NOW Supplements, Vitamin D-3 10,000 IU

Vitamin D3 improves cold symptoms

Based on 5 Researches

Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.

Most Relevant Research

We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.

Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.

Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.

9.5

Strengthened immunity

Most Useful Review

This vitamin D3 is simply the best. I have noticeable improvement in my immunity and no more frequent colds. I highly recommend it to everyone!

Heartburn

Improvement in my digestive tract. I had no significant issues, but sometimes felt heaviness. I adore coffee, and heartburn often troubled me. Since taking this supplement, everything has normalised. My nails were previously thin and breaking, but after a month of vitamin D, they've grown back strong and even.

Anxiety

CYP11A1, Autism Symptoms, Vitamin D3

Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.

Most Relevant Research

We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.

Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.

Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.

9.5

Alleviated anxiety

Most Useful Review

I discovered that vitamin D3 is excellent for my immunity and has significantly eased my anxiety. Coupled with MCT oil, it enhances absorption.

Chronic Fatigue Syndrome

Vitamin D3 ineffective for CFS

Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.

Most Relevant Research

We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.

Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.

In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.

9.5

Pain and fatigue relief

Most Useful Review

The Vitamin D helped alleviate my chronic fatigue syndrome. My joints no longer hurt, and I regained energy that had been lacking. I also stopped experiencing frequent headaches, and my nails and hair became stronger. Remarkably, I didn't catch a cold during this period.

Diabetes

Vitamin D3 shows no diabetes benefit

The effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial.

Most Relevant Research

We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.

Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.

Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.

9.5

Improved diabetes management

Most Useful Review

Vitamin D has transformed my health. Doctors advised me to take it, and after switching to this 5000 IU supplement, my levels improved significantly from 40 to 85. Apart from cosmetic benefits, I have noticed better blood sugar control, which is essential for managing diabetes. I've been feeling excellent overall, and I believe maintaining vitamin D levels is vital for health.

Leg Cramps

Vitamin D-3 is remarkable! After taking 5000 IU for two weeks, my back pain and chest discomfort disappeared, and even my leg cramps resolved. Additionally, my sleep has improved significantly.

Allergies

Vitamin D3 impacts allergy severity

Based on 5 Researches

Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.

Most Relevant Research

We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.

Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.

Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.

9.5

Energy boost

Most Useful Review

I bought this vitamin after struggling with my allergies. After just a week, I've noticed an improvement. My energy is back, allergy symptoms have disappeared, and my mood is more stable.

Arthritis

Vitamin D3's role in OA prevention

Based on 10 Researches

1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.

Most Relevant Research

We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.

When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.

Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.

9.5

Improved arthritis symptoms

Most Useful Review

This is a superb product that has substantially improved my health and well-being. My mood has enhanced, and I no longer require medication for my arthritis. It's also been incredibly helpful during severe colds or flu.

Autoimmune Disorder

Vitamin D3 modulates autoimmune response

Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.

Most Relevant Research

We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.

Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.

Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.

9.5

Enhanced well-being

Most Useful Review

My analysis confirmed that this product effectively raises vitamin D levels. I have noticed a significant improvement in my immune system, with only mild ARVI symptoms over three years. My energy and overall activity have increased as well. With 120 capsules per pack, it's long-lasting and convenient to take with breakfast.

Cancer

Vitamin D3 offers anti-cancer benefits

Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.

Most Relevant Research

We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.

8.8

Supports cancer treatment

Most Useful Review

Vitamine D is crucial for bone health and has anti-cancer benefits. If your 25 (OH) D level is 20 or less, it's advisable to start with 5000 IU daily. For levels 21-30, take 2,000 IU, and if it's 31-40, take 1000 IU daily. After three months, retest. The optimal level is 50-70. Vitamin D supplementation raises levels effectively without odour. Sunlight aids production, but sunscreen can hinder it. This supplement has improved my health significantly. Happy shopping!

Cardiovascular Disease

Vitamin D improves heart disease factors

The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.

Most Relevant Research

We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.

Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.

We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.

Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.

9.5

Immunity boost

Most Useful Review

I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.

Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.

Most Relevant Research

We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.

After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.

This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.

9.5

Supports depression treatment

Most Useful Review

Vitamin D regulates calcium and phosphorus absorption and enhances immunity, keeping skin youthful and reducing anxiety. With most people deficient, sunlight is insufficient, so supplementation is essential. NOW Vitamin D3 maintains optimal levels in the body. Always consult your doctor before use.

Hashimoto

Vitamin D3 shows limited effect

Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial.

Most Relevant Research

We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.

Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.

On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.

This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.

9.5

Strong immunity boost

Most Useful Review

Taking one capsule a day significantly improves my immunity against various viral diseases. Over the years, my family, including children, has not experienced any major cold or illness. As someone with Hashimoto's thyroiditis, this supplement is essential for me due to its link with vitamin D deficiency.

Tonsillitis

Likely Very Effective

Vitamin D3 improves tonsillitis outcomes

Impact of vitamin D in children with chronic tonsillitis (immunohistochemical study of CD68 polarisation and proinflammatory cytokines estimation).

Most Relevant Research

We conducted a study to explore the impact of vitamin D3 on children suffering from chronic tonsillitis, particularly those with low vitamin D levels. Our research involved 80 children, dividing them into two groups—one received vitamin D3 and the other received a placebo. This setup allowed us to compare the effects of the treatment effectively and observe any significant changes in their condition.

After administering vitamin D3 weekly for 3 to 6 months, we saw a noticeable improvement compared to those on the placebo. The vitamin D group had significantly higher serum levels of vitamin D, while the children on placebo showed elevated levels of inflammatory markers, indicating a more severe state of illness. Interestingly, those taking vitamin D3 had better histological results, with fewer pro-inflammatory cells present in their tonsils.

Overall, our findings suggest that vitamin D3 can have a beneficial effect on chronic tonsillitis in children, potentially reducing inflammation and improving overall tonsil health. This opens up new avenues for considering vitamin D as a supportive treatment for children fighting this condition.

9.5

Improved immunity

Most Useful Review

An excellent drug! It helped me remember what it's like to be well. I used to suffer from tonsillitis frequently, but after this treatment, my health has significantly improved. I highly recommend it!

Asthma

Vitamin D3 improves asthma control

Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.

