Garden of Life Probiotic Formula

Bifidobacterium may help combat acne

Based on 5 Researches

Lee DK, Kim MJ, Ham JW, An HM, Cha MK, et al. In vitro evaluation of antibacterial activities and anti-inflammatory effects of Bifidobacterium spp. addressing acne vulgaris. Arch Pharm Res. 2012;35:1065. doi:10.1007/s12272-012-0614-9

We examined the antibacterial and anti-inflammatory effects of Bifidobacterium in relation to acne. Our findings showed that certain strains, including Bifidobacterium longum, significantly lowered the viability of acne-causing bacteria. We also found that these strains reduced harmful inflammatory markers in cell tests.

Ultimately, while Bifidobacterium longum showed promise in reducing acne-related bacteria, the study suggests Bifidobacterium adolescentis may be more effective in tackling the problem.

Skin has cleared

Most Useful Review

51 people found this helpful

I've dealt with cystic acne for years and tried everything, yet nothing worked. I had no idea my gut flora was affecting my persistent acne. By taking two of these probiotics a day, my skin has been completely clear for months now! Any lapse in usage brings back the breakouts. I am excited to finally feel confident in my skin again!

Cold Sores details

3 people found this helpful

This product is incredible! Since I started taking Primal Defence, I've not been ill—not even a cold!

Reflux details

Bernard JN, Chinnaiyan V, Almeda J, Catala-Valentin A, Andl CD. sp. Facilitate the Repair of DNA Damage Caused by Bile-Induced Reactive Oxygen Species in Experimental Models of Gastroesophageal Reflux Disease. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12071314

Based on 6 Researches

Probiotics repair DNA in GERD

We explored the effects of Lactobacillus species on bile-induced DNA damage in esophageal cells, which occurs during gastroesophageal reflux disease (GERD). By exposing these bacteria to a bile-rich environment, we found they could survive and interact beneficially with injured cells.

Notably, adding Lactobacillus after bile injury boosted the repair of DNA damage and lessened inflammation. This suggests that these probiotics could play a role in protecting against long-term complications of GERD, like Barrett's esophagus and esophageal cancer.

Normal bowel movements

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27 people found this helpful

Amazing stuff! After suffering from constant diarrhea for nearly a decade and being diagnosed with IBS, I started taking this probiotic based on a friend's recommendation. It worked wonders! I no longer have acid reflux, have regained normal bowel movements, and feel energetic now.

Yeast Infection details

Lactobacillus salivarius effectively reduces yeast

Based on 28 Researches

Kang CH, Han SH, Kim Y, Paek NS, So JS. In Vitro Probiotic Properties of Lactobacillus salivarius MG242 Isolated from Human Vagina. Probiotics Antimicrob Proteins. 2018;10:343. doi:10.1007/s12602-017-9323-5

We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.

This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.

No yeast infections

Most Useful Review

76 people found this helpful

Life saver! This is the best probiotic I have ever used! After surgery and complications, I was on a high dose of antibiotics for nearly four weeks. I began taking this probiotic just after my antibiotics and before bed, four times a day. Previously, I developed terrible yeast infections while on antibiotics, but this time I’ve had none at all. I believe it has helped to combat bad bacteria in my gut and is boosting my immune system. I'm so thankful for this amazing product!

Cardiovascular Disease details

Probiotic lowers cholesterol in hamsters

Based on 5 Researches

Briand F, Sulpice T, Giammarinaro P, Roux X. changes lipidemic profile and gut microbiota in a hamster hypercholesterolemic model. Benef Microbes. 2019;10:555. doi:10.3920/BM2018.0134

We explored the effects of the CNCM I-745 probiotic on cholesterol levels and gut bacteria in hamsters with high cholesterol. This controlled study revealed that daily doses significantly lowered total plasma cholesterol and altered gut microbiota. Specifically, we noted that the abundance of certain gut microbes was linked to changes in cholesterol levels and liver gene expression. These findings suggest that this probiotic not only benefits cholesterol levels but also supports gut health, offering potential for safe treatments in managing hypercholesterolemia.

Improved gut health

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1 people found this helpful

My journey to better gut health led me to Garden of Life’s Primal Defense Ultra. After using it consistently for a month, I can confidently say it met my expectations. The potent blend of probiotics has greatly improved my digestive regularity, significantly reducing bloating and discomfort. I've also noticed stronger immunity and fewer colds, likely due to better gut health. Although the price point may deter some, the benefits justify the cost. Initially, I experienced mild discomfort as my body adjusted, but it passed with continued use.

