NOW Supplements Vitamin D-3

Vitamin D3 effectively treats warts

Al-Sabak H, Al-Hattab M, Al-Rammahi M, Al-Dhalimi M. The efficacy of intralesional vitamin D3 injection in the treatment of cutaneous warts: A clinical therapeutic trial study. Skin Res Technol. 2023;29:e13442. doi:10.1111/srt.13442

We conducted a clinical trial to explore the effectiveness of intralesional vitamin D3 as a treatment for cutaneous warts. Involving 40 patients, we injected a vitamin D3 solution into the bases of their warts over several sessions.

The results were promising, with 81.9% achieving complete clearance of their warts after treatment, while only a small percentage showed no improvement. Most patients tolerated the treatment well, reporting only minor side effects.

Overall, vitamin D3 proves to be an effective and affordable option for wart treatment.

Leg wart gone!

Most Useful Review

Excellent! This vitamin D works wonders. My whole family takes it, and my husband had a wart on his leg that completely disappeared after taking the vitamin.

We explored the connection between vitamin D levels and immunity to varicella-zoster virus (VZV), which causes shingles, in patients undergoing chronic dialysis. Recognizing that these patients often have weakened immune systems, we set out to see if vitamin D could play a vital role in boosting their immunity.

In a multicenter study involving 88 hemodialysis patients, we measured various vitamin D parameters in their blood and assessed their VZV immunity through specific antibody tests. The results were telling: patients with a vitamin D level of less than 30 ng/ml had significantly lower levels of VZV-specific IgG antibodies compared to those who had sufficient vitamin D. This difference became more pronounced when focusing on patients who were actively using vitamin D supplements.

We found that having a higher level of vitamin D was associated with increased immunity against VZV, highlighting a potential link between vitamin D treatments and shingles prevention. Our findings suggest that boosting vitamin D in chronic dialysis patients could be an effective strategy to enhance their immune response to shingles and, potentially, improve their overall health. However, patients with cancer in the study exhibited lower VZV immunity, indicating that other factors could also influence results.

Significant improvement

Most Useful Review

My wife has suffered from shingles for the past 12 months. The vitamin D-3 has significantly helped her overcome various issues, and I am also taking it as I recover from surgery.

Stroke details

Vitamin D3 protects neurons from stroke

Based on 26 Researches

Qiao J, Ma H, Chen M, Bai J. Vitamin D alleviates neuronal injury in cerebral ischemia-reperfusion via enhancing the Nrf2/HO-1 antioxidant pathway to counteract NLRP3-mediated pyroptosis. J Neuropathol Exp Neurol. 2023;82:722. doi:10.1093/jnen/nlad047

We explored the potential benefits of vitamin D3 (specifically, 1,25-vitamin D3) for protecting the brain during events such as strokes caused by impaired blood flow, known as cerebral ischemia-reperfusion injury (CIRI). In this study, rats received vitamin D3 supplementation for a week before undergoing a procedure that mimicked a stroke. The results were striking; those treated with vitamin D3 showed significant improvements in neurological function, with reduced areas of brain damage and more surviving neurons.

We also tested the effects of vitamin D3 on rat cortical neurons in a laboratory setting, specifically observing its influence on cell survival during oxygen-glucose deprivation and reoxygenation (a model for stroke). The vitamin D3 treatment not only improved cell viability but also appeared to reduce cell death and inflammation. Our analyses revealed that vitamin D3 boosts important protective proteins in the brain, which help combat oxidative stress and inhibit pathways linked to inflammatory cell death.

Overall, our findings strongly suggest that vitamin D3 could be a valuable resource in stroke management by protecting neurons through its antioxidant actions and reduction of harmful inflammation.

7.5

Health Maintenance

Most Useful Review

I purchased this for a family member who had a mild stroke, hoping he would continue taking it for his health.

Whooping Cough details

25 people found this helpful

Effective for whooping cough and asthma! I tried various inhalers but found them ineffective. After reading about vitamin D, I started this supplement and noticed a difference within two days; my whooping cough significantly improved. I haven't caught a cold in three years since taking it. I appreciate the doctor's article and am grateful for this NOW supplement, which is hard to find in Japan, and to iHerb.

Cold details

Harrison SE, Oliver SJ, Kashi DS, Carswell AT, Edwards JP, et al. Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. Med Sci Sports Exerc. 2021;53:1505. doi:10.1249/MSS.0000000000002604

Based on 6 Researches

Vitamin D reduces cold severity

We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.

In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.

Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.

While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.

Joint pain resolved

Most Useful Review

22 people found this helpful

Following my doctor's advice, I took a high dose of D3 to address my very low levels. It took time to reach normal levels, but I now need 10,000IU daily to stay healthy. I previously experienced joint pain and seasonal affective disorder due to lack of sunlight, but the additional D3 has significantly improved my mood and energy. I’m much happier during the cold winter months!

Anxiety details

Zaromytidou E, Koufakis T, Dimakopoulos G, Drivakou D, Konstantinidou S, et al. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study. Metabolites. 2022;12. doi:10.3390/metabo12100884

Vitamin D3 aids anxiety reduction

We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.

At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.

These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.

Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.

Anxiety reduction

Most Useful Review

97 people found this helpful

I have genetically predisposed anxiety, and after moving, it became debilitating. Following several doctors' visits, I discovered my vitamin D level was critically low. After starting 5,000 IU daily, I noted significant improvements in my anxiety attacks, which have nearly vanished, allowing me to face daily challenges again.

Bloating details

Sanaei M, Banasiri M, Shafiee G, Rostami M, Alizad S, et al. Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction. J Diabetes Metab Disord. 2015;15:9. doi:10.1186/s40200-016-0231-0

Likely Very Effective

Based on 2 Researches

Vitamin D3 may reduce bloating

We aimed to assess how the supplement OsteoCalVitFort, which includes 500 mg of calcium and 400 I.U. of vitamin D3, affects bloating and overall satisfaction among users. In our study, 186 participants aged between 18 and 65 were invited to take two tablets daily—one after breakfast and one after dinner—over a period defined by the contents of a single pack.

After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.

With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.

Bloating free

Most Useful Review

I purchased this potent vitamin D3 supplement, and the dosage works well for me. Now Foods' quality is reliable, and it doesn't lead to any bloating.

Blurred Vision details

Enhances night vision

195 people found this helpful

This is a fantastic supplement for those experiencing vision problems! It has effectively helped me cope with night blindness, as I can see much better in the evening now.

Colitis details

Vitamin D3 shows comparable effects

Based on 3 Researches

O'Donnell JEM, Leach ST, Bowcock NL, Chen S, Gupta N, et al. Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial. Dig Dis Sci. 2025. doi:10.1007/s10620-025-08913-3

We conducted a randomized controlled trial to investigate how vitamin D3 impacts children with inflammatory bowel disease (IBD), specifically aiming to address vitamin D deficiency in those suffering from colitis.

The study compared two different treatment approaches: a low daily dose of 2000 IU of vitamin D3 and a one-time high dose of the 'stoss' therapy, where children received a significantly larger dose of 400,000 IU or 800,000 IU, depending on their age. Children in both treatment groups were monitored over 12 months for various health indicators, including 25OHD levels and clinical disease activity.

Our findings revealed that the stoss therapy was non-inferior to the daily dosing regimen in raising vitamin D levels over the study period. Importantly, there were no significant differences in vitamin D levels at any of the checkpoints—3, 6, 9, or 12 months.

This indicates that both supplementation methods can effectively address vitamin D deficiency in children with colitis. However, the study emphasizes the absence of any superior benefits from one treatment over the other.

Helps inflammation

Most Useful Review

I can't live without my vitamin D! I have ulcerative colitis and it aids in reducing inflammation as well as supporting bone health. I trust the Now Foods brand!

