly beneficial for my condition.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.9
USERS' SCORE
Medium or Average
Based on 12 Reviews
6.6
9
LC-STH-13 counters lupus effects
LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
Most Relevant Research
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
8.3
Did not help
Most Useful Review
After years of dealing with intestinal dysfunction and an autoimmune disorder, I decided to try various probiotics, but unfortunately, they were ineffective for me. I even experienced negative side effects from one of them. Despite my efforts, I did not find relief and would suggest testing different options first to determine what works for you.
Food Poisoning
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.8
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.2
9.5
Saccharomyces boulardii reduces liver injury
Saccharomyces boulardii prevention of the hepatic injury induced by Salmonella Enteritidis infection.
Most Relevant Research
We explored how Saccharomyces boulardii might help prevent liver damage caused by Salmonella Enteritidis, a common foodborne pathogen. Using a mouse model, we noticed that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by 96%.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
9.5
Life-saving probiotic
Most Useful Review
THIS PROBIOTIC SAVED MY LIFE. As someone with IBS-D, I often felt confined to my bathroom. After years of suffering and various treatments, I discovered Primal Defense in a health food shop. Unlike previous probiotics that needed refrigeration, this one was different. I've felt amazing since using it for the past four years until I temporarily ran out. While another product was insufficient, I realised I depend on Primal Defense to avoid the return of my discomfort.