Cold details

6 people found this helpful

Best by far! I have been using this product for years and highly recommend it. I can't remember the last time either of us had a cold or sore throat! Previously, I was in an office where everyone was coughing, yet I never got sick! This is the best probiotic, and I won't use any other!

Heart Disease details

L. plantarum reduces heart disease risk

Based on 16 Researches

Hassan A, Din AU, Zhu Y, Zhang K, Li T, et al. Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE mice through modulation of proinflammatory cytokines and oxidative stress. Appl Microbiol Biotechnol. 2020;104:6337. doi:10.1007/s00253-020-10693-x

We set out to explore the effects of Lactobacillus plantarum ATCC 14917 on heart disease in ApoE-deficient mice. Over 12 weeks, these mice were given the probiotic, and we analyzed their heart health and inflammation levels.

The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.

Heart burn relief

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1 people found this helpful

Amazing! I have been meaning to write this review for months! I've had fantastic results using this product (Primal Defense Ultra). I suffered from severe heart burn for years and even developed an ulcer a couple of years ago. I took one capsule last Halloween, anticipating the usual discomfort from candy. To my delight, I felt near-instant relief. This product has provided what my gut needed! I highly recommend it to everyone! I haven't experienced heart burn since taking the first capsule!

Pelvic Pain details

Lactobacillus association with pelvic pain

Questionable

Based on 2 Researches

Abernethy MG, Rosenfeld A, White JR, Mueller MG, Lewicky-Gaupp C, et al. Urinary Microbiome and Cytokine Levels in Women With Interstitial Cystitis. Obstet Gynecol. 2017;129:500. doi:10.1097/AOG.0000000000001892

We examined the urinary microbiome of women with interstitial cystitis and found it less diverse and containing fewer Lactobacillus acidophilus compared to a control group.

This lack of Lactobacillus was linked to more severe symptoms and poor quality of life. While we noted some associations between higher inflammatory markers and the severity of symptoms, we didn’t see a clear causal relationship.

Essentially, we’re still unsure if the presence of Lactobacillus can effectively reduce pelvic pain in this context.

Pain alleviation achieved

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I know individuals who were painfully bedridden and unable to digest properly, and after a megadose of this probiotic, they are thriving. My own experience has been remarkable; after using multiple probiotics with little effect, this one has transformed my digestion. I am currently on 6 capsules a day, and the pelvic pain has diminished significantly, along with bloating, allowing me a regular bowel routine.

Ulcer details

Saccharomyces boulardii shows ulcer benefits

Based on 20 Researches

Gao H, Li Y, Sun J, Xu H, Wang M, et al. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2021;2021:1622375. doi:10.1155/2021/1622375

We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.

The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.

However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.

Relieved heartburn

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1 people found this helpful

Amazing! I have intended to write this review for months! This product (Primal Defense Ultra) has provided remarkable results. For years, I suffered from severe heartburn and even developed an ulcer a couple of years ago. On Halloween, I took one capsule before indulging in candy, which typically spells trouble. However, I felt almost immediate relief. Whatever my gut was lacking, this product supplied it! I highly recommend it to everyone, as I haven't experienced heartburn since taking the first capsule!

Celiac details

Probiotics may aid gluten digestion

Based on 13 Researches

Nikoloudaki O, Celano G, Polo A, Cappello C, Granehäll L, et al. Novel probiotic preparation with gluten-degrading activity and potential modulatory effects on the gut microbiota. Microbiol Spectr. 2024;12:e0352423. doi:10.1128/spectrum.03524-23

We examined a promising new probiotic preparation designed to break down gluten and assist people with celiac disease. Our study included a randomized double-blind placebo-controlled trial with 70 volunteers over a 42-day period, where participants consumed increasing amounts of gluten following a gluten-free diet.

Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.

7.5

Improved digestion

Most Useful Review

Happy customer. I have celiac disease and numerous other food allergies. This product has significantly improved my stomach health and has stabilised my condition. I highly recommend it to anyone facing similar issues. The capsules are also quite small and easy to swallow.

Colitis details

Heavey MK, Hazelton A, Wang Y, Garner M, Anselmo AC, et al. Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis. Nat Commun. 2024;15:3784. doi:10.1038/s41467-024-48128-0

Based on 16 Researches

Targeted probiotic shows promise

We explored the effectiveness of a specially engineered probiotic yeast, Saccharomyces boulardii, aimed at treating colitis. By cleverly binding this probiotic to proteins in the gut, we managed to significantly extend its stay in the gastrointestinal tract. This allowed us to observe a noteworthy increase in probiotic levels in the colon.

Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.

Avoided surgery

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12 people found this helpful

This product has saved me from colon surgery. I have tried numerous probiotics for my ulcerative colitis, but this is the only one that has genuinely helped. Before using it, I was advised to have my colon removed. Now, after almost two months of taking it, I am observing positive results. Be aware that this product is quite strong; I had to gradually work up to 12 capsules a day and experienced a few minor issues along the way. However, I am now reaping the benefits.

We investigated whether a probiotic mix containing Lactobacillus acidophilus could prevent recurrent urinary tract infections (UTIs) in children aged 4 months to 5 years.

The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.

Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.

Life-changing effect

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2 people found this helpful

Amazing! This was my first experience with this product and it truly was an overnight game-changer. I had been suffering from a stubborn yeast infection, but after just one night of use, it was gone!

Cancer details

Bifidobacterium longum shows potential benefits

Based on 36 Researches

Chen Y, Wu J, Cai K, Xiao X, Chen Y, et al. Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity. Int Immunopharmacol. 2025;150:114283. doi:10.1016/j.intimp.2025.114283

We investigated whether Bifidobacterium longum XZ01 could affect the progression of colon cancer in a mouse model. The results hinted that this probiotic might enhance immune responses by outcompeting harmful bacteria and protecting macrophages within tumors.

Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.

More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.

Essential for wellness

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10 people found this helpful

BEST ON THE MARKET. My husband and I have been taking this probiotic for over 5 years and have always appreciated its effects. Garden of Life is our go-to for supplements. My husband has stage IV metastatic melanoma, and I have Langerhans Cell Histiocytosis, making our choice of supplement critical. My husband has been cancer-free for over 2 years, and I have been tumour-free for 21 years.

Back Pain details

231 people found this helpful

I learnt about the benefits of probiotics for conditions like Crohn's disease from my cousin. Probiotics help control inflammation and improve digestive health. After starting on Primal Defense Ultra, my abdominal distention decreased, and I no longer experienced daily abdominal pain, joint pain, or flare-ups for the first time in 20 years. This product has been invaluable for managing my Crohn’s disease and arthritis. I highly recommend it for similar conditions.

Bacterial Infection details

Lactobacillus aids pigs' health

Cherrington T, Jordan D, Pluske J, Mansfield J, Lugsomya K, et al. Lactobacillus and Saccharomyces fermentation products impact performance and the fecal microbiome in weanling pigs inoculated with enterotoxigenic Escherichia coli. J Anim Sci. 2025;103. doi:10.1093/jas/skae394

We explored the effects of Lactobacillus acidophilus fermentation products on weanling pigs that were challenged with a harmful strain of bacteria known as enterotoxigenic F4 Escherichia coli (F4-ETEC). To better understand this, we conducted a detailed study involving eighty pigs, which were divided into five groups based on different diets. This included a control diet, as well as diets supplemented with various fermentation products and zinc oxide.

After inoculating the pigs with F4-ETEC to simulate infection, we observed significant changes in the pigs’ fecal microbiome when they were given a combination of Lactobacillus and Saccharomyces products. These changes in the microbiome were previously linked to better growth performance and overall health in young pigs.

Interestingly, the pigs receiving both Lactobacillus acidophilus and Saccharomyces cerevisiae products showed an increase in final live weight. This suggests that using these postbiotics could help manage performance issues associated with ETEC without needing to eliminate the bacteria entirely from the pigs' environment. Therefore, while Lactobacillus acidophilus was not the sole hero in this study, its combined use proved beneficial in combatting the negative effects of this bacterial challenge.

Cured infections

Most Useful Review

6 people found this helpful

These probiotics saved me from my female infections. They are the only ones strong enough to address my bacterial and fungal issues, which included discomfort and unusual discharge. Although I noticed some bloating initially, I soon felt much better. I believe these probiotics were crucial in my recovery and will continue using them to prevent future infections.

Bloating details

Bifidobacterium lactis alleviates bloating

Based on 47 Researches

Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2009;29:104. doi:10.1111/j.1365-2036.2008.03853.x

We conducted a study to see if a fermented dairy product with Bifidobacterium lactis DN-173 010 could help reduce bloating in patients with irritable bowel syndrome (IBS) and constipation. In a controlled trial with 34 participants over four weeks, we found that this probiotic significantly decreased abdominal girth and improved gastrointestinal transit times.