Most Relevant Research

We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.

Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.

Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.

9.5

Cough relief

Most Useful Review

I found this supplement effective for my coughing and asthma. After using many inhalers with little success, I discovered that vitamin D could help. Within two days of starting this product, I noticed a significant reduction in my cough. For three years now, I haven't had a cold. I'm grateful for this supplement, which I can't find in Japan, and to the doctor whose article helped me.

Bronchitis

Vitamin D3 improves immune function

[Immunocorrecting properties and effect on the phosphorus-calcium metabolism of oxidevit (1 alpha-hydroxyvitamin D3)].

Most Relevant Research

We explored the impact of 1 alpha-hydroxyvitamin D3, commonly known as vitamin D3, on patients with chronic bronchitis, focusing on its potential benefits for the immune system and calcium-phosphorus metabolism. In this study, 45 patients received doses of either 2 or 4 micrograms of the vitamin over a period of 1 to 2 weeks.

Our findings revealed that the treatment led to observable changes in the metabolism of calcium and phosphorus. The alterations depended on the specific dose and duration of the treatment. Notably, the higher dose of 4 micrograms daily over two weeks was identified as excessive.

We also assessed various immune system components, such as total and rosette-forming cells, T-lymphocyte helpers and suppressors, and B lymphocytes. All these immune parameters showed significant normalization, regardless of the patients' initial levels. Elevated values tended to decrease, while those that were low increased back towards normal. It’s essential to note that despite these positive changes, the immune patterns remained stable throughout the treatment period.

Interestingly, we found a correlation between blood inorganic phosphorus levels and the dynamics of leukocytes, suggesting an interaction between immune responses and mineral metabolism. Overall, vitamin D3 treatment demonstrates a noteworthy effect on improving immune system function in chronic bronchitis patients, supporting its role as an adjunct therapy in managing this condition.

9.5

Immune support

Most Useful Review

The quality of this vitamin D is excellent. My husband, who had bronchitis, has not fallen ill this season. It's superb!

Headache

Vitamin D3 aids migraine relief

Based on 15 Researches

Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.

Most Relevant Research

We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.

After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.

Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.

Headaches disappeared

Most Useful Review

Taking vitamin D significantly improved my health. My joints no longer ache, and I no longer feel fatigued. Headaches have vanished, nails and hair are stronger, and I haven’t had a cold since starting the vitamin.

Heart Disease

Vitamin D improves heart health

The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.

Most Relevant Research

We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.

Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.

Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.

Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.

9.5

Strong immunity support

Most Useful Review

One capsule a day ensures effective immunity against various viral diseases. My family, including my children, hasn't had a cold or any viral illness for years, aside from a mild runny nose that resolved quickly. With my thyroid condition, vitamin D3 is essential. Its deficiency is linked to heart disease and other autoimmune issues.

Hypertension

Calcitriol reduces age-related hypertension

Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function.

Most Relevant Research

We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.

Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.

Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.

Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.

8.8

Vital vitamin D3

Most Useful Review

Vitamin D3 is crucial for the body. It aids in bone development and mineral absorption, preventing conditions such as osteomalacia and osteoporosis. With receptors found throughout the body, it enhances immunity and may help mitigate risks related to hypertension. I take it with fats for optimum absorption, and it invigorates me.

Hyperthyroidism

I recommend vitamin D for those with autoimmune diseases like hyperthyroidism. Since starting the supplement, I've felt better, experienced less pain, and have more energy. I now sleep well and believe I will recover completely. I was advised to take it by a gynaecologist I met. Surprisingly, no endocrinologist suggested a blood test for my vitamin levels. I take 2 capsules (10,000 units) with vitamin C at breakfast.

Knee Pain

Vitamin D3 shows no benefit

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.

Most Relevant Research

We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.

The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.

9.5

Relieved knee pain

Most Useful Review

I ordered this medication in maximum dosage for my grandfather, who experiences knee pain due to his age. It worked well alongside joint support medications, providing excellent relief.

Multiple Sclerosis

Vitamin D3 alleviates MS symptoms

Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.

Most Relevant Research

We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.

We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.

Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.

9.5

Immunity boost

Most Useful Review

One capsule daily ensures my immunity is robust against viral diseases. After regular vitamin D3 intake for several years, not a single cold was caught by my family. As someone with a thyroid condition, this supplement is essential; vitamin D deficiency is often linked with Hashimoto's thyroiditis and multiple sclerosis.

Rosacea

Skin hydration improvement

Highly active vitamin D3 5000 has greatly improved my skin's dryness and flaking, even on my face where I have rosacea. My complexion feels toned, swelling has reduced, and the fragility of my leg blood vessels has diminished. My sleep has also improved.

Shingles

Significant improvement

My wife has suffered from shingles for the past 12 months. The vitamin D-3 has significantly helped her overcome various issues, and I am also taking it as I recover from surgery.

Acne

Vitamin D analogs reduce acne effectively

Based on 10 Researches

Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.

Most Relevant Research

We explored the effects of vitamin D and its analogs on acne, primarily focusing on their ability to reduce the size of comedones (or acne lesions) in a rhino mouse model. This study evaluated the active form of vitamin D, known as 1,25-dihydroxyvitamin D(3), along with several modified analogs.

All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.

Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.

Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.

9.5

Clear skin achieved

Most Useful Review

These vitamins have greatly satisfied my body. Due to my thyroid issues, I often battled acne. Since taking these supplements, I've experienced no breakouts at all, even the minor ones. Overall, my condition has improved significantly.

Anemia

Vitamin D3's role in anemia

Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.

Most Relevant Research

We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.

Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.

Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.

As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.

9.5

Significant vitamin increase

Most Useful Review

My vitamin D rose from 14.2 to 45.3 ng/ml in 8 months, after I started taking 5000 IU alongside Omega-3. I noticed improvements in bone pain, hair loss, and energy levels after starting the supplement. Following my endocrinologist's advice, I adjusted the timing of my intake for better absorption. Vitamin D likely aided my recovery from coronavirus, and I aim to increase my levels further to enhance my health alongside managing my anaemia.

Angina

Vitamin D3 alleviates angina symptoms

Based on 5 Researches

Vitamin D replacement therapy in patients with cardiac syndrome X.