Diabetes details

Vitamin D3 shows no diabetes benefit

Based on 11 Researches

Virtanen JK, Hantunen S, Kallio N, Lamberg-Allardt C, Manson JE, et al. The effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial. Diabetologia. 2024. doi:10.1007/s00125-024-06336-9

We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.

Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.

Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.

Improved diabetes management

Most Useful Review

309 people found this helpful

Vitamin D has transformed my health. Doctors advised me to take it, and after switching to this 5000 IU supplement, my levels improved significantly from 40 to 85. Apart from cosmetic benefits, I have noticed better blood sugar control, which is essential for managing diabetes. I've been feeling excellent overall, and I believe maintaining vitamin D levels is vital for health.

Erectile Dysfunction details

Vitamin D supplementation ineffective

Duarte Romero B, Waterhouse M, Baxter C, McLeod DSA, English DR, et al. The effect of three years of vitamin D supplementation on erectile dysfunction: Results from the randomized placebo-controlled D-Health Trial. Clin Nutr ESPEN. 2024;60:109. doi:10.1016/j.clnesp.2024.01.011

We explored the direct impact of vitamin D supplementation on erectile dysfunction among older men through the D-Health Trial, which followed nearly 11,530 participants aged 60 to 84. Participants were randomly assigned to receive either 60,000 IU of vitamin D monthly or a placebo over a period of up to five years.

After three years, we assessed erectile dysfunction and found that while vitamin D levels increased significantly in the treatment group, the prevalence of erectile dysfunction remained almost identical between both groups—58.8% in the vitamin D group compared to 59.0% in the placebo group. Importantly, our analyses showed no evidence that vitamin D supplementation made any difference in erectile dysfunction for any subgroup of older men evaluated.

In conclusion, our findings suggest that taking vitamin D supplements is unlikely to prevent or alleviate erectile dysfunction. This highlights the need for further exploration into effective treatments for this common condition among older men.

7.5

Vitamin D benefits

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6 people found this helpful

Dee recommends this vitamin D supplement as I have limited sun exposure and struggle with vitamin D production. I've chosen the 5000IU dosage because excessive vitamin D may cause kidney dysfunction, which is a concern I take seriously.

Hashimoto details

Chahardoli R, Robat-Jazi B, Azizi F, Amouzegar A, Khalili D, et al. Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial. Endocr Metab Immune Disord Drug Targets. 2024;24:1454. doi:10.2174/0118715303273297231226153751

Vitamin D3 shows limited effect

We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.

Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.

On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.

This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.

Strong immunity boost

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235 people found this helpful

Taking one capsule a day significantly improves my immunity against various viral diseases. Over the years, my family, including children, has not experienced any major cold or illness. As someone with Hashimoto's thyroiditis, this supplement is essential for me due to its link with vitamin D deficiency.

Heart Attack details

Yang S, Wang C, Ruan C, Chen M, Cao R, et al. Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction. Cells. 2022;11. doi:10.3390/cells11101676

Calcitriol aids heart recovery

We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.

Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.

We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.

Cancer protection

Most Useful Review

1 people found this helpful

It is essential for everyone to take vitamin D supplements as it protects against various cancers, especially breast cancer in women, and helps prevent heart attack. Moreover, it safeguards against heart disease, blood pressure issues, and strokes. Additionally, vitamin D plays a crucial role in preventing diabetes by stimulating the pancreas to produce more insulin and boosting immunity.

Leg Cramps details

Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. doi:10.1002/14651858.CD010655.pub3

Very Likely Ineffective

Based on 2 Researches

Minimal effects of vitamin D

We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.

In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.

Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.

No more leg cramps

Most Useful Review

11 people found this helpful

Vitamin D-3 is remarkable! After taking 5000 IU for two weeks, my back pain and chest discomfort disappeared, and even my leg cramps resolved. Additionally, my sleep has improved significantly.

Lupus details

Vitamin D enhances immune response in lupus

Mariz HA, Sato EI, Cardoso PRG, Gonçalves R, Duarte ALBP, et al. Vitamin D Presented In Vitro Immunomodulatory Property on T Lymphocyte-Related Cytokines in Systemic Lupus Erythematosus. Inflammation. 2023;46:730. doi:10.1007/s10753-022-01768-0

We explored how vitamin D influences immune responses in women with systemic lupus erythematosus (SLE). Blood samples from 27 patients were used to isolate immune cells and examine the impact of 1,25 dihydroxyvitamin D3 on various cytokines.

Our findings revealed that this form of vitamin D significantly reduced certain pro-inflammatory cytokines while simultaneously increasing beneficial ones, suggesting its potential to improve immune regulation in lupus. However, not all cytokine levels were affected.

Overall, vitamin D shows promise in helping manage inflammatory responses related to SLE.

Helps autoimmune disease

Most Useful Review

Excellent! It assists me with my autoimmune disease "lupus". However, I will now consume it with vitamin K2.

Rosacea details

Akdogan N, Alli N, Incel Uysal P, Candar T. Role of serum 25-hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case-control study. Clin Exp Dermatol. 2019;44:397. doi:10.1111/ced.13769

Based on 3 Researches

Link between vitamin D and rosacea

We designed a fascinating case-control study to investigate how vitamin D might influence the risk of developing rosacea, a common skin condition. In our research, we compared patients who have rosacea to healthy individuals, assessing their vitamin D levels and specific variations in their vitamin D receptor genes.

The findings indicated that patients with rosacea had notably higher levels of serum 25-hydroxyvitamin D. In fact, those with elevated vitamin D levels had a 1.36-fold increased risk of developing rosacea. We also discovered that certain genetic variations, such as the ApaI and TaqI polymorphisms, played a significant role in rosacea susceptibility, with heterozygous and mutant forms of the ApaI variants particularly increasing risk.

These results suggest that vitamin D and its receptor pathways may be contributing factors in rosacea development. However, it’s important to note that while these associations are compelling, causality remains unclear, meaning we cannot conclude that vitamin D treatment will definitively affect rosacea outcomes.

Skin hydration improvement

Most Useful Review

Highly active vitamin D3 5000 has greatly improved my skin's dryness and flaking, even on my face where I have rosacea. My complexion feels toned, swelling has reduced, and the fragility of my leg blood vessels has diminished. My sleep has also improved.

Toothache details

Vitamin D deficiency can cause various diseases, particularly affecting the immune system, bones, and teeth. After taking 5,000,000 units, my severe toothache began to subside within two days. A lower dose would not have sufficed.

Flu details

Zhu Z, Zhu X, Gu L, Zhan Y, Chen L, et al. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Front Nutr. 2021;8:799709. doi:10.3389/fnut.2021.799709

Based on 15 Researches

Vitamin D reduces flu risk

We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.

Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.

The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.

Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.

7.5

Flu-free for years

Most Useful Review

8 people found this helpful

I am very happy with this brand. While some information downplays Vitamin D's role, I find these studies flawed. I haven't had a severe cold or any flu for over a decade by supplementing with it, especially in winter. A balanced diet is essential, and I take 5000 IU as it is affordable and works for me.

Adrenal Gland Disorder details

Boosts energy effectively

Highly recommend it for anyone with chronic fatigue or adrenal gland fatigue. It effectively revitalises individuals deprived of natural sunlight. The product's quality is impressive, and it certainly provides a boost to energy levels.

Alzheimer details

Vitamin D may aid Alzheimer treatment

Based on 19 Researches

Kang J, Park M, Kim T. Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2024;97:1939. doi:10.3233/JAD-231033

We aimed to understand how vitamin D influences the progression of Alzheimer’s disease (AD) by examining its effects on the brain. Our study involved male 5xFAD mice that underwent various dietary regimes and received vitamin D injections. This allowed us to investigate both vitamin D deficiency and supplementation in relation to AD symptoms.

Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.

This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.

7.5

Potential cognitive benefits

Most Useful Review

39 people found this helpful

Vitamin D3 deficiency is common in older adults and linked to psychiatric and neurological disorders. In a study of 80 older adults, it was associated with low mood and cognitive impairment. Research shows that subjects deficient in vitamin D3 scored lower on mental function tests. These findings suggest a potential role for Vitamin D in enhancing cognition, especially for those with alzheimer's.

Angina details

Andishmand A, Ansari Z, Soltani MH, Mirshamsi H, Raafat S. Vitamin D replacement therapy in patients with cardiac syndrome X. Perfusion. 2015;30:60. doi:10.1177/0267659114526629

Based on 7 Researches

Vitamin D aids angina management

We set out to investigate how vitamin D affects angina and exercise-induced ischemia in individuals with cardiac syndrome X who have low levels of this important vitamin. In our study, we treated participants with intramuscular injections of vitamin D3, administered every other week for two months, and monitored changes in their angina episodes as well as their exercise capacity.

After completing the treatment, we observed a noticeable rise in serum vitamin D levels among participants, bringing them into the normal range. More importantly, the frequency of angina episodes significantly decreased, indicating a direct correlation between vitamin D levels and angina symptoms. We also noted impressive increases in exercise duration and maximum work capacity, alongside significant improvements in indicators of cardiac stress, such as ST-segment depression.

These findings strongly suggest that vitamin D replacement can dramatically enhance the quality of life for those experiencing angina due to cardiac syndrome X. Our research highlights an often-overlooked solution to managing heart-related symptoms by simply addressing vitamin D deficiency.

Angina improvement

Most Useful Review

1 people found this helpful

I started taking 5,000 IU of Vitamin D daily after years on lower doses. My wife's 15-year battle with night sweats and depression has ended, and her energy has returned. For my angina, which lasted five years, it has also vanished in the last month. We think the higher dose of Vitamin D is responsible. We previously found only temporary relief.

Benign Tumor details

This vitamin D3 was recommended by my doctor for my immunity. I also gave some to my dad as he has cancer and required a high potency dose. It actually shrank his benign tumour slightly and improved his levels! So it definitely works.

Bronchitis details

Vitamin D3 improves immune function

Based on 4 Researches

Babarykin DA, Vasipa SB, Gintere GB, Bigestan VIa. [Immunocorrecting properties and effect on the phosphorus-calcium metabolism of oxidevit (1 alpha-hydroxyvitamin D3)]. Vopr Med Khim. 1988;34:104.

We explored the impact of 1 alpha-hydroxyvitamin D3, commonly known as vitamin D3, on patients with chronic bronchitis, focusing on its potential benefits for the immune system and calcium-phosphorus metabolism. In this study, 45 patients received doses of either 2 or 4 micrograms of the vitamin over a period of 1 to 2 weeks.

Our findings revealed that the treatment led to observable changes in the metabolism of calcium and phosphorus. The alterations depended on the specific dose and duration of the treatment. Notably, the higher dose of 4 micrograms daily over two weeks was identified as excessive.

We also assessed various immune system components, such as total and rosette-forming cells, T-lymphocyte helpers and suppressors, and B lymphocytes. All these immune parameters showed significant normalization, regardless of the patients' initial levels. Elevated values tended to decrease, while those that were low increased back towards normal. It’s essential to note that despite these positive changes, the immune patterns remained stable throughout the treatment period.

Interestingly, we found a correlation between blood inorganic phosphorus levels and the dynamics of leukocytes, suggesting an interaction between immune responses and mineral metabolism. Overall, vitamin D3 treatment demonstrates a noteworthy effect on improving immune system function in chronic bronchitis patients, supporting its role as an adjunct therapy in managing this condition.

Immune support

Most Useful Review

The quality of this vitamin D is excellent. My husband, who had bronchitis, has not fallen ill this season. It's superb!

Gastritis details

Vitamin D3 benefits gastritis treatment

Based on 7 Researches

Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.

We investigated the impact of vitamin D3 (VD3) on gastritis, especially concerning Helicobacter pylori (Hp) infections and high cholesterol levels. Mice were used to establish conditions of hypercholesterolemia and Hp infection, allowing us to assess the effectiveness of VD3 over an eight-week treatment period.

Throughout the study, we observed significant improvements in the liver and gastric tissues of mice that received VD3. Specifically, levels of vitamin D receptors and Insig-2 increased in the liver, while serum gastrin levels decreased, indicating a positive response to the treatment. We also noted a reduction in inflammatory markers associated with the JAK/STAT3 signaling pathway, which suggests that VD3 plays a role in alleviating inflammation linked to gastritis.

Importantly, alongside these findings, we observed improvements in liver health, as the treatment reduced hepatic ballooning and gastric tissue inflammation in the high cholesterol and Hp infected groups. Overall, our results illustrate that VD3 is a promising aid in alleviating gastritis related to both high cholesterol and Hp, potentially through its mechanism of enhancing liver health and disrupting inflammatory pathways.

Successful vitamin D boost

Most Useful Review

Excellent product! After battling a severe vitamin D deficiency, I began with 5,000 for a month, then 10,000 for two months. My vitamin D levels rose significantly, and I experienced no pain or heartburn, even with gastritis.

Headache details

Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial. Neurol Sci. 2020;41:1183. doi:10.1007/s10072-019-04220-8

Vitamin D3 aids migraine relief

We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.

After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.

Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.

Headaches disappeared

Most Useful Review

487 people found this helpful

Taking vitamin D significantly improved my health. My joints no longer ache, and I no longer feel fatigued. Headaches have vanished, nails and hair are stronger, and I haven’t had a cold since starting the vitamin.

Hypertension details

Calcitriol reduces age-related hypertension

Based on 6 Researches

Hua R, Liu B, He W, Zhang H, Liu Y, et al. Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function. Clin Exp Hypertens. 2023;45:2277653. doi:10.1080/10641963.2023.2277653

We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.

Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.

Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.

Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.

Supports COVID recovery

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1 people found this helpful

My family and I took vitamin D during our COVID illness, and we all recovered well, even my dad with hypertension. This vitamin seemed to support our recovery and overall health.

Lung Cancer details

Liang Y, Zhang X, Peng J, Liu J, Chen H, et al. Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL. J Cancer Res Clin Oncol. 2024;150:51. doi:10.1007/s00432-023-05586-1

Based on 17 Researches

Vitamin D's role in lung cancer

We explored the impact of vitamin D treatment on non-small cell lung cancer (NSCLC) and how it may influence mitochondrial functions in cancer cells. By utilizing small RNA sequencing, we identified various tRNA-derived small RNAs (tsRNAs) that were differentially expressed in lung cancer cells treated with vitamin D.

Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.

Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.

Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.

Significant recovery

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Living in an area with little sun, my husband and I take vitamin D year-round. It has remarkably improved our immunity. I even gave it to my elderly in-laws during their lung cancer bout with coronavirus, leading to a rapid recovery within ten days.

Multiple Sclerosis details

Robat-Jazi B, Oraei M, Bitarafan S, Mesbah-Namin SA, Noori-Zadeh A, et al. Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice. Iran J Allergy Asthma Immunol. 2023;22:452. doi:10.18502/ijaai.v22i5.13995

Vitamin D3 alleviates MS symptoms

We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.

We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.

Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.

Immunity boost

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235 people found this helpful

One capsule daily ensures my immunity is robust against viral diseases. After regular vitamin D3 intake for several years, not a single cold was caught by my family. As someone with a thyroid condition, this supplement is essential; vitamin D deficiency is often linked with Hashimoto's thyroiditis and multiple sclerosis.