Patients reported feeling less bloated, and symptom severity also decreased. These findings suggest that fostering faster transit times may be an effective method to combat abdominal distension.

Keeps regularity maintained

Most Useful Review

124 people found this helpful

This probiotic is fantastic—it's the only one I use. I recommend starting with one capsule, as it can feel intense initially. However, it ultimately keeps me regular, eliminates bloating, and has even helped me lose weight. It's a family must-have for maintaining good health.

Candidiasis details

Probiotic shows promise against candidiasis

Based on 8 Researches

Murzyn A, Krasowska A, Augustyniak D, Majkowska-Skrobek G, Łukaszewicz M, et al. The effect of Saccharomyces boulardii on Candida albicans-infected human intestinal cell lines Caco-2 and Intestin 407. FEMS Microbiol Lett. 2010;310:17. doi:10.1111/j.1574-6968.2010.02037.x

We investigated the role of Saccharomyces boulardii, a helpful probiotic, in combating Candida albicans, a troublesome pathogen for those with weakened immune systems.

By examining the effects on specific human intestinal cell lines, we found that both S. boulardii and its culture extract notably reduced C. albicans' ability to adhere to these cells.

Additionally, the extract lowered the production of harmful inflammatory markers, suggesting it may help manage inflammation linked to these infections. Overall, our findings highlight the potential of S. boulardii as a supportive treatment against candidiasis.

Life-changing results

Most Useful Review

5 people found this helpful

After several rounds of antibiotics left my husband with intestinal candida, he tried numerous products before discovering this one. It’s the only product that has truly helped! He can’t imagine being without it now. Additionally, our daughter prefers this to prescription medications for her IBS. Thank you, Jordan!

Eczema details

Lactobacillus acidophilus helps eczema

Based on 30 Researches

Kim WK, Jang YJ, Park S, Min SG, Kwon H, et al. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. J Microbiol. 2024;62:91. doi:10.1007/s12275-024-00104-5

We explored the potential of Lactobacillus acidophilus KBL409 in addressing atopic dermatitis, a common form of eczema. By using a mouse model induced by house dust mites, we found that administering this probiotic led to significantly lower dermatitis scores and less immune cell infiltration in the skin.

Additionally, L. acidophilus KBL409 reduced serum immunoglobulin E and influenced various cytokines linked to inflammation. It also positively affected gut microbiota and concentrations of beneficial compounds, hinting at a broader impact on our immune responses. Overall, our findings suggest that L. acidophilus KBL409 may be a promising probiotic for eczema management.

Significant improvement

Most Useful Review

After just a week of using it, my eczema has improved significantly. The ingredients are also excellent.

Flu details

Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124:e172. doi:10.1542/peds.2008-2666

Likely Very Effective

Probiotics reduce flu symptoms

We examined how Lactobacillus acidophilus could help reduce cold and flu-like symptoms in young children during the winter months. In this well-structured study, 326 children aged 3 to 5 participated. They were randomly assigned to one of three groups: one received a placebo, while the others were given either Lactobacillus acidophilus alone or in combination with another probiotic, Bifidobacterium animalis subsp lactis.

Over a period of six months, the children in both probiotic groups reported significantly fewer symptoms and shorter durations of ailments compared to those on the placebo. For instance, the incidence of fever dropped by 53% to 73%, while coughing and rhinorrhea (a runny nose) also saw impressive reductions. Children taking probiotics needed antibiotics much less often and missed fewer days of childcare due to illness.

Overall, this study suggests that incorporating daily Lactobacillus acidophilus into children's diets can be an effective approach to bolster their health during flu season. It shows promise as a safe and helpful way to reduce common winter illnesses in young kids.

Improved well-being

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2 people found this helpful

Excellent product. It might be a bit pricey, but it's definitely worth it 100%. I felt much better after suffering from reflux gastritis and dysbacteriosis.

Nausea details

Probiotics improve stress-related nausea

Based on 20 Researches

Diop L, Guillou S, Durand H. Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Nutr Res. 2008;28:1. doi:10.1016/j.nutres.2007.10.001

We conducted a double-blind, placebo-controlled study to assess how Lactobacillus acidophilus might help with stress-related gastrointestinal issues, particularly nausea. Over three weeks, volunteers received either a probiotic called Probio-Stick or a placebo.