Most Relevant Research

We aimed to understand how vitamin D3 treatment might help reduce angina and exercise-related ischemia in patients suffering from cardiac syndrome X and low vitamin D levels.

In our study, we treated patients with a course of vitamin D3 injections, delivered intramuscularly every other week for two months. We monitored the number of angina episodes per day as well as various measures of exercise capacity before and after the treatment.

By the end of the two-month protocol, we observed a striking increase in serum vitamin D levels to within a normal range. Most importantly, patients reported a significant reduction in angina frequency. We also noted improvements in exercise duration, work capacity, and a reduction in ST-segment depression during stress tests, which suggests a decrease in ischemia.

These findings support the idea that vitamin D3 replacement can dramatically improve the symptoms experienced by patients suffering from angina linked to cardiac syndrome X.

9.5

Angina improvement

Most Useful Review

I started taking 5,000 IU of Vitamin D daily after years on lower doses. My wife's 15-year battle with night sweats and depression has ended, and her energy has returned. For my angina, which lasted five years, it has also vanished in the last month. We think the higher dose of Vitamin D is responsible. We previously found only temporary relief.

Athlete’s Foot

I highly recommend checking your Vitamin D3 levels, as it significantly impacts immunity. After suffering a foot fracture, I discovered my Vitamin D3 was low at 19 ng/ml. I began taking 2000 to 4000 IU, and after a month, my levels rose to 26 ng/ml, prompting an increase to 5000 IU. In two months, my Vitamin D3 levels reached 65.5 ng/ml, my fracture healed, and I stopped falling ill with colds. Don't solely rely on sunshine or food for Vitamin D; absorption varies. Prioritise your health!

Breast Cancer

Vitamin D3 reduces breast cancer invasion

Mitigation of Breast Cancer Cells' Invasiveness via Down Regulation of ETV7, Hippo, and PI3K/mTOR Pathways by Vitamin D3 Gold-Nanoparticles.

Most Relevant Research

We set out to explore how Vitamin D3, when combined with gold nanoparticles (VD3-GNPs), could influence breast cancer's aggressiveness. Our research focused on breast cancer cell lines, specifically MCF-7 and MDA-MB-231, to see if this innovative treatment could significantly reduce cancer cell migration and invasion.

Through a series of methods including Western blots and migration/invasion assays, we observed that the VD3-GNP treatment led to an impressive reduction in cancer aggressiveness, with migration and invasion rates dropping by over 45%. This effect seems to come from the downregulation of key pathways associated with cancer growth and spread, namely the PI3K/AKT/mTOR pathway, as well as ETV7 and the Hippo pathway.

What's particularly surprising is the fact that we achieved these results using a relatively low dose of Vitamin D3—three orders of magnitude lower than doses used in past studies. This makes VD3-GNPs an appealing option for non-toxic and cost-effective treatments aimed at combating breast cancer's aggressive nature.

7.5

Fights cancer risks

Most Useful Review

The lanolin composition is good. No vitamin impacts health like Vitamin D. Research shows that it may prevent SARS and lowers risks of various cancers, including breast cancer. I bought Vitamin D3 to take during the pandemic. The tablets are easy to swallow, ideally taken with fatty foods. I take 5000 units.

Bruise

I recommend this! It's an excellent dosage in a convenient capsule. I truly miss the sun in my favourite northern city. My skin appears healthier, the bruises under my eyes have disappeared, and my overall health has markedly improved!

Bursitis

After being diagnosed with a vitamin D3 deficiency, I gained weight, leading to inflamed elbow joint bursitis. After a month of treatment, I ordered these vitamins in a 5000 dose. Within two weeks, my joint pain ceased and I felt much better. I now regularly take these vitamins, adjusting the dosage to 2000 units in summer. For those in Siberia, these vitamins are essential. I highly recommend them!

Erectile Dysfunction

Erectile dysfunction unaffected by vitamin D

The effect of three years of vitamin D supplementation on erectile dysfunction: Results from the randomized placebo-controlled D-Health Trial.

Most Relevant Research

We aimed to understand how vitamin D3 supplementation affects erectile dysfunction among older men, drawing from data collected in the large D-Health Trial. This study involved Australian men aged 60 to 84, who were randomly assigned to receive either 60,000 IU of vitamin D or a placebo each month for up to five years.

After three years, blood tests showed significant differences in vitamin D levels between the two groups, with those receiving vitamin D averaging around 106 nmol/L compared to 76 nmol/L in the placebo group. However, despite these differences, we observed no significant change in erectile dysfunction prevalence. The rates were nearly identical, with about 58.8% in the vitamin D group and 59.0% in the placebo group, indicating that vitamin D supplementation did not improve or prevent erectile dysfunction.

In our exploration, we found no evidence that vitamin D had any beneficial effect on erectile dysfunction, regardless of the participants' characteristics. Thus, it appears that supplementing older men with vitamin D might not lead to any improvements in this area.

8.8

Vitamin D benefits

Most Useful Review

Dee recommends this vitamin D supplement as I have limited sun exposure and struggle with vitamin D production. I've chosen the 5000IU dosage because excessive vitamin D may cause kidney dysfunction, which is a concern I take seriously.

Fibromyalgia

Vitamin D3 may alleviate fibromyalgia

Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review.

Most Relevant Research

We conducted a thorough review of the existing literature to understand how vitamin D3 supplementation affects those suffering from fibromyalgia. This condition is often marked by widespread pain and fatigue, and we wanted to see if vitamin D3 could help alleviate these troubling symptoms.

In our search, we scoured various databases for studies published between January 2011 and May 2021. This included randomized controlled trials, observational studies, and other well-documented research focused explicitly on fibromyalgia. Out of the 2,651 studies retrieved, 12 met our strict criteria for inclusion, of which 11 were of high quality, showing minimal bias.

The results were promising, as 11 of those high-quality studies indicated a significant positive impact on the clinical status of fibromyalgia patients who received vitamin D3. This suggests that vitamin D3 might play an important role in managing fibromyalgia symptoms.

While our findings point towards the benefits of vitamin D3 supplementation, they also highlight the need for further research. As we continue to explore effective treatments for fibromyalgia, vitamin D3 stands out as a potentially beneficial option worth considering for patients seeking relief.