Pneumonia details

Effective against pneumonia

I take Vitamin D-3 to support my immune system and defend against colds and pneumonia, confirmed by various documentaries. After years of flu vaccinations and illnesses, my health improved dramatically once I started boosting my immunity, including the use of Vitamin D-3. I haven't been sick in thirty years, affirming its importance alongside other supplements like Vitamin C and zinc.

Rheumatoid Arthritis details

Vitamin D3 reduces rheumatoid arthritis inflammation

Zhu W, Zhu Y, Zhang S, Zhang W, Si Z, et al. 1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. J Steroid Biochem Mol Biol. 2023;228:106251. doi:10.1016/j.jsbmb.2023.106251

We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.

We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.

In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.

By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.

Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.

Improved joint health

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1 people found this helpful

Vitamin D! I can sing praises for this drug! My entire family takes it year-round. My dose is 5,000 IU every other day during autumn to spring, as I have rheumatoid arthritis, and my doctor monitors my vitamin D levels closely. Now Foods offers the best price-quality ratio for this medication. Thank you!

Tonsillitis details

Al-Rawashdeh BM, Altawil M, Khdair Ahmad F, Alharazneh A, Hamdan L, et al. Vitamin D Levels in Children with Recurrent Acute Tonsillitis in Jordan: A Case-Control Study. Int J Environ Res Public Health. 2022;19. doi:10.3390/ijerph19148744

Based on 9 Researches

Vitamin D may reduce tonsillitis

We aimed to understand the link between vitamin D deficiency and recurrent acute tonsillitis in children. In our study, we gathered data from 242 children suffering from repeated bouts of tonsillitis and compared it with a control group of 262 healthy children.

Our findings revealed that the average vitamin D levels were significantly lower in those with recurrent tonsillitis. Through detailed statistical analysis, we discovered that as vitamin D levels increased, the number of tonsillitis episodes decreased. Specifically, for every increase of one unit in vitamin D, we saw a 3.1% reduction in occurrences of tonsillitis each year.

These results strongly suggest that vitamin D deficiency may contribute to more frequent episodes of tonsillitis in children. To further enhance our understanding, we recommend future trials to explore the potential benefits of vitamin D supplementation for those frequently affected by this condition.

Improved immunity

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2 people found this helpful

An excellent drug! It helped me remember what it's like to be well. I used to suffer from tonsillitis frequently, but after this treatment, my health has significantly improved. I highly recommend it!

Allergies details

Vitamin D deficiency linked to allergies

Based on 11 Researches

Akbulut O, Köksal BT, Aydın B, Oznacar T, Haberal A, et al. Does vitamin D deficiency predispose to allergic proctocolitis?. Nutrition. 2025;131:112659. doi:10.1016/j.nut.2024.112659

We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.

We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.

Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.

Energy boost

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91 people found this helpful

I bought this vitamin after struggling with my allergies. After just a week, I've noticed an improvement. My energy is back, allergy symptoms have disappeared, and my mood is more stable.

Arthritis details

Vitamin D aids rheumatoid arthritis

Based on 23 Researches

Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9

We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.

Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.

Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.

Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.

Improved arthritis symptoms

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50 people found this helpful

This is a superb product that has substantially improved my health and well-being. My mood has enhanced, and I no longer require medication for my arthritis. It's also been incredibly helpful during severe colds or flu.

Asthma details

Niu H, He H, Zhao Z, Lu X, Zhao G. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference. Technol Health Care. 2024;32:3985. doi:10.3233/THC-231462

Vitamin D improves asthma outcomes

We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.

To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.

Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.

No more asthma attacks

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27 people found this helpful

!!!! REAL D3 BLOOD TEST RESULTS HERE !!!!. New test results for my Vitamin D3 25-hydroxy levels arrived. I was taking 40,000 IU of a different brand to reach my optimal level (85 ng/mL), but was still too low (43 ng/mL). With this brand of D3, I only need 15,000 IU to achieve the desired level. Under my doctor's supervision, I've discovered that Casein protein in milk products and my low D3 levels were causing my late-onset asthma, especially during exercise and allergies. Since seeing a sports medicine doctor, I have not experienced asthma attacks and have remained healthy for over a year. The advantages of Vitamin D3 alongside the identification of Casein as a trigger have significantly improved my quality of life, from alleviating knee pain to enhancing sleep quality and my outlook.

Cardiovascular Disease details

Vitamin D reduces foam cell formation

Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. doi:10.1530/JOE-24-0056

We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.

Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.

In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.

Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.

Immunity boost

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235 people found this helpful

I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.

Chemotherapy details

Good product to enhance immunity! My family has cancer. Taking this can help him strengthen his immunity, resist the side effects of chemotherapy and electrotherapy, and enable him to complete the entire treatment smoothly.

Cold Sores details

Genetic factors in cold sores

Santamaria P, Bowyer RCE, Nibali L. Associations between host genetic variants and Herpes Simplex Labialis in the TwinsUK cohort. Arch Oral Biol. 2023;145:105587. doi:10.1016/j.archoralbio.2022.105587

We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.

From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.

However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.

Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.

No colds anymore

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6 people found this helpful

This is the best vitamin D3! My three-year-old takes it easily and has not caught a cold or developed cold sores since. It's crucial for our health during troubling times. My purchases from iHerb always arrive promptly in Brazil.

Ear Infection details

Vitamin D reduces ear infection risk

Marchisio P, Consonni D, Baggi E, Zampiero A, Bianchini S, et al. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children. Pediatr Infect Dis J. 2013;32:1055. doi:10.1097/INF.0b013e31829be0b0

We explored the relationship between vitamin D (VD) supplementation and the risk of ear infections, specifically in children who frequently suffer from acute otitis media (AOM). The study involved 116 children with a history of recurrent ear infections, who were randomly assigned to receive either a daily dose of 1000 IU of vitamin D or a placebo for four months. Their number of AOM episodes was monitored for six months after the treatment period.

Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.

We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.

Effective hay fever treatment

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2 people found this helpful

As someone who suffers from hay fever, I found that taking vitamin D has dramatically helped regulate my immune system. This year, I barely needed other medications. After starting my regimen, my symptoms, which once made spring unbearable, have diminished significantly. It's made a noticeable difference.

Epilepsy details

Vitamin D3 improves epilepsy outcomes

Jiang H, Zhang S. Therapeutic effect of acute and chronic use of different doses of vitamin D3 on seizure responses and cognitive impairments induced by pentylenetetrazole in immature male rats. Iran J Basic Med Sci. 2022;25:84. doi:10.22038/IJBMS.2021.60123.13328

We aimed to understand how vitamin D3 affects seizures and cognitive problems related to epilepsy. In our study, we used sixty-six young male rats, dividing them into control and treatment groups. This allowed us to compare the outcomes of those treated with vitamin D3 against our control rats.

We observed that the rats with epilepsy showed notable issues with learning and memory, as their ability to retain information was impaired. Additionally, when exposed to pentylenetetrazole (a chemical that induces seizures), these rats experienced increased seizure duration and decreased latency before seizures. However, interestingly, when we administered vitamin D3, both acutely and chronically, these adverse effects were significantly improved.

Not only did vitamin D3 help reduce seizure severity, but it also positively influenced the levels of antioxidants and inflammatory markers in the hippocampus, a key brain area for learning and memory. Our findings suggest that vitamin D3 can indeed play a beneficial role in mitigating the cognitive and seizure-related challenges associated with epilepsy.

7.5

Critical for epilepsy

Most Useful Review

Vitamin D3 is essential; low levels can cause serious health problems, including epilepsy, strokes, and various cancers. Finding the right dosage varies by individual, but adults should consider 2000-5000 IU daily, while pregnant women may need 5,000 IU. It’s particularly important to supplement during months of limited sunlight to support overall health, especially for conditions like epilepsy.