We found that consumption of the probiotics significantly eased nausea and abdominal pain linked to stress. However, it didn't have a notable impact on other symptoms like sleep problems or psychological distress. Overall, our findings suggest that Probio-Stick is effective for alleviating certain gastrointestinal symptoms caused by stress.

Nausea relief during chemo

Most Useful Review

9 people found this helpful

Garden of Life is the best! I began using these while undergoing chemotherapy for stage 3 breast cancer, where the nausea was unbearable. While not a complete remedy, they significantly reduced my nausea and enhanced my immunity. If I stop taking them, I feel bloated and lethargic; resuming use brings back my energy and well-being. Moreover, if my stomach is upset after eating, two of these make it right again, and I can’t emphasise how phenomenal they are for bowel regularity and digestion. Highly recommend!

Diarrhea details

Bifidobacterium lactis reduced diarrhea duration

Based on 94 Researches

Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjudicative efficacy of Bifidobacterium animalis subsp. lactis BLa80 in treating acute diarrhea in children: a randomized, double-blinded, placebo-controlled study. Eur J Clin Nutr. 2024;78:501. doi:10.1038/s41430-024-01428-6

We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.

Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.

Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.

This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.

Tamed chronic diarrhea

Most Useful Review

54 people found this helpful

It really works. After over 20 years with Crohn's disease and having tried various treatments, I began taking some recommended supplements from a book. This one worked particularly well for me and helped tame chronic diarrhea caused by Crohn's. Initially, there may be gas and diarrhea, but after a few days, you'll see significant improvements in your bowel habits and digestion of roughage. Now I can enjoy a salad without spending hours on the toilet!

Heartburn details

Positive effects on gastrointestinal symptoms

Based on 3 Researches

Viramontes-Hörner D, Márquez-Sandoval F, Martín-del-Campo F, Vizmanos-Lamotte B, Sandoval-Rodríguez A, et al. Effect of a symbiotic gel (Lactobacillus acidophilus + Bifidobacterium lactis + inulin) on presence and severity of gastrointestinal symptoms in hemodialysis patients. J Ren Nutr. 2015;25:284. doi:10.1053/j.jrn.2014.09.008

Our research aimed to understand how a specific symbiotic gel, containing Lactobacillus acidophilus, affects gastrointestinal symptoms, including heartburn, in hemodialysis patients.

We conducted a double-blinded, placebo-controlled trial with 42 participants over two months. The group receiving the symbiotic gel reported significant improvements in the frequency and severity of symptoms like heartburn and stomachache compared to the control group.

Overall, the gel appeared safe with no adverse effects noted. More extensive studies are needed, but these findings suggest promising benefits for managing heartburn in dialysis patients.

Acid reflux healed

Most Useful Review

12 people found this helpful

Simply the best! After trying numerous probiotics without any noticeable results, Garden of Life’s Primal Defense Ultra proved effective. I took three capsules daily for three weeks, and I’m pleased to say my acid reflux is completely healed! I recommend this product wholeheartedly, and even after reducing my dosage, I haven't had any heartburn.

Indigestion details

Synbiotic improves digestive health

Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328

This study looked into how a specific synbiotic product, which includes Lactobacillus acidophilus along with other probiotics and fructooligosaccharides, affects digestive health among healthy adults. In a randomized, double-blind, placebo-controlled design, we monitored 36 participants—20 women and 16 men aged between 25 and 45 years—over six weeks.

Participants received either the synbiotic supplement or a placebo, taking three tablets daily. We gathered information on gastrointestinal symptoms and bowel habits through a self-administered questionnaire, focusing especially on those who experienced digestive disturbances like mild dyspepsia or bloating.

The results were promising; those who took the synbiotic product reported significant improvements in their overall gastrointestinal well-being and bowel movements. Interestingly, we also noted a reduction in a specific immune marker, L-selectin, in the synbiotic group, which could indicate a favorable shift in their immune profile. However, while the improvements in gut health were noteworthy, none of the other immunological parameters were significantly altered.

In summary, this study suggests that including Lactobacillus acidophilus as part of a synbiotic supplement can lead to better digestive comfort and may influence immune-related markers positively. However, pinpointing the exact effect of this specific strain on indigestion alone is challenging, given the multi-strain nature of the synbiotic treatment.

7.5

Routine relief

Most Useful Review

1 people found this helpful

Best probiotic on Earth. It routinely helps my indigestion.

Sleep Apnea details

Improved sleep quality

Most Useful Review

1 people found this helpful

Great item for those interested in gut health. Since I started using it, I believe my bowel movements have improved, and my sleep quality has also enhanced. I would recommend it for various physical conditions.