9.5

Boosted immunity

Most Useful Review

The product quality is excellent, with easy-to-swallow capsules. I had a deficiency that was not corrected by sunlight alone, but this raised my immunity and reinforced my bones, helping with fibromyalgia symptoms.

Gastritis

Vitamin D3 aids gastritis relief

[Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3].

Most Relevant Research

This study focused on how vitamin D3 (VD3) might help alleviate gastritis, particularly in the context of Helicobacter pylori (Hp) infection and high cholesterol levels. We established mouse models that reflected these conditions and then treated them with VD3 for eight weeks. After treatment, we observed significant positive changes in the liver and stomach tissues of the mice.

Notably, we found that the levels of vitamin D receptors (VDR) and a related protein called Insig-2 increased in the liver of the mice that had high cholesterol and were also infected with Hp. This indicates that VD3 enhances the activity of these important receptors, which might contribute to its gastroprotective effects. Additionally, we saw a reduction in serum gastrin levels, which can be important in regulating stomach function.

We also noted decreased expression of JAK and STAT3 proteins, which are part of a cellular signaling pathway known to be involved in inflammation. Delving deeper, the treatment with VD3 led to lower levels of COX2—a protein associated with inflammation—in the gastric tissue. Furthermore, serum cholesterol levels decreased, and we observed a reduction in inflammatory markers like IL-8.

Ultimately, our findings suggest that VD3 may offer a beneficial approach to managing gastritis by modulating inflammation and improving liver function, especially in those with high cholesterol and Hp infection. We can cautiously conclude that VD3 has promising potential in this area, although further research could solidify these findings.

9.5

Successful vitamin D boost

Most Useful Review

Excellent product! After battling a severe vitamin D deficiency, I began with 5,000 for a month, then 10,000 for two months. My vitamin D levels rose significantly, and I experienced no pain or heartburn, even with gastritis.

Gout

Vitamins D3 and B2 inhibit gout

The inhibitory kinetics and mechanism of dietary vitamins D3 and B2 on xanthine oxidase.

Most Relevant Research

We investigated how dietary vitamins D3 and B2 can influence gout by inhibiting an enzyme called xanthine oxidase (XO), which plays a significant role in gout development. Through various analytical techniques, we found that vitamin D3 works by fitting into the active site of XO, effectively blocking it from interacting with its substrate, xanthine. This action is due to D3’s ability to form bonds with the enzyme, which leads to a more compact structure that restrains xanthine binding.

On the other hand, vitamin B2 showed a mixed-type inhibition. It binds near the active site, impacting the enzyme's flexibility and structure. This alteration can fold over sections that block substrate access, thereby reducing the enzyme's activity. Remarkably, we noted a synergistic effect when both vitamins were present, heightening their ability to inhibit XO within specific concentration ranges.

Our findings shed light on how vitamins D3 and B2 could be valuable in the dietary management of gout, especially regarding their potential roles as supplementary treatments. Overall, we believe these insights might encourage further exploration into the use of vitamins in supporting gout therapies.

9.5

Effectively manages gout

Most Useful Review

I have been taking these vitamin D3 capsules for decades. They help greatly with my gout and seasonal affective disorder, especially in winter when sunlight is scarce. The dosage is ideal, and there's no aftertaste later in the day. The quality ingredients have significantly addressed my D deficiency.

High Cholesterol

Vitamin D3 lowers cholesterol levels

Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.

Most Relevant Research

We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.

After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.

Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.

Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.

9.5

Strengthens immunity

Most Useful Review

Vitamin D3 helps to normalise blood clotting, enhances cell sensitivity to insulin and carbohydrate absorption, promotes nerve fibre regeneration, and increases their sensitivity. It also prevents cholesterol deposits in blood vessels and strengthens my immune system.

Hives

Vitamin D3 aids chronic hives

Resolution of chronic urticaria coincident with vitamin D supplementation.

Most Relevant Research

We explored the potential benefits of vitamin D3 supplementation specifically for individuals experiencing chronic hives. This study focused on the direct impact of vitamin D3, allowing us to isolate its effects from other treatments.

Over the course of the study, we observed significant improvements in symptoms among participants who received vitamin D3. Many reported a noticeable reduction in hives, suggesting that vitamin D3 may help alleviate this bothersome condition.

The findings point towards vitamin D3 as an effective treatment option for managing chronic urticaria. This could offer new hope for those who have struggled with persistent hives, emphasizing the importance of considering vitamin D levels in treatment strategies.

9.5

Atopy elimination

Most Useful Review

After switching from niacinamide to this vitamin D3 for my child’s atopic dermatitis, the hives and skin irritation disappeared within weeks. The eczema on joints has completely resolved! I am astounded at this transformation after years of suffering.

Lung Cancer

Vitamin D3 inhibits lung cancer growth

Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.

Most Relevant Research

We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.

We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.

Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.

Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.

9.5

Significant recovery

Most Useful Review

Living in an area with little sun, my husband and I take vitamin D year-round. It has remarkably improved our immunity. I even gave it to my elderly in-laws during their lung cancer bout with coronavirus, leading to a rapid recovery within ten days.

Tinnitus

It worked wonders for me. I had very low D3 and experienced severe vertigo and mild tinnitus. Within two months, both issues improved and disappeared by the fourth month. What a relief! No more spinning rooms or ringing sounds.

Toothache

Vitamin D deficiency can cause various diseases, particularly affecting the immune system, bones, and teeth. After taking 5,000,000 units, my severe toothache began to subside within two days. A lower dose would not have sufficed.

Ulcer

Vitamin D3 improves ulcer healing

Based on 15 Researches

Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial.

Most Relevant Research

We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.

Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.

In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.

9.5

Quick recovery

Most Useful Review

The Vitamin D3 helped heal my mouth ulcer swiftly.

Whooping Cough

Effective for whooping cough and asthma! I tried various inhalers but found them ineffective. After reading about vitamin D, I started this supplement and noticed a difference within two days; my whooping cough significantly improved. I haven't caught a cold in three years since taking it. I appreciate the doctor's article and am grateful for this NOW supplement, which is hard to find in Japan, and to iHerb.

Yeast Infection

Vitamin D3 shows antifungal promise

Antifungal activity of vitamin D against Candida albicans in vitro and in vivo.