Heart Disease details

Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. doi:10.30476/ijms.2024.101112.3372

Based on 18 Researches

Vitamin D's role in heart health

We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.

The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.

Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.

Strong immunity support

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235 people found this helpful

One capsule a day ensures effective immunity against various viral diseases. My family, including my children, hasn't had a cold or any viral illness for years, aside from a mild runny nose that resolved quickly. With my thyroid condition, vitamin D3 is essential. Its deficiency is linked to heart disease and other autoimmune issues.

Hyperthyroidism details

I recommend vitamin D for those with autoimmune diseases like hyperthyroidism. Since starting the supplement, I've felt better, experienced less pain, and have more energy. I now sleep well and believe I will recover completely. I was advised to take it by a gynaecologist I met. Surprisingly, no endocrinologist suggested a blood test for my vitamin levels. I take 2 capsules (10,000 units) with vitamin C at breakfast.

Polycystic Ovary Syndrome details

YES, IT WORKS. 10 OUT OF 10. After three months of consistent use, I came to share my honest review: the package arrived in excellent condition. This vitamin D is high quality, supported by my studies. I began taking it due to a deficiency caused by Polycystic ovary syndrome and insulin resistance. I sunbathe daily, but this is insufficient for vitamin absorption. I took one capsule daily for two months, then one every third day. The pearls are small in size, odourless, and tasteless. This could be a superb option for those needing vitamin D.

Prostate Cancer details

Vitamin D may reduce prostate cancer mortality

Based on 23 Researches

Vaselkiv JB, Shui IM, Grob ST, Ericsson CI, Giovannucci I, et al. Intratumoral vitamin D signaling and lethal prostate cancer. Carcinogenesis. 2024;45:735. doi:10.1093/carcin/bgae055

We set out to understand how vitamin D signaling within prostate cancer tumors might impact patient outcomes, particularly the risk of developing lethal forms of the disease. In our exploration, we analyzed data from 404 men with primary prostate cancer over a long follow-up period, assessing specific gene expressions linked to vitamin D in their tumor tissues.

Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.

Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.

Enhances sexual health

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7 people found this helpful

This product has numerous benefits, including improving sperm health, increasing sexual desire, and aiding in achieving erections. Vitamin D3 may help prevent prostate cancer and also promotes bone and joint health. Understanding these benefits makes one fortunate.

Tinnitus details

It worked wonders for me. I had very low D3 and experienced severe vertigo and mild tinnitus. Within two months, both issues improved and disappeared by the fourth month. What a relief! No more spinning rooms or ringing sounds.

Abscess details

Improved thyroid health

Great drug! I began taking this medication for thyroid disease, previously having lower vitamin D levels indicating deficiency. I took 10,000 every day for a month and now maintain 5,000 daily. My thyroid condition has improved significantly, and vitamin D is essential for cell regeneration and immunity. This supplement works well for me and absorbs easily into my body. Overall, I trust this manufacturer for many dietary supplements. 🙏🙏🙏

Bacterial Infection details

Prevents infections effectively

14 people found this helpful

I ensured my son took vitamin D during the pandemic, which proved effective. While my family contracted corona, my son's PCR test was negative. This supplement significantly boosts immunity and improves calcium absorption. I take it every two days, keeping in mind the dosage to avoid liver issues, and I hope it continues to aid our health.

Bruise details

70 people found this helpful

I recommend this! It's an excellent dosage in a convenient capsule. I truly miss the sun in my favourite northern city. My skin appears healthier, the bruises under my eyes have disappeared, and my overall health has markedly improved!

Common Cold details

Based on 7 Researches

Vitamin D reduces cold severity

We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.

Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.

Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.

Strengthened immunity

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564 people found this helpful

This vitamin D3 is simply the best. I have noticeable improvement in my immunity and no more frequent colds. I highly recommend it to everyone!

Eczema details

Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128

Based on 24 Researches

Vitamin D reduces eczema severity

We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.

Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.

Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.

Cleared up eczema

Most Useful Review

103 people found this helpful

I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!

Fibromyalgia details

Vitamin D improves fibromyalgia symptoms

Based on 23 Researches

Ersoy S, Kesiktas FN, Sirin B, Bugdayci D, Paker N. The effect of vitamin D treatment on quality of life in patients with fibromyalgia. Ir J Med Sci. 2024;193:1111. doi:10.1007/s11845-023-03521-4

We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).

After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.

Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.

Boosted immunity

Most Useful Review

The product quality is excellent, with easy-to-swallow capsules. I had a deficiency that was not corrected by sunlight alone, but this raised my immunity and reinforced my bones, helping with fibromyalgia symptoms.

Frozen Shoulder details

5 people found this helpful

I experienced constant lethargy and pain in my shoulder, linked to vitamin D deficiency. After using this product, I felt significant improvement. My shoulder pain subsided, and I highly recommend it, but don't forget to consult your doctor.

Hives details

Vitamin D may alleviate chronic hives

Based on 19 Researches

Yuan I, Katari P, Shaker M. Vitamin D treatment for chronic urticaria: a case report. J Med Case Rep. 2019;13:193. doi:10.1186/s13256-019-2121-9

We explored the intriguing connection between vitamin D and chronic hives, also known as chronic urticaria. This condition involves recurring itchy welts that can be quite frustrating, especially when the triggers are often elusive. In this case, we observed a 14-year-old boy suffering from persistent hives that weren’t responding to conventional treatments. Thankfully, during his medical evaluation, we discovered he had a vitamin D deficiency.

The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.

Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.

Atopy elimination

Most Useful Review

After switching from niacinamide to this vitamin D3 for my child’s atopic dermatitis, the hives and skin irritation disappeared within weeks. The eczema on joints has completely resolved! I am astounded at this transformation after years of suffering.

Psoriasis details

Vitamin D3 ethosomal gel for psoriasis

Based on 13 Researches

Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. doi:10.1038/s41598-024-72951-6

We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.

Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.

The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.

As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.

7.5

Reduced infections

Most Useful Review

281 people found this helpful

Adequate intake of vitamin D3 lowers the incidence of acute respiratory infections, while deficiency increases illness risk and autoimmune conditions like psoriasis. Insufficient cholecalciferol also affects insulin secretion. This supply lasts 120 days and is cost-effective.

Tuberculosis details

Vitamin D improves EPTB treatment outcomes

Based on 12 Researches

Eletreby R, Elsharkawy A, Mohamed R, Hamed M, Kamal Ibrahim E, et al. Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis. BMC Infect Dis. 2024;24:681. doi:10.1186/s12879-024-09367-0

We assessed vitamin D levels in patients with extrapulmonary tuberculosis (EPTB) and evaluated the effects of vitamin D3 supplementation on their treatment.

In our study, 47 EPTB patients received vitamin D3 or standard anti-TB treatment alone. We found that vitamin D levels were much lower in EPTB patients compared to healthy controls.

Those receiving vitamin D3 showed improvements, such as better weight gain, higher albumin and hemoglobin levels, and reduced inflammation markers, suggesting that vitamin D supplementation can enhance anti-TB therapy.

Supports immune function

Most Useful Review

Vitamin D is key for the immune system, supporting both innate and acquired immunity. It aids in producing antibodies that are crucial in fighting tuberculosis. Additionally, it plays a role in the formation of blood cells. It also supports skin health and helps manage autoimmune reactions, making it an essential vitamin for overall well-being.

Ulcer details

Halschou-Jensen PM, Sauer J, Bouchelouche P, Fabrin J, Brorson S, et al. Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial. Int J Low Extrem Wounds. 2023;22:466. doi:10.1177/15347346211020268

Vitamin D3 improves ulcer healing

We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.

Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.

In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.

Quick recovery

Most Useful Review

The Vitamin D3 helped heal my mouth ulcer swiftly.

Adenoiditis details

Very effective vitamin

44 people found this helpful

Excellent budget vitamin D. They are small, don’t get stuck in the throat, are pleasant to drink, and most importantly, effective. 👍🏻👌 Quality is top-notch.

Anemia details

Ahmad Fuzi SF, Su Peng L, Zabaha Zalbahar N, Ab Manan N, Mohamad Alwi MN. Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial. PLoS One. 2022;17:e0265772. doi:10.1371/journal.pone.0265772

Vitamin D3's role in anemia

We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.

Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.

Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.

As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.

Significant vitamin increase

Most Useful Review

1 people found this helpful

My vitamin D rose from 14.2 to 45.3 ng/ml in 8 months, after I started taking 5000 IU alongside Omega-3. I noticed improvements in bone pain, hair loss, and energy levels after starting the supplement. Following my endocrinologist's advice, I adjusted the timing of my intake for better absorption. Vitamin D likely aided my recovery from coronavirus, and I aim to increase my levels further to enhance my health alongside managing my anaemia.

Back Pain details

Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.

Vitamin D3 improves back pain

We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.

Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.

The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.

Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.

Reduced back pain

Most Useful Review

104 people found this helpful

I take vitamin D-3 to support my immune system and noticed significantly less back pain. I used to be ill frequently, but since starting this, I've experienced fewer illnesses. My hair loss has also decreased, with no side effects, and my back pain has stopped. The capsules are small and easy to take.

Bone Pain details

Vitamin D3 correction improves pain

Based on 3 Researches

Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002

We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.

Eases bone pain

Most Useful Review

566 people found this helpful

An ideal solution for those struggling to swallow large capsules. After recovering from COVID, I experienced significant bone pain, but after taking Vitamin D3 for a week, the pain improved. Now my family joins me in taking it.

Breast Cancer details

Schömann-Finck M, Vogt T, Reichrath J. Umbrella Review on the Relationship Between Vitamin D Intake and Cancer. Anticancer Res. 2025;45:855. doi:10.21873/anticanres.17474

Based on 29 Researches

Vitamin D and breast cancer link

We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.

While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.

Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.

Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.

7.5

Fights cancer risks

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12 people found this helpful

The lanolin composition is good. No vitamin impacts health like Vitamin D. Research shows that it may prevent SARS and lowers risks of various cancers, including breast cancer. I bought Vitamin D3 to take during the pandemic. The tablets are easy to swallow, ideally taken with fatty foods. I take 5000 units.

Chronic Fatigue Syndrome details

Vitamin D3 ineffective for CFS relief

Based on 4 Researches

Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial. Nutr Metab Cardiovasc Dis. 2015;25:287. doi:10.1016/j.numecd.2014.10.007

We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.

Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.

In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.

Pain and fatigue relief

Most Useful Review

487 people found this helpful

The Vitamin D helped alleviate my chronic fatigue syndrome. My joints no longer hurt, and I regained energy that had been lacking. I also stopped experiencing frequent headaches, and my nails and hair became stronger. Remarkably, I didn't catch a cold during this period.

Depression details

Vitamin D3 improves depressive symptoms

Based on 30 Researches

USERS' SCORE

Good

Based on 103 Reviews

Kaviani M, Nikooyeh B, Etesam F, Behnagh SJ, Kangarani HM, et al. Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. BMC Psychiatry. 2022;22:694. doi:10.1186/s12888-022-04305-3

We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.

After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.

This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.

Supports depression treatment

Most Useful Review

120 people found this helpful

Vitamin D regulates calcium and phosphorus absorption and enhances immunity, keeping skin youthful and reducing anxiety. With most people deficient, sunlight is insufficient, so supplementation is essential. NOW Vitamin D3 maintains optimal levels in the body. Always consult your doctor before use.

Menopause details

G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. doi:10.52225/narra.v4i1.452

Vitamin D supports bone health

We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.

7.5

Improved symptoms

Most Useful Review

33 people found this helpful

I previously had low vitamin D levels at 11ng/ml, alongside muscle pain, tiredness, and recurrent colds. After using this product, I'm experiencing improvement in these symptoms. Vitamin D also aids in alleviating menopause and PMS symptoms. I purchased it on sale for 18 reais, which is much cheaper than other markets. I live in Minas Gerais, and my orders arrived within 10 days.

Sinusitis details

Vitamin D helps alleviate CRS symptoms

Baruah B, Gupta A, Kumar A, Kumar A. The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency. J Family Med Prim Care. 2020;9:2877. doi:10.4103/jfmpc.jfmpc_448_20

We explored the potential benefits of vitamin D supplementation for individuals suffering from Chronic Rhinosinusitis (CRS), a common condition marked by inflammation of the nose and sinus linings. In a study involving 200 patients with vitamin D deficiency, we divided participants into two groups: one receiving oral vitamin D supplements and the other receiving a placebo.

Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.

This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.

Mood improvement

Most Useful Review

Initially, my vitamin D was at 12. After three months at 10,000 IU, my level increased to 110. I now take 5000 IU, maintaining my levels around 60-65. I’ve noticed significant improvements in my immunity and mood, and I used to suffer from tonsillitis and sinusitis without respite.

Uterine Fibroids details

Vitamin D plays a crucial role in blood minerals, immune regulation, and maintaining bone health. It's needed for metabolism and weight optimization, which is crucial for managing Uterine Fibroids. Having noticed improvements in my overall vitality and mood since taking Vitamin D from November to March, I highly recommend it to others experiencing similar issues.

Corns details

Corns vanished completely

After taking D3 vitamins, I feel that my immune system has strengthened. I had 7.8 corns on the soles of my feet previously. After a month of taking it, I found that they had all disappeared. It's astonishing!

Hypothyroidism details

Vitamin D improves thyroid function

Based on 17 Researches

Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. doi:10.1097/MD.0000000000036759

We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.

The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.

Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.

Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.

7.5

Improved mood

Most Useful Review

4 people found this helpful

The mood has improved, and my TTG has decreased. I have hypothyroidism, and after taking vitamin D, my levels rose, leading to better well-being. A doctor prescribed 50,000 IU (one tablet every other day) for three weeks, with a follow-up on vitamin D levels due to individual digestibility variations.

Influenza details

Vitamin D3 may reduce influenza severity

Based on 20 Researches

Hayashi H, Okamatsu M, Ogasawara H, Tsugawa N, Isoda N, et al. Oral Supplementation of the Vitamin D Metabolite 25(OH)D Against Influenza Virus Infection in Mice. Nutrients. 2020;12. doi:10.3390/nu12072000

We aimed to understand how oral supplementation of 25-hydroxyvitamin D, a key metabolite of vitamin D3, influences influenza A virus infection in mice. In our study, mice were given a diet enriched with a high dose of 25(OH)D before they were exposed to the influenza virus.

The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.

These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.

7.5

Decreases infection rate

Most Useful Review

281 people found this helpful

Adequate vitamin D intake is key to reducing the incidence of influenza and other viral infections. Insufficient levels increase infection rates. This product is cost-effective for a 120-day supply.

Irritable Bowel Syndrome details

Huang H, Lu L, Chen Y, Zeng Y, Xu C. The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Nutr J. 2022;21:24. doi:10.1186/s12937-022-00777-x

Based on 25 Researches

Vitamin D benefits IBS patients

We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.

Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.

Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.

7.5

Vitamin benefits noted

Most Useful Review

I highly recommend continuing vitamin intake, particularly for those with irritable bowel syndrome, as absorption can be poor. This vitamin D supplement from a reputable company offers essential support for gut health, which we often struggle to maintain.