Chronic Fatigue Syndrome details

Lactobacillus aids chronic fatigue treatment

Questionable

Based on 2 Researches

Singh PK, Chopra K, Kuhad A, Kaur IP. Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences. Neurogastroenterol Motil. 2012;24:366. doi:10.1111/j.1365-2982.2011.01861.x

We explored the effects of Lactobacillus acidophilus, both free and in floating beads, as a possible treatment for chronic fatigue syndrome in a rat model. The study involved inducing fatigue through a forced swim test and then administering the probiotics over the last week of the experiment.

Remarkably, we found that both forms of Lactobacillus led to significant reductions in fatigue-like behaviors and improved biomarkers associated with stress. This indicates that lactobacilli may serve as a beneficial option for alleviating symptoms of chronic fatigue syndrome.

Improved bowel health

Most Useful Review

21 people found this helpful

5 billion of the best strains of bacteria I’ve tried. I recommend this product for those suffering from chronic fatigue syndrome. After starting, my health improved, no more constipation or bloating, and my digestion is better. I appreciate that the capsules don’t require refrigeration and are gluten-free and vegan. The inclusion of the strain Saccharomyces Boulardii is significant, as it’s highly regarded for colonic issues.

Allergies details

Bifidobacterium bifidum improves CMPA

Based on 83 Researches

Jing W, Liu Q, Wang W. Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. J Food Biochem. 2020;44:e13489. doi:10.1111/jfbc.13489

We explored how Bifidobacterium bifidum TMC3115 could help infants with cow's milk protein allergy (CMPA). In our controlled trial with 256 infants, half received B. bifidum while the other half received a placebo.

Over six months, we observed significant reductions in allergic scores and improvements in anti-inflammatory responses among those taking B. bifidum. We also found changes in gut microbiota, increasing beneficial bacteria and decreasing potentially harmful ones.

Though promising, these interventions indicate that managing CMPA may benefit from focusing on gut health.

Life saver

Most Useful Review

27 people found this helpful

Amazing stuff! I have suffered from constant diarrhoea for nearly 10 years. Diagnosed with IBS, the medication only worked to an extent. I began taking these capsules based on a friend's recommendation from a vitamin shop. Initially sceptical, I expected side effects, but after three weeks, my diarrhoea stopped, and I resumed normal bowel movements—something that hadn't happened for almost a decade! Increasing my intake to two capsules has been phenomenal! I no longer experience acid reflux, have more energy, and my allergies have improved significantly. This probiotic is a lifesaver! It's worth investing in rather than buying cheaper options.

Irritable Bowel Syndrome details

Bifidobacterium bifidum improves IBS symptoms

Based on 65 Researches

Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33:1123. doi:10.1111/j.1365-2036.2011.04633.x

We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.

Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.

With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.

Satisfying improvement

Most Useful Review

21 people found this helpful

I’ve tried numerous probiotic strains, and this product has greatly improved my health, notably reducing my irritable bowel syndrome symptoms. My discomfort from bloating and constipation has vanished, and I feel more absorbed with my food. The capsules don’t require refrigeration, and the ingredients are pure and vegan-friendly, making them suitable for vegetarians. I particularly appreciate the inclusion of Saccharomyces Boulardii, which research suggests is effective for irritable bowel syndrome.

Constipation details

Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x

Based on 89 Researches

Probiotic improves IBS-C symptoms

We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.

After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.

Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.

Improved digestion

Most Useful Review

196 people found this helpful

After two months, my 49-year-old mother, who has chronic constipation and has used laxatives for years, saw fantastic improvements with this probiotic. The blend of 12 strains, including Lactobacillus and Saccharomyces Boulardii, restored her intestinal flora. Within a week, she forgot about her constipation and is now hesitant to stop using the probiotic. Along with flax seeds, her nutrient absorption has significantly increased. I'm truly delighted I chose this product despite the cost.

Autoimmune Disorder details

Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. doi:10.1039/d4fo03966a

Based on 43 Researches

LC-STH-13 counters lupus effects

We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.

We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.

Did not help

Most Useful Review

13 people found this helpful

After years of dealing with intestinal dysfunction and an autoimmune disorder, I decided to try various probiotics, but unfortunately, they were ineffective for me. I even experienced negative side effects from one of them. Despite my efforts, I did not find relief and would suggest testing different options first to determine what works for you.

Food Poisoning details