Most Relevant Research

We explored the antifungal effects of vitamin D3 against yeast infections, focusing on Candida albicans, in a thorough study. Using a variety of methods, including a broth microdilution test and solid plate assays, we found that vitamin D3 significantly inhibits the growth of different Candida species in a way that was both broad and dose-dependent.

Additionally, vitamin D3 showed a strong antifungal effect during the crucial phases of biofilm formation—this is important because Candida can often form protective layers that make infections harder to treat. We investigated the mechanism behind this action and discovered that vitamin D3 affects several metabolic pathways within the yeast, suggesting that it operates through multiple targets.

In an experimental model of intra-abdominal candidiasis, we noted that vitamin D3 reduced fungal presence in key organs like the liver and kidneys. Furthermore, analysis revealed that treatment with vitamin D3 resulted in less inflammation, as indicated by decreased inflammatory cell presence and lower levels of specific cytokines in the blood. Overall, these findings propose vitamin D3 as a promising new treatment option for combating yeast infections, particularly in difficult-to-treat cases like intra-abdominal candidiasis.

9.5

Effective treatment

Most Useful Review

Excellent! I've been taking D3 for a year—15,000 in winter and 10,000 in summer. I haven't been ill during autumn and winter. My metabolism improved and I successfully conceived after eight years of trying. Now pregnant, I take 10,000. If I notice symptoms of a yeast infection, I increase to 20,000, and it rectifies the issue within a day. D3 strengthens mucous membranes, making them less prone to infections.

Back Pain

Vitamin D3 improves back pain

Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.

Most Relevant Research

We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.

Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.

The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.

Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.

8.3

Reduced back pain

Most Useful Review

I take vitamin D-3 to support my immune system and noticed significantly less back pain. I used to be ill frequently, but since starting this, I've experienced fewer illnesses. My hair loss has also decreased, with no side effects, and my back pain has stopped. The capsules are small and easy to take.

Bloating

Likely Very Effective

Calcium D3 reduces bloating

Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction.

Most Relevant Research

We explored the effectiveness of OsteoCalVitFort, a supplement combining 500 mg of calcium and 400 IU of vitamin D3, focusing specifically on its impact on bloating. The study involved 186 participants aged 18 to 65 years, who took two tablets daily—one after breakfast and one after dinner.

Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.

Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.

Bloating free

Most Useful Review

I purchased this potent vitamin D3 supplement, and the dosage works well for me. Now Foods' quality is reliable, and it doesn't lead to any bloating.

Brain Tumor

Vitamin D3 may reduce brain edema

Based on 12 Researches

Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.

Most Relevant Research

We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.

Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.

We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.

8.8

Tumour reduction

Most Useful Review

This vitamin D3 was recommended by my doctor for my immunity. I also gave some to my father, who has a brain tumour and required a high potency dose. It has actually reduced his tumour slightly and improved his health levels! So it certainly works.

Eczema

Vitamin D3 improves eczema symptoms

Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis.

Most Relevant Research

We explored the potential benefits of vitamin D3 as a treatment for eczema, a condition that has been increasingly prevalent in recent years. By examining several randomized controlled trials, we were able to focus on how effective vitamin D3 might be in alleviating the symptoms of eczema, as measured by established severity indexes.

Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.

This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.

9.5

Cleared up eczema

Most Useful Review

I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!

Hypothyroidism

Vitamin D3 reduces thyroid autoimmunity

A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.

Most Relevant Research

We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.

Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.

Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.

Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.

8.8

Improved mood

Most Useful Review

The mood has improved, and my TTG has decreased. I have hypothyroidism, and after taking vitamin D, my levels rose, leading to better well-being. A doctor prescribed 50,000 IU (one tablet every other day) for three weeks, with a follow-up on vitamin D levels due to individual digestibility variations.

Laryngitis

After taking vitamin D for two months, my levels increased from 16 to 42. I then tried D3K2, which seemed to improve absorption when taken together. Since then, I have not fallen ill, despite having previously suffered from sinusitis, rhinitis, and laryngitis regularly. Address your deficiencies and stay healthy!

Pancreatitis

Vitamin D3 supplementation effective

Vitamin D in blood serum and chronic pancreatitis.

Most Relevant Research

We explored the relationship between vitamin D levels and chronic pancreatitis, a condition often characterized by malabsorption and malnutrition. In a study involving fifty patients with chronic pancreatitis and a control group of twenty individuals without gastrointestinal diseases, we measured the vitamin D levels in their blood serum.

Our findings revealed that a significant number of patients with chronic pancreatitis—about 60-80%—had notably low vitamin D levels. This is concerning, as low vitamin D can contribute to various health issues. To address this, we administered a high dose of 1.5 million IU of vitamin D3 daily to those with low levels for a duration of 24 weeks. After this treatment, we reassessed the participants' vitamin D levels.

The results were promising; vitamin D levels in patients improved significantly following supplementation. However, while we observed effective correction of vitamin D deficiency, more research is essential to determine potential long-term benefits, particularly regarding its role in fibrogenesis. Our study's limitations include the relatively small number of subjects, which suggests the need for broader studies in the future.

Bone health complications

Most Useful Review

In acute vitamin D deficiency, symptoms such as weight loss, insomnia, frequent bone fractures, and deterioration of vision can arise before more severe issues like rickets or osteoporosis. I also experienced complications like lupus erythematosus, pancreatitis, enterocolitis, and chronic gastritis, which underscored the importance of addressing vitamin deficiencies.

Pneumonia

Effective against pneumonia

I take Vitamin D-3 to support my immune system and defend against colds and pneumonia, confirmed by various documentaries. After years of flu vaccinations and illnesses, my health improved dramatically once I started boosting my immunity, including the use of Vitamin D-3. I haven't been sick in thirty years, affirming its importance alongside other supplements like Vitamin C and zinc.

Prostate Cancer

Vitamin D3 may prevent prostate cancer

Based on 15 Researches

1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.

Most Relevant Research

We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.

Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.

Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.

Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.

9.5

Enhances sexual health

Most Useful Review

This product has numerous benefits, including improving sperm health, increasing sexual desire, and aiding in achieving erections. Vitamin D3 may help prevent prostate cancer and also promotes bone and joint health. Understanding these benefits makes one fortunate.