Knee Pain details

Vitamin D3 shows promise for knee OA

Based on 26 Researches

Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0

We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.

Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.

Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.

Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.

Relieved knee pain

Most Useful Review

175 people found this helpful

I ordered this medication in maximum dosage for my grandfather, who experiences knee pain due to his age. It worked well alongside joint support medications, providing excellent relief.

Mild Cognitive Impairment details

Master antidepressant

Wonderful! The primary vitamin-hormone must be taken year-round at proper dosages. It influences over 2000 genes and is vital for our nervous system, often termed the Master Antidepressant. Vitamin D deficiency exacerbates depression, anxiety, and cognitive impairment. Sufficient levels are crucial for overall well-being.

Reflux details

Vitamin D3 reduces early reflux inflammation

Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056

We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.

Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.

Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.

These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.

Effective dosage

Most Useful Review

This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.

Urinary Tract Infection details

Gan Y, You S, Ying J, Mu D. The Association between Serum Vitamin D Levels and Urinary Tract Infection Risk in Children: A Systematic Review and Meta-Analysis. Nutrients. 2023;15. doi:10.3390/nu15122690

Vitamin D linked to UTIs

We set out to explore the connection between serum vitamin D levels and urinary tract infections (UTIs) in children. Our thorough investigation involved a systematic review and meta-analysis of various studies, including 12 case-control studies and a cross-sectional study. This comprehensive analysis incorporated data from a total of 839 children suffering from UTIs and 929 healthy controls.

Through our analysis, we observed that children diagnosed with UTIs had notably lower levels of serum vitamin D when compared to healthier counterparts. The findings indicated that low vitamin D levels were indeed associated with a higher likelihood of experiencing a UTI, with a significant increase in this risk for children whose vitamin D levels fell below 20 ng/mL. Specifically, children with vitamin D levels under this threshold had a much higher risk of developing UTIs.

Overall, our review strengthens the case for considering vitamin D levels as a potential risk factor in urinary tract infections among children, especially when those levels drop below the critical point.

Improved immunity

Most Useful Review

2 people found this helpful

I purchased this vitamin as I lack sunlight. I've felt fatigued and suffered from pain in my back and legs, likely due to vitamin D3 deficiency. After six days of taking it, I noticed increased energy, improved mood, and less pain. It’s beneficial for immunity and may assist in preventing respiratory infections.

Vertigo details

Vitamin D reduces vertigo recurrence

Kong TH, Jung SY, Seo YJ, Shim DB. Vitamin D supplementation in preventing the recurrence of benign paroxysmal positional vertigo. Laryngoscope Investig Otolaryngol. 2024;9:e1225. doi:10.1002/lio2.1225

We conducted a study to see how vitamin D affects the recurrence of benign paroxysmal positional vertigo (BPPV), a condition that can cause sudden bouts of dizziness. Our research was carefully designed as a randomized controlled trial, involving two groups: one received vitamin D supplements, while the other was given a placebo. We specifically focused on patients with low vitamin D levels, as previous evidence suggested they might benefit the most from supplementation.

Over the course of a year, the group receiving vitamin D supplements, at a dosage of 7000 IU weekly, showed significantly better results compared to the placebo group. At the six-month and one-year mark, the participants who took vitamin D not only had raised their vitamin D levels but also experienced fewer episodes of vertigo. The statistics revealed a marked decrease in recurrence rates for those taking vitamin D supplements, highlighting its potential role in preventing this frustrating condition.

In conclusion, our findings suggest that vitamin D supplementation could be an effective strategy for those prone to repetitive BPPV episodes, particularly if their initial vitamin D levels were on the low side.

Resolved vertigo issue

Most Useful Review

Worked wonders. I had very low vitamin D3 and suffered from severe vertigo and mild tinnitus. Within two months, both conditions improved, and by four months, they were gone. What a relief! No more spinning rooms or ringing bells. It's very inexpensive and effective.

Celiac details

NOW® Vitamin D3 capsules significantly improved my general health, supporting bones, immunity, and teeth. The product quality is exceptional, and they don’t contain allergens like gluten. I appreciate how easy they are to consume—only needing one capsule a day with a fat-containing meal.

Chest Pain details

Vitamin D deficiency affects symptoms

Based on 8 Researches

Khater WA, Alfarkh MA, Allnoubani A. The Association Between Vitamin D Level and Chest Pain, Anxiety, and Fatigue in Patients With Coronary Artery Disease. Clin Nurs Res. 2023;32:639. doi:10.1177/10547738221126325

We aimed to understand how vitamin D deficiency (VDD) might influence symptoms like chest pain, anxiety, and fatigue in people living with coronary artery disease (CAD). In our investigation, we collected data from 90 CAD patients, focusing on their vitamin D levels and experiences with these symptoms.

The findings were quite revealing. A significant 80% of the participants were found to have low vitamin D levels. Interestingly, we discovered that lower vitamin D levels were linked to increased chest pain and heightened anxiety and fatigue. Specifically, there were strong negative relationships noted: as vitamin D levels dropped, chest pain, anxiety, and fatigue scores rose.

This suggests that addressing vitamin D deficiency might be an important step for managing cardiac-related symptoms in patients with CAD. As this connection unfolds, it seems valuable for healthcare providers to monitor vitamin D levels in CAD patients and consider interventions to correct deficiencies.

7.5

Joint pain relief

Most Useful Review

12 people found this helpful

This vitamin has greatly improved my health. After two months of taking it, I found it easier to wake up, had more energy, and my joint pain vanished, which was attributed to a vitamin D deficiency. I’ve experienced no side effects, and I'm very satisfied with this product.

Acne details

Hasamoh Y, Thadanipon K, Juntongjin P. Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis. Dermatology. 2022;238:404. doi:10.1159/000517514

Vitamin D's effect on acne

We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.

Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.

This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.

Clear skin achieved

Most Useful Review

362 people found this helpful

These vitamins have greatly satisfied my body. Due to my thyroid issues, I often battled acne. Since taking these supplements, I've experienced no breakouts at all, even the minor ones. Overall, my condition has improved significantly.

Autoimmune Disorder details

Vitamin D3 modulates autoimmune response

Based on 25 Researches

Zhang Q, He X, Chen W, Jiu J, Gao C, et al. Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis. Immunol Lett. 2024;269:106890. doi:10.1016/j.imlet.2024.106890

We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.

Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.

Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.

Enhanced well-being

Most Useful Review

264 people found this helpful

My analysis confirmed that this product effectively raises vitamin D levels. I have noticed a significant improvement in my immune system, with only mild ARVI symptoms over three years. My energy and overall activity have increased as well. With 120 capsules per pack, it's long-lasting and convenient to take with breakfast.

Cancer details

Vitamin D3 offers anti-cancer benefits

Based on 14 Researches

Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. doi:10.3389/fimmu.2025.1529007

We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.

7.5

Supports cancer treatment

Most Useful Review

4809 people found this helpful

Vitamine D is crucial for bone health and has anti-cancer benefits. If your 25 (OH) D level is 20 or less, it's advisable to start with 5000 IU daily. For levels 21-30, take 2,000 IU, and if it's 31-40, take 1000 IU daily. After three months, retest. The optimal level is 50-70. Vitamin D supplementation raises levels effectively without odour. Sunlight aids production, but sunscreen can hinder it. This supplement has improved my health significantly. Happy shopping!

Liver Disease details

Derogar Kasmaei SR, Parastouei K, Hosseini Ahangar B, Saberifiroozi M, Taghdir M. Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial. BMJ Nutr Prev Health. 2024;7:e000938. doi:10.1136/bmjnph-2024-000938

Vitamin D improves liver health

We explored the effects of vitamin D supplementation in patients with liver cirrhosis—a progressive disease that often manifests alongside vitamin D deficiency. In a carefully designed study, we involved sixty patients who participated in a double-blind, randomized controlled trial. Each patient received either a weekly dose of 50,000 IU of vitamin D or a placebo over 12 weeks.

Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.

Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.

Essential for thyroid

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4 people found this helpful

Having thyroid diseases, vitamin D is an essential daily supplement for me. It's crucial because Hashimoto's autoimmune thyroiditis is linked to vitamin D deficiency. It aids calcium absorption and contributes to the health of the thyroid, skin, hair, and nails. We take it daily and I highly recommend it!

Premenstrual Syndrome details

210 people found this helpful

With regular intake of vitamin D, I noted a reduction in drowsiness and apathy during winter months, making it easier to wake up. I felt less tired; previously, I experienced chronic fatigue, but this began to improve after a month of taking vitamin D. There was also a decrease in chronic pain in injured joints, improvement in skin condition, mood enhancement, and more regular cycles with milder PMS symptoms. My child and I have caught colds less frequently, and the herpes on my lips appeared less often.

Cholecystitis details

5 people found this helpful

Perfectly raises the level of D3! The best product for mastering D3! It effectively addresses an acute deficiency in conjunction with fat-containing food, taking care to avoid gallbladder problems. Initially, I took 10,000 IU for two months, then transitioned to 5,000 IU. During summer, I take one 5,000 IU capsule every other day and plan to revert to daily 5,000 IU in autumn. Wishing everyone good health; I hope my review is helpful!

Pelvic Pain details

Eliminated pelvic pain

6 people found this helpful

After pregnancy, I had low levels of vitamin D3. Thanks to a 5000 IU dosage, my vitamin D3 level increased from 10 to 39, which improved my well-being; the pelvic pain and joint pain in my hands stopped. I wholeheartedly recommend it!

Blood Clot details

Vitamin D counteracts blood clotting

Cimmino G, Conte S, Morello M, Pellegrino G, Marra L, et al. Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?. J Cardiovasc Dev Dis. 2022;9. doi:10.3390/jcdd9010027

Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.

Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.

Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.

Cramps disappeared

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2 people found this helpful

My vitamin D level was only 11 ng/ml, but after just a month of taking this supplement, it rose to 35 ng/ml and my leg cramps vanished. I highly recommend it.

Migraine details

Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. doi:10.1016/j.ajem.2021.07.062

Based on 29 Researches

Vitamin D helps reduce migraines

We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.

Reduces migraine frequency

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4 people found this helpful

Possibly reduced the frequency of my migraines. I started taking this D3 supplement in late 2009 after a blood test showed low vitamin D levels. My migraines, which had been frequent for 17 years, became less frequent while taking this supplement. After running out, they returned to their previous frequency. I'm convinced this vitamin D helps, so I’ll continue taking it and monitoring my levels.

Obesity details

Vitamin D reduces triglycerides effectively

Based on 12 Researches

Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226

We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.

Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.

Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.

Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.

7.5

Improves obesity issues

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235 people found this helpful

Vitamin D3 deficiency is prevalent and affects many people. It can arise from various factors such as poor sunlight exposure and genetic issues. When taking vitamin D, start with small doses if you have anaemia. It’s advisable for seniors with gastrointestinal issues to use sublingual forms for better absorption. For breastfeeding mothers, ensure optimal levels before dosing infants. Those with obesity may need nearly double the recommended dose, and adequate levels of magnesium and vitamin A are vital.

Rash details

Rash on back reduced.

101 people found this helpful

Drowsiness and increased fatigue have disappeared since I started taking this vitamin. Despite working long hours with little sleep, daytime sleepiness faded quite quickly after I began the treatment. My fatigue is easier to manage now. Vitamin D3 improves not only my physical but also my mental wellbeing. Additionally, the condition of my skin has improved; each time I take vitamin D, the rashes on my back, which have troubled me due to lack of sunlight, vanish.

Swollen Lymph Nodes details

Great dosage! The endocrinologist prescribed it, and I donated blood for vitamin D, finding a significant shortage close to critical levels. Now, vitamin D3 feels essential. With it, the swelling from my swollen lymph nodes subsided, I started losing weight, and my hair loss decreased significantly, with new hairs sprouting. Most importantly, my fatigue vanished, and I began to feel much better. Thank you.

Kidney Stones details

Vitamin D's limited effect on kidney stones

Based on 9 Researches

Sardari Masihi L, Borumandnia N, Taheri M, Basiri A, Imani H, et al. Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial. Eur J Med Res. 2023;28:246. doi:10.1186/s40001-023-01226-z

We conducted a clinical trial to explore how different vitamin D treatment protocols affect kidney stones in patients who frequently experience them and have low vitamin D levels. We involved 62 participants, all with serum vitamin D levels between 10 to 20 ng/ml, and split them into two groups: one received 2000 IU of oral vitamin D daily for 12 weeks, while the other took 50,000 IU weekly for 8 weeks.

Our results showed that both treatment approaches led to a significant increase in 24-hour urine calcium. However, we observed no notable difference between the two therapies regarding this measure. Importantly, while there was an increase in 24-hour urine calcium, neither treatment affected the supersaturation levels of calcium oxalate or calcium phosphate, which are critical in the formation of kidney stones.

We also noted a significant rise in serum 25-hydroxyvitamin D levels, with the weekly regimen showing a greater increase. Alongside these changes, parathyroid hormone levels decreased in both groups. Ultimately, while vitamin D supplementation did elevate urine calcium levels, it did not enhance supersaturation factors that contribute to kidney stone formation, indicating that the benefits of vitamin D in this context may be limited.

Recommended care

Most Useful Review

6 people found this helpful

Verified option! This vitamin D is proven to be beneficial, but it should be taken with vitamin K2 to prevent kidney stones. Additionally, magnesium is necessary for optimal absorption. While many are deficient in vitamin D, it's wise to get tested to determine the right dosage and duration. Stay healthy!

Diarrhea details

No significant benefit from vitamin D3

Based on 14 Researches

Aluisio AR, Maroof Z, Chandramohan D, Bruce J, Mughal MZ, et al. Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial. Pediatrics. 2013;132:e832. doi:10.1542/peds.2012-3986

We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.

Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.

However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.

Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.

Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.

Improved condition

Most Useful Review

Excellent! I took this vitamin as I have a deficiency. My doctor mentioned that this type of diarrhoea is beneficial. I've started taking the vitamin, and I find the capsule easy to swallow, which I appreciate.

Insomnia details

Sharifan P, Khoshakhlagh M, Khorasanchi Z, Darroudi S, Rezaie M, et al. Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial. Food Sci Nutr. 2020;8:4484. doi:10.1002/fsn3.1750

Based on 5 Researches

Vitamin D benefits for insomnia

We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.

In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.

Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.

In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.

Improved sleep quality

Most Useful Review

87 people found this helpful

I had a significant lack of vitamin D, leading to lethargy, apathy, and insomnia. When I discovered my low levels, I started taking these small capsules. There were no side effects, and my condition began to improve. I now take one capsule daily with my family and can sleep better.

Sleep Apnea details

Vitamin D3 improves mild sleep apnea

Ayyıldız F, Yıldıran H, Afandiyeva N, Gülbahar Ö, Köktürk O. The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome. Turk J Med Sci. 2021;51:2524. doi:10.3906/sag-2101-83

We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.

By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.

Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.

Improved sleep quality

Most Useful Review

130 people found this helpful

I found melatonin and niacin from iHerb effective for my severe sleep apnea, allowing me to withdraw from strong benzo medication. After starting vitamin D, my sleep quality markedly improved, and I could sleep through the night without frequent awakenings. Despite my daily sun exposure, I now realise the significant role of vitamin D in stabilising my mental health and enhancing sleep.

Dizziness details