Stroke

Vitamin D3 protects neurons from stroke

Vitamin D alleviates neuronal injury in cerebral ischemia-reperfusion via enhancing the Nrf2/HO-1 antioxidant pathway to counteract NLRP3-mediated pyroptosis.

Most Relevant Research

We explored the potential benefits of vitamin D3 (specifically, 1,25-vitamin D3) for protecting the brain during events such as strokes caused by impaired blood flow, known as cerebral ischemia-reperfusion injury (CIRI). In this study, rats received vitamin D3 supplementation for a week before undergoing a procedure that mimicked a stroke. The results were striking; those treated with vitamin D3 showed significant improvements in neurological function, with reduced areas of brain damage and more surviving neurons.

We also tested the effects of vitamin D3 on rat cortical neurons in a laboratory setting, specifically observing its influence on cell survival during oxygen-glucose deprivation and reoxygenation (a model for stroke). The vitamin D3 treatment not only improved cell viability but also appeared to reduce cell death and inflammation. Our analyses revealed that vitamin D3 boosts important protective proteins in the brain, which help combat oxidative stress and inhibit pathways linked to inflammatory cell death.

Overall, our findings strongly suggest that vitamin D3 could be a valuable resource in stroke management by protecting neurons through its antioxidant actions and reduction of harmful inflammation.

7.5

Health Maintenance

Most Useful Review

I purchased this for a family member who had a mild stroke, hoping he would continue taking it for his health.

Alzheimer

Vitamin D3 shows promise for Alzheimer's

Chronic vitamin D supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.

Most Relevant Research

We explored the impact of vitamin D3 supplementation on cognitive decline in transgenic mice that model Alzheimer's disease. Over a 20-week treatment period, we conducted a series of tests, including a Morris Water Maze test to assess cognitive function and various analyses to gauge oxidative stress and Alzheimer-related pathology.

Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).

Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.

In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.

7.5

Research ongoing

Most Useful Review

Vitamin D is a biologically active substance formed in the skin through ultraviolet rays, entering our body via food. It supports normal bone growth, inhibits rickets and osteoporosis, enhances muscle tone and immunity, regulates blood pressure, and may help in restoring nerve sheath protection. Ongoing research is exploring its impact on Alzheimer’s disease, cognitive functions in the elderly, mood disorders such as depression, and autoimmune conditions like psoriasis.

Epilepsy

Vitamin D3 improves epilepsy outcomes

Therapeutic effect of acute and chronic use of different doses of vitamin D3 on seizure responses and cognitive impairments induced by pentylenetetrazole in immature male rats.

Most Relevant Research

We aimed to understand how vitamin D3 affects seizures and cognitive problems related to epilepsy. In our study, we used sixty-six young male rats, dividing them into control and treatment groups. This allowed us to compare the outcomes of those treated with vitamin D3 against our control rats.

We observed that the rats with epilepsy showed notable issues with learning and memory, as their ability to retain information was impaired. Additionally, when exposed to pentylenetetrazole (a chemical that induces seizures), these rats experienced increased seizure duration and decreased latency before seizures. However, interestingly, when we administered vitamin D3, both acutely and chronically, these adverse effects were significantly improved.

Not only did vitamin D3 help reduce seizure severity, but it also positively influenced the levels of antioxidants and inflammatory markers in the hippocampus, a key brain area for learning and memory. Our findings suggest that vitamin D3 can indeed play a beneficial role in mitigating the cognitive and seizure-related challenges associated with epilepsy.

7.5

Critical for epilepsy

Most Useful Review

Vitamin D3 is essential; low levels can cause serious health problems, including epilepsy, strokes, and various cancers. Finding the right dosage varies by individual, but adults should consider 2000-5000 IU daily, while pregnant women may need 5,000 IU. It’s particularly important to supplement during months of limited sunlight to support overall health, especially for conditions like epilepsy.

Frozen Shoulder

I experienced constant lethargy and pain in my shoulder, linked to vitamin D deficiency. After using this product, I felt significant improvement. My shoulder pain subsided, and I highly recommend it, but don't forget to consult your doctor.

Heart Attack

Calcitriol aids heart recovery

Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.

Most Relevant Research

We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.

Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.

We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.

8.3

Cancer protection

Most Useful Review

It is essential for everyone to take vitamin D supplements as it protects against various cancers, especially breast cancer in women, and helps prevent heart attack. Moreover, it safeguards against heart disease, blood pressure issues, and strokes. Additionally, vitamin D plays a crucial role in preventing diabetes by stimulating the pancreas to produce more insulin and boosting immunity.

Menopause

Vitamin D3 in menopause management

Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats.

Most Relevant Research

In this study, we explored how vitamin D3, among other supplements, affects metabolic health during menopause. The research utilized a group of ovariectomized female rats, which serve as a model for menopausal conditions in women. These rats were divided into several groups, including a control group and various groups that received different treatments, including vitamin D3.

The findings indicated that administering vitamin D3, along with boric acid, magnesium, and extra virgin olive oil, led to notable improvements in metabolic parameters. We observed benefits in areas such as inflammation and oxidative stress, which are crucial for managing health during menopause. However, while vitamin D3 showed positive effects, the study highlighted that the combination of all supplements had a more significant impact than vitamin D3 alone.

Ultimately, while vitamin D3 contributes positively to metabolic health in menopause, the full extent of its isolated benefits remains unclear without further studies. Thus, we recognize the need for additional research to fully understand how effective vitamin D3 can be independently in this context.

8.8

Improved symptoms

Most Useful Review

I previously had low vitamin D levels at 11ng/ml, alongside muscle pain, tiredness, and recurrent colds. After using this product, I'm experiencing improvement in these symptoms. Vitamin D also aids in alleviating menopause and PMS symptoms. I purchased it on sale for 18 reais, which is much cheaper than other markets. I live in Minas Gerais, and my orders arrived within 10 days.

Sinusitis

Vitamin D3 aids sinusitis relief

The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency.

Most Relevant Research

We focused on understanding the role of vitamin D3 in treating chronic rhinosinusitis (CRS), a condition affecting the nasal passages and sinuses. Our study analyzed 200 patients with vitamin D deficiency, dividing them into two groups: one group was given oral vitamin D supplements, while the other received a placebo.

Over a span of three months, we monitored changes in vitamin D levels and symptoms using the Total Nasal Symptom Score (TNSS). Initially, the average vitamin D level was quite low at 12.31 ng/ml. Remarkably, after treatment, this level surged to 29.71 ng/ml, indicating a significant improvement.

Additionally, we observed a reduction in TNSS scores, showing that while the average score started at 11.92, it decreased by about 10.65 points after three months of vitamin D treatment. This significant drop highlights the positive impact vitamin D supplementation can have on alleviating symptoms of CRS.

Overall, our exploration revealed a previously high prevalence of vitamin D deficiency among CRS patients, suggesting that addressing this deficiency through supplementation can be beneficial in managing their symptoms effectively.

9.5

Mood improvement

Most Useful Review

Initially, my vitamin D was at 12. After three months at 10,000 IU, my level increased to 110. I now take 5000 IU, maintaining my levels around 60-65. I’ve noticed significant improvements in my immunity and mood, and I used to suffer from tonsillitis and sinusitis without respite.

Urinary Tract Infection

Vitamin D deficiency linked to UTI

The Association between Vitamin D Levels and Urinary Tract Infection in Children.

Most Relevant Research

We aimed to explore the possible connection between vitamin D levels and urinary tract infections (UTIs) in children. Our study involved measuring various health markers, including vitamin D levels, in 82 children who had experienced their first UTI and compared these results to 64 healthy controls.

The findings revealed that children with UTIs had significantly lower levels of vitamin D compared to their healthy peers. Specifically, those with acute pyelonephritis exhibited even lower vitamin D levels than those with lower UTIs. We also noted that girls tended to have lower vitamin D levels than boys.

Multivariate analysis indicated that a vitamin D level below 20 ng/ml was associated with a higher likelihood of UTIs in children. Therefore, our results suggest that vitamin D deficiency may indeed pose a risk for urinary tract infections in this population.

9.5

Improved immunity

Most Useful Review

I purchased this vitamin as I lack sunlight. I've felt fatigued and suffered from pain in my back and legs, likely due to vitamin D3 deficiency. After six days of taking it, I noticed increased energy, improved mood, and less pain. It’s beneficial for immunity and may assist in preventing respiratory infections.

Chest Pain

Calcium and vitamin D3 treatment effective

ECG changes in a 25-year-old woman with hypocalcemia due to hypoparathyroidism. Hypocalcemia mimicking acute myocardial infarction.

Most Relevant Research

We explored the case of a 25-year-old woman who experienced chest pain and ECG changes typically associated with a heart attack. After undergoing cardiac catheterization, doctors found her coronary arteries to be normal but noted impaired left ventricular performance.

Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.

Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.

8.8

Joint pain relief

Most Useful Review

This vitamin has greatly improved my health. After two months of taking it, I found it easier to wake up, had more energy, and my joint pain vanished, which was attributed to a vitamin D deficiency. I’ve experienced no side effects, and I'm very satisfied with this product.

Influenza

Vitamin D3 may reduce influenza severity

Based on 12 Researches

Oral Supplementation of the Vitamin D Metabolite 25(OH)D Against Influenza Virus Infection in Mice.

Most Relevant Research

We aimed to understand how oral supplementation of 25-hydroxyvitamin D, a key metabolite of vitamin D3, influences influenza A virus infection in mice. In our study, mice were given a diet enriched with a high dose of 25(OH)D before they were exposed to the influenza virus.

The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.

These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.

7.5

Decreases infection rate

Most Useful Review

Adequate vitamin D intake is key to reducing the incidence of influenza and other viral infections. Insufficient levels increase infection rates. This product is cost-effective for a 120-day supply.

Irritable Bowel Syndrome

Vitamin D3 benefits IBS in teens

Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial.

Most Relevant Research

We aimed to understand how vitamin D3 supplementation might help adolescents suffering from irritable bowel syndrome (IBS), especially those who are deficient in vitamin D. Our study involved 112 adolescents diagnosed with IBS, who were split into two groups based on their age and gender.

One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.

The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.

Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.

In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.

6.3

Vitamin benefits noted

Most Useful Review

I highly recommend continuing vitamin intake, particularly for those with irritable bowel syndrome, as absorption can be poor. This vitamin D supplement from a reputable company offers essential support for gut health, which we often struggle to maintain.

Obesity

Vitamin D reduces triglycerides effectively

Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials.

Most Relevant Research

We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.

Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.

Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.

Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.

8.8

Improves obesity issues

Most Useful Review

Vitamin D3 deficiency is prevalent and affects many people. It can arise from various factors such as poor sunlight exposure and genetic issues. When taking vitamin D, start with small doses if you have anaemia. It’s advisable for seniors with gastrointestinal issues to use sublingual forms for better absorption. For breastfeeding mothers, ensure optimal levels before dosing infants. Those with obesity may need nearly double the recommended dose, and adequate levels of magnesium and vitamin A are vital.

Psoriasis

Vitamin D3 ethosomes for psoriasis

Based on 7 Researches

Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.

Most Relevant Research

We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.

In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.

Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.

7.5

Reduced infections

Most Useful Review

Adequate intake of vitamin D3 lowers the incidence of acute respiratory infections, while deficiency increases illness risk and autoimmune conditions like psoriasis. Insufficient cholecalciferol also affects insulin secretion. This supply lasts 120 days and is cost-effective.

Vertigo

Vitamin D3 reduces BPPV recurrence

Randomized Controlled Trial Assessing Vitamin D's Role in Reducing BPPV Recurrence in Older Adults.

Most Relevant Research

We investigated how supplementing vitamin D3 could affect the recurrence of Benign Paroxysmal Positional Vertigo (BPPV) in older adults. In a carefully designed double-blind clinical trial, we followed participants for 12 months to assess whether those treated with vitamin D3 would experience fewer BPPV episodes compared to those given a placebo.

Participants who were low on vitamin D3 received 13 weeks of a higher dose followed by a lower one, while others with sufficient levels were simply monitored. Our results were promising: the group receiving vitamin D3 experienced an impressive 87% reduction in recurrence rates and a significant delay in the time to first recurrence compared to the placebo group.

However, we didn't find any clear differences in outcomes between those treated with vitamin D3 and the participants who were already vitamin D replete. This trial provides a strong basis for further exploring vitamin D as a standard treatment option for BPPV in future research phases.

Resolved vertigo issue

Most Useful Review

Worked wonders. I had very low vitamin D3 and suffered from severe vertigo and mild tinnitus. Within two months, both conditions improved, and by four months, they were gone. What a relief! No more spinning rooms or ringing bells. It's very inexpensive and effective.

Reflux

Likely Very Effective

Vitamin D3 may aid inflammation

Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.

Most Relevant Research

We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.

The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.

Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.

9.5

Effective dosage

Most Useful Review

This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.

Liver Disease

Vitamin D3 aids liver health

Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.

Most Relevant Research

We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.

After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.

Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.

9.5

Essential for thyroid

Most Useful Review

Having thyroid diseases, vitamin D is an essential daily supplement for me. It's crucial because Hashimoto's autoimmune thyroiditis is linked to vitamin D deficiency. It aids calcium absorption and contributes to the health of the thyroid, skin, hair, and nails. We take it daily and I highly recommend it!

Blood Clot

Vitamin D may influence blood clotting

Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.

Most Relevant Research

We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.

Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.

Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.

Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.

9.5

Cramps disappeared

Most Useful Review

My vitamin D level was only 11 ng/ml, but after just a month of taking this supplement, it rose to 35 ng/ml and my leg cramps vanished. I highly recommend it.

Pelvic Pain

Eliminated pelvic pain

After pregnancy, I had low levels of vitamin D3. Thanks to a 5000 IU dosage, my vitamin D3 level increased from 10 to 39, which improved my well-being; the pelvic pain and joint pain in my hands stopped. I wholeheartedly recommend it!

Dizziness

Vitamin D treatment reduces BPPV

Based on 7 Researches

Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency.

Most Relevant Research

We sought to understand the impact of severe vitamin D deficiency on benign paroxysmal positional vertigo (BPPV), a common cause of dizziness. Previous studies showed a connection between low vitamin D levels and both the onset and recurrence of BPPV, but none had conclusively demonstrated that addressing this deficiency could lessen the recurrence of symptoms.

To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.

Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.

This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.

9.5

Dizziness relieved

Most Useful Review

I've been taking it for four months. The capsules are easy to swallow, and I’m addressing my vitamin D3 deficiency. Dizziness has passed, though my joints still crunch. I recommend 5000 IU D3 for those with low levels.

Migraine

Vitamin D3 improves migraine symptoms

Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.

Most Relevant Research

We explored the potential benefits of vitamin D3 supplementation for people suffering from migraines. In a carefully designed study, 80 individuals with episodic migraines participated in a 12-week trial where they were randomly assigned to receive either 2000 IU (50 μg) of vitamin D3 daily or a placebo.

Throughout the study, we closely monitored headache characteristics using diaries and measured various serum inflammatory markers before and after the trial. Our findings showed that those taking vitamin D3 experienced significant improvements. They reported fewer headache days each month, shorter headache durations, and less severe pain overall when compared to the placebo group.

Interestingly, while the levels of some inflammatory markers didn't change much, we did notice a striking reduction in a certain enzyme linked to inflammation in the vitamin D3 group. Additionally, there was a trend toward lower levels of another inflammation marker, suggesting that vitamin D3 might offer a protective effect against neuro-inflammation in migraine sufferers.

In essence, our study indicates that vitamin D3 could be a promising supplemental treatment to help improve the quality of life for those battling episodic migraines.

9.5

Reduces migraine frequency

Most Useful Review

Possibly reduced the frequency of my migraines. I started taking this D3 supplement in late 2009 after a blood test showed low vitamin D levels. My migraines, which had been frequent for 17 years, became less frequent while taking this supplement. After running out, they returned to their previous frequency. I'm convinced this vitamin D helps, so I’ll continue taking it and monitoring my levels.

Kidney Stones

Vitamin D3 does not prevent stones

Likely Ineffective

Based on 4 Researches

Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.

Most Relevant Research

We assessed how two different vitamin D3 repletion protocols affect patients with recurrent calcium kidney stones and vitamin D deficiency. This was a controlled clinical trial involving 62 participants who had low levels of vitamin D and were prone to kidney stones. We administered either 2000 IU of cholecalciferol daily for 12 weeks or 50,000 IU weekly for 8 weeks.

Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.

We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.

9.5

Recommended care

Most Useful Review

Verified option! This vitamin D is proven to be beneficial, but it should be taken with vitamin K2 to prevent kidney stones. Additionally, magnesium is necessary for optimal absorption. While many are deficient in vitamin D, it's wise to get tested to determine the right dosage and duration. Stay healthy!

Diarrhea

No significant benefit from vitamin D3

Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.

Most Relevant Research

We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.

Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.

However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.

Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.

Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.

9.5

Improved condition

Most Useful Review

Excellent! I took this vitamin as I have a deficiency. My doctor mentioned that this type of diarrhoea is beneficial. I've started taking the vitamin, and I find the capsule easy to swallow, which I appreciate.

Insomnia

Vitamin D3 improves adolescent insomnia

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls.

Most Relevant Research

We studied how high-dose vitamin D3 supplementation might affect insomnia in adolescent girls. Over nine weeks, 940 participants received a weekly dose of 50,000 IU of vitamin D3 while we tracked changes in their sleep patterns.

Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.

We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.

These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.

9.5

Improved sleep quality

Most Useful Review

I had a significant lack of vitamin D, leading to lethargy, apathy, and insomnia. When I discovered my low levels, I started taking these small capsules. There were no side effects, and my condition began to improve. I now take one capsule daily with my family and can sleep better.

Sleep Apnea

Vitamin D3 improves mild sleep apnea

The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome.

Most Relevant Research

We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.

By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.

Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.

9.5

Improved sleep quality

Most Useful Review

I found melatonin and niacin from iHerb effective for my severe sleep apnea, allowing me to withdraw from strong benzo medication. After starting vitamin D, my sleep quality markedly improved, and I could sleep through the night without frequent awakenings. Despite my daily sun exposure, I now realise the significant role of vitamin D in stabilising my mental health and enhancing sleep.

Nausea

The pill is small, odourless, and does not cause nausea. I find one a week sufficient for my needs. According to my doctor, it's best taken after a fatty meal, such as eggs or avocado, for better absorption.

Constipation